Manolis Kellis
@manoliskellis
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Dissecting disease mechanism. Single-cell, Epigenomics, Regulatory Genomics, Disease Genetics, Brain, Cancer, Metabolism. @MIT Prof, @MIT_CSAIL, @BroadInstitute
Cambridge, MA
Joined July 2009
Kellis Lab is hiring! New grants in #Alzheimers #Schizophrenia #Cancer #EHR #SingleCell #Genome #Epigenome #Transcription #Disease integration. Computational & experimental positions, profiling and circuitry dissection. Join us! @MIT_CSAIL @BroadInstitute
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Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful
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This week in @Nature we present our #SingleCell dissection of #ApoE4, the strongest genetic variant for #Alzheimers. ApoE4 impairs #cholesterol #transport, leading to #oligodendrocyte ER accumulation, decreased #myelination. Restoring transport restores mouse cognition. #Hope #AD
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Excited to share our #MultiRegion #SingleCell dissection of #Alzheimers out in @Nature today.studying #Reelin in #RegionSpecific #NeuronalVulnerability, #CholineMetabolism and #PolyAmineBiosynthesis in #CognitiveResilience, #Astrocyte diversity, #Thalamus-specific #Interneurons,
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Today was my last lecture for @MIT #ComputationalBiology: #Genomes, #Networks, #Evolution, #Health. I recorded each and immediately posted online here: Please do share, and let me know which topics need more explanations, clarifications, and corrections!.
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To the colleagues and friends who find our paper overwhelming, and instead prefer to write and read more manageable papers with more focused messages: .I respect your perspective and your approach to science greatly, and find it invaluable, of course. Both broad and focused.
Excited to share our #MultiRegion #SingleCell dissection of #Alzheimers out in @Nature today.studying #Reelin in #RegionSpecific #NeuronalVulnerability, #CholineMetabolism and #PolyAmineBiosynthesis in #CognitiveResilience, #Astrocyte diversity, #Thalamus-specific #Interneurons,
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The field of #ComputationalBiology has changed dramatically in the last few years with #GenerativeAI. I'm excited to be recording my lectures again this year, and to be teaching with the awesome @EjAlm. You can find the first lecture here: and more will
Today was my last lecture for @MIT #ComputationalBiology: #Genomes, #Networks, #Evolution, #Health. I recorded each and immediately posted online here: Please do share, and let me know which topics need more explanations, clarifications, and corrections!.
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The first six lectures of #DeepLearning for #Genomics and #LifeSciences are posted on @YouTube here:..covering #MachineLearning #CNNs #RNNs #GNNs #RepresentationLearning #InterpretableML #Convolution.Linking to them individually in the thread below 1/n.
Interested in #DeepLearning for #Genomics and the #LifeSciences? Our @MIT course starts again today. Recommend your favorite papers and topics to cover, and we *will* cover them! Watch our 2020 lectures with @DavidKGifford at and
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Our #EpiMap paper is now @Nature: systematic dissection of #DiseaseCircuitry, including predicted driver variants, enhancers, regulators, target genes, and relevant tissues/cell types across 30,000 genetic loci, 540 traits, 833 tissues #Epigenomics #GWAS
@yongjinp28 @ENCODE_NIH @EncodeDCC @NIEHS @MIT @broadinstitute @MIT_CSAIL @IHEC_Epigenomes @GeneticsSociety And the #EpiMap paper is now posted on @bioRxiv Integrative analysis of 10,000 #Epigenome maps across 800 samples for #RegulatoryGenomics and #DiseaseDissection.#GWAS #ENCODE #preprint #genomics #epigenomics #ASHG19
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Such an honor to be back on @LexFridman to talk about #humanity, #AI, #intelligence, #ChatGPT, #DeepLearning, #DrugDiscovery, #Genomics and the #FutureOfWork. Lex is an amazing human being, curious, driven, smart, humble, kind, and unapologetically open. Thank you Lex for the.
Here's my conversation with @manoliskellis, his 5th time on the podcast. He is a computational biologist at MIT and one of the smartest & kindest human beings I know. It's an honor to sit down with him for a chat and to be able to call him a friend.
