FrezzaLab
@FrezzaLab
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We are a group of metabolism-lovers, focused on mitochondrial metabolism. Tweets are from Christian. https://t.co/EbWsJo6DnZ
Koln, Germany
Joined December 2017
This is a topic I am very passionate about, and something I am learning every day. I hope you will enjoy the read, and you will find it useful. Happy to hear your views about the topic. The mindful scientist #FEBSnet.
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I am thrilled to announce that the Frezzalab will join the @CECAD_ @UniCologneNY as @AvHStiftung professor in October. I am sad to leave Cambridge and the wonderful colleagues I met here, but also incredibly excited to start this new adventure in Cologne.
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Happy to share the results of our collab with @LabPrudent, led by @vincentZecchin1 and Vincent Paupe @Nature ! We show that Fumarate drives mtDNA release in the cytosol via mitochondrial-derived vesicles (MDVs) to trigger innate immunity!
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I am honoured to have been awarded the #AvHProfessorship. This is testament of the great work of the lab members over the past years. A huge "thank you" to @CECAD_ for sponsoring and supporting me on this endeavour.
šCongratulations to Christian Frezza @FrezzaLab to be awarded a #AvHProfessor. Appointment negotiations are ongoing and we hope to see him soon at our #AgingResearch campus @CECAD_ @UniCologne.
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Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired.
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Here it is. @Alestang01 and I are flying to Cologne. It is not easy to move, especially during a pandemic, Brexit, and a fuel shortage. And moving the lab. But we are getting there. See you on the other side!
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"Cellular ATP demand creates metabolically distinct subpopulations of mitochondria".
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Mitochondrial shape alteration by metabolites | Nature Cell Biology
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Nucleotide imbalance decouples cell growth from cell proliferation | Nature Cell Biology
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We have discussed many times what it means to leave your own country for a job in science. Here are my thoughts, inspired as always by many friends, including @alesposito75 @Pluchinolab @Alestang01 and all my lab members. Leaving home for science #FEBSnet.
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We are very proud to present our latest work and first preprint, a tour de force driven by Dylan Ryan. A short š§µ below. Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
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In academia, you often hear "I love my job" as self-justification for enduring despite instability, long working hours, and low-paid job, to the great advantage of the employer. Why can't it be considered a normal job? This narrative has to change.
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This is an interesting protocol for rapid fractionation of mitochondria from @Mito_Redox with some help from us @ASofiaHCosta . Rapid fractionation of mitochondria from mouse liver and heart reveals in vivo metabolite compartmentation
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. and here the paper, a milestone for the field! . Manipulating mitochondrial electron flow enhances tumor immunogenicity | Science
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Lactate: the ugly duckling of energy metabolism | Nature Metabolism
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CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH
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Hi everyone! The official advert for the immunometabolism position in our lab is now out. To all freshly minted PhD and postdoc, please, apply here if you have experience in macrophage biology and metabolism, we need you!.there is a really exciting project waiting for you!
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I am incredibly happy to share this work from our lab and @saezlab, and a lot of fantastic collaborators. We hope you enjoy it!. Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression | Nature Communications
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A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements | Nature Metabolism
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"Experiments suggest a 10Ā°C temperature difference between the mitochondrion and its surroundings in a millionfold disagreement with steady-state theoretical estimates." whoa, that's a statment. millionfold! .
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A question I had since I started to work on this. Is mitochondrial morphology important for cellular physiology?: Trends in Endocrinology & Metabolism
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A masterpiece from the Chandel lab. "Mitochondrial integrated stress response controls lung epithelial cell fate".
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Metabolic communication in the tumourāimmune microenvironment | Nature Cell Biology
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A must-read review about targeting metabolism in cancer. Great job @SchugLab & the reset. Targeting cancer metabolism in the era of precision oncology | Nature Reviews Drug Discovery
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CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity | Nature
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Hi all, thanks to funding through the @CRC_1218, we are recruiting a PhD student to work on the role of FH in mitochondrial physiology within a fantastic group of mito-experts. Please contact us if interested. šš
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"Mitochondrial ATP generation is more proteome efficient than glycolysis".
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Identification of an alternative triglyceride biosynthesis pathway.
