Immensely proud to share our four papers on
#SingleCell
dissection of
#Alzheimers
Disease coming out in
@CellCellPress
today, reporting 2.3M
#scRNA
profiles and 850k
#scATAC
profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful
To the colleagues and friends who find our paper overwhelming, and instead prefer to write and read more manageable papers with more focused messages:
I respect your perspective and your approach to science greatly, and find it invaluable, of course. Both broad and focused
Here's my conversation with
@manoliskellis
, his 5th time on the podcast. He is a computational biologist at MIT and one of the smartest & kindest human beings I know. It's an honor to sit down with him for a chat and to be able to call him a friend.
Excited and proud to share our
#SingleCell
dissection of
#ALS
and
#FTLD
out in
#Cell
this week, across 620,000 cells, 44 cell types, 73 donors, and two brain regions.
Although ALS affects
#movement
vs. FTLD
#cognition
, the two are nearly identical in the cell types, genes, and
If a critic *never* genuinely points out the slightest positive about a work or author they're constantly criticizing, it's much easier to 'see through them' and understand that their motivations might be shooting down, bullying, settling scores, belittling, self-aggrandizing,
How bullying becomes a career tool: "Bullies spring into action when their targets become too successful for their liking". "Planting false stories, publicly ridiculing, insulting, or tarnishing".
Do we have mechanisms to combat this? Can kindness prevail?
#StopBullying
@prmshra
Parm, this is such a sweet note. Truly grateful for your kindness. I'm still that immigrant kid who will not insult anyone, and will always look for the good in people, so this behavior is quite foreign and baffling to me as well. So happy that my lectures and papers have been
How bullying becomes a career tool: "Bullies spring into action when their targets become too successful for their liking". "Planting false stories, publicly ridiculing, insulting, or tarnishing".
Do we have mechanisms to combat this? Can kindness prevail?
#StopBullying
Uh-oh... 144443 citations. This is where you drive ever-so-slowly to catch 144444 on the dashboard (but invariably miss it).
Okay, back to that grant report [adding our latest papers]. No distractions, already past 5am, kids waking up soon, whoosh...
Our new
@GenomeResearch
paper reports hundreds of new protein-coding genes in human, mouse, fly, worm & mosquito, including 118 protein-coding genes/exons overlapping previously-non-coding
#GWAS
hits. Eg. new eye-specific TJP2 exon associated with
#myopia
It's amazing how cordial and kind a critic can be in a face-to-face private conversation (eg. offering feedback after a seminar when others are *not* watching), and how the language changes to almost performative insults, as soon as that same otherwise-kind person goes on twitter
@NimwegenLab
Peak Twitter is knocking down a fellow scientist because of too much data in a paper. There are actual people working on these publications for years. Don't think it's very practical to dismiss their work as 'landfill'.
Some Coronavirus Advice for my friends Don't panic, but don't underestimate this either. Act rationally, minimize the spread to protect others, enjoy time with your loved ones, and act as if it's a pandemic, so it doesn't become one
As
#COVID19
cases skyrocket throughout the world, a recent
#VitaminD
randomized clinical trial in hospitalized patients offers hope, with
#25fold
reduction in ICU admissions. Our mathematical analysis indicates its results are real
#Calcifediol
#C
órdoba
Artificial intelligence is a powerful new technology with seemingly endless, exciting possibilities—and risks. What’s the future of A.I.?
“A.I. Revolution” premieres WEDS MARCH 27 at 9/8c on PBS.
Guess what? The
@NIHDirector
's awards for
#NIHHighRisk
research have been announced! Read about innovative
#biomedical
and behavioral research early career, and seasoned scientists will conduct through these awards: .
Our new
@GenomeResearch
paper reports the most accurate yet update of human protein-coding genes, using
#PhyloCSF
of 58 mammals and 100 vertebrates, MassSpec, RNA transcription, CAGE, PolyA-seq, and
@GencodeGenes
curators sifting through 4000+ candidates 1/6
No, SARS-CoV-2 does not integrate into your genome.
No, vaccines will not change your DNA.
Please help get everyone vaccinated and help put this pandemic behind us
Our paper refuting earlier claim of SARS-CoV-2 genomic integration is now online
@CellReports
The virus does not enter human DNA
The same would be true of COVID-19 mRNA vaccines
Particular thanks to
@UQ_SCMB
authors for SARS-CoV-2 experiments
@UQ_News
What's the
#MeaningOfLife
: Think, Love, Humanity, Life, Time, Family, Layers, Planet, Legacy, Diversity, Ideas, Space, Mind, Facts, Music, Laughter, Giving, Sharing, Feeling, Connected, and 42, at least according to our
#Podcast
#WordCloud
with
@LexFridman
Meaning of Life Symposium
@MIT
. Scientists, Humanists, and Luminaries reflect on the Meaning of Life, from the human scale to the cosmic scale. Blending neuroscience, philosophy, evolution, astrophysics, spirituality Wed 3/13/2019, 4pm-8pm 34-101. Join us!
For those wondering if
#COVID19
shutdowns were needed. New study estimates they prevented 530M infections, 62M cases (i.e. 5M deaths, with CFRs lower than Italy's overrun hospitals). This is not over. Stay home, stay safe, avoid gatherings, wear your masks
This is embarrassing science denialism. Yes, we would certainly prefer that mental illness is not genetic, but it is. How does one respond to such pieces?
Just made a donation to IITMAANA to support India Covid-19 Relief. This is a trusted effort that I have received personal vouching for by Hari Balakrishnan at MIT, run by his personal connection Mohammed Siddique, head of Chennai COVID management efforts
Tomorrow is not about politics, it's between lies and false promises vs. truth and action. Let's
#vote
populism out and bring the US back to reality. Let's invest in science, research, infrastructure, progress, and let the Beacon of the World shine again
My views on the
#MeaningOfLife
, horizontal and vertical evolution, the importance of diversity, the danger and fallacy of eugenics, the horizontal transfer of knowledge through humanity and fellowships, and the evolution and sharing of ideas March 13, 2019
So honored to be back in Athens, speaking at EmTech Europe (Emerging Technologies) on "The AI Frontier: Transforming Health, Knowledge, and Human Achievement" on Thursday morning at 9:45am Greek Time. The talks will be live in person at the stunning Megaron Athinon Concert Hall,
The last Plenary session at
#EASCongress2023
is starting in just 10 minutes!🤩
We will discuss "Advancing therapy" with Winfried März, Lale Tokgozoglu, Khurram Nasir, Manolis Kellis, Pam R. Taub, and Sek Kathiresan.
📍Hall: Anitschkow
#EASCongress2023
@rikvanderkant
Thanks for the kind words Rik. It's hard to please everyone. If a paper has too little data, someone will criticize the lack of transparency. If it has too much, someone else will comment that it's overwhelming. [Sometimes it's the same person too]. Best way to avoid their
This year we'll have short guest lectures on the most influential papers in
#DeepLearning
in
#Genomics
and
#LifeSciences
. Please nominate your favorite researchers and papers (including your own!) and we'll try to cover them & even invite. Topic list below. Suggestions? Please RT
Second talk by Yosuke Tanigawa
@yk_tani
on Transcriptional Hallmarks and Subtypes of
#Alzheimers
from
#SingleCell
#scRNA
across 430 individuals.
His tweet:
Yosuke was honored with a Charles Epstein Trainee award too, congrats!