TLecuitLab
@LecuitLab
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How are biological forms encoded? GL @IBDMmarseille , director of Turing Center for living systems @centuri_ls . Professor at Collège de France @cdf1530
Marseille, France
Joined August 2017
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Check this new Review from our group. It has been a great pleasure to work through this large set of articles from the litterature and to offer a different perspective on the nature of morphogenetic information comprising biochemistry, mechanics and geometry.
Fresh from press
#Review
by Claudio Collinet and Thomas Lecuit discussing how tissues are shaped during development - program versus self-organization
@LecuitLab
@centuri_ls
@cdf1530
#morphogenesis
#development
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Check our new paper revealing self-organising properties of dendritic neuron morphogenesis. Wonderful collaboration between Amrutha
@a_palavalli
and Jean-François Rupprecht and Nicolas Tizon at
@centuri_ls
.
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Our newly published paper by
@BDehapiot
et al is now out in
@NatureCellBio
. The Formin Frl/Fmnl regulates cell deformability during epithelial morphogenesis. A persistent actin network tunes the range of deformations induced by pulsatile contractions.
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Live dynamics of branching morphogenesis in a dendritic neuron
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Last dosa and coconut chutney for breakfast 😋 before leaving tonight…
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Very pleased to share this new review
@AnnualReviews
, "Mechanochemical principles of spatial and temporal patterns in cells and tissues". Congrats to
@AnaisBailles
and Emily Gehrels for a huge amount of work. 10.1146/annurev-cellbio-120420-095337. Enjoy & hope it will be useful!
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Leaving
@IISERPune
with amazement and gratitude. The research done by so many curious and talented students is impressive🤩. Do visit them! Thank you so much Richa Rikhy (couldn’t find you on Twitter?) for being such a wonderful host, for science, drinks/meals & more 🙏🏼😊
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On my way for 10 days in India, TIFR Mumbai,
@IISERPune
and
@NCBS_Bangalore
&
@DBT_inStem
:
@cdf1530
lectures and research seminars. Looking forward to meeting many new people + visiting friends and collaborators. See you soon 😊
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Please RT: For those living in Paris, or willing to come and visit Paris for 1-2 days, here is an important announcement. Rob Phillips will give a series of 4 lectures at the Collège de France on Mondays 9, 16, 23 and 30 May. It's free, no registration needed. Just come and enjoy
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Here is the link to Rob Phillips' 1st lecture
@cdf1530
It introduces a view of quantitative biology, culminating in a definition of understanding that can answer the question of what sets the scale of sizes, time scales, concentrations, rates, energies etc
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Excited to share some recent movies we made using the amazing foldscope! Simple lenses combined with folded paper are enough to discover the beauty of a hidden world! Hereafter: zoospores released from green algae that we collected in the Calanques. Enjoy!
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This jackfruit from
@NCBS_Bangalore
definitely gastrulates and undergoes endoderm invagination!
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The
@NCBS_Bangalore
campus is a gem, one of the most beautiful I know, yet it is pale in comparison to the science! Exciting discussions with different people eg. here with Mukund
@thattai
and students on information flow and evolution of trafficking 🤩
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Bye TIFR Bombay, and the great discussions with students over their work, the course and seminar, and meals! Thank you 🙏🏼 Maithreyi Narasimha for being such a great host 😊. I will come back 🤩
Now at
@IISERPune
for the next blast 💥
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On my way to Bangalore
@NCBS_Bangalore
, first long trip in 2 years, looking fwd to giving 1
@cdf1530
lecture and 2 research seminars, visiting friends
@jitumayor_lab
and Madan Rao, meeting new people, and, may be eating fresh indian mangoes🥭 (the best!)
