Our new paper is out in Circulation
@CircAHA
! We applied
#machinelearning
causal forest model to uncover the heterogeneity in the association between positive CAC and incident CVD. This will be presented at
#AHA22
Early Career Award session!
#HTE
#grf
#CAC
因果フォレストという機械学習モデルを用いて「誰をターゲットにCAC(冠動脈石灰化)スクリーニングを行うべきか」について議論した論文が、AHAでの発表に先立ち、Circulationから出版されました!今週Early Career Awardセッションで発表するのでシカゴにいる方は少し覗いていただけると嬉しいです🤗
Our new paper is out in Circulation
@CircAHA
! We applied
#machinelearning
causal forest model to uncover the heterogeneity in the association between positive CAC and incident CVD. This will be presented at
#AHA22
Early Career Award session!
#HTE
#grf
#CAC
Our new paper
@IntJEpidemiol
showed that the high-benefit approach (treating🧍♀️with high estimated benefit) using
#ML
#CausalForest
outperformed the conventional high-risk approach (treating🧍with high risk) in BP management.
(thread) 1/
Honored to receive MIT Technology Review's Innovators Under 35 Japan Award in 2023!! Hope the high-benefit approach will be one of the key strategies in the future precision medicine & public health era.
Excited to announce our new paper in
@AmJEpi
! With
@ki_endoepi
, we discussed how causal forests (and other ML methods for estimating heterogeneous treatment effects) can advance research in population health and health equity, along with practical tips for its implementation.
Our new
@JAMAHealthForum
study including 5.6 million adults in Japan found that adults in the lowest income decile showed increased risks of rapid
#CKD
progression and
#dialysis
initiation compared with the highest income decile.
#JHIA
@KyotoU_News
Our
#GWAS
paper on primary aldosteronism (PA), the leading cause of secondary hypertension, is published today in Circulation
@CircAHA
! Our cross-ancestry study revealed novel risk loci and an unexpectedly large genetic contribution of PA to hypertension.
In our new
@JAMANetworkOpen
paper, walking ≥8000 steps for 1-2 days/week showed a substantial mortality risk⬇️ as did those who were active more regularly🚶♀️.
I’m honored to receive an NIH F99/K00 transition award. This would not have been possible without the help of
@beate_ritz
,
@ER_Mayeda
, and Dr. Duru. I also appreciate heartful support from my mentors/collaborators around the world. So excited to keep working on this project.
Honored to present my research at Elizabeth Barrett-Connor Research Award session!
#AHA22
#EPI
Congratulations to all of our five presenters🎊 Here is a quick overview of my research simultaneously published in Circulation
@CircAHA
.
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Our new paper is out in Circulation
@CircAHA
! We applied
#machinelearning
causal forest model to uncover the heterogeneity in the association between positive CAC and incident CVD. This will be presented at
#AHA22
Early Career Award session!
#HTE
#grf
#CAC
Our new
@JAMAHealthForum
study including 5.6 million adults in Japan found that adults in the lowest income decile showed increased risks of rapid
#CKD
progression and
#dialysis
initiation compared with the highest income decile.
#JHIA
@KyotoU_News
We described increasing socioeconomic disparities in obesity prevalence among US adolescents. Collaboration work with
@Dr_KID_
& Roch, and great thread by our first author/rising star,
@Ryunosuke_Goto
1/ New research published in
@JAMAPediatrics
with Drs Roch Nianogo,
@Dr_KID_
, and
@ki_endoepi
! We evaluated the trends in adolescents' obesity prevalence by socioeconomic status in the US.
Our recent paper was selected as a High Impact Paper for fall 2020 in
@HyperAHA
! This study highlights the importance of aldosterone levels (even within the reference range) with respect to the cardiovascular system and overall health.
@kewatson
Our recent paper described the concept and application example of Generalizability & Transportability analysis for the general audience.
@ki_endoepi
@uclawillhsu
@oacarah
Ashley, Deni, and Alex.
Emphasized the importance of funding opportunities for early career researchers at Japanese-German University Presidents’ Conference (HeKKSaGOn). Even a small amount of money would be helpful to build international networks and start collaborations for larger projects in future!
In our new
@JAMANetworkOpen
paper, walking ≥8000 steps for 1-2 days/week showed a substantial mortality risk⬇️ as did those who were active more regularly🚶♀️.
Cohort study finds even subclinical, mildly elevated TSH levels are associated with all-cause mortality, and cardiovascular disease mediates the association.
@fjorios
@HyperAHA
A12. Thank you! Yes, our mediation analysis showed that aldo may increase CVD in both pathways through BP and not through BP. Thus it would be really important to target aldo in addition to BP itself
#HYPHIP
@HyperAHA
@DrDudenbostel
Our
@JAMANetworkOpen
commentary with
@uclawillhsu
explores recent thought-provoking work on transportability analysis by Robertson et al.
#transportability
"Transportability Analysis—A Tool for Extending Trial Results to a Representative Target Population"
Interesting analysis in
@JAMANetworkOpen
showing estimated effects from NLST were similar when data was reweighted to match a nationally representative target population. Paper: Commentary on transportability methods w
@ki_endoepi
:
@DrDudenbostel
@fjorios
we did not see clear difference in BMI and urinary sodium between those with suppressed renin and unsuppressed renin. This is a little tricky because we are examining general population rather than PA patients
#HYPHIP
@HyperAHA
@DrDudenbostel
@DrDudenbostel
@HyperAHA
A1-3. In our study, we found that aldosterone was associated with increased risk of subclinical CVD (i.e., higher CAC) and death particularly when renin was suppressed. Moreover, around 45% of this association was mediated by BP↑.
