Dixon Group
@dixon_group
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Making and breaking bonds in Oxford - Student-run account
Oxford, England
Joined November 2016
We're thrilled to announce that our enantioselective desymmetrization of phosphorus (V) is now out in Nature Chemistry! π₯. Congratulations to @formica_michele and the team @tanya_rogova, Yao, Naoto, Bran, @FarleyAlistair @fjduarteg @KenYamazaki5 .ππ.
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Great to see our total synthesis of madangamine E is out now in @J_A_C_S and #openaccess!. Congratulations to Shinya (@r6vT6hSx6jdB2xP), @benshennan11, @KenYamazaki5, Angel, Vasu and of course a great #compchem collaboration with @TrevorAHamlin!π₯.
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Switchable, diastereodivergent photocatalytic carbocyclisation of Ξ±-amino radicals out now in @angew_chem in collaboration with @AstraZeneca! Many congratulations to @andrewmaitland0, @JamieLeitch165, @KenYamazaki5 (#compchem with @TrevorAHamlin)!.
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Out now in @J_A_C_S - 1,2-Redox Transpositions of Tertiary Amides. We combine Ir-catalysed reduction of amides with enamine functionalization to bring about 1,2-carbonyl transpositions and more. Congrats to the team - @benshennan11, Sergio & Gabriele!.
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A New Organocatalytic Desymmetrization Reaction Enables the Enantioselective Total Synthesis of Madangamine E - out now on @ChemRxiv!. Congrats to Shinya (@r6vT6hSx6jdB2xP), @benshennan11, @KenYamazaki5 (for #compchem with @TrevorAHamlin), Angel and Vasu!.
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Enantioselective Total Synthesis of (+)-Incargranine AΒ Enabled by Bifunctional Iminophosphorane and Iridium Catalysis, out now in @angew_chem!. Congratulations to @Annamiller1414, @PBiallas and @benshennan11.
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Bifunctional Iminophosphorane-Catalyzed Enantioselective Sulfa-Michael Addition to Unactivated Ξ±,Ξ²-Unsaturated Amides - out now in @J_A_C_S!. Congratulations to @DRozsar, @formica_michele and @KenYamazaki5 (#compchem with @TrevorAHamlin).
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Now hiring! We have an available PDRA position available in the group investigating photochemical coupling reactions. Deadline closing soon - please see the link for more details.
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Redox Transpositions of Tertiary Amides - now online at ChemRxiv!. Oxidation states dance in our new reductive activation of amides to enable one-pot synthesis of beta-functionalized amines. Congratulations to @benshennan11 and Sergio! .
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New and improved access to chiral at P(V) structures - check out our 2nd generation solution to enantioselective desymmetrization at P(V):. Congrats to @formica_michele, @branislav_ferko, @TomMars73108305, @KenYamazaki5 & @Tim_Davidson14!
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Difluoroalkylation of Tertiary Amides and Lactams by an Iridium-Catalyzed Reductive Reformatsky Reaction β out now in Org Lett! @JOC_OL . Congratulations to @PBiallas and @KenYamazaki5 π₯.
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Great to see our 2nd generation approach to the enantioselective desymmetrization at P(V) out now in @angew_chem!. Brilliant work from all the team - @formica_michele @branislav_ferko @TomMars73108305 @Tim_Davidson14 @KenYamazaki5
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Massive congrats to Roman, Sam, and the team for their enantioselective total synthesis of himalensine A! π. A new cyclization reaction enables efficient, enantioselective construction of the core - modelled by @KenYamazaki5 and @TrevorAHamlin.
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Check out our BIMP-catalyzed intramolecular oxa-Michael reaction - out now in @J_A_C_S!. Well done Guanglong and the rest of the team - another great collaboration with @KenYamazaki5 @TrevorAHamlin.@VUamsterdam.