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"The only thing more full than the auditorium tonight is @ManolisKellis poster" @LB_Barreiro intro at #BoG22. Ahem. you be the judge. Poster #135, come say hi! Full res here: #Alzheimers #SingleCell
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Our #SingleCell #Alzheimers dissection of 80,000 cells across 48 human brains with @DrLiHueiTsai is now online @Nature @MIT_Picower @MIT_CSAIL @MIT @BroadInstitute @ScienceMIT @MITbrainandcog @HarvardMed @MITEngineering @MITEECS
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Excited and proud to share our #SingleCell dissection of #ALS and #FTLD out in #Cell this week, across 620,000 cells, 44 cell types, 73 donors, and two brain regions. Although ALS affects #movement vs. FTLD #cognition, the two are nearly identical in the cell types, genes, and
Excited to share our #SingleCell dissection of #MotorCortex in #ALS and #FTLD.#BetzCells #VENs #C9orf72 #TDP43 #POU3F1 #ADRD #NeuroDegen #MCx #Alzheimer.with #SebastianPineda #VeroniqueBelzil #MyriamHeiman #HyeseungLee @B_Fitzwalter @Mohammadi_PhD @MTPA_US
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Our #scMetab paper is out today #SingleCell dissection of #Obesity-#Exercise axis in #Adipose-#Muscle metabolic tissues.@Cell_Metabolism #MultiTissue #CellCommunication #Diet #healthy @MIT.News: Paper: Data:
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Excited to share our #SingleCell dissection of human #vasculature with #MyriamHeiman across 17 cell subtypes, human-specific #zonation, vasculature-coupled glia/neurons, and #Huntington's-associated #immune activation and #BBB integrity breakdown. #scBBB
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Proud to share our #eGTEx multi-tissue dissection of #enhancer H3K27ac across 387 brain, muscle, heart, and lung samples from #GTEx in @NatureGenet .#eQTLs #haQTLs #SexDiffs #Epigenomics #GWAS #linking.Paper: (H3K27ac, today).News:
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Our #SingleCell dissection of #Schizophrenia genes/pathways, a new #TranscriptionalResilience cell type, target genes at #GWAS loci, and upstream #MasterRegulators is out @medRxivPreprint #PsychENCODE #BradRuzicka @Mohammadi_PhD #JoseDavila @NIMHgov
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Excited to share our #SingleCell dissection of #Schizophrenia, out in @ScienceMagazine today, reporting 470k cells in 27 cell types across 140 individuals from 2 cohorts, .revealing key insights on #ExcitatoryNeurons, #NeuroDevelopment, #Synapses, #1Cmetabolism, #Genetics,
Our #SingleCell dissection of #Schizophrenia genes/pathways, a new #TranscriptionalResilience cell type, target genes at #GWAS loci, and upstream #MasterRegulators is out @medRxivPreprint #PsychENCODE #BradRuzicka @Mohammadi_PhD #JoseDavila @NIMHgov
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Excited to share our #SingleCell #MultiTissue Dissection of #Obesity-#Exercise axis in #Adipose #Muscle tissues.Central roles of #StemCells #Thermogenesis #ExtraCellularMatrix #Circadian #Tcells #CellCommunication.#scMetab #Metabolism #scWAT #vWAT #SkM
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Excited to share our #SingleCell dissection of #Alzheimers brain #vasculature changes across 6 brain regions with @DrLiHueiTsai. AD- & ApoE4-associated DEGs, upstream regulators & modules, cell-cell communication changes and links to #GWAS variants #ROSMAP
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Excited to share our #SingleCell dissection of #LivingHeart and #HeartFailure Led by #SuviLinnaKuosmanen @EloiSchmauch w/ #KikiGalani #TuomasKiviniemi #GuillermoGarciaCardena #MinnaKaikkonen @Calum_OG.#OpenHeartSurgery #Ischemic #Cardiac #CAD #scCAD #GWAS
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Interested in #DeepLearning for #Genomics and the #LifeSciences? Our @MIT course starts again today. Recommend your favorite papers and topics to cover, and we *will* cover them! Watch our 2020 lectures with @DavidKGifford at and
Interested in #ConvolutionalNeuralNetworks #DeepLearning #MachineVision and how machines/humans can see/understand the world around us? Watch my @MIT 6.874 lecture today #CNNs #Brain @BroadInstitute @MIT_CSAIL @MITEECS @MIT_Picower @DavidKGifford @MITOCW.
