Jay Bradner, M.D.
@jaybradner
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Physician-scientist making medicines with friends, memories with family. EVP R&D at Amgen
Thousand Oaks, CA
Joined September 2011
Metastatic colorectal cancer is a difficult illness and targeted therapy has been elusive. Today brings new hope. Read about today’s landmark @US_FDAapproval for patients with previously treated KRAS G12C-mutated disease👇#MyCompany
The @US_FDA approved Amgen’s targeted combination therapy for the treatment of adult patients with chemorefractory KRAS G12C-mutated #mCRC. 🔗 Press release: $AMGN
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@alexrives @ScienceMagazine Congratulations @alexrives, looking very much forward to seeing ESM3 in action for therapeutics.
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Terrific discussion of core strategy, bleeding edge technology and ideal partnerships with @drcwestphal and @StanfordMed Dean Lloyd Minor @LongwoodFund JPM25.
A fantastic and fun discussion with @jaybradner @Amgen and @StanfordMed Dean Lloyd Minor led by @drcwestphal @longwoodfund #longwoodhealthcareleaders #SanFranciscoCEO #JPM25
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Elegant use of dTAG to characterize the immediate consequences of ZFN143 loss on transcriptional targets.
ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF
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RT @behnamnabet: Ready, set, degrade! So proud to share our work in @jclinicalinvest, establishing a versatile approach for creating trans…
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Looking forward to JPM25 and time with these bioluminaries.
Join Peter Marks, @StanfordMed Dean, CEOs/R&D heads of @Amgen, @BayerPharma, @bmsnews, Merck Research Laboratories, @Novartis, @Roche @genentech & more the weekend prior to #JPM2025. See more:
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The juice is worth the squeeze. Elegant use of dTAG to model KRAS degradation in vivo, for therapeutic hypothesis validation by @CrisMayorRuiz and colleagues.
We are thrilled to share our new preprint around oncoprotein degradation in vivo —a fantastic collaboration with our friends in Salamanca @lab_santamaria @ciccancer! 😃 @IRBBarcelona #TPD #KRAS 👇
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Excited to welcome @HowardYChang to @Amgen as our new SVP for Research & CSO! A pioneering physician-scientist, Howard’s expertise in genetics, oncology, & inflammation will help us push the boundaries of discovery. We’re excited to embark on this journey together to redefine the future of science and medicine!
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Through our deCODE genetics subsidiary in Iceland, we’re leveraging AI and high-performance computing to explore how genetics and environment shape health. Discover how this is driving innovation in precision medicine in this interview with VP of Research, Kari Stefansson. #Genetics #PrecisionMedicine
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Welcome AMPLIFY, a new AI protein design tool from Amgen R&D. Here, we report a Protein Language Model that is efficient and accurate, and best of all is open-source for broad consideration and innovation. Now, labs worldwide can AMPLIFY their ambitions for iterative protein engineering. Huge congrats to the team on this remarkable contribution. #MyCompany Learn more:
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Today’s approval by Japan’s Ministry of Health, Labour and Welfare (MHLW) marks a major milestone in our effort to expand access to the first and only nonsurgical option for the treatment of TED that targets the underlying mechanism of the disease.
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Left lane on the Cambridge exit is the Accelerated Approval of Kendall Square commuting.
If you're an OG Boston driver, you know that there are two lanes in the Cambridge exit of the Mass Pike...
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