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Cp*Rh(III)-Catalyzed Enantioselective C(sp3)βH Amidation of Azine-Linked Cyclobutanes, out now in @ChemRxiv . Congrats to @xuxing0313, and many thanks to @KenYamazaki5 for his computational work
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Out now in @NatureSynthesis - Iridium-catalysed synthesis of C,N,N-cyclic azomethine imines enables entry to unexplored N-rich 3D chemical space. Congrats to the team - @YaseenAlmehmadi, Jack, @Nandini_Guzman & @KenYamazaki5. @OxfordChemistry #OpenAccess
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BIMP catalysed enantioselective nucleophilic desymmetrisation of phosphonate esters out now on .@ChemRxiv! Congratulations to @formica_michele, @tanya_rogova (for π₯ #compchem with @fjduarteg), Yao, @FarleyAlistair and Naoto (on loan from @PIodide)!.
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Congrats Darren for receiving the Charles Rees Award and thanks to the @RSC_HSG for the recognition:. Looking forward to seeing the boss give a talk in the Lakes next year and highly recommend everyone to attend this fantastic conference!.#oxfordchemistry.
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Delighted to share our latest work on Iridium-Catalyzed reductive azomethine ylide generation out now in @ChemRxiv!. Congratulations to Ken, @pabs_gabs and all others involved!. Computational studies by Ken in collaboration with @TrevorAHamlin .
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Incredibly happy to share this work on the a metal-free reductive functionalization of amides using NaH-NaI. Wonderful collab with @Chiba_Group and hopefully will find widespread application in academia and industry alike! Out now in @angew_chem. π
Glad to share our joint paper with @dixon_group on transition-metal free reductive functionalization of carboxamides for Ξ±-branched amine synthesis that is driven by controlled reduction of amides with our NaH-NaI system. Congrats Derek and Dongyang!!π₯³.
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πππ.
Prof Darren Dixon (@dixon_group) gets the Tilden Prize for the discovery, development and applications of iridium-catalysed reductive functionalisation of amides and lactams #RSCPrizes
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we are very proud to say that Org Lett today is Dixon b2b Dixon b2b Dixon. @JOC_OL @OxfordChemistry #triplethreat (1/4)
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Very happy to announce that Tanya's (@tanya_rogova) work on combining two of our research areas β amide hydrosilylation and reductive photocatalysis β is now online at @ChemRxiv, feat @pabs_gabs @MatinaZav @JamieLeitch165 & in collaboration with @fjduarteg
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We are pleased to say that Jamie (@JamieLeitch165), Thomas (@TRossolini), and Tanya's (@tanya_rogova) paper on the photocatalytic synthesis of Ξ±-Tertiary Dialkyl Ethers from Enol Ethers is now live on @ChemRxiv. πππ. @OxfordSynthesis @OxChemRF.
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A great week for BIMPs: Check out our latest BIMP-catalysed enantioselective desymmetrization, out now in @angew_chem! . Great work Charmaine, @DRozsar and the rest of the team.
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Thrilled to publish our account on bifunctional iminophosphorane catalysis in Acc Chem Res. Big thank you to all that contributed to the field over the past 8 years (cc @JohnsonGroup) π₯ ππΎ. @formica_michele @DRozsar #GL @FarleyAlistair . #BIMP.
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General Iridium-Catalyzed Reductive Dienamine Synthesis and Five-Step Synthesis of Catharanthine out now in @J_A_C_S ! Many congratulations to @pabs_gabs , @YaseenAlmehmadi and Zeng Rong (now @Toste_Group)!!.
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We are delighted to announce that Jonny's work on enantioselective prototropic shifts is now out in .@angew_chem! Great collaboration with @bobbypaton. and @Syngenta. As seen previously on @ChemRxiv. [LINK] ππ₯π. @OxfordSynthesis. #BIMP
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Difluoroalkylation of tertiary amides and lactams by an iridium-catalyzed reductive Reformatsky reaction out now on @ChemRxiv!. Congratulations to Phillip and @KenYamazaki5!.