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If a critic *never* genuinely points out the slightest positive about a work or author they're constantly criticizing, it's much easier to 'see through them' and understand that their motivations might be shooting down, bullying, settling scores, belittling, self-aggrandizing,.
How bullying becomes a career tool: "Bullies spring into action when their targets become too successful for their liking". "Planting false stories, publicly ridiculing, insulting, or tarnishing". Do we have mechanisms to combat this? Can kindness prevail? #StopBullying
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Excited to share our #SingleCell dissection of human #Hippocampus #EntorhinalCx #Anatomical substructures & stage-specific changes in #Alzheimers.with @DrLiHueiTsai #JoseDavilaVelderrain @MathysHansruedi @Mohammadi_PhD @Brad_Ruzicka #DavidABennett #ROSMAP
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My academic family surprised me with a birthday cake and celebration today. A bit of warmth and hope among all the suffering in the world. Wishing health, safety, and peace to all
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High-altitude adaptation #StructuralVariants signals in #SingleMolecule @nanopore sequencing between 119 #Tibetan and 201 #HanChinese samples reveals cis/trans rewiring of #hypoxia, #energy, #lung pathways, expanding #GWAS. #SVs #InDels #SNPs #LongReads
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Excited to share our #eGTEx #m6A #QTL profiling and analysis of #brain #heart #muscle #lung in @NatureGenet .by @Xushen18 @kdyhl @ypp_lab #BenoitMolinie #RichardGregory @GTExPortal @NIH @NIH_CommonFund.#GTEx #EpiTranscriptomics #m6AQTLs #eQTLs #RBPs #GWAS
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End of evolution: transforming medicine through AI to reverse human disease @TEDTalks #TEDxMIT #Genomics @MIT @BroadInstitute @MIT_CSAIL @MITEECS @HarvardMed #pharma.
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Excited to kick off the @MIT #Bioinformatics Seminar Series at 11:30am-1pm today. Please do join us! .Title: From #Genomics to #Therapeutics: #SingleCell dissection and manipulation of #DiseaseCircuitry.Info: Where: MIT Stata Center 32G-575 .Zoom:
The MIT Bioinformatics Seminar is back this semester! We have an exciting series of speakers, with some joining virtually and others hybrid/in-person. Please check out the talk schedule here: (1/n).
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How bullying becomes a career tool: "Bullies spring into action when their targets become too successful for their liking". "Planting false stories, publicly ridiculing, insulting, or tarnishing". Do we have mechanisms to combat this? Can kindness prevail? #StopBullying
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Excited to co-teach "#Neurogenomics: Computational Molecular Neuroscience" this Spring at @MIT, a new 6-9 (#EECS & #BCS) course with #MyriamHeiman. More info at Course syllabus below. @MITEECS @MITBrainAndCog.Please spread the word! #AI #CogSci #ML #MolBio
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@prmshra Parm, this is such a sweet note. Truly grateful for your kindness. I'm still that immigrant kid who will not insult anyone, and will always look for the good in people, so this behavior is quite foreign and baffling to me as well. So happy that my lectures and papers have been.
