Nick Damiano
@nickdamian0
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Building next level tech to help patients. Co-founder & CEO @andromedasurg . 3x founder, 3x Stanford, YC W15/S23, girl dad.
San Francisco, CA
Joined January 2010
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@LauraMiers
Spoiler alert: We’re going to accept doing nothing. Humans have had a good run vs. viruses for the past 50+ years but now we’ve abandoned science and public health and it’s the viruses’ time to shine again.
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4K
Was just notified that I won a 10-year Long Bet that the Large Hadron Collider wouldn't destroy earth: . Pretty cool to win after all this time, and I'm also pretty stoked that the earth still exists.
@longnow
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@Austen
Thanks for this perspective. I was starting to get worried that my 5 yo daughter hasn’t led even one company to a billion-dollar IPO yet.
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"I used to know a girl, she had a dozen guys. One of them found out about it...
[see photo]
Hahahaha what a story, Mark."
@TheRoom
@DisasterArtist
@TommyWiseau
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@DrEricDing
The current US COVID response is indistinguishable from what it would be if the virus itself became sentient and ran the government
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@60Minutes
@DrLaPook
They didn’t miss it. Governments intentionally ignored it because they didn’t want to be on the hook for fixing it. But yes, pretty clear that cleaning indoor air would massively improve population health just like cleaning water did. We should do it.
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@LeahLibresco
@slooterman
Endemic means a disease occurs in a population at a predictable rate. This is not the case with COVID. Flu is endemic but the average person gets it once every 7 years.
Getting infected 2-3x/year with a virus this severe is unheard of in the modern world and won’t turn out well
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@Anton_Vikstrom
Current attitude is more like “You can’t avoid Covid forever, so why not just get it all the time?”
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@KempoJesse
@farid__jalali
Just had BA.5 forced on me by failed public health policies despite 💉💉💉💉, no large crowd/indoor activities, KN95 or better when I have to be indoors. Hoping it’ll be “mild” and to dodge long COVID and hold on to my T cells.
We really need to get transmission under control.
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@_mbdr_
I’m 40 years younger than him, vaxxed to the max and took antivirals, and COVID has still been a brutal > 2-week ordeal. I call shenanigans on the White House narrative here.
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@ZackBornstein
But maybe we only thought 3,000 deaths was a big deal on 9/11 because we didn’t consider:
1) Survival rate for New Yorkers was 99.96%
2) Mostly only people with the preexisting condition of being in the WTC died (+ some essential workers)
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@DrJBhattacharya
I don’t think anyone is arguing for Zero COVID, just that the current level of infection is unsustainable. Infecting everyone 2-3x/year with a SARS virus that causes cardiovascular and neurological damage won’t end well.
Even flu would cause long-term damage at this attack rate.
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@friendlycovid19
Why not bring back asbestos while we’re at it? It’s a very cost-effective insulator and inhalation is mild in many cases. If people want to live in fear of mesothelioma, they can stay home or strap a P100 respirator to their face for all eternity.
/s
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@WHCOS
Yikes, another horrific COVID take from Leana Wen. Can she stop already?
I’ve had COVID for 14 days and counting now. Easily the worst illness I’ve had in a decade. We’re just supposed to get this once a year or more and keep risking long COVID? No thanks.
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@BethKellySF
Based on the BoE recall results so far, somewhere between 70-80% of SF is apparently billionaire republicans. Huge political swing from 2020 when Biden won SF by a 72% margin.
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@_mbdr_
@TRyanGregory
Welp, just gotta learn to live with being disabled and having brain damage! What else would we do, try to prevent it? LOL
- CDC Director, probably
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@MaryFernando_
@lisa_iannattone
It’s a weird kind of reverse ad hominem when someone refutes your central point and you frame it as a personal attack.
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@elizavetaka
I’m similar - healthy 39 yo, active runner - and COVID knocked my O2 sats down to a “mild” 89-90 for a couple days.
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@mhdksafa
ChrINOs (Christians in name only): “I’m pro-life but I’m going to run around infecting everyone with a deadly virus. Who cares if it’s killing 3000+ people a day? Also let’s block this long-overdue aid package for struggling Americans on Christmas Eve.”
