Ben-David Lab
@BenDavidLab
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Investigating #aneuploidy in #cancer 🧬 @TelAvivUni
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@ras_nielsen
@mbeisen
I’m probably also going to regret getting back to this discussion, but since you’re making some thoughtful comments, I thought I’d try to explain why I think many people (myself included) found Prof. Eisen’s comments so offensive. It’s a bit long, so attached as an image.
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Our response letter to
@AACR
following its weak statement on the crisis in Israel-Gaza. Already signed by >1,000 Israeli cancer researchers and oncologists, including Nobel Laureates, Israel Prize awardees and the leading oncologists in the country.
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Very happy to announce that I was tenured and promoted to Associate Professor!😊
Uri
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To our friends and colleagues abroad: we’re experiencing a terror attack the size of 9/11 with war crimes and atrocities that remind us of the holocaust. ISIS-type barbaric mass murdering of civilians, slaughtering of babies, torturing and raping of abductees.
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Our newest paper just published
@NatureBiotech
, describing the emergence of aneuploidy following CRISPR editing of primary human T cells. Great collaboration w/
@madi_lab
&
@barzel_adi
!
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@eLife
Thank you. Israeli scientists cannot have any trust in your journal until Prof. Eisen is removed from office. We’ll be looking forward to the outcome of your investigation, hoping that you have the “courage, insight and moral clarity” to act according to your code of conduct.
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A terrible, heart-breaking day in Israel. To our friends and colleagues: thank you for your support. Liberal democracies will beat fanatic terrorism, and will prevail, in Israel and everywhere!
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1/6 Excited to share our new preprint, in which we discovered that p53 inactivation (often achieved by loss of chr17p) is required for breast cancer brain metastasis. A close collaboration with
@RSFLab
with important contributions from multiple labs!
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Looking forward for a fascinating week of aneuploidy science at
@Aneuploidy22
in the memory of Angelina Amon!
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Happy to share our new preprint, a close collaboration w/
@YegerLotemLab
.
We applied ML to explain the tissue-specificity of aneuploidy cancer patterns. Bottom line: negative selection plays an important role. Great work by Juman Jubran & Rachel Slutsky!
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For the 3rd (and last!) time this week, happy to present our new preprint:
Another close collaboration w/ the great
@Foijer_lab
!
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Fighting for Israeli Democracy. Today, again, instead of doing science we’re fighting for our ability to keep doing good science (among other good reasons to maintain democracy). We will not give up!
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Hello Twitter! Thanks for the warm welcome. Stay tuned for exciting research! 🧬
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Awesome science, great discussions & lots of fun at the
@EMBO_YIP
Sectorial Cancer Meeting at Benasque, Spain. Thanks,
@valientelab
&
@Medyoufh
for organizing it!
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Happy to share this new preprint, a joint study with
@RameenBeroukhim
@Foijer_lab
&
@colomemaria_epi
, led by Veronica Rendo and Michael Schubert!
A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer
#bioRxiv
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Since the Israeli elections, the fragile Israeli democracy has been under attack. The new elected government has declared war on democracy, and is moving full speed toward subjugating the courts to its control, effectively eliminating the separation of powers in the country.
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Listen to Adi’s PhD student, Nufar, whose brother is held hostage in Gaza for 81 days. My cousin, Itai Svirsky, is there as well. 129 hostages are still there, most of them are still alive. Help them. Help us.
#BringThemAllHomeNow
My brilliant PhD student Nufar, whose brother is a hostage in Gaza for over 80 days. Nothing prepared me to being a mentor under such a scenario. How can we even continue research in the lab?? Please help her, help us, spread this heart-breaking humanitarian call.
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There’s absolutely no room for Whataboutism and for victim blaming. You can object the Israeli occupation AND unequivocally condemn such atrocities, it’s not contradictory and it’s not hard to do.
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Unwinding at the Tree House Brewery
@TreeHouseBrewCo
@FASEBorg
@SteSantaguida
@MaricaIppolito
@Tom_Winkler_
@LeorGil
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At the end of a wonderful joint lab retreat with
@SteSantaguida
lab.
Fruitful discussions, amazing science, and a lot of fun! 🧬📊
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This was the front page of the main national newspapers in Israel this morning, after our parliament made a big step toward ending democracy yesterday. A black day indeed, but we will not give up, and we will win!
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We’re currently experiencing both gaslighting and Gazalighting. Time to wake up, folks.
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Great people, thoughtful discussion and fantastic science at the Mark Foundation CIN Meeting in London, UK.
Thanks, Sarah, Florian, James and Becky for organizing!
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But if you can watch these atrocities and blame Israel for them, or if what’s really important to you at this very moment is to condemn the Israeli policy in Gaza or criticize Israel for its role in the conflict, then, simply put — you’re an immoral person.
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Week 28. We will take to the streets for as long as it’s needed. We won’t let Israel become a fascist, corrupt theocracy!
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Wow, President Biden, we salute you!
@POTUS
Friends in American academia: this is what your announcements should have looked like.
@Harvard
@gay_claudine
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It's a pleasure to meet such great scientists!
Had a great time presenting our work at the
@ILANITFISEB
conference!
#ILANIT2023
@JohannaZrb
@Tom_Winkler_
@eliezer_yonatan
@gilleor23
@talbenyishay
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We’re looking for talented, motivated postdocs interested in working on cancer aneuploidy (ERC-funded project). If you’re U.S. citizens who’d like to spend some time in TLV, and would like to apply for a Fulbright Fellowship, please contact Uri directly!
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Great science and great weather at the
#ILANIT2023
meeting in Eilat! 12 participants from the Ben-David lab, presenting 6 posters and 3 flash talks (plus a talk by Uri). If you’re around, please check out our posters this afternoon and tomorrow morning!