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So excited to share our #SingleCell dissection of #Alzheimers brain #vasculature changes across 6 brain regions, out in @NatureNeuro today. Paper: News: Open Access Link: With @DrLiHueiTsai @NaSun818
Excited to share our #SingleCell dissection of #Alzheimers brain #vasculature changes across 6 brain regions with @DrLiHueiTsai. AD- & ApoE4-associated DEGs, upstream regulators & modules, cell-cell communication changes and links to #GWAS variants #ROSMAP
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Excited to share our #SingleCell dissection of #MotorCortex in #ALS and #FTLD.#BetzCells #VENs #C9orf72 #TDP43 #POU3F1 #ADRD #NeuroDegen #MCx #Alzheimer.with #SebastianPineda #VeroniqueBelzil #MyriamHeiman #HyeseungLee @B_Fitzwalter @Mohammadi_PhD @MTPA_US
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Happy 200 years #Greece! @MFABoston dons its blue & white stripes for your #bicentennial. So proud to live in the #AthensOfAmerica #Boston.#Greece200years #Greece1821 #Greece2021 #ÎλλαΎα2021 #GreekIndependence #Hellenic #IndependenceDay #Greece200 @MIT @Harvard #BU #Tufts #NEU
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Excited and grateful to be inaugural recipients of a @BiswasFamilyFdn Transformative Computational Biology Grant w/ @MarinkaZitnik & Brad @PenteluteLab at @MIT & @HarvardMed. Our goal: #AI for #GenomicMedicine: #DiseaseCircuitry, #DrugDevelopment, #Personalization. Including:
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Congratulations to Aviv Regev for her induction in the National Academy of Sciences, a much deserved honor! @theNASciences @BroadInstitute @MIT @ScienceMIT @MITBiology
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Excited to share our #SingleCell dissection of #Huntingtons Disease, showing distinct #striatum direct-vs-indirect-pathway projection neuron vulnerability in human and mouse #iSPNs #dSPNs #Neurodegeneration @MIT #Heiman.Paper: News:
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Congrats to #AvivRegev who will lead @Genentech Research & Early Development. Great collaborator & friend, she helped shape the current @BroadInstitute. Her loss will be greatly felt in our community but her impact will only grow in industry. Best of luck!
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Here's my #DarwinDay lecture, on the 20th anniversary of the #HumanGenome Project, linking #AncientGreece, #CharlesDarwin, #GregorMendel, #ComplexTrait Inheritance, #PolygenicDisease, #DiseaseCircuitry, #Epimap and #SingleCell #Genomics .Happy #Darwin Day!
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Uh-oh. 144443 citations. This is where you drive ever-so-slowly to catch 144444 on the dashboard (but invariably miss it). Okay, back to that grant report [adding our latest papers]. No distractions, already past 5am, kids waking up soon, whoosh.
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Our new @GenomeResearch paper reports hundreds of new protein-coding genes in human, mouse, fly, worm & mosquito, including 118 protein-coding genes/exons overlapping previously-non-coding #GWAS hits. Eg. new eye-specific TJP2 exon associated with #myopia
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The Greek-Turkish friendship behind the Pfizer-BioNTech vaccine that could save the world. Very inspiring story of immigrants with dreams, drive, perseverance #COVID19 #Vaccine #Greece #Turkey #Immigrants #Pfizer #BioNTech @AlbertBourla @BioNTech_Group.
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HiDRA: Building on Sharpr-MPRA+STARR-Seq+ATAC-Seq to dissect millions of human regulatory regions in one experiment
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It's amazing how cordial and kind a critic can be in a face-to-face private conversation (eg. offering feedback after a seminar when others are *not* watching), and how the language changes to almost performative insults, as soon as that same otherwise-kind person goes on twitter.
@NimwegenLab Peak Twitter is knocking down a fellow scientist because of too much data in a paper. There are actual people working on these publications for years. Don't think it's very practical to dismiss their work as 'landfill'.
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Excited to share our #MetabolicResilience & #GenomePlasticity preprint.by @LeandroAgudeloZ @RTuyeras #TeresaFemenia #Obesity #Adaptation #Condensates #HumanAccelR #ChromatinArchitecture #Metabolism #Fasting #PGC1A #PhaseTransition #Environment #Metabolism
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Truly grateful for my extraordinary research team of students, postdocs, and trainees at @MIT @BroadInstitute @MIT_Picower @MITEECS @MITCSBPhD @MIT_SCC. I keep pinching myself in disbelief, working with such amazing, driven, intelligent, creative, and diverse scientists â€ïžđ„°đđ
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Some Coronavirus Advice for my friends Don't panic, but don't underestimate this either. Act rationally, minimize the spread to protect others, enjoy time with your loved ones, and act as if it's a pandemic, so it doesn't become one
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It was truly a pleasure to speak on #AI for #Innovation, #Genomics, and #Medicine at our @MIT #IAP class with @RickardGabriels on #FoundationModels and #GenerativeAI. So many extraordinary advances to cover, each more exciting than the other. Video here:
𧏠Honored to have Professor @manoliskellis guest lecture at MIT's course on Foundation Models & Generative AI. This session delves into the exciting interface of AI, Biology & Genomics, a field seeing incredible advancements. It's a must-see:
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Such a relief to see that #ScienceIsBack on the table at the @WhiteHouse, with @JoeBiden and @KamalaHarris nominating a top-notch Science Team, with @Eric_Lander, @Maria_Zuber, @NIHDirector, @Alondra. Let the US Beacon shine again
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Truly honored that @BillGates, a true giant of computing, philanthropy and human health, choose to highlight our #SingleCell work on #Alzheimers disease with @DrLiHueiTsai out in @Nature this week.
