Manolis Kellis Profile Banner
Manolis Kellis Profile
Manolis Kellis

@manoliskellis

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27,481
Following
4,285
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531
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3,551

Dissecting disease mechanism. Single-cell, Epigenomics, Regulatory Genomics, Disease Genetics, Brain, Cancer, Metabolism. @MIT Prof, @MIT_CSAIL , @BroadInstitute

Cambridge, MA
Joined July 2009
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@manoliskellis
Manolis Kellis
6 years
Kellis Lab is hiring! New grants in #Alzheimers #Schizophrenia #Cancer #EHR #SingleCell #Genome #Epigenome #Transcription #Disease integration. Computational & experimental positions, profiling and circuitry dissection. Join us! @MIT_CSAIL @BroadInstitute
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@manoliskellis
Manolis Kellis
11 months
Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful
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@manoliskellis
Manolis Kellis
2 years
This week in @Nature we present our #SingleCell dissection of #ApoE4 , the strongest genetic variant for #Alzheimers . ApoE4 impairs #cholesterol #transport , leading to #oligodendrocyte ER accumulation, decreased #myelination . Restoring transport restores mouse cognition. #Hope #AD
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@manoliskellis
Manolis Kellis
27 days
To the colleagues and friends who find our paper overwhelming, and instead prefer to write and read more manageable papers with more focused messages: I respect your perspective and your approach to science greatly, and find it invaluable, of course. Both broad and focused
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@manoliskellis
Manolis Kellis
3 years
The first six lectures of #DeepLearning for #Genomics and #LifeSciences are posted on @YouTube here: covering #MachineLearning #CNNs #RNNs #GNNs #RepresentationLearning #InterpretableML #Convolution Linking to them individually in the thread below 1/n
@manoliskellis
Manolis Kellis
4 years
Interested in #DeepLearning for #Genomics and the #LifeSciences ? Our @MIT course starts again today. Recommend your favorite papers and topics to cover, and we *will* cover them! Watch our 2020 lectures with @DavidKGifford at and
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@manoliskellis
Manolis Kellis
1 year
Such an honor to be back on @LexFridman to talk about #humanity , #AI , #intelligence , #ChatGPT , #DeepLearning , #DrugDiscovery , #Genomics and the #FutureOfWork . Lex is an amazing human being, curious, driven, smart, humble, kind, and unapologetically open. Thank you Lex for the
@lexfridman
Lex Fridman
1 year
Here's my conversation with @manoliskellis , his 5th time on the podcast. He is a computational biologist at MIT and one of the smartest & kindest human beings I know. It's an honor to sit down with him for a chat and to be able to call him a friend.
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@manoliskellis
Manolis Kellis
5 months
Excited and proud to share our #SingleCell dissection of #ALS and #FTLD out in #Cell this week, across 620,000 cells, 44 cell types, 73 donors, and two brain regions. Although ALS affects #movement vs. FTLD #cognition , the two are nearly identical in the cell types, genes, and
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@manoliskellis
Manolis Kellis
2 years
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@manoliskellis
Manolis Kellis
11 months
Proud to share our #eGTEx multi-tissue dissection of #enhancer H3K27ac across 387 brain, muscle, heart, and lung samples from #GTEx in @NatureGenet #eQTLs #haQTLs #SexDiffs #Epigenomics #GWAS #linking Paper: (H3K27ac, today) News:
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@manoliskellis
Manolis Kellis
3 years
Excited to share our #SingleCell dissection of #Alzheimers brain #vasculature changes across 6 brain regions with @DrLiHueiTsai . AD- & ApoE4-associated DEGs, upstream regulators & modules, cell-cell communication changes and links to #GWAS variants #ROSMAP
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@manoliskellis
Manolis Kellis
4 years
Interested in #DeepLearning for #Genomics and the #LifeSciences ? Our @MIT course starts again today. Recommend your favorite papers and topics to cover, and we *will* cover them! Watch our 2020 lectures with @DavidKGifford at and
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@manoliskellis
Manolis Kellis
25 days
If a critic *never* genuinely points out the slightest positive about a work or author they're constantly criticizing, it's much easier to 'see through them' and understand that their motivations might be shooting down, bullying, settling scores, belittling, self-aggrandizing,
@manoliskellis
Manolis Kellis
2 years
How bullying becomes a career tool: "Bullies spring into action when their targets become too successful for their liking". "Planting false stories, publicly ridiculing, insulting, or tarnishing". Do we have mechanisms to combat this? Can kindness prevail? #StopBullying