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@sbuss
@michelletandler
The anti-recall movement was 100% gaslighting. Every single SFUSD parent I know was pro-recall and not one was a Republican or a billionaire. They’re all just parents who care about all kids getting a decent education.
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@DeanPreston
@sp6runderrated
You have to see the irony in what you just said.
The more you block market-rate housing, the higher the market rate gets, and the less affordable market-rate housing becomes.
Build housing. Affordable, market rate, all of it. We need it all.
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@JReinerMD
@PeterHotez
@EricTopol
This 100%. I’m suffering through Pax rebound now. Started Pax day 0, tested negative and was symptom-free starting day 3. Rebound started day 8 and now I’m feeling the worst I ever have on day 10.
The problem with “we have the tools” Is that those tools are highly flawed.
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@transitbiker
@mikejohansenmd
The vaccine is outdated but a lot better than nothing. The current alternative is nothing.
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@yishan
So much this. People have bought into the collective delusion that COVID is over and just a cold/flu now. It’s mind-blowing to see them deny the obvious.
No disease in modern history has caused anywhere near this level of sickness & disability. And it’s getting worse, not better
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@flindall_steve
If only it were gone in 10 days for all of us! I’m on day 12, which CDC would call completely good to go.
Still positive, still very symptomatic, SpO2 down to 90% last night (better now). BA.5 is an absolute beast.
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@snarkypeds
@CDCgov
I’m still positive on day 11, still isolating and wearing N95 around family. Yet based on CDC guidelines I could be going to indoor public spaces unmasked.
Five days is and always was insane, and people should absolutely have to test negative before exiting isolation.
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@rohindhar
Wow, I own a below-median house in SF and pay A LOT more property tax than this. The boomers really set themselves up nicely at the expense of the rest of us with Prop 13.
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@wsbgnl
We just die and get disabled in huge numbers every year now, NBD just a part of the “new normal”
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@michelletandler
The alternative - which apparently the SFUSD “progressives” want - is that only rich kids in private school have access to a better education. So much for social mobility.
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@hknightsf
Hard to believe anyone falls for this ridiculous characterization. Maybe 5-10% of SF is Republican and polls show 60-70% support
@recallsfboe
.
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@jasmith_yorku
Are you really going to live in fear and keep wearing your seatbelt forever? Car rides have like a 99.999% survival rate and there’s plenty of trauma ward capacity.
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@lisa_iannattone
Risk level = probability x severity
It’s amazing to see people like
@VPrasadMDMPH
claiming flu is worse than COVID for kids when pediatric COVID deaths have outnumbered pediatric flu deaths by > 200:1 during the pandemic.
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@kimmaicutler
SF is trying to keep tech companies out, but Prop E may end up driving up rents so only tech companies can afford to be here. Everything SF does backfires in a predictable way, resulting in greater unaffordability, higher crime, more homelessness, etc.
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@thehill
@AndiLou12
@TheHillOpinion
Calling it now: monkeypox will spread aggressively in schools despite policymakers assuring us this won’t happen
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@mwseibel
@apartovi
@garrytan
I’ve been in the YC community for 9 years and can verify. YC was there for me throughout my last company (and we weren’t one of the hot ones), when we almost ran out of $ pre-Series A, after I left the company, and with my new company. YC hasn’t fallen off at all from W15 to S23.
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@GininaTeacup1
@LauraMiers
People are already claiming it’s the vaccines causing the damage. It’s amazing how much more they trust an aggressive SARS virus that’s known to invade multiple organ systems than innocuous mRNA that breaks down quickly in the body.
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@TRyanGregory
Here’s one from a scientifically illiterate minimizer company - named for a COVID variant nonetheless - that backfired.
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@TRyanGregory
Nothing we can do. If only there were a wearable device to prevent the virus from entering our bodies, or a device in buildings to replace virus-laden air with clean air.
But let’s be real, those are magical technologies that could never exist.
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@SRAPhilly
@HeadHeadynew
@w48941242
@AshleyySpencer
This is an insane take. Florida has about 9000 new cases and 100 deaths per day. Australia has near zero. There is no comparison.
Australia has secured vaccine doses for its entire population and will likely reach herd immunity with < 5% the per capita death toll of the US.