Iâm excited about the progress weâre making toward understanding Alzheimerâs. For the first time, @MIT researchers have completed an analysis of the genes that are expressed in individual brain cells of Alzheimerâs patients.
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As #COVID19 cases skyrocket throughout the world, a recent #VitaminD randomized clinical trial in hospitalized patients offers hope, with #25fold reduction in ICU admissions. Our mathematical analysis indicates its results are real #Calcifediol #CĂłrdoba
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New podcast conversation on the #FutureOfAI, from ChatGPT to #AGI, how #AI is transforming #business, #medicine, #DataScience, and #collaboration: .We dive deep into the evolution of AI and representation learning, visual data landscapes, human-AI
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Traveled 5000 miles to Greece for my second #GenomeReconnects entry #BoG22 #WHBA #MostMilesTraveledCategory @CSHLPress @cshlmeetings #GenomeResearch #FavoriteShirt đđœ đ¶ đ¶đŹđ„œ
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Excited to be part of the #AIrevolution episode of @PBS @NovaPBS premiering at 9pm tonight. Already here: With @MilesOBrien, @MustafaSuleyman (@InflectionAI, @GoogleDeepMind), #YoshuaBengio (@Mila_Quebec, #TuringAward), @ManolisKellis (@MIT),
Artificial intelligence is a powerful new technology with seemingly endless, exciting possibilitiesâand risks. Whatâs the future of A.I.?. âA.I. Revolutionâ premieres WEDS MARCH 27 at 9/8c on PBS.
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Honored and grateful to be among @NIHDirector #TransformativeAward awardees w/ @Donnelly_Lab #VeroniqueBelzil & #MyriamHeiman on #SingleCell CNS dissection of #ALS #FTLD #MotorNeuronDisease #TDP43 neuropathology/neurotoxicity #genetics #epigenomics #transcriptomics #modifiers.
Guess what? The @NIHDirector's awards for #NIHHighRisk research have been announced! Read about innovative #biomedical and behavioral research early career, and seasoned scientists will conduct through these awards:
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For those interested in #SingleCell analyses, #ACTIONet is our main workhorse for #Alzheimers #Schizophrenia #ALS #HD and more: a multi-scale network-based archetype approach for learning cell types and cellular states in health and disease Out today!.
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So excited to speak at the #AthensScienceFestival 2021 next Monday on "Breaking the Code of #HumanDisease" #ASF2021 @AthensSciFest #Genomics #ComputationalBiology #AI #ML #CS #DeepLearning #Alzheimers #Schizophrenia #Obesity #HeartDisease.Register here:
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Interested in #ConvolutionalNeuralNetworks #DeepLearning #MachineVision and how machines/humans can see/understand the world around us? Watch my @MIT 6.874 lecture today #CNNs #Brain @BroadInstitute @MIT_CSAIL @MITEECS @MIT_Picower @DavidKGifford @MITOCW.
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Our new @GenomeResearch paper reports the most accurate yet update of human protein-coding genes, using #PhyloCSF of 58 mammals and 100 vertebrates, MassSpec, RNA transcription, CAGE, PolyA-seq, and @GencodeGenes curators sifting through 4000+ candidates 1/6
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Excited to share our Inclusive Polygenic Score (iPGS) work and iPGS+refit, out at #AJHG today by @yk_tani. We improve #polygenic prediction of #DiseaseRisk and other traits across individuals from #diverse populations/ancestries, that have been traditionally excluded from
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Don't miss #CarlesBoixAdsera's Poster on #EpiMap: 833 epigenomes, enhancer modules, motifs, and #GWAS dissection of 30,247 variants across 534 traits .Poster #3334 at 3pm today #ASHG19 .
