Sudheer Kumar
@IBDologist
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DM Gastroenterology AIIMS, Delhi, Advanced fellowship in IBD University of Western Ontario Canada and Nottingham University Hospitals NHS trust, United Kingdom
Nottingham, England
Joined April 2020
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Important study from our group. Patients with ostomies are universally excluded from CD trials. Time to identify barriers to enrollment.
#ostomy
@vipuljairath
@IBD_FloMD
@virgisolitano
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After a incredible journey of learning, IBD fellowship came to an end. My heart felt thanks to my extraordinary mentor
@vipuljairath
and wonderful team. Excited for the next chapter in my life
@WesternU
@SchulichMedDent
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Do we need to wait for washout of biologics when switching?
Limited evidence.
Our study fills the gap!
We found that early switch is safe!
@vipuljairath
@WesternU
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Check out our NMA on comparative efficacy of advanced therapies for achieving endoscopic outcomes in CD
@vipuljairath
@NarulaNeeraj
@PeyrinBiroulet
@TBessissow
@AGA_CGH
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@theliverdr
It is clearly evident from your comment that you haven’t read the full paper nor did basic background research before commenting...
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Delighted to share our uptodate detailed review on targeting IL-23 in IBD.
@vipuljairath
@alimentiv
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Checkout our new paper on stoma.
Majority focussed on devices and surgical procedures
Limited studies in CD and none evaluating medical therapies.
There is urgent need for future research in CD with stoma.
@IBD_FloMD
@vipuljairath
@NarulaNeeraj
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Our recent publication on scoring indices for pCD.
Although there are many indices, none of them are fully validated. Much more work is required in this area.
@vipuljairath
@virgisolitano
#JCC
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Check out our recent SR and MA on pCD.
@vipuljairath
@virgisolitano
@NarulaNeeraj
#SidSingh
@alimentiv
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Check-out our systematic review and meta-analysis on IL-23 agents in CD.
@vipuljairath
@alimentiv
@virgisolitano
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@theliverdr
This is a carefully planned proof of concept study backed by sound scientific evidence and biological plausible rationale from a premier institute which is leading high quality IBD research in India.
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@theliverdr
I would be more careful before and do sound research before commenting not just looking at the abstract.
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@vipuljairath
Never imagined that I would get a chance to do IBD fellowship
@SchulichMedDent
. Thank you,
@vipuljairath
, for being an excellent mentor. Excited about future collaborations!
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@theliverdr
An in vitro study from AIIMS showed effect of potassium significantly reduced the IL-17 and IFNγ expression on Th17 cells and also promoted the Foxp3 expression in a dose dependent manner. Several other studies support the same.
DOI: 10.1038/s41598-017-18046-x
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@shanilkadir
@IBD_Afzali
@ibdseb
@ibdnurse
@DCharabaty
A course of antibiotics+ loose Seton + increase dose of IFX. If no response drug levels and ABs
Can try changing to ADA
If no response other therapies Which can be tried depending on availability
VAAFT
HBOT
Mesenchymal stem cell injection
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@theliverdr
It is well reported that potassium has immune modulatory properties. Many studies have shown that over expression of potassium channels in inflammatory cells in active UC.
DOI: 10.1016/j.crohns.2014.04.003
doi: 10.1016/j.yexmp.2016.03.009
DOI: 10.3389/fimmu.2016.00554
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Interesting study
New therapeutic target in IBD
Bezedoxifene(gp130 blocker) reduces DSS mediated bowel injury in NOD2 mutated zebrafish
A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease
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@theliverdr
This study was conducted to see if potassium rich diet/coconut water in this case aids in reducing inflammation in mild to moderate active UC along with standard medical therapy but not as standalone therapy.
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@vipuljairath
@CTU_LSHTM
@WesternU
@SchulichMedDent
@LSHTM
@LSHTMstatmethod
@VPRWesternU
One of the best lectures I have ever heard. Inspiring
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@doctorboletoh
@MondayNightIBD
@DCharabaty
@ibddoctor
@stevenbollipo
@drkeithsiau
I would like to add local therapy in the form of foam enema +/- suppository and re-evaluate later. We cannot justify adding azathioprine.