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Congrats @Caroline_Bartma & the rest of the Rabinowitz lab, a must read for the cancer metabolism field. Slow TCA flux and ATP production in primary solid tumours but not metastases | Nature
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This is a must-read review from @RutterLab . Metabolites as signalling molecules | Nature Reviews Molecular Cell Biology
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The pentose phosphate pathway in health and disease. A must-read from Tara Tesla and Josh Rabinowitz, Jing Fan, and @RalserLab.
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whoa, what a day. a milestone for mitochondrial biology in cancer from the Shackelford lab!
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In case you missed it, I find this a masterpiece. Cause and Effect in Biology | Science . I think that misinterpretation of causality is one of the biggest problems in biology (and probably medicine.
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As anticipated by @DylanRy1937, here is his masterpiece where we described the consequences of the inhibition of the TCA cycle enzymes FH and SDH. Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
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Some of you may have noticed we moved to @CECAD_ a few months ago and I want to introduce our new team, jumping into this new adventure. A huge welcome to our Lab Manager Desiree Schatton, Lab Technician Monica Cremades Rodelgo and our student Karina Polkovnychenko.
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We are excited to share our paper about a new player in the anti-oxidant response triggered by Fumarate Hydratase loss, FOXA2. Big congratulations to @doctorconnor, who drove this project!. FOXA2 controls the anti-oxidant response in FH-deficient cells.
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Ferroptosis of tumour neutrophils causes immune suppression in cancer | Nature
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We are delighted to share our new pre-print on the metabolic reprogramming during renal cancer progression. [1/7]. Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression
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It is with great pleasure that I present this review written with two stars in the field of cancer metabolism @FendtLab and @AyeletErez. Enjoy and feedback!. Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy
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I am in!. An open invitation to the Understudied Proteins Initiative | Nature Biotechnology
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are we writing grants for doing the science, or we do science to get grants? š¤.
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100 years of the Warburg effect: A cancer metabolism endeavor: Cell directly from Sara @FendtLab.
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Cell size is a determinant of stem cell potential during aging
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Do you think it is possible that with all this single-cell sequencing we will end up showing that there is no two equal cells in the body?.
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Very interesting and relevant article for new PIs. It also includes a TCA-cycle-like scheme about how to develop research. Running a research group in the next generation: combining sustainable and reproducible research with values-driven leadership
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Visualization of cristae and mtDNA interactions via STED nanoscopy using a low saturation power probe.
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Mechanisms driving the immunoregulatory function of cancer cells | Nature Reviews Cancer
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Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress: Molecular Cell
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The mitochondrial pyruvate carrier regulates memory TĀ cell differentiation and antitumor function
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it is a bit embarrassing to see me in a video, but the rest is very good! thanks @AvHStiftung !!.
Krebszellen stoppen: Humboldt-Professor Christian Frezza erforscht @UniCologne, wie man das Wachstum von mutierten Zellen ausbremst, um Krankheiten wie #Krebs zu bekƤmpfen. #AvHProfessor #Weltkrebstag #WorldCancerDay @CECAD_
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"Inhibition of fatty acid oxidation enables heart regeneration in adult mice".
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. and after 3 months, our first day back in the lab (well, not for me, though!) Thanks to the @MRC_CU for the massive effort to enable a safe re-start. Good luck everybody!!
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Very excited to share our latest lab photo, with some new members (some are missing). From the top down (left to right): @DrSegarmond, Ditte, @moschandrea @RGhodrat, Theo, Dimitrios, @AitorJarit, Nish, @GollwitzerPeter, Debarati, @RobertaColapie1 Desiree and me (getting older)!
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The worst pandemic of our time is not covid but this. the illusion of knowledge and expertise
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When I was doing my postdoc 15 years ago, this would have been nothing but a dream!!.
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mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. Congrats @BarakRotblat and @AGLeprivier.
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When I see videos like this, I struggle to imagine how any of our "mechanistic" explanations about cellular processes (pathways, cascades, etc) can operate beyond randomness.
See whatās really going on inside your nervesā ends - real-time analysis of protein mobility at the #synapse courtesy of Rizzoli lab.