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Our latest review on C-H methylation is out now in @ChemSocRev ! Huge collaborative effort by the @OxfordSynthesis #2019cohort including our very own @benshennan11 and Charmaine Poh!.Darren and @JamieLeitch165 producers.
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A Three-Component Ugi-Type Reaction of N-Carbamoyl Imines Enables a Broad Scope Primary Ξ±-Amino 1,3,4-Oxadiazole Synthesis, out now in @JOC_OL! Congrats to Dan MR, Lizzie and @tanya_rogova!.
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Wonderful news finding out that Jamie (@JamieLeitch165) and Thomas' (@TRossolini) work on the reductive functionalization of dialkyl enol ethers, including comp from Tanya (@tanya_rogova), is now out in @ACSCatalysis. Previously on @ChemRxiv. πΎπ₯πΎ.
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Our general pyrrolidine synthesis via Vaska catalysed reductive azomethine ylide generation is out in @ACSCatalysis and #openaccess!. Congratulations to @KenYamazaki5, @pabs_gabs and the rest of the team! . #compchem by @KenYamazaki5 and @TrevorAHamlin!.
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We are happy to announce that Lin's work on the Dual Catalytic Enantioselective Desymmetrization of Allene-Tethered Cyclohexanones is now out in @ChemRxiv . with computational studies from our own Ken Yamazaki in collaboration with @TrevorAHamlin! .
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Welcome to our new starters!! Kang, @Annamiller1414 and Cailean join us for their PhD studies and Oskar and Nandini for their Master's. Looking forward to all the exciting future discoveries ππ₯³π€ @OxfordChemistry @OxfordSynthesis
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Second @ChemRxiv of the day!. A novel squaramide BIMP catalyst for enantioselective intramolecular Aza-Michael additions π₯. Excellent work by Guanglong, Connor and @DRozsar!. Beautiful #compchem by the one and only Ken Yamazaki with @TrevorAHamlin .
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Huge congratulations to @benshennan11 and #Pete for their work on the modular synthesis of spirocyclic pyrrolidines, which is now out in @ChemicalScience!. @OxfordSynthesis . π₯π₯π₯.
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We are back, 4 person strong, and keeping our distance, but it's a good start. π π§ͺ
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Delighted to see that two of our recent papers have been highlighted in @thiemechemistry Synfacts!. First, @formica_michele's @NatureChemistry "Enantioselective Nucleophilic Desymmetrization of Phosphonate Esters Using Bifunctional Superbases". (1/2)
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we are very pleased to say that Jamie (@JamieLeitch165) and Tanya's (@tanya_rogova) work on the dearomatization of quinolines to create bridged diazepanes is now online on @ChemRxiv, and hopefully out out soon!#preprints @OxfordSynthesis @OxfordChemistry .
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Congratulations to @tanya_rogova for passing her DPhil viva today! πΎπΎ . Thanks to @bobbypaton and @DonohoeGroup for doing the honours. Best of luck in your next position with @Schoenebeck_Lab!. @fjduarteg @OxfordSynthesis @OxfordChemistry
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We are delighted to announce that Jamie (@JamieLeitch165) and Tanya's (@tanya_rogova) work in collaboration with @fjduarteg on the dearomatization of quinolines with Ξ±-amino radicals, is now online in Angewandte (@angew_chem). previously on @ChemRxiv. π.
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Late stage, general 1,3,4-heterodiazole synthesis via reductive functionalization of tertiary amides and lactams #justaccepted in @angew_chem! Many congratulations to Dan Matheau-Raven for this one-man show! π₯π₯. Previously on @ChemRxiv.
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Our review on the use of Vaska's complex in the activation of tertiary amides for the synthesis of amines and natural products is now out in @ACSCatalysis. Congrats to DMR, @pabs_gabs, @JamieLeitch165, @YaseenAlmehmadi, and Ken!. π. #Vaska.
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Congratulations to @YaseenAlmehmadi on passing his viva today! ππ. Many thanks to Profs Burton and Procter @GroupProcter for doing the honours!