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@manoliskellis
Manolis Kellis
3 years
High-altitude adaptation #StructuralVariants signals in #SingleMolecule @nanopore sequencing between 119 #Tibetan and 201 #HanChinese samples reveals cis/trans rewiring of #hypoxia , #energy , #lung pathways, expanding #GWAS . #SVs #InDels #SNPs #LongReads
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@manoliskellis
Manolis Kellis
3 years
End of evolution: transforming medicine through AI to reverse human disease @TEDTalks #TEDxMIT #Genomics @MIT @BroadInstitute @MIT_CSAIL @MITEECS @HarvardMed #pharma
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@manoliskellis
Manolis Kellis
26 days
@prmshra Parm, this is such a sweet note. Truly grateful for your kindness. I'm still that immigrant kid who will not insult anyone, and will always look for the good in people, so this behavior is quite foreign and baffling to me as well. So happy that my lectures and papers have been
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@manoliskellis
Manolis Kellis
3 years
Excited to co-teach " #Neurogenomics : Computational Molecular Neuroscience" this Spring at @MIT , a new 6-9 ( #EECS & #BCS ) course with #MyriamHeiman . More info at Course syllabus below. @MITEECS @MITBrainAndCog Please spread the word! #AI #CogSci #ML #MolBio
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@manoliskellis
Manolis Kellis
1 year
So excited to share our #SingleCell dissection of #Alzheimers brain #vasculature changes across 6 brain regions, out in @NatureNeuro today. Paper: News: Open Access Link: With @DrLiHueiTsai @NaSun818
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@manoliskellis
Manolis Kellis
3 years
Excited to share our #SingleCell dissection of #Alzheimers brain #vasculature changes across 6 brain regions with @DrLiHueiTsai . AD- & ApoE4-associated DEGs, upstream regulators & modules, cell-cell communication changes and links to #GWAS variants #ROSMAP
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@manoliskellis
Manolis Kellis
2 years
How bullying becomes a career tool: "Bullies spring into action when their targets become too successful for their liking". "Planting false stories, publicly ridiculing, insulting, or tarnishing". Do we have mechanisms to combat this? Can kindness prevail? #StopBullying
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@manoliskellis
Manolis Kellis
5 months
Excited and grateful to be inaugural recipients of a @BiswasFamilyFdn Transformative Computational Biology Grant w/ @MarinkaZitnik & Brad @PenteluteLab at @MIT & @HarvardMed . Our goal: #AI for #GenomicMedicine : #DiseaseCircuitry , #DrugDevelopment , #Personalization . Including:
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@manoliskellis
Manolis Kellis
5 years
Congratulations to Aviv Regev for her induction in the National Academy of Sciences, a much deserved honor! @theNASciences @BroadInstitute @MIT @ScienceMIT @MITBiology
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@manoliskellis
Manolis Kellis
2 years
Excited to share our #SingleCell dissection of #Huntingtons Disease, showing distinct #striatum direct-vs-indirect-pathway projection neuron vulnerability in human and mouse #iSPNs #dSPNs #Neurodegeneration @MIT #Heiman Paper: News:
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@manoliskellis
Manolis Kellis
2 years
Uh-oh... 144443 citations. This is where you drive ever-so-slowly to catch 144444 on the dashboard (but invariably miss it). Okay, back to that grant report [adding our latest papers]. No distractions, already past 5am, kids waking up soon, whoosh...
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@manoliskellis
Manolis Kellis
5 years
Our new @GenomeResearch paper reports hundreds of new protein-coding genes in human, mouse, fly, worm & mosquito, including 118 protein-coding genes/exons overlapping previously-non-coding #GWAS hits. Eg. new eye-specific TJP2 exon associated with #myopia
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@manoliskellis
Manolis Kellis
4 years
The Greek-Turkish friendship behind the Pfizer-BioNTech vaccine that could save the world. Very inspiring story of immigrants with dreams, drive, perseverance #COVID19 #Vaccine #Greece #Turkey #Immigrants #Pfizer #BioNTech @AlbertBourla @BioNTech_Group
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@manoliskellis
Manolis Kellis
25 days
It's amazing how cordial and kind a critic can be in a face-to-face private conversation (eg. offering feedback after a seminar when others are *not* watching), and how the language changes to almost performative insults, as soon as that same otherwise-kind person goes on twitter
@NiklasGrimm824
Niklas Grimm
26 days
@NimwegenLab Peak Twitter is knocking down a fellow scientist because of too much data in a paper. There are actual people working on these publications for years. Don't think it's very practical to dismiss their work as 'landfill'.
