IdoAmitLab
@IdoAmitLab
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Single Cell Gescheft @WeizmannScience
ישראל
Joined November 2017
We are proud to share our latest work, in collaboration with Amos Tanay lab, presenting a framework for in vivo tracking of CD8+ T cells' response to immunotherapy over time & at single-cell resolution, led by @orenbarboy and Akhiad Bercovich. (1/19).
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We are very excited to present the development of Zman-seq (“Zman”, Hebrew for “time”), the 1st technology that measures single-cell transcriptomes and physical time in vivo, led by @D_Birschenkaum, @CuriousKX, @FlorianIngelfi1, @AssafWeiner. (1/19)
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We are very excited to present INs-seq, a new technology for massively parallel single-cell RNA-sequencing (scRNA-seq) integrated with recording of intracellular protein activities. Developed by @YonatanKatza @FadiSheban @AdamYalin and @AssafWeiner (1/14).
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We're thrilled to share our recent @NatureMedicine study, cracking the decades-old mystery surrounding the identity of cells responsible for producing erythropoietin (Epo) - the key regulator of erythropoiesis and oxygen homeostasis in our bodies. (1/16).
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We are excited to present PIC-seq, a novel single cell technology for investigating cell-cell interactions, developed by @AmirGiladi and @meravcohen8, in collaboration with Amos Tanay. (1/11)
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when you had a looong day in the lab but it was worth it (and you have fun people around) #peopleofIdoAmitLab #BottleCapChallege #bottletopchallenge @FadiSheban @YonatanKatza
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We are excited to share our @NatureCancer paper showing how interactions between subtypes of T and dendritic cells shape the tumor microenvironment in patients with different types of cancers and can enhance the response to checkpoint blockade therapy
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Super excited to share our work on microglia diversity across evolution by @microgliaandme Eyal David @HadasKerenShaul @AssafWeiner and co. Now in @CellCellPress !
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Proud to share our collaboration in the latest @CellCellPress paper led by @li_hanjie. The study presents an immune cell atlas & the dynamics of human macrophage specification in prenatal development. (1/11)
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Excited and honored to have been awarded @ERC_Research Advanced Grant for our project „TROJEN-Cell“. A new program for synthetic immunology aiming to revolutionize the landscape of immunotherapy. Synthetic, systems immunology and cell therapy enthusiasts are welcome to apply!.
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We are excited to share ‘Host-viral infection maps reveal signatures of severe COVID-19 patients’ led by @bost_pierre and @AmirGiladi. Collab with the Zheng Lab from the Shenzhen Third People’s Hospital and Benno Schwikowski from @institutpasteur 1/13.
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We are excited to share our @NatureBiotech paper introducing DestVI for identifying continuous cellular states in spatial transcriptomics (ST) data
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#coronavirus #COVID19 #COVID2019 #scRNAseq .We have developed a new and exciting tool (#ViralTrack) to detect viruses in scRNA-seq data. **We are looking for SARS-COV2 scRNA-seq patient data**. If you have such data and wish to collaborate, please contact us ASAP! Please RT!
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Ukranian scientists/postdocs/PhD students 🇺🇦 looking for a short/long term position- we at the Amit lab in @WeizmannScience will be happy to host you and your families. DM us if you are interested.
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We are excited to share our new @Cell paper, revealing important & diverse roles played by skin fibroblasts. Our research shows how perturbations in a subset of fibroblasts characterize the development of scleroderma (SSc), a deadly autoimmune disease .
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We’re happy to present “Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner” by @diego_jaitin, @LorenzAdlung, @ChristophThaiss (@ThaissLab), @AssafWeiner, @Li_baoguo, in collaboration with @Elinav_Lab (1/11):
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Out now- check out our new @NatureCancer paper! Together with @QuezadaLab we started to march down the rabbit hole toward the molecular and cellular dissection of immune checkpoints MOA. Led by @IdoYofe, @tomerlands and @AdamYalin.
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We are very excited to share our new study identifying resistance pathways and therapeutic targets in relapsed multiple myeloma lead by @MorZada3, @MoonspiriTYin, and @AssafWeiner @WeizmannScience (1/14).
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We are excited to share our new paper, a beautiful collaboration with Prof. Michal Schwartz's lab led by @MKenigsbuch @bost_pierre discovering a shared oligodendrocyte signature among multiple CNS pathologies: (1/10).
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We proudly present our work on dysfunctional T cells in melanoma by the fantastic four: @li_hanjie, Anne van der Leun, @IdoYofe and @y_lubling. Collaboration with Amos Tanay and Ton Schumacher labs @WeizmannScience @NKI_nl @merckgroup @CellCellPress
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Our new @immunityCP perspective, led by @adamyalin @FGinhoux & @caduterte, outlines the creation of a “Rosetta Stone” integrating the many layers of single-cell information from vastly growing datasets that will enable the next revolution in immunology>>> .