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Please RT PhD position offer: We are looking for an outstanding student willing to work in interdiscliplinary environment
@LecuitLab
,
@centuri_ls
and
@IBDMmarseille
. Fully funded position by ERC (
@ERC_Research
) grant. Send application by email: thomas.lecuit
@univ
-amu.fr
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Every time I hear about Mangold & Spemann I am reminded of the forgotten contribution of Ethel Browne 15 years before them. See: DOI: 10.2307/1542490. Original paper: Browne, E. 1909. The production of new hydranths in hydra by the insertion of small grafts. J. Exp. Zoo/. 7: l-37
A great event is coming up: the celebration of the 100th anniversary of the Mangold & Spemann experiment. Stay tuned for the news here.
'Spemann-Mangold at 100: An interview with Eddy De Robertis
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Here is the link to (almost) all talks at the conference on cell motility organized
@cdf1530
. We had a wonderful time hosting this awesome group of scientists. We are happy to share this resource. Have fun!
@CellMigration
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30 years ago, then 20 years old, I was lucky enough to do an internship in Claude Desplan's lab at Rockefeller Univ. This was a turning point. I discovered how much fun and exciting life in a lab can be + the huge importance of a great mentor. Thank you Claude! 🙏😀
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Release🤩: Great collaboration btw
@EmilyGehrels
& Bandan Chakrabortty,
@MatthiasMerkel1
,
@PNASNews
Tissue flow critically depends on curvature of the embryo. This geometric information, coupled to genetically patterned mechanics orient morphogenesis.
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6 new lectures on cell motility. 9th Nov: Principles of cell motility: I will explain how physics constrained motility from prokaryotes to eukaryotes.
Followed by 3 lectures on Mechanics of crawling in 2D, 16 Nov, in 3D confinement, 23 Nov, and of swimming & also walking, 30 Nov.
#Biologie
🦠
"Motilité de cellules uniques" : c'est le titre du cours 2021/2022 du Pr Thomas Lecuit
@LecuitLab
(chaire Dynamiques du
#vivant
)
⏰ 1er cours le 9 novembre prochain à 10h !
Accès libre et gratuit 😊
👉
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Happy Diwali! 🔥 Pictures from 11 years ago in Bangalore,
@NCBS_Bangalore
hosted by
@kvijayraghavan
,
@jitumayor_lab
and Madan Rao. Great memories.
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Please RT: Announcement for a conf. on cell motility organized with JF Joanny on 13-14 June
@cdf1530
in Paris. Awesome list of speakers here: . It's free, no registration. Video recording online soon after for those from far away.
@CellMigration
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10 years ago, came back from 1 year sabbatical at NCBS
@NCBS_Bangalore
to initiate collaborations with
@jitumayor_lab
and Madan Rao
@NCBStheory
. A life changing experience scientifically and personnaly. Thank you! I encourage everyone doing a sabbatical at some point.
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Thank you Manu for who you are! A wonderful and inspiring interview of
@PrakashLab
. « I want to turn stones » Just Curious | STANFORD magazine
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~20 years ago we discovered that planar polarized contractility drives junction remodeling in fly embryos. This is conserved in vertebrates.
In new article , Sanjay and Mehdi show that Serotonin signaling controls MyoII activation in both systems. Enjoy🤩
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Excited to share our newest article 👉
led by terrific
@StefanHarmansa
(expts) and Alex Erlich (theory). Growth and Form in developing wings.
Key finding: Geometric frustration due to mismatch in growth anisotropy of ECM and tissue drives shape changes 🤩
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Video and pdf of course 1
@cdf1530
available 👇.
#CellMigration
. Text in english . Don’t hesitate to use, transform for your own teaching.
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Here is the announcement of my new series of lectures
@cdf1530
on "Collective cell motility". Stay tuned. The videos will be available online within 48h, pdf accessible for download as usual. Slides and pdf in English, the course in French. Good to practice your bilingualism!
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I have a good news: The video of Rob Phillips' lectures will be available online at the Collège de France website. The link will be sent a couple of days after each lecture. Stay tuned!
