Broad Institute
@broadinstitute
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A multidisciplinary community of researchers on a mission to improve human health.
Cambridge, MA, USA
Joined April 2009
Congratulations to @eric_lander who will become Presidential Science Advisor to @JoeBiden! As Eric transitions to this new role, we welcome Broad’s Chief Scientific Officer Todd Golub as Director of the Broad Institute. Learn more:
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Eli Broad was one of the great philanthropists of our time, and his impact on biomedicine is immeasurable. His extraordinary vision and support launched the Broad Institute, and leaves behind formidable legacies in education, art, and beyond.
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We are thrilled to announce the launch of the Eric and Wendy #SchmidtCenter. Merging biology and machine learning to understand the programs of life, the Center will enable a new field of interdisciplinary research aimed at improving human health.
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Congratulations to Aviv Regev, who moves on to an amazing opportunity with @Genentech in August. She was the first faculty member hired at Broad and is a remarkable scientific leader and mentor. Thanks, Aviv!
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Researchers have developed a new way to deliver molecular therapies to cells. The system, called SEND, can be programmed to encapsulate and deliver different RNA cargoes. Learn more:
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Prime editing, a new #CRISPR #genomeediting tool created by @davidrliu/@liugroup, directly edits human cells in a precise, efficient, and highly versatile fashion. The tool has the potential to correct up to 89% of #genetic defects.
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Today we recognize, thank, and celebrate the women in our Broad community – and worldwide! We need more #WomenInScience, more women scientists from all backgrounds, and more young girls choosing STEM careers! #InternationalDayOfWomenInScience #WomenAndGirlsInScience
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Six leading scientists and longtime members of the Broad community have been named as new core institute members at Broad: @getz_lab, @AnnaGreka, Nir Hacohen, @macosko, @bmneale, and @pardissabeti Congratulations to all!
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Cost of sequencing the first human genome was $3 billion. Today it costs $600 dollars. #BroadAt15 #HumanGenome
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A new class of base editor, developed in a collaboration between @davidrliu, Joseph Mougous @UW, @VamsiMootha, and colleagues, enables precision editing of mitochondrial DNA (mtDNA). Read more:
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Slide-seq technique generates high-resolution maps of cellular relationships in tissues, without the need for a microscope
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A new method called Slide-tags lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds upon Slide-seq, both developed by the labs of @insitubiology & @macosko.
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In a matter of days, the @BroadGenomics Platform converted its clinical processing lab to a #COVID19 testing facility capable of testing 2,000 samples a day. Read how the platform worked to modify protocols, train staff members, and reshape lab spaces: .
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Today @BroadGenomics processed their 500,000th #COVID19 test! In partnership with @MassDPH, @CambMA, hospitals, nursing homes, and low-income housing, the lab is working ‘round the clock. Thank you to everyone who is a part of this fantastic team!
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Single-cell biologists, are you looking for a faster way to annotate cells in your scRNA-seq experiments? Try a tool developed by Broad researchers that reduces that task from hours to minutes. Learn more about the Cell Annotation Service, now in beta.
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Congratulations to Broad core institute member @zhangf on receiving the National Medal of Technology and Innovation, the nation’s most prestigious honor for American innovators!
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Broad Institute is working closely with @MassGeneralNews, @BrighamWomens, and other area hospitals to put our high-throughput genomic capabilities at the disposal of @MassGov to enable increased capacity for #COVID19 diagnostic testing. Learn more:
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Today @BroadGenomics processed its 10 millionth #COVID19 test! In the US, about 1 in every 20 tests performed daily are processed at the Broad. Thank you to all of our Broadies for their hard work, innovation, & dedication, especially to the 500+ Broadies working 24/7 onsite!
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Scientists have developed a prime editing approach that efficiently corrects the most common cystic fibrosis mutation in human lung cells, which could pave the way to a one-time treatment as effective as existing daily therapies.
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Broad set to sequence its 100K whole human genome on #DNADay18; milestone to be crossed on 15th anniversary of completion of #HumanGenomeProject
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Researchers from Broad and @DanaFarber scanned thousands of drugs in hundreds of cell lines and found that dozens of non-oncology drugs can unexpectedly kill #cancer cells
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The first ever study to sequence single cells infected with a BSL-4 level pathogen has revealed new details of how the #Ebola virus alters the host immune response for its own benefit during infection. @PardisSabeti @dkotliar @Aaron_E_Lin @sabeti_lab
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A single-cell atlas of the colon, generated from hundreds of thousands of cells, offers new clues into what goes wrong in ulcerative colitis and why some patients don’t respond to drugs. Check out the paper in @CellCellPress:
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After nearly five years of work from researchers including @amitvkhera, a Broad discovery — polygenic scoring for genetic risk assessment for a common disease — has found its way into the clinic. an important step for genomic medicine.