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We are excited to introduce our new Immunotherapy Research Center, a hub for innovation integrating immunology, genomics, synthetic biology, protein engineering and AI. We welcome partners and collaborations between academia, industry and the clinic.
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Happy Hanukkah from @IdoAmitLab!!!. ‘Hanukkiat Haematopoesah’ .Scientific consultant @AmirGiladi.Jewish tradition consultant @YonatanKatza.Artwork @ADeczk
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Fantastic technology!!! || Single-cell metabolic profiling of human cytotoxic T cells | Nature Biotechnology
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Holiday Wishes from @IdoAmitLab!.*Hanukkyat-Macrophage*.featuring the MIRACLE OF MACROPHAGES that evolved an enormous number of ways to interact with diverse cell types and play a key role in physiology and disease. Featured are nine macrophage-interacting cell types.
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We are in the dark on how the #COVID2019 spreads. Cannot stress more on how critical it is to test, test, test!!! We are working with @Elinav_Lab @EranElinav @WeizmannScience to develop a new technology for MASSIVE testing of #COVID2019. More info here: .
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Perturb-ATAC is here!!! || Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks
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Beautiful study! Engineered myeloid cells will be a very impactful therapeutic tool in the future!!.
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Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization | Nature Cell Biology
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THIS IS HUGE - Combined quantification of intracellular (phospho-)proteins and transcriptomics from fixed single cells.
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Killer Alert! Excited to share our new study creating the first multi tissue transcriptional map of mouse Natural Killer cells. (1/8) .
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Together with @DahanLab we are very excited to introduce BiCE (Bispecific DC-T Cell Engager)- a new platform to engineer immune cell communication for #Cancer #Immunotherapy. Led by the amazing @yuval_shap and @orenbarboy, now available at @CellCellPress .
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We are excited to share our new work on the role of cDCs in NASH, championed by @ADeczk, Eyal David and @AssafWeiner, close colab with @CancerInflam, @eranelinav and The Center for Liver Diseases at Sheba Medical Center, out today @NatureMedicine (1/16).
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Very impressive study showing the potential of high resolution spatial transcriptomics for biological discovery.
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I am honored to receive the @pezcoller foundation- @EACRnews Translational Cancer Research Award. It is truly inspirational when our research is recognized by the community and motivates us even further to push the boundaries of immunotherapies for currently incurable cancers.
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Very comprehensive review from Miriam, Florent and co. on macs in health and disease.
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At the end of the day, when all the dust clears, it’s not the stem cells, but the MACROPHAGES that do the job || An acute immune response underlies the benefit of cardiac stem-cell therapy | Nature
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Embryo-scale, single-cell spatial transcriptomics | Science.
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United we stand. Message from Alon Chen, president of Weizmann Institute of Science.
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Deciphering human macrophage development at single-cell resolution | Nature
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Single-cell transcriptomic analysis of Alzheimer’s disease (HUMAN!!!) = something we’ve all waited for || @nature
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How can we advance the development of immunotherapies? In this perspective we outline how single-cell genomics can revolutionize drug development. By @IdoYofe together with @DahanLab now @NatureMedicine. (1/6).
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Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer.
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We are very excited to share our new multi-resolution deconvolution approach for spatial transcriptomics (ST) measurements, DestVI, a joint work by @YosefLab and @IdoAmitLab led by @_romain_lopez, @lbgbox, and @HadasKerenShaul on bioRxiv: (1/12).
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Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19 patients
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Fantastic paper by the Amos Tanay group! || Single-cell analysis of clonal maintenance of transcriptional and epigenetic states in cancer cells | Nature Genetics
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Macrophages do a whole lot more. They are a major subunit of basically all tissues. They protect the brain from damage, regulate thermogenesis in adipose tissue, and are electrically coupled to cardiomyocytes in the heart. They are the immune system's ultimate Swiss Army knife!.
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Ido got the Sanofi Pasteur prize!!! (and they made a nice movie about our lab for this occasion - check it out .photo credit ©chiscano
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We are very excited to share our manuscript lead by @meravcohen8 @AmirGiladi and Anna Dorothea Gorki - fun collaboration with the @SylviaKnapp_Lab - Lung single cell signaling interaction map reveals basophil role in macrophage imprinting @CellCellPress
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We are excited to share our new work, out in @NatImmunol: led by Alexander Mildner @MDC_Berlin and our own @AmirGiladi. We applied scRNA-seq to characterise the protective and pathogenic myeloid cells in EAE.
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COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis | Nature Biotechnology
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Stimulating review! Cell-cell interactions are a new and very important frontier! || Deciphering cell–cell interactions and communication from gene expression | Nature Reviews Genetics
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Congratulations Nir for receiving your ERC grant to advance spatial technologies
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We are very excited to share ‘Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma’ – led by Guy Ledergor and @AssafWeiner (thread 1/13)
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Beautiful paper! Congratulations Jonathan, Tyler, Nir and teams. Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution: Cell.