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Squaramide BIMP catalyzed enantioselective sulfa-Michael addition to unactivated Ξ±,Ξ²-unsaturated amides out now in @ChemRxiv! Congratulations to @DRozsar, @formica_michele and @KenYamazaki5! Slick #compchem by Ken and @TrevorAHamlin!.
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We are excited to announce that Jonny's work on the enantioselective prototopic shift of cyclohexenones using our bifunctional iminophosphorane catalysts in collaboration with @bobbypaton and @Syngenta , is now online on @ChemRxiv. @OxfordSynthesis. ππ.
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Great news to find out that Tanya's paper with @duarte_group on the selective activation and reverse polarity functionalization of tertiary amides is now online in @ACSCatalysis! @pabs_gabs @MatinaZav @JamieLeitch165 @fjduarteg, previously @ChemRxiv . π₯.
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Branching out: redox strategies towards the synthesis of acyclic Ξ±-tertiary ethers β our latest review out now in @ChemSocRev!. A massive collaborative effort by members of the @OxfordSynthesis SBM CDT 2020 Cohort and our own @benshennan11. Well done all!.
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Congratulations to Jonny Golec for passing his DPhil viva today! Thank you to Profs Clayden (@JonathanClayden) and Fletcher (@spfletcher) for doing the honours. Best of luck in your next position at @SygnatureDiscov!.@OxfordSynthesis @OxfordChemistry
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Lovely to see two of our photoredox papers out in the same issue of @ACSCatalysis. Congrats to all involved, especially to @tanya_rogova and @JamieLeitch165 who worked on both projects . π.
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Huge congratulations to @formica_michele for passing his DPhil viva today! Thank you to Profs Smith (@MDSgroup_Oxford) and Phipps (@ChemCambridge) for doing the honours. Best of luck in your next position @HoveydaLab!.@OxfordSynthesis @OxfordChemistry
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Squaramide BIMP catalysed intramolecular Aza-Michael out now in @ChemicalScience #openaccess ! Congratulations to Guanglong, Connor, @KenYamazaki5 and @DRozsar! π₯ #compchem with @TrevorAHamlin !. Previously on @ChemRxiv.
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If you're interested in making alpha-tertiary amines from simple branched amines using a one-pot process, have a look at our latest paper in @ChemicalScience @RoySocChem
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General Ξ±-Amino 1,3,4-heterodiazole Synthesis via Late-Stage Reductive Functionalization of Tertiary Amides and Lactams is out on @ChemRxiv! One man show by Dan M. R. and check out that scope!π₯π₯. @OxfordSynthesis @OxfordChemistry
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Good start to 2020 keeps coming . Connor's paper on the enantioselective addition of acetophenones to trifluoromethylketones is now out in @angew_chem. check out the speed vs. tertiary amine catalysts. Continuing our great collab with @Bayer. #BIMP π.
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Huge congratulations to @TRossolini who passed his DPhil viva earlier this week π₯³πΎ! Thank you to @RhPdCu and @LeonoriLab for assessing. Best of luck with your post-doc in the @LcsoLab (take good care of him!)!!!! @OxfordChemistry
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Out now - BIMP-catalyzed enantioselective nitroalkane addition to unactivated Ξ±,Ξ²-unsaturated esters. Congratulations to @DRozsar and the rest of the team (@FarleyAlistair, Iain, @benshennan11 & @KenYamazaki5).
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congrats to Pablo for having the most read article in Org Lett this month, and also to Thomas and Langui for making the top ten as well! .@JOC_OL, @OxfordChemistry, @OxfordSynthesis
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"Cobalt-Catalyzed Multi-Substituted Alkene Synthesis from 1,3-Dithiolanes and Grignard Reagents" out now!. We're pleased to have this work included in @AsianJOrgChem's special edition dedicated to Prof Keiji Maruoka.