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@drvishal82
@drdeepakmadhu
@morerajdeep
@Sanchit30497977
Differentiating ITB from CD is still an enigma. None of the present scoring system or investigations are 100% specific and sensitive. For a given patient its either TB or CD. Combination of clinical, radio, histopath and other inv aid in diagnosis. Mx should be individualised.
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@GKochharMD
Nice work sir. Can we do stricturotomy even in presence of ulcers at the site of stricture. When should we avoid stricturotomy?
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Another indication for FCP
Validation of the Red Flags Index for Early Diagnosis of Crohn’s Disease: A Prospective Observational IG-IBD Study Among General Practitioners
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@DCharabaty
@MondayNightIBD
@DrHarryThomas
@dr_fcalderaibd
@AsadurRahman87
@SultanMahmoodMD
@SophieBalzoraMD
@ibdseb
@DrRosenIBD
@DrMikeDolinger
@moss_md
@fudmanMD
@drdhruvmehta
What if a adolescent with IBD who had one shot of MMR in childhood currently on AZA planning for international travel? what do u recommend?
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@morerajdeep
@drvishal82
@drdeepakmadhu
@Sanchit30497977
Ulcers look non specific. Difficult to say TB or CD. In our center we do CT chest (pulm TB) and FOXP3 levels also. If still inconclusive we can try ATT trial and repeat colonoscopy after 2months.
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@propelacure
@IBD_FloMD
Wonderful work
@IBD_FloMD
Any thoughts on mechanisms of colonic structures and why creeping fat is not so common in the colon...
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@elhence_anshu
@KewinSiah
@Prof_NickTalley
@JNMjournal
@neurogastroent1
@NGMJournal
@neurogastromot1
@DGNM_DE
@Being_Medico
@ashishchauhan__
@Sanchit30497977
Much needed program. 👍🏻
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@adilrashid83
@Sanchit30497977
@Sam_ogre
@DakshKhooni
@drdeepakmadhu
@docvjg
@EricTopol
@spkalantri
@drvishal82
@drnipunjindal
Is Cycle threshold is of any value in this situation?
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@Being_Medico
@Sanchit30497977
@abhinav_anand28
@drshalimar
@aiims_newdelhi
@JustSagnik
@elhence_anshu
@EASLnews
Congratulations Manas
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@bottomlineibd
If u look at various studies including population based studies across world the prevalence of familial occurrence of IBD is <5%...
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@bottomlineibd
Kuwahara E et al. J Gastroenterol 2012; 47: 961–968.
Banerjee R, et al. Intest Res 2019; 17: 486–495.
Palli D, et al. The Euro J of Public Health 1997; 7: 109–112.
Moller FT, et al. Am J Gastroenterol 2015; 110: 564–571.
Childers RE, et al. J Crohns Colitis 2014; 8: 1480–1497.
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@drvishal82
@EdwardLoftus2
@IBD_FloMD
@DCharabaty
@ownyourcrohns
@BatManishSingla
@Khanna_S
@IBDmedicaldoc
@ibdseb
@GKochharMD
All lectures are available in youtube.
follow the link
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@Suddoc
@doc_zubin
Sir, how much time it will take for re epithelialization of such large defect.
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@ashishchauhan__
@Sanchit30497977
@DrAshokGastro
@drashu123
@UjjwalSonika
@DrAnuraagJ
If stalk is thick (>5mm), you can place a clip then polypectomy or do polypectomy then place clip acc to your convenience
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@bottomlineibd
Familial prevalence is high (upto 12%) in west compared to Asian countries (<5%)
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@ashishchauhan__
@DrAnuraagJ
@drvishal82
@Sanchit30497977
@rajputmaheee
@Basky12349915
@elhence_anshu
@DrSrikanthGopi
Congratulations🎉👏🏻
@ashishchauhan__
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@drvishal82
@EdwardLoftus2
@IBD_FloMD
@DCharabaty
@ownyourcrohns
@BatManishSingla
@Khanna_S
@IBDmedicaldoc
@ibdseb
@GKochharMD
Don't know sir. Lectures were live streamed and since then still available in youtube
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@morerajdeep
@drvishal82
@drdeepakmadhu
@Sanchit30497977
Considering short duration of symptoms could be non specific ileitis
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