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@DataDrivenMD
Just watched
#DontLookUp
today and it’s by far the most realistic depiction of US response to a crisis of any movie I’ve seen.
Movies like “Armageddon” where people unite in the face of disaster and gov’t mounts a competent response now seem laughably naive.
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@Helenreflects
I still mask indoors whenever possible in KN95+, but don’t outdoors. There is a social cost to it and my calculation is the risk outdoors is low enough.
“COVID isn’t going away” is irrelevant. There’s cumulative damage so we should minimize # of infections.
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@jbf1755
@burritojustice
“Hospital system fires about 175 workers for recklessly endangering patients’ and colleagues’ health” could also work
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@jeffgilchrist
This is all well & good, but it’s virtually impossible for most people to get Novavax in the US. I drove 50 miles for a Novavax booster and still got denied. Had to settle for the Moderna bivalent.
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@NickCho
@lopez4schools
@AliMCollins
Regardless of their tweets, I support removing
@AliMCollins
&
@lopez4schools
because they’re disastrously bad at their jobs. Our kids deserve much better.
@recallsfboe
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@LauraMiers
They’re already sowing seeds of doubt with the “experts are perplexed” and “nobody saw it coming” takes.
Whereas we’ve known the realities of Long COVID since 2020 and could have predicted it before that from the long-term effects of SARS-1.
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@Noahpinion
In cases where outcomes vary between groups, why is the solution always lowering standards rather than giving the lower performing group the tools they need to succeed?
The latter seems like the obviously better solution. Too hard?
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@j_g_allen
The problem with “you do you” public health is that even if you’re in one of the low-risk groups, spreading COVID willy-nilly will inevitably cause high-risk people to get infected.
It’s shocking how many people seem to have zero concern for others.
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@joelkotkin
Or we could just build more housing instead of saying, “Welp, I guess the poors can always just go live in District 9”
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@YouAreLobbyLud
It’s become blasphemy to do literally anything to avoid COVID. Even if that thing would be super easy. 🤡🌎
Any cost a business incurs in cleaning the air will easily pay for itself in healthier, more productive employees.
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@rpoconnor
Science evolves over time for a novel virus. Data on the benefit of a third shot after 6 months is now conclusive.
Just because you’re poorly informed about something doesn’t make that thing a government conspiracy.
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@lisa_iannattone
That’s a good framing. Almost nobody seems to understand that risk level = probably x severity.
Seems like a lot of people would choose a 50% chance of getting a 0.2% fatal disease over a 5% chance of a 1% fatal disease.
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@DrEricDing
@CDCgov
@BiobotAnalytics
This is sad and shortsighted. I invested in Novavax based on the data only to watch it drop 90% when it turned out politics mattered more.
Mencken said “No one ever went broke underestimating the intelligence of the American people.” But you can go broke overestimating it.
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@thatalicewu
@chrislhayes
Taiwan's approach sounds a lot like Australia’s, where I’ve been since early Oct. People here are enjoying normal, COVID-free lives.
Yes, islands with small populations, but the US could’ve used a lot of the same tactics and had 10X fewer cases/deaths than we have.
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@immad
Autonomous robots for safer, more effective & efficient surgery. Starting with a procedure that cures a prostate condition affecting 90% of men. We will be the Intuitive Surgical ($110B company) of the AI age. Founders have built medtech & autonomous vehicle companies worth >$1B.
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@var_epsilon
Altman’s comeback will be an app with 8 recipes for Chinese octopus (it’s a water animal). That was an amazing idea.
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@CDCDirector
COVID risk is tied to transmission level, not hospital capacity. Hospitalizations are a lagging indicator. Please stop with this misleading map.
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@rdmorris
I’m pro free speech but something seems wrong with the fact that uninformed nonsense-spouters like Kirsch get equal platform as real experts.
People who don’t know the subject matter well themselves can’t tell the difference. There has to be a better way.
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@TRyanGregory
Did they do an RCT to determine whether breathing asbestos occasionally builds immunity to asbestos? Without evidence to the contrary I think we have to assume it does.
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@ASlavitt
What if I told you there’s an obvious, cheap, easy way to limit airborne viral spread without relying on individual behavior?
It’s cleaning the air - ventilation and purification.