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Excited to share our #GenoBoost paper out in @NatureComms today, a flexible #PolygenicScore #PGS modelling framework for additive and #NonAdditive dominance effects, incorporating non-zero dominance effects in 40%-67% of variants across multiple traits, including #psoriasis,
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Don't miss @ZunpengLiu 's #ASHG talk on #SingleCell #MultiRegion #Epigenomic dissection of #Alzheimers next in Room 207A/Level 2 (11:30am) #ASHG23.Integrate: 576 samples, 2.3M cells (1.5M #scRNA x 900k #scATAC), 6 brain regions, 30 cell types and subtypes.Results: 419k regulatory
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Next #ASHG23 #ASHG talk after the break: @NaSun818 on #SingleCell #eQTLs #genetic regulation of #Alzheimers in BallroomC/Level3 (10:30am).Integrate: 427 individuals, 2.3M cells, 23 cell types and subtypes, genotypes.Results: 457k sc-eQTLs, 8.8k sc-eGenes, cell-type- / conditon-
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CRISPR @NobelPrize in Chemistry to @jadoudna and @e__charpentier. This is a big deal in genomics, medicine, and the world
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Very excited for Carles Boix #ThesisDefense at 10am today on #SingleCell #Mosaicism #Brain #Alzheimers #Epigenomics Join us!.With @MITCSBPhD @MIT_CSAIL @BroadInstitute @MIT @MIT_Picower @MITEECS @DrLiHueiTsai @Peter_J_Park @YoungRickA #PReddien #ChrisBurge.Then off to @CSH #BoG22
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Thrilled to speak at @NatureGenet and @NatureRevGenet webcast on #GWAS mechanism dissection on Thu@11amET with @AnnaGloyn. I'll cover #Epigenomics #Alzheimers #Obesity #Schizophrenia #SingleCell #SpatialTranscriptomics #TFs #CRISPR #HiDRA #EpiMap Join us!
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No, SARS-CoV-2 does not integrate into your genome. No, vaccines will not change your DNA. Please help get everyone vaccinated and help put this pandemic behind us.
Our paper refuting earlier claim of SARS-CoV-2 genomic integration is now online @CellReports. The virus does not enter human DNA. The same would be true of COVID-19 mRNA vaccines. Particular thanks to @UQ_SCMB authors for SARS-CoV-2 experiments @UQ_News.
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Please join us for a public lecture and fireside chat with @ManolisKellis and @LeoAlexopoulos on #AI and the Future of #Medicine and #Innovation this coming Tue Oct 31 at 5:30pm at @NTUA (Metsovio Polytechnio).RSVP: (for this and future such gatherings).
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What's the #MeaningOfLife: Think, Love, Humanity, Life, Time, Family, Layers, Planet, Legacy, Diversity, Ideas, Space, Mind, Facts, Music, Laughter, Giving, Sharing, Feeling, Connected, and 42, at least according to our #Podcast #WordCloud with @LexFridman
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Article: Perspective: News & Views: Big congrats to an amazing team led by @DrLiHueiTsai @JoelWBlanchard1 @Leyla_Aakay @_JoseDavila @DjunaVM. Truly grateful to be part of this extraordinary collaboration.
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Meaning of Life Symposium @MIT. Scientists, Humanists, and Luminaries reflect on the Meaning of Life, from the human scale to the cosmic scale. Blending neuroscience, philosophy, evolution, astrophysics, spirituality Wed 3/13/2019, 4pm-8pm 34-101. Join us!