Please RT: For those living in Paris, or willing to come and visit Paris for 1-2 days, here is an important announcement. Rob Phillips will give a series of 4 lectures at the Collège de France on Mondays 9, 16, 23 and 30 May. It's free, no registration needed. Just come and enjoy
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Reunion of 3 ex-Princetonians: Sashi Thutupalli
@stpalli
, Tapomay (Tapa) Bhattacharjee. Great discussions, amazing work on synthetic evolution of yeast, bacterial motility etc. Go visit
@NCBS_Bangalore
! A source of inspiration everytime I visit.
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Thrilled to share our latest work on how the Frl formin and a persistent apical actin network impact epithelial cells deformations upon pulsatile contractility
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Save the dates! June 19th-20th
@cdf1530
in Paris, two symposium in series on ‘Growth and Form’ (org.
@LecuitLab
) and ‘Embryonic Timing’ (org.
@Duboule
). Open to everyone, free access. Programs below.
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Legend Masatoshi Takeichi at
#InSDB
on the history of adhesion and Cadherin discovery 🤩 Thank you 🙏🏼🙏🏼
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Next year, Jean-François Joanny and I will prepare our lectures in tight connection: cell motility, focussing on single cell mechanics and information decoding, comparing strategies accross scales, from prokaryotes to eukaryotes. Year after, collective motility. Stay tuned.
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Biological self-organisation at its best! 🤩
Here's the hypnotic time-lapse I used : Dictostelium cAMP signal waves are in gold🟧 and nuclei in Blue🟦, enjoy!
I used the dataset from this paper :
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Rob Phillips kick-starts the Colloque Francois Jacob
@cdf1530
today on The Mathematical Beauty of the Living. Talks will be available online soon.
Fantastic line of speakers showing how mathematics pervades in biology accross scales
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New lab pic!! We welcome great new colleagues: postdoc Soichi Hirokawa from CalTech/Rob Phillips (arrow), Patrick Breier (top right) from Dresden, master w.
@StephanGrill
, &Kaïna Roche, master intern (in front of Soichi). Wonderful, diverse team! 🙏🏼 for joining us! 🤩
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Really so nice to meet former PhD student
@akankshi
Munjal at
@NCBS_Bangalore
before heading back to France🤩. This is where we met 12yrs ago while on sabbatical. Many things happened since then. Now head of terrific
@MunjalLab
at Duke University 👏👏👏
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A great example of many invigorating meetings while
@IISERPune
. Very beautiful work by
@MabelMathew_M
in
@kalikapg
lab on self-organisation during plant regeneration👏: .
+stunning art work on cover 😊
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Our story on MyoII waves shaping endoderm morphogenesis is now online at
@Nature
. Check it out!
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Goodbye Bangalore, friends and colleagues
@NCBS_Bangalore
. What an intense and rejuvinating week! Met many great people, learned a lot, had fun, and enjoyed delicious food. See you soon and thank you all 🙏🏼😊
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Really excited to head to Brussels for 1st Solvay Conference on Biology, co-chaired with
@briscoejames
, Frank Jülicher, Ed Munro,
@PrakashLab
& Aleks Walczak. 23 wonderful colleagues will join to discuss and delve into the central pb of information processing & computation.
🧵
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Arts and Science at TIFR Bombay. Paintings all over the place from the entrance to the labs… Great community, great campus, a wonderful place to visit! 🤩
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Today I plounge in deep waters as I turn 50. What a scientific gift to host a conference on such an inspiring topic.
I feel in middle of the ocean, 20 years since I started my group, 20 years from retirement. No shore nore island in sight. The adventure goes on more than ever! 😊
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Stationary waves (created by wings?) and traveling waves (induced by leg motion). PS: the bee was rescued and is safe!
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Rob Phillips in action with students & postdocs
@centuri_ls
#PhysicalBiology
of the Cell course in Marseille.
