Sven Dorkenwald
@sdorkenw
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PhD student @PrincetonCS & @PrincetonNeuro, graduating Aug 2023. Student researcher @Google. Next up: Shanahan Fellow @AllenInstitute
Joined February 2017
We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses! Explore the connectome: Reconstruction paper: Annotation paper: 1/6
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Incredibly proud and grateful to be part of the #FlyWire team that made this happen. This was an immensely collaborative project - on every level from early open data sharing, to tool building, to analysis - over many years, across many institutions. It's been a fantastic journey
Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! Check out the thread for an overview of the 9 #flywire papers published today
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RT @BrainsExplained: Papers reporting the fly whole-brain connectome were published in @Nature today 🎉 and it was my honor to write a News…
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RT @FlyWireNews: Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the c…
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RT @DavidZipper: What should we do? 🔹 Tax vehicles by weight. 🔹 Test vehicles for pedestrian and cyclist safety (still doesn’t happen in th…
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RT @alin1194: Our paper with @RunzheYang describing the network statistics of the whole-brain connectome of a complete adult Drosophila bra…
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RT @PhotonPhilipp: It’s done! LIONESS is out @naturemethods! With the pipeline you can not only create a dense 4D nanoscale reconstructio…
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RT @ariadne_ai: Very exciting to see this monumental work out! We are humbled and proud for having contributed to this milestone in neurosc…
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RT @YaronMeirovitch: We mapped the connections between high order sensory inputs and memory cells in the octopus brain, first-ever reconst…
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@dissel_lab I dont think either is a better representation. There are differences caused by different sources of variability (biological, technical). The "annotations" paper analyzed that nicely Fig 4:
Building the FlyWire #connectome from the FAFB brain was a massive team effort. But neuroscientists need to find their favourite neurons in this huge dataset. We report an indexed parts list, systematically annotating all 127k neurons (Schlegel et al 1/7
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Its like having the map for an entire city where before you only had knowledge of a few streets that others traveled and told you about. Now you can see all the paths, get a better understanding how the city works, and design new experiments using this knowledge. There is more:
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@BadMuthaHubbard We were limited by the image dataset that was used. Imaging is always a trade-off and imaging "more" comes with more challenges. Whole CNS image datasets now exist and I am sure they will be used to produce connectomes for all neurons in the coming years.
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@SK_R402 The first steps in this direction have been made. We do not have simulations that ultimately "produce" behavior yet though
Can brain function be simulated using just the connectome? We show in a new study led by @Philip_Shiu that a leaky integrate-and-fire model based on the FlyWire connectome and neurotransmitter identity accurately predicts complete sensorimotor transformations.
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The map has small mistakes - the "annotation" paper analyzes that a bit. The TLDR is that this is accurate enough for almost all analyses. Human brains are >100,000x larger and it will take a long time to get there. There is already a connectomics dataset for a human brain sample:
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@idgallagher Quite a lot of it is stereotyped but there is variation between brains. Our friends at Cambridge did one of the first analyses on that
The core connectome is highly stereotyped, but an exception is the #mushroombody memory centre. The most common Kenyon Cell (KCg-m) is ~ 2x as numerous (1100 vs 600) in FlyWire as the hemibrain. We find evidence for homeostatic connectivity changes that maintain E/I ratio /7
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@bara_ban A lot of it is stereotyped but there is some variation - we are only now starting to understand what and how much neurons and synapses vary between brains. The "annotations" paper has one of the first analyses on this
The core connectome is highly stereotyped, but an exception is the #mushroombody memory centre. The most common Kenyon Cell (KCg-m) is ~ 2x as numerous (1100 vs 600) in FlyWire as the hemibrain. We find evidence for homeostatic connectivity changes that maintain E/I ratio /7
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RT @AdrianAWanner: The release of the first whole adult fly brain wiring diagram marks a turning point for neuroscience: end-to-end reconst…
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