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Congrats #KellisLab, with 4 platform presentations, 1 Epstein award winner, and 5 posters, all by #trainees at #ASHG22.Each talk/poster in the thread below đ§”.Congrats to @__ben_james__ @Xushen18 @yk_tani @boix_carles #ChristianHwa & the whole team! .Proud & grateful đ§âđđ©âđŹđ»đ§Șđ§Ź
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For those wondering if #COVID19 shutdowns were needed. New study estimates they prevented 530M infections, 62M cases (i.e. 5M deaths, with CFRs lower than Italy's overrun hospitals). This is not over. Stay home, stay safe, avoid gatherings, wear your masks
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Excited to speak at the #FestivalOfGenomics #FOGBoston at 2:20pm-2:50pm today [Secret Stage] on #SingleCell dissection of #DiseaseCircuitry. Info: Speakers: Program: Eager to re-connect with many friends old
We can't wait to hear from Manolis Kellis @manoliskellis, Professor, MIT Computer Science and Artificial Intelligence Lab, @broadinstitute at #FOGBoston!.See the full speaker list here:
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Excited to share our research on #SingleCell dissection and manipulation of #Disease circuitry for #Schizophrenia #Alzheimers #Obesity #Exercise #Cancer #Epigenomics #SpatialTranscriptomics #eQTLs #ALS #Microglia #GWAS #EHR #Aging #EpiMap.Watch here:
Today at 2:00 p.m., do not miss @manoliskellis' (@broadinstitute @MIT) seminar on single-cell dissection & manipulation of disease circuitry. #signalife #genomics #therapeutics @uca_research @ircaninstitute . Contact: @BrestLab
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This is embarrassing science denialism. Yes, we would certainly prefer that mental illness is not genetic, but it is. How does one respond to such pieces?.
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Outstanding news article by the always-insightful @AlzForum on our #SingleCell #MultiRegion study of #Alzheimers Disease. Thanks for the wonderful coverage of our work! .
Excited to share our #MultiRegion #SingleCell dissection of #Alzheimers out in @Nature today.studying #Reelin in #RegionSpecific #NeuronalVulnerability, #CholineMetabolism and #PolyAmineBiosynthesis in #CognitiveResilience, #Astrocyte diversity, #Thalamus-specific #Interneurons,
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Don't miss our four #ASHG20 talks today/tomorrow on #SingleCell dissection of #Alzheimers #Obesity #Exercise #Schizophrenia using #scRNA #scATAC #GWAS #eQTLs #Mosaicism Big congrats to #MariaKousi #AustinWang #XushenXiong #JackieYang and our collaborators!
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Just made a donation to IITMAANA to support India Covid-19 Relief. This is a trusted effort that I have received personal vouching for by Hari Balakrishnan at MIT, run by his personal connection Mohammed Siddique, head of Chennai COVID management efforts
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My #CompBio class is starting again @MIT next week. #MachineLearning for #Genomics: Dissecting Disease Circuitry. Overwhelmed by the #OnlineLectures support last year. I hope your students can join in person this year! More info:
Today was my last lecture for @MIT #ComputationalBiology: #Genomes, #Networks, #Evolution, #Health. I recorded each and immediately posted online here: Please do share, and let me know which topics need more explanations, clarifications, and corrections!.
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Couldn't be happier for #science and its return to the US presidency agenda. @Eric_Lander is perfect for the role, and being part of the @JoeBiden Cabinet is a big deal. Our country needs this badly. Congratulations!! #ScienceIsBack.
Humbled and excited to serve as WH science advisor for President-elect @JoeBiden. He has assembled a diverse team of brilliant scientists and is elevating the role of science. So much to be done, and it will take everyone working together. #Scienceisback!.
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Do you know/have/are high-school students interested in #AI for #DataScience? We've developed a 5-session course with @therobohub for 5 Saturdays from Oct 19-Nov 16, covering (1) data science, (2) predictive modeling, (3) AI agents, (4) data scraping, and (5) the integration of
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Excited to present our #SingleCell dissection of #Alzheimers #Schizophrenia #Bipolar #Huntingtons at #ASHG19.800 Brains, 5.5M cells #scRNA #scATAC #scQTLs.4:15pm today Level3/BallroomB Session029 Talk52 with @DrLiHueiTsai #MyriamHeiman #BradRuzicka #ROSMAP
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Tomorrow is not about politics, it's between lies and false promises vs. truth and action. Let's #vote populism out and bring the US back to reality. Let's invest in science, research, infrastructure, progress, and let the Beacon of the World shine again
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Today I responded to the #TakeYourShots challenge. Spread the word about #VaccinesSaveLives, and drink a shot of 1 lemon. Nominate at least 5 others. I nominate @Eric_Lander @GeoChurch @AndrewWLo @DrLiHueiTsai @SafiBahcall @natalya926 @quantum_spiros @LRafaelReif @NIHDirector
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From Genomics to Therapeutics: Single-Cell Dissection and Manipulation of Human Disease Circuitry.My talk at @GenomicsEngland #DiscoveryForum.Slides here (w/QR codes): #Alzheimers #Obesity #Disease #TeamWork.
