Nature - The extent, origins and consequences of genetic variation within human cell lines are studied, providing a framework for researchers to measure such variation in efforts to support...

Nature Medicine - A potent and selective inhibitor of KRASG12D, the most common mutant form of the KRAS oncoprotein, has anti-tumor efficacy in multiple pre-clinical cancer models, opening the...

Nature - LRRC15-positive cancer-associated fibroblasts constitute a pivotal axis in tumorigenesis and are potential therapeutic targets to improve responses to immune checkpoint blockade.

Background Hundreds of functional genomic screens have been performed across a diverse set of cancer contexts, as part of efforts such as the Cancer Dependency Map, to identify gene dependencies—ge...

『国の「創薬力強化策」製薬企業の研究者はこう読んだ』 執筆はノブさん（@chemordie）です

Bao et al. establish a CRISPR strategy for unbiasedly probing functional amino acid residues at the genome scale. They systematically survey the functional lysine residues that affect cell fitness....

Cancer cells require high levels of iron for rapid proliferation, leading to a significant upregulation of the iron carrier protein Transferrin Receptor (TfR) on their cell surface. Leveraging this...

Immune checkpoint proteins such as programmed death-ligand 1 (PD-L1) promote tumor progression and new approaches are needed to block signaling through these pathways. Ludwig et al. engineer anti-P...

Pacini et al. identify selective gene dependencies from CRISPR screens in 930 cell lines. Using clinically curated multi-omics data and protein-protein interaction networks, they curate 370 candidate...

Nature Communications - Proteolysis-targeting chimeras (PROTACs) offer new avenues for drug development. Here the authors investigate E3 ligases—key to PROTAC function—and identify...

社外研修制度を利用した海外留学から帰国後に退職した大成建設の元社員の男性が、同社に留学費用と相殺された未払い賃金などの支払いを求めた訴訟の判決で、東京地裁は20日、元社員の請求を棄却した。その上で会社側の請求に基づき、留学費用の残金約729万円を支払うよう元社員に命じた。判決によると、元社員は2009年に総合職として入社。社外研修に応募して18年に米国の大学に入学し、20年5月に修士課程を修了

Chemically induced proximity refers to co-opting naturally occurring biological pathways using synthetic molecules. These proximity-inducing modalities are rapidly evolving to offer tremendous...

Kwak et al. developed a proximity-dependent target-ID system (PROCID) that identifies the proteomic landscape of drug-binding proteins in live cells. This system revealed dasatinib-binding proteins,...

厚生労働省は日本の医薬品産業の競争力強化に向けて、その問題点と方向性をまとめた指針を8年ぶりに見直す。新型コロナウイルスの国産ワクチン開発で後���をとった現実を直視した上で、国内企業が苦手なバイオ医薬品分野での開発力向上を打ち出す。新薬の価格の在り方をはじめ税財政面での支援など国によるテコ入れを訴えていく考えだが、課題は多い。厚労省が今夏にも改定するのは、2013年につくった「医薬品産業ビジョン

Nature - A non-covalent inhibitor that binds preferentially to the inactive state of KRAS while sparing NRAS and HRAS is reported, indicating that most KRAS oncoproteins cycle between an active...

■連載「ベンチャー巡訪記」 注目ベンチャーの経営者に、創業のきっかけや事業にかける想い、今後の展望などを語ってもらいます。今回は、武田薬品から2017年にスピンアウトして設立されたChordia Therapeutics の森下大輔CSOを訪ねました。

DrugMap serves as a roadmap to develop covalent ligands for oncogenic drivers.

Sun et al. provide proof-of-concept for signaling-disabled R-spondin chimeras (ROTACs) as a new technology for targeted transmembrane protein degradation. A ROTAC (R2PD1) targeting the immune...

📰 概要 パソコン操作、プログラミングが苦手な方でも薬物候補化合物をデザインしたい方、気軽にin silico創薬を試したい方、創薬分野に関心のあるエンジニアの方へ。 本書はwetな創薬研究の経験があり、現在ITエンジニアである著者の視点から、wetな研究者からもdryの創薬研

Bifunctional PhosTACs combine the strength of a phosphatase and a kinase inhibitor to achieve dual inhibition of EGFR.

Attempts to improve dual anti-PD-1+CTLA-4 ICB efficacy by including additional therapeutics have been largely discouraged due to concerns of further increasing toxicity. Xue et al. identify that the...

Small molecule inhibitors that target the phosphatidylinositol 3-kinase (PI3K) signaling pathway have received significant interest for the treatment of cancers. The class I isoform PI3Kα is most...

Nature Metabolism - Wang et al. provide insight into how acetate promotes tumour growth by reprogramming lung cancer metabolism and promoting immune evasion.

Nature - A synthetic proteome-scale strategy enables the identification of a diverse range of human proteins that can induce the degradation or stabilization of a target protein in a...

The first activator-based photoswitchable proteolysis-targeting chimera (PS-PROTAC) was developed for the optical control of NAMPT and NAD+ in biological systems. The novel PS-PROTAC enabled the...

Protein dysregulation has been characterized as the cause of pathogenesis in many different diseases. For proteins lacking easily druggable pockets or catalytically active sites, targeted protein...

The DNA translocase SMARCAL1 favors tumor immune evasion by two distinct mechanisms: it suppresses the cGAS-STING pathway by limiting endogenous DNA damage and induces PD-L1 expression by modulating...

In targeted protein degradation (TPD) a protein of interest is degraded by chemically induced proximity to an E3 ubiquitin ligase. One limitation of using TPD therapeutically is that most E3 ligases...

YTHDF proteins bind the N6-methyladenosine (m6A)-modified mRNAs, influencing their processing, stability, and translation. Therefore, the members of this protein family play crucial roles in gene...

ひろゆき、成田悠輔、後藤達也…、新たな視点で経済・社会を見つめ直すビジネス動画メディア「ReHacQ」！”研究者”と”教育者”それぞれの側面を深掘りしていく番組「まったりFUKABORIN」今回は筑波大学国際統合睡眠医科学研究機構機構長・教授の柳沢正史さんが専門で研究している「睡眠研究」とは何か、睡眠不足がもたら...

Nature - Whole-transcriptome sequencing of a subset of 75 non-small-cell lung cancer specimens in a multi-institutional genome screening study identified a fusion of the CLIP1 and LTK genes with...