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Broad researchers led by @davidrliu/@liugroup have developed a new #CRISPR genome-editing approach, with a wide range of versatility in human cells, by combining two of the most famous proteins in molecular biology into a single machine.
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Ben Neale, senior co-author of the @Sciencemagazine paper “Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior,” provides perspective on the scientific findings: . “What did this study find?” (1/6)
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Broad recently launched the Gene Regulation Observatory to build thorough map of the non-coding genome, elucidate disease risk factors and roots of cell diversity, and inform cellular engineering. Learn more about #BroadGRO:
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Last night, Boston's Prudential building lit up “Broad blue” for our 20th anniversary! We're proud to be part of the Massachusetts life sciences ecosystem, making an impact locally and globally. Thank you to this amazing community for 20+ years of collaboration and inspiration!
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With 12 industry and non-profit partners, Broad has launched a cell imaging consortium, led by @DrAnneCarpenter, to fuel efforts for discovering and developing new therapeutics. Read more about creating the largest collection of #CellPainting cell images:
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It's International Day of Women and Girls in Science! Today (and every day) we celebrate and thank the many inspiring and innovative #WomeninScience in the Broad community and beyond!
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Science (@sciencemagazine) recognizes single-cell RNA-seq, and its potential for spurring advances in basic research and medicine, as the 2018 Breakthrough of the Year! @humancellatlas.
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A new gene-editing treatment extends lifespan by about 50 percent in a mouse model of prion disease and could lead to a preventative, one-time treatment for the deadly neurodegenerative disorder.
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Researchers have developed a new version of prime editing that can install or swap out gene-sized DNA sequences in human cells — and could be a safer approach to gene therapy.
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Researchers at the Broad Institute have developed a new, efficient, and scalable microscopy system for creating maps of cells, using chemical reactions to encode spatial information. Read more here and in @CellCellPress:
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#Scientists: Need help writing papers or grants, making posters, preparing for a talk, or assembling your CV? Check out the CommKit:
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The Broad Institute stands with Ukraine during these attacks on the country’s freedom and democracy. We support the Ukrainian community, locally and across the world, and hope for peace.
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In a new Broad video, @NIHDirector, Jonathan Brown (@VUMChealth), and @davidrliu describe the impact of their recent work on treating #progeria in an animal model -- a story that began thirty-six years ago. Watch:
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A research team including @LukeKoblan, Mike Erdos (@NIH), Leslie Gordon (@Progeria), Jonathan Brown (@VanderbiltU), @NIHDirector, and @davidrliu significantly extended the lives of mice with #progeria using base editing, with "stunning" results.
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“Every cell is an experiment now.” In @techreview, Aviv Regev talks about single-cell genomics and the @humancellatlas’s efforts to map each of the human body’s biological building blocks.
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Data set of half a million human immune cells openly accessible on preview site that provides initial access to @humancellatlas data:
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An international effort called Zoonomia Project has released the largest dataset of mammalian genomes, aimed at advancing both human health research and biodiversity conservation, also revealed species at risk of extinction.
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Using #AI, a Broad/@jacksonlab /@YaleMed team has developed a way to decipher the language of genetic switches that turn genes on and off, and designed new, synthetic switches that control genes' expression in specific cell types. @ReillyLikesIt
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Prime editing can correct most known disease-causing mutations, and now has a new vehicle to deliver its machinery in mice. The @davidrliu lab has engineered virus-like particles that deliver prime editors efficiently enough to have a therapeutic benefit.
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In @CellCellPress, researchers used single-cell RNA sequencing to define four states of glioblastoma cells and showed that the cells can flip between states, shedding light on why the brain cancer is so hard to treat.
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For 8 years, the #gnomAD Consortium has been working to compile and study a collection of >125,000 human exomes & 15,000 genomes. Today, they've revealed their first set of discoveries in a set of 7 @nature, @NatureComms & @NatureMedicine papers.
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Another use for #CRISPR: not as a tool for cutting DNA, but for capturing the proteins controlling a given gene's transcription.
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Today, @BroadGenomics sequenced its 100,000th whole human genome! The full recording of our event marking the milestone is now available on Facebook. Happy #DNADay18!