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A lovely farewell dinner last night to celebrate Ken's prolific time in the group! @KenYamazaki5 has been a PhD student with us for 4 years, and will be sorely missed!. Best of luck in your next position with @tmiura_chem at @okayama_uni πΎ
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Congratulations to Guanglong Su for passing his viva today! π₯ Thank you to @arseniyadis and @RhPdCu for doing the honours! @OxfordChemistry
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A jubilant couple of weeks celebrating the successful thesis defences of Charmaine and @benshennan11! .Thanks @andrecobb and @MDSgroup_Oxford for doing the honours for Charmaine and @KarlGademann and Prof Burton for Ben. Good luck for the future to both! πΎπ»π
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Congratulations to β¦@DRozsarβ© for passing his viva this morning! πΎπΎ. Best of luck with your upcoming postdoc in the Radosevich group β¦@ChemistryMITβ© . Many thanks to Profs Phipps and β¦@spfletcherβ© for doing the honours! π
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This work also marks paper #200 for the Dixon group!!! π₯³π₯³πΎπΎπΎ.
Our general pyrrolidine synthesis via Vaska catalysed reductive azomethine ylide generation is out in @ACSCatalysis and #openaccess!. Congratulations to @KenYamazaki5, @pabs_gabs and the rest of the team! . #compchem by @KenYamazaki5 and @TrevorAHamlin!.
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What a great few days! Earlier this week @UniofOxford hosted the 7th UK-Japan Catalysis Meeting and we were blown away by the formidable chemistry on display. Thanks once again to all the Japanese contingent for making the trip!
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We were really honoured to be approached to contribute to @OrgSynth to showcase our Reductive Coupling of Grignard Reagents and Tertiary Amides. Thanks to @sarah_reisman group for checking the prep. Congrats to Pablo (@pabs_gabs) and Lan-Gui!
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Congratulations to Roman for passing his DPhil viva today! Thanks to Profs Hayes (@ProfCJH) and Burton for doing the honours πΎπΎπΎ. @OxfordSynthesis @OxfordChemistry
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Thanks @GSK for putting on an inspiring postgraduate symposium! We saw some awesome chemistry over the two days and great to see our very own @YaseenAlmehmadi and @benshennan11 presenting their work!
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It's with great pleasure that we can announce that Lin 's work on the Dual Catalytic Desymmetrization of Allene-Tethered Cyclohexanones is now online at @ChemicalScience. Great computational by Ken and @TrevorAHamlin. Previously on @ChemRxiv . π₯ππ₯.
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Great to see our review about the creation and manipulation of alpha amino radicals through the single electron reduction of imine derivatives is now out in @ACSCatalysis. Congrats to team photoredox π@JamieLeitch165 @tanya_rogova @TRossolini #japm.
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Happy holidays from the Dixon group - wishing you all a peaceful festive period! π
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Congrats to Bran (we miss you) and @formica_michele for their new paper on the total synthesis of Berkeleylactone A in collaboration with the CaletkovΓ‘ group and our legendary alum Pavol, now in @JOC_OL.
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A great day on the river Cherwell for the annual Dixon group punting!
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Great work Dan and Iain!. Check out our BIMP-catalysed enantioselective nitroalkane addition to unactivated Ξ±,Ξ²-unsaturated esters - out now on @ChemRxiv!.
I'm very happy to share our latest work, published now in @ChemRxiv, the BIMP-catalysed enantioselective nitroalkane addition to unactivated Ξ±,Ξ²-unsaturated esters!. Congrats to @FarleyAlistair and Iain McLauchlan!. @OxfordSynthesis @dixon_group.
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Many congratulations to @ben_list and @dmac68!! Exciting news for the field π₯ #nobelprize2021 #Chemistry.