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This movie very nicely illustrates this really great paper from
@PrakashLab
. DOI: 10.1016/j.cub.2019.09.034. Coupled Active Systems Encode an Emergent Hunting Behavior in the Unicellular Predator Lacrymaria olor.
This microscopic creature is called Lacrymaria olor & can stretch its neck 7 times the length of its body to catch prey!
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Here is the link to the 2nd great lecture by Rob Phillips
@cdf1530
. Rob addresses the notion of "sameness" in biology, revealed by the conceptual framework of physics and mathematical language. Allostery and Boltzmann distributions as an illustration...
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Please RT. We are looking for a PhD student in physics or CS to develop modeling of stochastic branching dynamics in dendritic neurons in collaboration between
@JFRupprecht_OM
and our group🤩. More info 👉
Please reach to us by email if you are interested.
Ready… Set… Start ! 🏁
CENTURI is launching the 2024 edition of the PhD call! 📣
8 open PhD positions available!
⏰Applications open until February 15
🎙️Interviews via zoom on April 10-11
Check all our projects here!
#interdisciplinarity
#call
#phd
#job
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Visiting the toilets at Isaac Newton Institute … Interesting 😁
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Great way to complete my visit to Bangalore with Madan Rao from
@NCBS_Bangalore
and Vijay Krishnamurthy from
@ictstifr
. Wonderful colleagues, collaborators and friends 🤩.
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Looking back at 6 years of teaching
@cdf1530
, I focussed on 3 big topics: Cell and tissue SHAPE🦋🐚 (2017, 2018), Cell and tissue SIZE📏🦣🦠(2019, 2020) and single & collective cell MOTILITY🐌🐎(2021, 2022). Next year, I plan to address the concept of biological INFORMATION...
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« Ceci n’est pas une mouche »
Photoactivated fly on a fly by Florencia Di Pietro
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Paper accpetance celebration for
@ClaudioCollinet
and
@AnaisBailles
! 🍾🤩 Huge congratulations for this terrific collaboration. This is the follow up of
Link to original submission here. Details will follow soon !
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Fantastic talk
@centuri_ls
from Kinneret Keren on Hydra regeneration: organizer, mechanics, nematic order, biochemistry.
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Week-end escape in the Calanques, the first in a long time, enjoying almond trees blossom. Wonderful...
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Biologists should be reminded of this statement, as so many experiments fall in the first category ("consistent with...").
There are two possible outcomes: if the result confirms the hypothesis, then you've made a measurement. If the result is contrary to the hypothesis, then you've made a discovery
— Enrico Fermi
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We are excited to share the publication of this collaborative work by Jules
@J_Lavalou
, Qiyan Mao and colleagues. The study addresses how Toll signalling controls interfacial contractility via the adhesion GPCR Cirl/Latrrophilin. Enjoy!
New Article online now at Dev Cell: Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry -
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Time to close 10 terrific days
@TIFRScience
Bombay,
@IISERPune
and
@NCBS_Bangalore
. A real blast: students are amazing, playful yet serious. Heartful thanks to all my hosts, + Institut Francais. I feel at home here. See you next year!
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Here is the translation of my inaugural lecture at the College de France. Direct access to the text here:
[New Book] Thomas Lecuit's inaugural lecture, "The
#Dynamics
of Living Systems",
@EditionsCdF
, is now available in English in
#openaccess
freemium:
#LifeScience
#biology
#biophysics
#genetics
#morphogenesis
@OpenEditionNews
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Video of 1st course
@cdf1530
available 👉 + pdf of slides. I introduce principles of collective dynamics starting with Toner-Tu model of herding/swarming, addressing then how collective cell motion arises at high density in spite of adhesion. Enjoy +share!
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Open
@cdf1530
@Duboule
@LecuitLab
and
@embl
joint Webinar on ‘Constraints and Plasticity in Development and Evolution’ by June 3-4. Program:
. Registration: .
@the_Node
@TLM_Cambridge
#ParisInJune
. Please RT
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This is an opportunity to re-read the best manifesto I know of curiosity driven research.