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@manoliskellis
Manolis Kellis
7 years
HiDRA: Building on Sharpr-MPRA+STARR-Seq+ATAC-Seq to dissect millions of human regulatory regions in one experiment
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@manoliskellis
Manolis Kellis
4 years
Some Coronavirus Advice for my friends Don't panic, but don't underestimate this either. Act rationally, minimize the spread to protect others, enjoy time with your loved ones, and act as if it's a pandemic, so it doesn't become one
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@manoliskellis
Manolis Kellis
4 years
Such a relief to see that #ScienceIsBack on the table at the @WhiteHouse , with @JoeBiden and @KamalaHarris nominating a top-notch Science Team, with @Eric_Lander , @Maria_Zuber , @NIHDirector , @Alondra . Let the US Beacon shine again
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@manoliskellis
Manolis Kellis
4 years
As #COVID19 cases skyrocket throughout the world, a recent #VitaminD randomized clinical trial in hospitalized patients offers hope, with #25fold reduction in ICU admissions. Our mathematical analysis indicates its results are real #Calcifediol #C órdoba
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@manoliskellis
Manolis Kellis
5 months
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@novapbs
NOVA | PBS
5 months
Artificial intelligence is a powerful new technology with seemingly endless, exciting possibilities—and risks. What’s the future of A.I.? “A.I. Revolution” premieres WEDS MARCH 27 at 9/8c on PBS.
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@manoliskellis
Manolis Kellis
4 years
For those interested in #SingleCell analyses, #ACTIONet is our main workhorse for #Alzheimers #Schizophrenia #ALS #HD and more: a multi-scale network-based archetype approach for learning cell types and cellular states in health and disease Out today!
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@manoliskellis
Manolis Kellis
3 years
@NIH_CommonFund
NIH Common Fund
3 years
Guess what? The @NIHDirector 's awards for #NIHHighRisk research have been announced! Read about innovative #biomedical and behavioral research early career, and seasoned scientists will conduct through these awards: .
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@manoliskellis
Manolis Kellis
5 years
Our new @GenomeResearch paper reports the most accurate yet update of human protein-coding genes, using #PhyloCSF of 58 mammals and 100 vertebrates, MassSpec, RNA transcription, CAGE, PolyA-seq, and @GencodeGenes curators sifting through 4000+ candidates 1/6
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@manoliskellis
Manolis Kellis
3 months
Excited to share our #GenoBoost paper out in @NatureComms today, a flexible #PolygenicScore #PGS modelling framework for additive and #NonAdditive dominance effects, incorporating non-zero dominance effects in 40%-67% of variants across multiple traits, including #psoriasis ,
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@manoliskellis
Manolis Kellis
10 months
Next #ASHG23 #ASHG talk after the break: @NaSun818 on #SingleCell #eQTLs #genetic regulation of #Alzheimers in BallroomC/Level3 (10:30am) Integrate: 427 individuals, 2.3M cells, 23 cell types and subtypes, genotypes Results: 457k sc-eQTLs, 8.8k sc-eGenes, cell-type- / conditon-
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@manoliskellis
Manolis Kellis
3 years
No, SARS-CoV-2 does not integrate into your genome. No, vaccines will not change your DNA. Please help get everyone vaccinated and help put this pandemic behind us
@Faulkner_Lab
Geoff Faulkner
3 years
Our paper refuting earlier claim of SARS-CoV-2 genomic integration is now online @CellReports The virus does not enter human DNA The same would be true of COVID-19 mRNA vaccines Particular thanks to @UQ_SCMB authors for SARS-CoV-2 experiments @UQ_News
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@manoliskellis
Manolis Kellis
10 months
Please join us for a public lecture and fireside chat with @ManolisKellis and @LeoAlexopoulos on #AI and the Future of #Medicine and #Innovation this coming Tue Oct 31 at 5:30pm at @NTUA (Metsovio Polytechnio) RSVP: (for this and future such gatherings)
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@manoliskellis
Manolis Kellis
4 years
What's the #MeaningOfLife : Think, Love, Humanity, Life, Time, Family, Layers, Planet, Legacy, Diversity, Ideas, Space, Mind, Facts, Music, Laughter, Giving, Sharing, Feeling, Connected, and 42, at least according to our #Podcast #WordCloud with @LexFridman
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@manoliskellis
Manolis Kellis
2 years
Article: Perspective: News & Views: Big congrats to an amazing team led by @DrLiHueiTsai @JoelWBlanchard1 @Leyla_Aakay @_JoseDavila @DjunaVM . Truly grateful to be part of this extraordinary collaboration
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@manoliskellis
Manolis Kellis
5 years
Meaning of Life Symposium @MIT . Scientists, Humanists, and Luminaries reflect on the Meaning of Life, from the human scale to the cosmic scale. Blending neuroscience, philosophy, evolution, astrophysics, spirituality Wed 3/13/2019, 4pm-8pm 34-101. Join us!