A COVID Preparedness Plan ignoring airborne mitigations is 🤡🤡🤡.
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@AnjKhem
@G_Commish
FFS where is
@US_FDA
on approving this? Novavax seems like the best bet for preventing infection by the newly emerging variants. Could prevent many, many deaths and
#LongCovid
cases.
We need this available as a booster or new primary series ASAP.
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@DrEricDing
@CDCgov
@CDCDirector
But the problem is that if people wore masks to avoid monkeypox, then they wouldn’t be able to spread COVID as efficiently. We can’t have that now that we’re in the “learning to live with as much COVID as possible” era.
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@dianaberrent
@Delta
@DeltaNewsHub
@Delta
’s penalty for this incident should be having to officially go by Omicron Airlines for a month
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@alexmeshkin
I just did 5 days of Paxlovid, was testing negative and feeling great, then a hellish rebound hit on day 8 and I was testing + with symptoms until day 17.
Five days is NOT enough for BA.5. But why has it taken so long to get any data on this?
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@DrTomFrieden
Follow-up question: “How much would people care if coronavirus killed a million Americans?”
For many people the answer is not in the slightest as long as they aren’t one of the million.
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@RichMoo50267219
@NateB_Panic
A negligible percentage of them, and orders of magnitude fewer than the vaccine saved.
Everyone understands that except ignorant kooks who trust random unhinged podcasters over mountains of clinical data.
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Looking forward to getting the
#BidenVaccine
soon.
In my book, holding superspreader rallies during a deadly pandemic and racking up a 6-figure kill count by spreading misinformation nullifies ALL credit you would’ve gotten for anything good that happens.
@ProjectLincoln
@realDonaldTrump
It would be a shame if Trump lost the PR battle for the vaccine, too. We should definitely not try to get
#BidenVaccine
to trend.
No, that would crush Trump’s fragile ego. Plus it would keep him from undermining the science.
I implore you: don’t try to make
#BidenVaccine
trend
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@7NewsMelbourne
No new variants? That’s patently absurd. XBB is more divergent from baseline Omicron that baseline Omicron was from the original strain. It has nearly complete immune escape from BA.1.
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@ohios_fav_son
@thehill
What’s even the corporate interest in not recommending high-quality masks?
With this policy they’re only acting in the virus’s interest.
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@TRyanGregory
No matter how bad the situation is, the world will have to be ending before people go back to excruciating hell of having to wear a mask occasionally or run an air purifier.
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New company is coming together! Starting to build product, first investors committed, got office space, incorporating this week. This stage is always fun.
3
1
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@financejonE
@EricTopol
We already know the US model isn’t the right choice. Exhibit A: Over 1 million dead.
China’s model was probably roughly the right one early in the pandemic to get to COVID zero, but it’s too late now.
At this point Japan’s approach looks really good.
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@AshishKJha46
We need to do better than that.
😷 Masks (N95 or equivalent)
💨 Ventilation/filtration/UV
💉 Sterilizing vaccines - start by opening Novavax to everyone
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@MeetJess
Spoiler alert
We’re not going to do much.
Phase 1: “The risk to the public is low”
Phase 2: “Well, it’s everywhere now, but we’re over NPIs so nothing we can do”
Phase 3: “You do you” for a 50% fatal virus. Half of America says it’s a cold, blames the deaths on the vaccine.
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@JeromeAdamsMD
You’ve had some of the most consistently reasonable takes the whole pandemic.
I’m also a girl dad and got myself Novavax and my 8 and 5yo Pfizer this week. People can criticize that, but the vast preponderance of data is on my side.
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After many trips to Bulgaria, finally summited Vitosha/Cherni Vrah 7520 ft. Would be a great view if we weren’t in a cloud.
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@ChrisJBakke
When someone says they were an “operator” I assume they were either manually connecting phone calls or doing surgery.
I believe the correct term for the jobs the VCs are referring to is “in the arena”.
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@keetmuise
They’re actually the ones demanding apologies now.
The warped logic is something like “Protections didn’t completely stop the virus -> they had no effect whatsoever -> people should apologize for the economic harm with no benefit.”