Amazing day meeting key stakeholders in the Transformation of #Medicine with #Genomics at @GenomicsEngland's #DiscoveryForum yesterday. Amazing UK ecosystem for this transformation with @UK_BioBank, @UKFutureHealth, @NHSgms, @NHSEngland .
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My views on the #MeaningOfLife, horizontal and vertical evolution, the importance of diversity, the danger and fallacy of eugenics, the horizontal transfer of knowledge through humanity and fellowships, and the evolution and sharing of ideas March 13, 2019.
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Really honored and proud to speak at the @HarvardMed #PostdoctoralFellows program, with the #HMS Biomedical Sciences Program #BSCP, the Diversity Inclusion and Community Partnership #DICP, and the HMS Black Postdoc Association #HBPA. #Diversity is the bedrock of our community,
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Really looking forward to #RECOMB2024 this week, and reconnecting with the #ComputationalBiology community joining us at @MIT @Harvard @HarvardMed @Tufts @BroadInstitute #BU #NE and more. This is one of the most successful RECOMB meetings to date, with near-record registrations.
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How badly are we underestimating #coronavirus cases in the US? Probably 150-fold (5000 diagnosed, 750,000 actual). Quick analysis on 3/19-3/20 numbers, doubling rate (3 days), incubation (20 days), death rate (1%): So stay home, the only param you control!
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So honored to be back in Athens, speaking at EmTech Europe (Emerging Technologies) on "The AI Frontier: Transforming Health, Knowledge, and Human Achievement" on Thursday morning at 9:45am Greek Time. The talks will be live in person at the stunning Megaron Athinon Concert Hall,
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So excited to speak next at the European #Atherosclerosis Society Congress in the closing plenary session. So many parallels across #cardiac, #obesity, and #Alzheimers with #lipids, #cholesterol, #vasculature, #immune/#monocyte/#macrophage/#microglia dysregulation, #metabolism,
The last Plenary session at #EASCongress2023 is starting in just 10 minutes!đ€©. We will discuss "Advancing therapy" with Winfried MĂ€rz, Lale Tokgozoglu, Khurram Nasir, Manolis Kellis, Pam R. Taub, and Sek Kathiresan. đHall: Anitschkow.#EASCongress2023
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Excited to speak at #CMU #CS #CompBio at 1pm today (in person and on #zoom). #AI for #GenomicMedicine: #SingleCell Dissection and Manipulation of #DiseaseCircuitry.1pm at GatesHillman GHC 6115.Zoom link: Info: Hosts: @jmuiuc and
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@rikvanderkant Thanks for the kind words Rik. It's hard to please everyone. If a paper has too little data, someone will criticize the lack of transparency. If it has too much, someone else will comment that it's overwhelming. [Sometimes it's the same person too]. Best way to avoid their.
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My #TEDx talk at @TEDxCambridge on "Decoding a Genomics Revolution" was a 10-min crash course on #genomics Super excited to speak again at #TEDxMIT on Dec 4th. What should I talk about? :-) Requests welcome!.
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I had a wonderful time chatting with #CurtJaimungal on his Theories of Everything podcast @TOEwithCurt.We discussed the extraordinary unification of medicine and biology with AI, how this will shape the future of personalized and precision medicine, and.
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Don't miss @XikunHan 's #ASHG talk on #SingleCell dissection of #BipolarDisorder starting now Room207A/Level 2 (11:15am, Friday) #ASHG23 Integrate: 88 samples, 500k cells, #GWAS, single cell-#eQTLs in 2.3M cells .Results: #BD differentially expressed genes (#bdDEGs), enriched
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