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@manoliskellis
Manolis Kellis
2 years
Congrats #KellisLab , with 4 platform presentations, 1 Epstein award winner, and 5 posters, all by #trainees at #ASHG22 Each talk/poster in the thread below 🧵 Congrats to @__ben_james__ @Xushen18 @yk_tani @boix_carles #ChristianHwa & the whole team! Proud & grateful 🧑‍🎓👩‍🔬💻🧪🧬
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@manoliskellis
Manolis Kellis
4 years
For those wondering if #COVID19 shutdowns were needed. New study estimates they prevented 530M infections, 62M cases (i.e. 5M deaths, with CFRs lower than Italy's overrun hospitals). This is not over. Stay home, stay safe, avoid gatherings, wear your masks
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@manoliskellis
Manolis Kellis
4 years
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@MSI_UCA
MSI
4 years
Today at 2:00 p.m., do not miss @manoliskellis ' ( @broadinstitute @MIT ) seminar on single-cell dissection & manipulation of disease circuitry. #signalife #genomics #therapeutics @uca_research @ircaninstitute . Contact: @BrestLab
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@manoliskellis
Manolis Kellis
2 years
This is embarrassing science denialism. Yes, we would certainly prefer that mental illness is not genetic, but it is. How does one respond to such pieces?
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@manoliskellis
Manolis Kellis
3 years
Just made a donation to IITMAANA to support India Covid-19 Relief. This is a trusted effort that I have received personal vouching for by Hari Balakrishnan at MIT, run by his personal connection Mohammed Siddique, head of Chennai COVID management efforts
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@manoliskellis
Manolis Kellis
27 days
Outstanding news article by the always-insightful @AlzForum on our #SingleCell #MultiRegion study of #Alzheimers Disease. Thanks for the wonderful coverage of our work!
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@manoliskellis
Manolis Kellis
4 years
Tomorrow is not about politics, it's between lies and false promises vs. truth and action. Let's #vote populism out and bring the US back to reality. Let's invest in science, research, infrastructure, progress, and let the Beacon of the World shine again
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@manoliskellis
Manolis Kellis
5 years
Excited to present our #SingleCell dissection of #Alzheimers #Schizophrenia #Bipolar #Huntingtons at #ASHG19 800 Brains, 5.5M cells #scRNA #scATAC #scQTLs 4:15pm today Level3/BallroomB Session029 Talk52 with @DrLiHueiTsai #MyriamHeiman #BradRuzicka #ROSMAP
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@manoliskellis
Manolis Kellis
5 years
Today I responded to the #TakeYourShots challenge. Spread the word about #VaccinesSaveLives , and drink a shot of 1 lemon. Nominate at least 5 others. I nominate @Eric_Lander @GeoChurch @AndrewWLo @DrLiHueiTsai @SafiBahcall @natalya926 @quantum_spiros @LRafaelReif @NIHDirector
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@manoliskellis
Manolis Kellis
4 years
My views on the #MeaningOfLife , horizontal and vertical evolution, the importance of diversity, the danger and fallacy of eugenics, the horizontal transfer of knowledge through humanity and fellowships, and the evolution and sharing of ideas March 13, 2019
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@manoliskellis
Manolis Kellis
2 years
From Genomics to Therapeutics: Single-Cell Dissection and Manipulation of Human Disease Circuitry My talk at @GenomicsEngland #DiscoveryForum Slides here (w/QR codes): #Alzheimers #Obesity #Disease #TeamWork
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@manoliskellis
Manolis Kellis
2 years
Amazing day meeting key stakeholders in the Transformation of #Medicine with #Genomics at @GenomicsEngland 's #DiscoveryForum yesterday. Amazing UK ecosystem for this transformation with @UK_BioBank , @UKFutureHealth , @NHSgms , @NHSEngland
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@manoliskellis
Manolis Kellis
4 months
Really looking forward to #RECOMB2024 this week, and reconnecting with the #ComputationalBiology community joining us at @MIT @Harvard @HarvardMed @Tufts @BroadInstitute #BU #NE and more. This is one of the most successful RECOMB meetings to date, with near-record registrations.
