Guillaume Laconde
@Glaconde34
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Medicinal chemist, PROTAC and #TPD technology OXELTIS Scientist, https://t.co/F8c4eERuOA Communication Deputy for the SCT, https://t.co/8j34whJXIQ Tweets = my own.
Montpellier, France
Joined May 2010
PROTACs coupled with oligonucleotides to tackle the undruggable
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Factors to Consider for Synthesis in 1536-Well Plates─An Amide Coupling Case Study for PROTAC Synthesis | The Journal of Organic Chemistry
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Identification of a Potent and Selective CDK9 Degrader as a Targeted Therapeutic Option for the Treatment of Small-Cell Lung Cancer | Journal of Medicinal Chemistry
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Innovative Protein Degraders for Targeted Cancer and Viral Therapy | ACS Medicinal Chemistry Letters
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Analyzing the Linker Structure of PROTACs throughout the Induction Process: Computational Insights | Journal of Medicinal Chemistry
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Rational Design, Synthesis, and Biological Evaluation of Novel c-Met Degraders for Lung Cancer Therapy | Journal of Medicinal Chemistry
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Discovery of DCAF16 Binders for Targeted Protein Degradation | ACS Chemical Biology
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Development of Potent and Selective CK1α Molecular Glue Degraders | Journal of Medicinal Chemistry
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Use of Aldehyde–Alkyne–Amine Couplings to Generate Medicinal Chemistry-Relevant Linkers | ACS Medicinal Chemistry Letters
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Design and Discovery of Preclinical Candidate LYG-409 as a Highly Potent and Selective GSPT1 Molecular Glue Degraders | Journal of Medicinal Chemistry
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Protein-Based Degraders: From Chemical Biology Tools to Neo-Therapeutics | Chemical Reviews
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Macrocyclic peptides as a new class of targeted protein degraders - now published in RSC Chemical Biology
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In 2024 the focus of the team was on quality management system, and it resulted in ISO 9001:2015 certification obtained on Dec 28th. This great achievement enforces team cohesion, quality and productivity. Congratulations to Oxeltis team!
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Mass Spectrometry Analysis of Chemically and Collisionally Dissociated Molecular Glue- and PROTAC-Mediated Protein Complexes Informs on Disassembly Pathways | Journal of the American Society for Mass Spectrometry
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Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs | Journal of Medicinal Chemistry
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Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders | Journal of Medicinal Chemistry
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Selective Degradation of TEADs by a PROTAC Molecule Exhibited Robust Anticancer Efficacy In Vitro and In Vivo | Journal of Medicinal Chemistry
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Journey of PROTAC: From Bench to Clinical Trial and Beyond | Biochemistry
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