#HYPHIP
@HyperAHA
@DrDudenbostel
@DrDudenbostel
@HyperAHA
A11-1. In general, renin (at least partially) regulates aldo secretion in
#RAAS
, thus low renin & high aldo indicates autonomous secretion of aldo independent of renin (and suppress renin through negative feedback system)
#HYPHIP
@HyperAHA
@DrDudenbostel
@DrDudenbostel
@HyperAHA
A4-2. Aldo↑ is associated with many kinds of CVD including heart failure, coronary artery disease, and stoke. However, most of the previous studies have been investigated among people with primary aldosteronism (PA) or essential HTN.
#HYPHIP
@HyperAHA
@DrDudenbostel
@DrDudenbostel
A3. MESA is a multicenter longitudinal cohort study of adults (45-84 years) free of CVD from 6 communities in the US. Its main goals include the identification of the risk factors for clinical and subclinical CVD progression.
#HYPHIP
@HyperAHA
@DrDudenbostel
Our new research using MESA with the amazing team at UCLA showed the association between elevated urinary stress hormones and incident hypertension/CVD events. Findings highlight the critical role of stress hormones in the pathogenesis of HTN.
@DrDudenbostel
@HyperAHA
A20-2. I am also interested in identifying who we really need to consider treatment/intervention for aldo↑ to prevent CVD (i.e., heterogeneous treatment effects). Any advice & collaboration would be greatly appreciated!!
#HYPHIP
@HyperAHA
@DrDudenbostel
@DrDudenbostel
@HyperAHA
A11-2. This is one of the major characteristics of primary aldosteronism (PA), the common type of secondary hypertension. Recently, the spectrum of subclinical PA has been established for normotensive persons ().
#HYPHIP
@HyperAHA
@DrDudenbostel
@DrDudenbostel
@HyperAHA
A20-1. Because the present study used a single point of aldo measurements, I am very interested in further investigating the possible cardiovascular burden of dynamic change in aldo (and other hormones) over time.
#HYPHIP
@HyperAHA
@DrDudenbostel
Today’s fantastic chat is complete and on behalf of
@HyperAHA
#SoMe
Editor team we thank
@ki_endoepi
for a great discussion and for joining us today! Good luck with ongoing research & we look forward to seeing you join us again for
#HYPHIP
@Carmendemigue12
@HyperAHA
A21-1. Given that we see the sex difference particularly among adults<60 yrs (Table S1), we assume this difference might be attributed at least in part to difference in sex hormones (i.e. protective effect of estrogen).
#HYPHIP
@HyperAHA
@DrDudenbostel
@NakagawaPablo
@HyperAHA
A15-1. I agree with your idea. Although we did not use the measurement of arterial stiffness (e.g., PWV) in our study, several studies have already investigated the association particularly among hypertensive patients, as you know
#HYPHIP
@HyperAHA
@DrDudenbostel
@DrDudenbostel
@HyperAHA
A1-1. It has been well known that aldosterone has a key role in the pathogenesis of CVD, but the evidence as to the long-term health outcomes of aldo↑ had been limited particularly among the general population.
#HYPHIP
@HyperAHA
@DrDudenbostel
Are physicians who receive industry marketing payments for high-cost 🫀drugs like
#PCSK9i
more likely to prescribe the drugs? Is the sky blue (on average)?
We offer a nuanced take on this controversial topic in
@CircOutcomes
.
(thread) 1/
Our new research w/
@liew_zeyan
(PI),
@beate_ritz
and amazing collaborators in Denmark finds some gestational-week–specific associations between PFAS and TSH in early pregnancy.
@EHPonline
.
@DrDudenbostel
@HyperAHA
A19-3. Not sure about Asian Americans, but ample evidence has shown the CVD burden of aldo↑ among Asians. Thus, I hypothesize that our findings may be applied to all of these racial/ethnic groups but need more studies to validate my hypothesis.
#HYPHIP
@HyperAHA
@DrDudenbostel
Honored to contribute to this prestigious journal in clinical endocrinology. Thank you very much,
@vtangpricha
, and all editorial staff of
#EndocrinePractice
!
@fjorios
@HyperAHA
A18. Yes, our data include many people with aldo within the reference range but renin suppressed. Increased CAC even among these people is important for our reconsideration of "what the reference range is" for this nasty hormone.
#HYPHIP
@HyperAHA
@DrDudenbostel
Our recent work was published from
#JCEM
@EndoSocJournals
!. Also presented in
#AHA22
.
Sodium-Glucose Cotransporter 2 Inhibitors and New-onset Type 2 Diabetes in Adults with Prediabetes: Systematic Review and Meta-analysis of Randomized Controlled Trials
2020 Brian MacMahon Early Career Award Winner Elizabeth Rose Maveda
@ER_Mayeda
is an assistant professor of epidemiology at
@UCLA
. Her research interests include racial, ethnic, and other social inequalities in Alzheimer’s disease and methods. Award sponsored by
@HarvardChanSPH
.
Congratulations on this great achievement Dr. Ritz
@beate_ritz
! She has been a wonderful advisor and helped me a lot to build a career path as an epidemiologist. I was so lucky to be her advisee at
@UCLAFSPH