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@RECOMBconf
RECOMB Conference Series
4 months
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@manoliskellis
Manolis Kellis
5 months
Really honored and proud to speak at the @HarvardMed #PostdoctoralFellows program, with the #HMS Biomedical Sciences Program #BSCP , the Diversity Inclusion and Community Partnership #DICP , and the HMS Black Postdoc Association #HBPA . #Diversity is the bedrock of our community,
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@manoliskellis
Manolis Kellis
7 months
So honored to be back in Athens, speaking at EmTech Europe (Emerging Technologies) on "The AI Frontier: Transforming Health, Knowledge, and Human Achievement" on Thursday morning at 9:45am Greek Time. The talks will be live in person at the stunning Megaron Athinon Concert Hall,
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@manoliskellis
Manolis Kellis
1 year
So excited to speak next at the European #Atherosclerosis Society Congress in the closing plenary session. So many parallels across #cardiac , #obesity , and #Alzheimers with #lipids , #cholesterol , #vasculature , #immune / #monocyte / #macrophage / #microglia dysregulation, #metabolism ,
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@EASCongress
EAS Congress
1 year
The last Plenary session at #EASCongress2023 is starting in just 10 minutes!🤩 We will discuss "Advancing therapy" with Winfried März, Lale Tokgozoglu, Khurram Nasir, Manolis Kellis, Pam R. Taub, and Sek Kathiresan. 📍Hall: Anitschkow #EASCongress2023
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@manoliskellis
Manolis Kellis
11 months
Excited to speak at #CMU #CS #CompBio at 1pm today (in person and on #zoom ). #AI for #GenomicMedicine : #SingleCell Dissection and Manipulation of #DiseaseCircuitry 1pm at GatesHillman GHC 6115 Zoom link: Info: Hosts: @jmuiuc and
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@manoliskellis
Manolis Kellis
29 days
@rikvanderkant Thanks for the kind words Rik. It's hard to please everyone. If a paper has too little data, someone will criticize the lack of transparency. If it has too much, someone else will comment that it's overwhelming. [Sometimes it's the same person too]. Best way to avoid their
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@manoliskellis
Manolis Kellis
10 months
Don't miss @XikunHan 's #ASHG talk on #SingleCell dissection of #BipolarDisorder starting now Room207A/Level 2 (11:15am, Friday) #ASHG23 Integrate: 88 samples, 500k cells, #GWAS , single cell- #eQTLs in 2.3M cells Results: #BD differentially expressed genes ( #bdDEGs ), enriched
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@manoliskellis
Manolis Kellis
4 years
This year we'll have short guest lectures on the most influential papers in #DeepLearning in #Genomics and #LifeSciences . Please nominate your favorite researchers and papers (including your own!) and we'll try to cover them & even invite. Topic list below. Suggestions? Please RT
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@manoliskellis
Manolis Kellis
4 years
Interested in #DeepLearning for #Genomics and the #LifeSciences ? Our @MIT course starts again today. Recommend your favorite papers and topics to cover, and we *will* cover them! Watch our 2020 lectures with @DavidKGifford at and
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@manoliskellis
Manolis Kellis
2 years
Big big congrats to Yosuke Tanigawa @yk_tani for receiving the #ASHG22 /Charles J. Epstein award for Excellence in #HumanGenetics research by the American Society for Human Genetics @GeneticsSociety #Genetics #ProudMentor cc @ManuelRivasCruz @Stanford @MIT @BroadInstitute @MITEECS
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@manoliskellis
Manolis Kellis
2 years
Second talk by Yosuke Tanigawa @yk_tani on Transcriptional Hallmarks and Subtypes of #Alzheimers from #SingleCell #scRNA across 430 individuals. His tweet: Yosuke was honored with a Charles Epstein Trainee award too, congrats!
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@manoliskellis
Manolis Kellis
3 years
Dear @Guardian , @Independent , @BBC , @nytimes , et al. This is no light-bending illusion. Calmer water simply better reflects the sky, making the horizon line subtler. #flyingship
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