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The ONLY humane response is to call it by its name, stand with us and sympathize with the incredible amount of human suffering. And, most importantly, for the free world to demand unequivocally the immediate release of the ~130 abductees.
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Happy to present our work at the Computational and Cancer Genomics conference at the Technion.
@TechnionLive
@TelAvivUni
#CCG2022
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200K people demonstrating against the government and for democracy, tonight in Tel Aviv. Thanking president Biden for denouncing the coup attempt and supporting the Israeli people.
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The entire leadership of TAU (pst and present presidents, rectors and deans), leading the demonstration for democracy today at Tel Aviv. We must resist!
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General strike in Israeli academia starting today. The fight for a liberal democracy is ongoing full force now, and we cannot afford to lose it!
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Here, we found that CDC20 expression levels (rather than those of APC/C itself) determine the sensitivity to SACi. This preferential effect is achieved through the regulation of CDC20 on the length of mitosis and the fidelity of chromosome segregation. Read more in the paper!
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@EitanHoch
@MIT
Dear U.S. colleagues, it’s time for you to act to stop the incitement and the tots collapse of morality in the American academia. “From the river to the sea, Palestine will be free” is a call for the abolishment of Israel. It’s also the slogan used by Hamas as a call for genocide
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@SteSantaguida
@MaricaIppolito
@JohannaZrb
Congrats
@JohannaZrb
and
@MaricaIppolito
! And thanks,
@SteSantaguida
, for a very fruitful collaboration!
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@CorboLab
@ras_nielsen
@mbeisen
I haven’t seen these responses, and I agree that they are unjustified and excessive. I was only referring to the comments I saw from our academic colleagues.
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We followed up on our previous observation that highly-aneuploid cells are preferentially sensitive to SAC inhibitors (Cohen-Sharir et al. Nature 2021):
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@TAUMedFaculty
Thanks so much for the continuous support, very proud to be part of the amazing
@TAUMedFaculty
!
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@lemergenz
@CorboLab
@ras_nielsen
@mbeisen
I’ve seen them since, so let me be very clear on that: I don’t think Prof. Eisen is a Hamas supporter, and I think it’s unjustified to accuse him of that. This debate should be much more nuanced than that, though. My letter expressed my opinion why I found his comment offensive.
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5/6 We validated the association between p53 inactivation, astrocytes infiltration, and FA synthesis in clinical human BCBM samples.
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We reveal a new class of genes that reside within commonly gained genomic regions, but are not over-expressed as their overexpression is toxic for the cells. We experimentally validated a couple of these genes and explored the related mechanism of toxicity.
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אנחנו מנהלים מאבק תודעתי נגד מוסדות אקדמיים מכובדים שבשם חופש הביטוי מאפשרים אנטי-ישראליות ואנטישמיות בוטה, ואפילו תמיכה בזוועות שביצע החמאס. אם אנחנו רוצים תוקף מוזרי לדברינו, אז ״נאה דורש נאה מקיים״.
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@SteSantaguida
@NatureComms
@IEOufficiale
@LaStatale
@semm_it
@AIRC_it
Congratulations, Stefano & team, for an important and stimulating study! We’re very happy to have taken a small part in it :)
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6/6 Therefore, we identify p53 inactivation as a driver of BCBM; demonstrate a p53-dependent effect of astrocytes on BCBM; and reveal FA metabolism as an underlying therapeutically-targetable mechanism.
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@leeat_keren
@yaelam75
@yuvalbussi
@OneViTaDay
Congratulations, Leeat.
Looks like a very useful too!
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There’s no other way to interpret it, even though many of those shouting it e too ignorant to understand it. Just like you can’t use “Ein Volk, Ein Reich, Ein Fuhrer” and pretend you mean something else. Stop this before it’s too late!
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Tomorrow, in order to stop this legal coup, many of us at the Ben-David lab, together with thousands of Israeli researchers and students, will join hundreds of thousands of protestors in front of the Israeli parliament.
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Basic human rights, and especially minority rights, will be abolished. The rule of law will be seriously jeopardized. The Israeli regime will change its face beyond recognition.
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@JSheltzer
We usually use bulk low-pass (~0.2X) WGS. We do it externally with BGI for 95 USD per sample.
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@inna_slutsky
@jonykipnis
@freund_lab
I was also blocked. Simply for liking
@ShaharTaiber
comment, I guess. Or perhaps for my own tweets that ask our colleagues to stand in solidarity with Israel, who knows.
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@HebAcademy
שלום לאקדמיה ללשון עברית ולחבריה. האיש הזה חבר באקדמיה ללשון עברית והוא הנציג מטעמכם לוועדת השמות הממשלתית. האם תקיאו מקרבכם אדם שמאשים בזוועות את הליברלים, הלהט״בים ואלה אשר חסים על פליטים שאינם יהודים?
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4/6 Mechanistically, p53-deficient BC cells exhibited increased fatty acid (FA) synthesis and uptake, which was further enhanced by astrocytes in a p53-dependent manner, resulting in increased sensitivity of p53-deficient cells to FA synthesis inhibitors.
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3/6 Importantly, p53 pathway activity was already perturbed in primary tumors giving rise to BCBM. Experimentally, p53 knockout was sufficient to increase BCBM formation and growth in vivo, providing a causal link between p53 inactivation and brain tropism.
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This is expected to be the largest demonstration that our country has ever known. Our liberal and democratic values are under attack, and we do not intend to give up without a fight.
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There are many many good reasons to protect democracy. Preserving the independence of academia and the quality of science is one of them. Because where there’s no democracy, there’s no academia!
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