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“We want images to become as computable as the genome.” . @DrAnneCarpenter and her lab are using computer vision and machine learning to turn microscope images of cells into rich sources of data that can be systematically analyzed.
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Feng Zhang on gene-edited embryo work: "Not only do I see this as risky, but I am also deeply concerned about the lack of transparency surrounding this trial."
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A new mathematical model picks out cancer “driver” mutations from less important “passenger” ones more accurately than previous models. It analyzed genomic “hotspots”, where #cancer mutations tend to recur, using sequencing data from about 10,000 patients.
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Our community values equality, respect, and understanding. We stand with the Black community, and commit to facilitating these necessary, open and honest conversations. Racism and hate have no place at Broad, in science, or anywhere. We are listening and learning.
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Two scientists are urging the scientific community to create a more comprehensive map of #cancer’s genetic dependencies. They are calling on institutions & researchers to probe all 20,000 genes & test 10,000 drugs & drug candidates in 20,000 cancer models.
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A new version of prime editing makes gene-sized edits in human cells at therapeutic levels — and could pave the way to one-size-fits-all gene therapies for diseases such as cystic fibrosis.
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65+ centers and studies have signed on to be part of the COVID-19 Host Genetics Initiative and answer the question: Why do some people have worse #COVID19 symptoms than others? @dalygene talks about the initiative's origin stories and goals. #coronavirus
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.@davidrliu / @liugroup has improved prime editing, which can make a wide range of genome edits. The new version can work in cells & tissues that have been difficult to edit and could potentially be easier to deliver to cells in the body as new treatments.
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Researchers post genetic profiles of half a million human immune cells on @humancellatlas online portal
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Congratulations to Gad Getz, Aviv Regev, and Chuan He, winners of the 2017 Paul Marks Prize for Cancer Research:
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Today we announce @EricSchmidt as the next Chair of the Broad Institute Board of Directors, succeeding Louis V. Gerstner, Jr. Learn more:
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A new study finds that an important part of #CRISPR screens called CRISPR guides do not perform equally well in cells from people of all ancestries, which could cause experiments to miss potential new drug targets.
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Ribosomes are molecular machines in the cell that make proteins. Researchers have come up with a high-throughput method for building ribosomes using parts from different microbes and that measures and optimizes ribosome function.
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Broad launches the Gene Regulation Observatory (#BroadGRO) to build thorough map of the non-coding genome, elucidate disease risk factors and roots of cell diversity, and inform cellular engineering.
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#SlideSeq uses sequencing to build detailed tissue maps without need for a microscope; shows numerous cell types and patterns of gene expression
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Congratulations to Feng Zhang, Ben Ebert, Beth Stevens, and Ed Boyden on being named Howard Hughes Medical Institute (HHMI) investigators!
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The nervous and immune systems have long been thought to be separate entities, but new research from @shaleklab has uncovered a direct cellular interaction between the two: Pain-sensing neurons that surround lymph nodes in mice and modulate their activity.
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“Prime editing,” a new #CRISPR genome-editing tool, created by @davidrliu/@liugroup combines two key proteins and a new #RNA to make targeted insertions, deletions, and all possible single-letter changes in the #DNA of human cells. Learn how it works:
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Curious what Broad’s #COVID19 testing process looks like? Come, take a video tour of the Broad’s COVID-19 testing lab with scientists who will explain a novel automation system for test processing that is scalable, modular, and high-throughput.
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1,300+ scientists and clinicians analyzed 2,600+ whole genomes of 38 different tumor types over the last six years, completing the most comprehensive study of whole #cancer genomes to date and significantly improving our understanding of cancer.
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Congratulations to @PardisSabeti for being named as one of BBC's 100 inspiring and influential women from around the world for 2020! #BBC100Women.
🎉The BBC 100 Women list 2020 is out! 🎉. #BBC100Women.
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The @BroadGenomics team has completed over 30,000 #COVID19 tests to date! Today, a public portal was launched displaying real-time testing stats.
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Researchers have developed a way to get #GeneEditing proteins inside cells in animal models with high enough efficiency to show therapeutic benefit.
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A team at Broad and @stjuderesearch used base editing to convert the mutation underlying sickle cell disease to a benign variant in an animal model — enabling long-lasting, healthy blood cell production. Read more about this @nature paper:
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Sheila Dodge of @BroadGenomics shares how she and her collaborators are gearing up to run more than 1,000 #COVID19 tests a day.