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We've submitted to @ChemRxiv for the first time! Check out Vasu's paper on alpha C-H functionalisation of primary amines! #preprints
Bio-Inspired Primary Amine Ξ±-CβH Functionalization by Darren Dixon & co-workers. #biochempreprints #catalysispreprints
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Congratulations to Daniel Matheau-Raven for passing his DPhil viva today! Thanks to Profs Greaney (@greaneygroup) and Willis (@RhPdCu) for examining Dan. Best of luck in your next position with @SyngentaUK! πΎπΎ. @OxfordSynthesis @OxfordChemistry
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>5000 followers!! Thanks all for the support on here over the years. Looking forward to sharing some very exciting chemistry in the near future! ππ
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Great to see some of our recent published work highlighted! Thanks @ScienceMagazine and @thiemechemistry for the features. Check out our synthesis of incargranine A and our amide 1,2-redox transpositions if you missed them.
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pleased to kick off 2020 with a new paper from an old project, now out in J Org Chem! . congrats to Gerard and Alistair (@FarleyAlistair), . Silver-Catalyzed Enantioselective Mannich Reaction of Diazoacetate Esters with NβBoc Aldimines. @JOC_OL .
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Congratulations to Cailean for winning a prize at the department's second year poster symposium yesterday! Thanks to @pharmaron for sponsoring, and congratulations to the other winners!
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Great to see our recent BIMP-catalyzed addition of nitroalkanes to unsaturated esters has been highlighted in Synfacts! @thiemechemistry .Check it out:.And if you missed the paper:.
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Congrats to the Liu group (@XYLiuSUSTech) for the great paper using our ligand in a such an impressive way
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many thanks to each one of our 2,000 followers, especially the bots. πΎπΎπΎπΎ
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Pleased that our Iridium catalysed Ugi-type reaction is out now in @NatureComms . Tetriary amides can be converted to alpha amino (thio)amides or alpha amino tetrazoles. Works as a late-stage functionalisation tool for bioactive compounds. Have a look!
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Cortex Organics is hiring! An exciting opportunity to join a fast-growing chemistry start-up in Oxford, UK.
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It turns out Darren takes a long time to get through his emails. Congrats to Connor who's work on the enantioselective synthesis of pyrazolines was one of the top read last year in @angew_chem . ππ.
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Yao's work on Rh(III) catalysed amidation of C(sp3)-H bonds is a HOT article @ChemicalScience! Great work Yao! @OxfordSynthesis @OxfordChemistry.
Issue 13 is now online! Check out HOT article on 'Dithiane-directed Rh(III)-catalyzed amidation of unactivated C(sp3)βH bonds' by @dixon_group @OxfordChemistry
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Fantastic to see that our account on the history of BIMP catalysis was one of the top downloaded articles in #AccChemRes in September!. π. Read below.ππππππ.
Thrilled to publish our account on bifunctional iminophosphorane catalysis in Acc Chem Res. Big thank you to all that contributed to the field over the past 8 years (cc @JohnsonGroup) π₯ ππΎ. @formica_michele @DRozsar #GL @FarleyAlistair . #BIMP.
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Huge congratulations to @YaseenAlmehmadi and Roman KuΔera for winning prizes for excellence in organic chemistry research! Yaseen is working on novel Vaska catalyzed reactions while Roman has been tackling complex natural product synthesis! @OxfordChemistry @OxfordSynthesis
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This week we also welcome two new group members, firstly Phillip who joins us a postdoc (@MSCActions), and Dana who is with us for her second rotation as part of the SBM CDT @OxfordSynthesis
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Thanks to all those involved for choosing our recent @ChemicalScience paper on amine Ξ±-functionalization as a highlight for process R&D chemists in @OPRD_ACS . We really hope it can be a applicable protocol for industry.
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Thomas' work on the Photocatalytic Three-Component Umpolung Synthesis of 1,3-Diamines is out now in @JOC_OL!
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Congratulations to @tanya_rogova and @formica_michele for winning prizes for their talks at the @OxfordChemistry organic chemistry colloquium! And congratulations to Jonny for getting an honorable mention! @OxfordSynthesis.
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Congratulations to @Annamiller1414 on being awarded a Fellowship by the Royal Commission for the Exhibition of 1851, which will support her DPhil research in collaboration with @Syngenta . @OxfordChemistry @OxfordSynthesis.
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