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great review from @Aslan_Tasdogan & team about metabolic changes in metastasis. Emerging metabolomic tools to study cancer metastasis
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Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis | Science congrats to @bensahralab!!! whoa!.
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"Lactate activates the mitochondrial electron transport chain independently of its metabolism".
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The extracellular matrix integrates mitochondrial homeostasis: Cell
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An exercise-inducible metabolite that suppresses feeding and obesity | Nature
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very interesting work from the @mvh_lab ! congrats to all in the team!. Increased demand for NAD+ relative to ATP drives aerobic glycolysis
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Presenting metabolomics analyses: what is in a number? @JohannesMeiser and I wrote this short piece to raise awareness about how present metabolomics data. We hope you will find it useful. Any comment is welcome! thanks @DanielKlimmeck for the support!.
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And probably every metabolic pathway. in other words everything is associated with everything, and what we are doing is to (merely) connect the dots. Perfect example of "normal science". Every gene can (and possibly will) be associated with cancer
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Two very important papers for the field of ferroptosis: . Congrats to @AngeliFriedmann fantastic work!!.
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How many molecules of mitochondrial complex I are in a cell? short answer: Using mouse primary astrocytes as an example, we calculated an average value of 2.2 Ć 10^5 complex I molecules/cell.
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Excited to share our work led by our postdoc @_Christina_Sch and @ArianeNMora from @mikaelboden lab. We started from a crucial question: How can we integrate DNA methylation, RNAseq and proteomics data to understand where dysregulation occurs first? (1/13).
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"Perhaps it is a good time for the field to pause and rigorously assess the side effects of metabolic drugs, as implored by the Hippocratic oath āPrimum non nocereā, before embarking on further clinical studies." .
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@FrezzaLab is asking Government to protect #ResearchAtRisk . I look a bit too beardy.
In the wake of #COVID19 we must minimise damage to UK research infrastructure, preventing cuts to thousands of scientific jobs essential for treating the worldās deadliest diseases. Unite with @MRC_CU Dr Frezza this Wednesday 28thOct asking Government to protect #ResearchAtRisk
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Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis: Cell
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totally agree, we cannot *reverse" what we cannot even define. let's pause and redefine the questions. (big lesson from cancer too) . We need to shift the focus of aging research to aging itself | PNAS
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ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1 | Nature Communications
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"Iron drives anabolic metabolism through active histone demethylation and mTORC1".
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Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity
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Very excited to share this work led by @MarlousKamp.and the @bondieklab where we managed to visualise fumarate in label free conditions, and at intracellular resolution! congrats to all! .
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Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo | Nature Metabolism
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"Subcellular quantitative imaging of metabolites at the organelle level".
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Hi all, we have two postdoctoral positions open that wait for you to do some great projects on Fumarate Hydratase biology and fumarate. Please check the advert here: and contact me if you need more details.
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Massive paper from @KimrynRathmell and @JeffRathmell. Congratulations to the team!. Cell-programmed nutrient partitioning in the tumour microenvironment | Nature
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In our life, we all carry an invisible backpack, full of our experiences, fears, joys, and sorrows that inevitably shapes us. No one sees it, and sometimes we too ignore it to feel more normal. Next time you meet someone take this into account. What will this person be carrying?.
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A genome-scale gain-of-function CRISPR screen in CD8 TĀ cells identifies proline metabolism as a means to enhance CAR-T therapy . @DylanRy1937 check this.
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This is a new review from Dylan from the @FrezzaLab and @laoneill111. We focused on some very interesting evolutionary aspects of mitochondrial biology. We hope you like it. Congratulations Dylan, the main driver of the piece.
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Metabolic remodelling during early mouse embryo development | Nature Metabolism
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In the spirit of Carnival, here is a "glitter and colour" lab photo! Crazyyyy
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At this time of uncertainty, I am with all the PhD students, post-docs, and young PIs who just started with excitement their endeavours and need to face lockdowns. To you, be reassured that things will change, we will go back to normal and united we will again make a difference.
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difficult to add something insightful among these giants in the field of cancer metabolism. thanks @NatMetabolism.to provide this Viewpoint. A century of the Warburg effect".
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"The pleiotropic functions of reactive oxygen species in cancer".
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