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We’re excited to introduce #HCRFlowFISH, a new method for characterizing the function of gene regulatory elements developed by @ReillyLikesIt, @r_tewhey, @SagerGosai, @PardisSabeti and colleagues. Now in @naturegenet; some highlights below. 1/6
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A group of gut bacteria can metabolize enough cholesterol to potentially affect people’s metabolism. This discovery suggests a possible reason why some people can consume more cholesterol in their diet with minimal effect on their blood cholesterol levels.
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Scientists built a massive, diverse library of potential molecular glues that might stabilize a target protein and reverse its disease-causing effects. In it, they found one that targets a Crohn’s risk factor and reverses its effects on the cell.
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In @CellCellPress, researchers describe a single-cell map of the enteric nervous system and its connections to the intestinal, immune, and central nervous systems -- as well as links to disorders of the gut and diseases affecting the brain. Learn more:
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We are thrilled to announce Fei Chen as Broad's newest core institute member. Fei will also be joining @HSCRB as an assistant professor. Congratulations, Fei!
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Newly discovered class of molecules may boost #cancer vaccine development. A team led by @VanAllenLab demonstrates the presence of an entirely new class of #neoantigens in this new study published in @NatureBiotech.
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Scientists have developed a suite of molecular tools that increase the efficiency of prime editing, a gene editing method with the potential to correct the vast majority of known disease-causing genetic mutations.
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A new study of whole genomes from more than 250,000 people reveals new complexity in how the nuclear and mitochondrial genomes interact.
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Big milestone today for the #NeuroGAP-P study! The largest genetics study on #psychosis in Africa recruited its 10,000th participant today. Moi Uni PI @LukoyeAtwoli says he never expected we would have this success so early. @StanleyCenter (1/2)
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15 years ago today, MIT, Harvard, Beth Israel Deaconess Medical Center, Boston Children’s Hospital, Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Massachusetts General Hospital came together to launch the Broad Institute. (2/3) #BroadAt15
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Most #scRNAseq methods lose spatial info (cell location within tissue, interactions with neighbors). @broadinstitute & @KTHresearch scientists teamed up to develop HDST, which captures spatial info & helps researchers see a tissue's architecture as never before.
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The Broad Institute Clinical Research Sequencing Platform, in partnership with @MassGov, @MassDPH, and area hospitals, has begun processing #COVID19 patient test samples. The CLIA-certified lab now has capacity to process ~2,000 tests per day. #coronavirus
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Congratulations @AnnaGreka on the fantastic @TEDTalks! Hear from Anna on "The world's rarest diseases — and how they impact everyone." @GrekaLab.
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Through @count_me_in's patient-partnered research approach, Broad and @DanaFarber researchers, led by @corrie_painter and @Nikhilwagle, have conducted the largest study of #angiosarcoma, revealing new mutations and therapeutic possibilities. @ASCaProject
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Researchers at Broad, @VanderbiltU, @NIH, and other institutions have used base editing in mice to treat progeria, a progressive and fatal genetic condition. The work, published in @Nature, provides a blueprint for addressing other genetic disorders.
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Researchers combine population genetics with electronic health records from Finland to get insights into rare diseases. Read more in this Q & A with Alicia Martin, a postdoc in the @dalygene lab.
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Congratulations to @BroadGenomics for reaching another big milestone – over 300K #COVID19 tests processed in partnership with @MassDPH, @CambMA, hospitals, nursing homes, low-income housing, and more. Take a behind the scenes look at our team at work:
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A new class of base editor, developed in a collaboration between @davidrliu, Joseph Mougous @UW, @VamsiMootha, and colleagues, enables precision editing of mitochondrial DNA (mtDNA). Read more:
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The Precision Cardiology Lab of @broadinstitute and @BayerPharma has created the most comprehensive cellular map to date of the human heart. The team uncovered new cell types and gene expression patterns that could be key to treating heart disease someday.
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Fei Chen began his career studying electrical engineering, then an experiment with #DNA inspired him to apply his expertise to #biomedical research. Since then, Chen has invented two innovative microscopy techniques, and he’s pursuing even more bold ideas:
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Five Broad researchers — @BalskusLab, @redmakeda, Sun Hur, @CKadoch, and @KajimuraLab — are among the 33 biomedical researchers nationwide who will become @HHMINEWS investigators this fall. Congratulations to all!
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Can we cure genetic diseases by rewriting DNA? David Liu shared his story of scientific discovery at @TEDTalks
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