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Important paper showing the critical role of tumor Macs/Mregs (SPP1+, TREM2+) in regulating the suppressive immune microenvironment and tumor progression. (1/2) .
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Beautiful study. Congratulations Barbara and Gray, the dynamic duo.
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Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization | Nature Neuroscience.
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A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition | Nature Genetics
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Single cell enthusiasts, get your flip-flops ready!. Less than 24 hours until the registration to SCG2024 in Corinthia, Greece opens (April 3rd 3PM EU time) .Space is limited, don’t miss your spot!
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We are happy to release a detailed protocol for MARS-seq2.0 -> new developments of our original FACS-based scRNA-seq pipeline with integrated computational analysis. Work by @HadasKerenShaul and @effiken. Powered by @IdoAmitLab
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Very stimulating study🔥 showing that to effectively treat cancer, in conjunction with activation of T cell immunity, myeloid populations in the TME will need to be robustly activated.
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Super cool! Macrophages are the Swiss army knife among cells!! .VCAM-1 + macrophages guide the homing of HSPCs to a vascular niche | Nature
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ZipSeq: barcoding for real-time mapping of single cell transcriptomes | Nature Methods
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Fibroblasts as a source of self-antigens for central immune tolerance | Nature Immunology
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!!! Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells ||| Nature Methods
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Congratulations Ali @erturklab, Matthias @labs_mann, Fabian @fabian_theis and teams for this tour de force study, brilliant!.
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🥳🥳🥳.
Congratulations to Prof. Ido Amit of the Immunology Department, who has been awarded the Landau Prize by Mifal Hapais 👏👏👏.@IdoAmitLab
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Three labs point to important considerations when combining CRISPR and scRNAseq. Gary Hon lab. Paul C Blainey lab. Cole Trapnell lab @coletrapnell.
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Regulatory DC (mregDC) are here!!! 🎉🎉🎉 Congratulations @dendriticBabs @effiken, Brian D. Brown and @MiriamMerad on this fascinating study! || A conserved dendritic-cell regulatory program limits antitumour immunity
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Getting ready with premier of new single cell tech for this super fun event. Join us!
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We are excited to share our work; Alzheimer’s disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mice in Nature Aging.Championed by Raz Dvir @ds_raz and in collaboration with the lab of Michal Schwartz.
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Beautiful research with important translational implications by Brian Brown and @MiriamMerad 's groups showing how tumor-secreted IL4 leads to immune evasion through tumor macrophages .
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This is hilarious!.
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BRACE YOURSELVES! NEXT GEN IMMUNOLOGY 2020 LINE-UP IS HERE! .and it's BRILLIANT! check it out!.(registration opens soon)
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Beautiful paper looking into cell-cell interactions (ProximID) using #scRNA-seq by Jean-Charles Boisset, Alexander van Oudenaarden and co. Pairs are separated and sequenced individually; interesting interaction between megakaryocytes and neutrophils.
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“Systems meets Neuroimmunology” – Coming soon joint meeting in Spring 2023 between @WeizmannScience.@Sys_Immunology and @WUSTLmed @BIG_CenterWashU. Get ready for the best meeting since COVID.
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A map of transcriptional heterogeneity and regulatory variation in human microglia | Nature Genetics.
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Next Gen Immunology 2020 - the opening movie. The Next Gen Hangover. (Luckily all actors are already tenured).#NGI2020.
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🎯 🎯.Every disease should be considered immunological, until proven otherwise.
I stand by my mantra. Every disease should be considered immunological, until proven otherwise. #neuroimmunology.
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what an impressive and important technology! || Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2 | Nature Biotechnology
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Microglia shape human brain! || Human fetal microglia acquire homeostatic immune-sensing properties early in development | Science
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Celebrating @FadiSheban 🎉 Congratulations for your PhD defence to better define the regulatory circuits of tumor associated macrophages and apply this knowledge for novel immunotherapy 🏆
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We are very excited to present: Tuft-TECs - a new subset of IL-25 expressing Thymic Epithelial Cells regulating ILC2s – by Chamutal Bornstein, in collaboration with the Abramson’s lab @WeizmannScience - now @Nature.
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TREM2 signaling in macrophages emerges as an important regulator of Alzheimer’s, metabolic syndrome and cancer. In this perspective, we summarize what is known and what remains to be discovered about TREM2 function Work by @ADeczk, @AssafWeiner. (1/8)
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A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment | Nature Neuroscience
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Early demonstration of the massive impact single cell genomics will have on future medicine! || Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report | Nature Medicine
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Today we are saying goodbye to @li_hanjie, a phenomenal single cell and immunotherapy champion. We are also excited and very very proud to see Hanji start his own lab at Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences!!!
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Making B cells cool again! PHENOMENAL!!! || Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10 @CellCellPress
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