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@GavinNewsom
Clinical support staff from medtech/biotech companies should be in a higher-priority tier for the vaccine. We’re sending our employees (myself included) into hospitals and clinics regularly to support our trials, which will put us at risk of infection.
0
0
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@rabbitholeseek
@POTUS
So much this. The only thing this administration has been effective at when it comes to COVID is gaslighting the public on actual transmission levels, reinfection risk, long COVID, etc.
0
0
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@angie_rasmussen
A massive campaign to clean indoor air would go a long way.
Zero COVID isn’t possible, but a lot less COVID certainly is and would be a very good thing.
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@alexmeshkin
The right was probably right about the lab leak but has been dangerously idiotic about most of COVID policy.
The left started off far better then soon after Biden took office he adopted Trumpian policy.
Both sides are underestimating the long-term harms of COVID.
1
1
19
@mildanalyst
But you can predict it. They say rebound happens to 1-2% of people who take Paxlovid. Who wants to give me 9:1 odds on a public figure rebounding (i.e., you take the under on 10%)?
Anyone?
6
0
18
@JT_Grindrod
@lisa_iannattone
You’ll likely get COVID eventually ➡️might as well get infected over and over again
You’ll likely get cancer eventually if you live long enough ➡️just chain smoke and don’t use sunscreen, no point in avoiding it
0
5
18
Day 10 and the Paxlovid rebound that started day 8 is hitting hard. Headache, congestion, fatigue have come on strong.
It’s crazy this has to be said, but this virus is really bad. Much worse than flu. I’ll go even more out of my way to avoid getting it again.
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15
@AlexWals
@flindall_steve
PCR tests can stay positive for a long time due to remnant viral RNA in the respiratory tract, but rapid tests should only show positive when there is significant active viral load.
@michaelmina_lab
explains this clearly.
4
0
17
Wrote a post about
@ycombinator
funding medtech companies. Hoping this is a trend that lasts!
1
1
17
@TracyBethHoeg
You know this is misleading and dishonest. The number that matters is 1400 pediatric COVID deaths vs. 6 pediatric flu deaths since the pandemic started. COVID is orders of magnitude worse than flu for all age groups including kids. Also Long COVID exists.
1
1
13
@sf_leilani
@hknightsf
@recallsfboe
I believe SF has a lot of moderate Democrats, but calling them Republicans is a stretch. Trump got only 12% of the SF vote in 2020 and > 80% of the city is fully vaccinated. Agreeing with Republicans on a single issue and being a Republican overall are very different things.
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@friendlycovid19
1) P100 respirator all of your waking hours for all eternity and never leave your house
2) Never wear a mask again and go indoor dining and clubbing every night for the rest of your life
Make your choice, people. There is no third option.
4
0
17
@Kit_Yates_Maths
@TRyanGregory
The thing with the pro-virus crowd is that if you say anything short of “You should go to as many public indoor spaces as possible while sick and cough in everyone’s face”, they consider that a lockdown.
1
1
16
@deonandan
How do you explain the studies showing rebound is far more likely when you start Paxlovid right away (day 0-1) vs later (day 3-4)? Maybe rebound is common in general but a late course of Paxlovid significantly reduces the incidence?
5
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@kprather88
Cleaning indoor air is such an obvious win/win that I have no idea why we don’t do it. Would be game-changing for public health, yet 99% of people aren’t even aware it’s an option.
3
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17
@firefoxx66
We’re at the point now where new variants have sub-variants that can each infect you.
Time to start adding modifiers to the names: Omicron Prime, Omicron Air Pro, Omicron X Catalina, etc.
2
1
17
@Julietilsen
People who haven’t had COVID have typically minimized their cumulative probability of getting COVID by avoiding high-risk settings and wearing good masks.
That’s it. Not at all a mystery.
0
1
19
@saugarmaripuri
Is it possible the plane air filters remove particulates but not CO2? From what I understand CO2 level is a proxy for air cleanliness but has its flaws as a metric.
5
1
16
@ashishkjha
@DrLeanaWen
@washingtonpost
I recently got COVID for the second time in a year despite still taking lots of precautions - N95 on planes, no indoor dining except when I can’t avoid it for business reasons.
It’s not under control. It’s rampant. We need something that reliably blocks infection.
1
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