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Starting in 30 min for the in person and online Zoom audience! Great line of speakers. We will start with Keynote from Jean-François Joanny
@cdf1530
!
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Look at the happy faces! Physicists say: « I learn biology lile I never did before ». Biologists add: « I learn physics lile I never did before ». Thank you Rob and Soichi!
#PhysicalBiology
of the Cell
@centuri_ls
2022
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Spectacular cannon ball tree (Couroupita guianensis) at NCBS today. The scent is equally amazing…
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An exciting paper from Bastiens lab showing the importance of geometric feedback in (cell) morphogenesis. This point is addressed at the tissue scale in our recent review on self-organization. Same concept accross scales.
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Lewis pioneered the study of cell mechanics in development (67), revolutionised developmental biology by introducing the concept of positional information (69). His contributions continued on and on. We will miss the company of a man full of wit and humour, and a wonderful person
I am very sad to hear that the great developmental biologist Lewis Wolpert died this morning at the age of 91. He was a giant in my field, and will be missed.
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New course from earlier this available 👇 My course on Mechanics of cell crawling on 2D substrate:
and Jean-François Joanny's course on Physics of cytoskeleton in the context of cell motility
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The content of past courses is now available on YouTube. The courses from past 6 years are on Cell/tissue Mechanics💪, Cell/tissue Growth🦟🐘and Cell/collective Motility🦠🏎️. pdfs in English ➡️. Videos on YouTube in French: subtitles are bit rough but help.
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This week´s courses
@cdf1530
on the mechanics of cell motillity: I addressed how cells swim (and walk!), video and pdf here: ,
Jean- François Joanny’s course was on lamellipodes and keratocytes, video and pdf here:
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Group Leader positions open to
#ECR
to join the
@IBDMmarseille
community! Please RT. We study developmental biology, in an interdisciplinary setting
@centuri_ls
, a fantastic campus, and strongly supportive environment. More info here:
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Super exciting talk today
@centuri_ls
from
@BaumBuzz
@lab_baum
on cell division in Archea. How do cells go through the cell cycle and divide without cdk/cyclins? Thanks for visiting us!
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Congratulations to the 2 collaborating heroes of this work,
@ClaudioCollinet
and
@AnaisBailles
who discovered originally this self-organized morphogenetic wave in Drosophila, and delved deeper to reveal the underlying mechanochemical underpinnings. 👋👋👋
It’s out!
Learn how a self-organized wave of adhesion, contractility and de-adhesion is mechanically regulated at the cellular scale.
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Here is another view if our renovated building in our gorgeous campus…
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How many “instruments “ do you count in this bird symphony 🎶🦜
@NCBS_Bangalore
? Help: I’d be curious to know their name, and how they look. 🙏🏼
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Wonderful time for science and drinks with friends and colleagues at
#EMBOlivingsys23
@PoLDresden
! 🤩
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Congratulations Pierre Ronceray, Group leader
@centuri_ls
for being awarded an ERC StG in biophysics.
🍾🥂👏👏👏
Can’t wait to see what will follow!
@univAMU_Europe
@INP_CNRS
🎉 The latest ERC Starting Grant competition results are out!
400 bright minds have been awarded over €628 million to fund ideas at the frontiers of science & scholarship.
Find out who, where and why 👉
🇪🇺
#EUfunded
#FrontierResearch
#ERCStG
@HorizonEU
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Yes, this is what a number of scientists interested in development and morphogenesis like us and many others from cell biology to biophysics have been advocating for 20 years: neither in genes nor in cells alone but accross scales, through feedbacks and integration!
Yes! This is what biology needs - without privileging any one of those levels. Causation works in all directions.
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Please RT,
#JobOffer
@centuri_ls
| CENTURI
#PI
Call 2022 open for applications!
Looking for an exciting, creative, interdisciplinary and collaborative place to work? Do apply.
More details on the offer ⬇
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