Nature - Single-cell RNA sequencing and imaging of macrophages in human non-small cell lung cancer and in a mouse model of lung adenocarcinoma show that tissue-resident macrophages have a key role...

Nature - In a mouse model of breast cancer, a low-protein diet induces engulfment activities and mTORC1 signalling in tumour-associated macrophages to suppress engulfment-dependent mTORC1...

Nature Communications - Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM)...

The cancer-immunity cycle provides a framework to understand the events that generate anti-cancer immune responses. Mellman, Chen, Powles, and Turley consider the last 10 years of research in cancer...

El futuro CaixaResearch Institute, que contará unos 50 grupos de investigación, iniciará su actividad en 2025

The Casanova Acebes Lab focuses on understanding how innate immune cells behave, respond, and shape adaptive immunity in the tumor microenvironment. We are interested in the molecular and functional...

Nature - COVID has shown we must study immunity in the whole body — let’s sort the logistics to acquire the right samples.

The eradication of antigenically heterogeneous tumors by T cell immunotherapies requires neutrophils.

Nature Medicine - Being a parent scientist can feel like a catch-22, feeling guilty for both the time spent away from the children and the time spent away from the bench. Embracing healthy...

Nature Communications - Circadian rhythms are known to impact a range of biological processes including in the immune system. Here the authors show how circadian rhythms modulate the T cell...

We are looking for 2 motivated postdoctoral fellows to join our team! We aim to elucidate how immune circadian rhythms are coopted by cancer cells in lung cancer.

Nature Medicine - Response to anti-PD-1 in patients with hepatocellular carcinoma is associated with clonal expansion of intratumoral CXCL13+ CD4+ helper T cells and effector-like CD8+ T cells, and...

Nature Immunology - Rinkevich and colleagues show that preexisting matrix is transferred by neutrophils across organs into injured sites in a manner dependent on integrin activation.

Current understanding is that, in the steady state, macrophages acquire tissue residency in response to local tissue signals. Finlay et al. show that during nematode infection of the pleural cavity,...

Nature Immunology - In non-small cell lung cancer, the presence of monocyte-derived macrophages inversely correlates with the presence of NK cells. Merad and colleagues propose that when monocytes...

Invasive candidiasis has high mortality rates with limited therapeutic options. Gander-Bui et al. show how macrophage-secreted IL-1 receptor antagonist (IL-1Ra) restricts recruitment of fungicidal...

We are looking for 2 motivated postdoctoral fellows to join our team! We aim to elucidate how immune circadian rhythms are coopted by cancer cells in lung cancer.

Nature Immunology - Blacher et al. examine the effect of aging on the myeloid circadian clock. They find that aging disrupts circadian transcriptional responses and identify KLF4 as a critical...

Liu et al. find that Aspergillus sydowii, the enriched tumor-resident fungus, promotes lung adenocarcinoma progression by inducing MDSCs expansion and activation through IL-1β secretion via β-gluca...

In humans and in mouse models, pineal gland denervation by immune cells causes sleep disturbance in cardiac disease.

Nature - A transcriptomics study demonstrates cell-type-specific responses to differentially aged blood and shows young blood to have restorative and rejuvenating effects that may be invoked...

Weeden et al. find that ever-smoker lungs have greater activation of T cells with a tissue-resident memory phenotype (TRM). Lung tumors growing in TRM cell-rich environments develop immune evasion,...