Emma J Chory
@chorye
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Assistant professor @Duke , guerilla knitter, pipettor of small volumes of liquid. Biologist masquerading as engineer, or the other way around.
Durham, NC
Joined November 2009
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The US has spent more money in the last 2 weeks on one stimulus bill than the total amount it spent on biomedical research from 1887-2020.
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If you're fully vaccinated, the CDC recommends no longer validating your RNAseq with RT-qPCR
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The word "aliquot" is so heavily underused outside of science
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I am thrilled to announce that I'll be joining the faculty of
@DukeEngineering
as an Assistant Professor of Biomedical Engineering in 2023! The Chory lab will be developing new therapies & tools to study gene regulation using robotic directed evolution. 1/n…
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Omg I have a bruise on my finger from too much crochetting. Happy CRISPmas from this family of E. coli, bacteriophage, Cas9, and macrophage!
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This week I learned that most snowflakes are made by bacteria which express ice-nucleating proteins when they get stuck too high up in the atmosphere and need to come down.
So basically every snowflake is just a little lonely bug looking for love.
🦠❤️❄️
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BREAKING NEWS: Nobel Peace Prize also awarded to
@CarolynBertozzi
for brokering the first ever conflict-free day on scienceTwitter.
@YSPTSPS
What has struck me is the absolute outpouring of joy and goodwill for
@CarolynBertozzi
Really speaks to the hunger for role models like her. 🏳️🌈👩🏾🔬👩🔬
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Best way to ring in the new year!
@erika_alden_d
and I are excited to share our story on high-throughput continuous evolution, available now in
@naturemethods
. We've added a ton to the story since the preprint, and hope you'll check it out! thread 1/n...
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Inspired by this
@eLife
article: “Why every lab needs a handbook”, I thought I’d share ours. We're just getting started and this is a work in progress, so feedback is much appreciated!
There are a few easter eggs if you can find them.🔍
I can’t describe how important it is to establish roles, responsibilities and a general ethos for research labs. Especially in academia where so many labs turn dysfunctional due to internal competition and lack of structure.
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Excited to share that my 1st 1st-author paper is out in
@MolecularCell
! With chem-induced proximity, histone exchange simulations & 100+ publicly avail datasets we found that nucleosome turnover is a master regulator of histone methylation state (me1,2,3)
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It's a crazy time to be a scientist, but I feel fortunate and excited to be able to share the first bit of work from my postdoc... introducing PRANCE!
"A high-throughput platform for feedback-controlled directed evolution"
Here's the rundown... 1/n
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@CardiBthequeen1
@MariahCarey
Discovered radium & polonium (1890s) physics nobel prize (1900s) chemistry Nobel prize (1910s) Ben Franklin Centennial Medal (1920s) 1st woman w element named after her (1990s)
So no, she's got
#1
's in 5 decades.
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Was digging for a protein extract protocol and found the exact notebook page that became my whole PhD thesis
#TBThursday
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I am a very serious university professor and I expect to be taken very seriously.
@DukeFOOTBALL
@DukeUBME
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If you’re wondering what it’s like to juggle things as a new professor, this is where I just found my keys.
This is street parking.
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PSA that if you put a lot of trust in your students, you should also be prepared to return from travel with 100 miniature cats hidden all over your office. Respect the vibe.
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Gonna be in the market for a new job once my PI fires me for this yankee swap gift
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STOP talking shit about different histone modifications
H3K27ac is BEAUTIFUL
H3K79me is ENLIGHTENING
H3K9me is FASCINATING
H2Aub119 is EXCITING
H3K4me1
H2A.Zac is INSPIRING
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New professor walking to lecture on her first day of class.
Wish me/them luck! (But mainly me)
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I write all my papers in
@googledocs
. A🧵:
Unpopular opinion: switching to overleaf when you have been using Word forever is super hard and time-consuming. I am banging my head against the wall trying to fix references and, worse, get quotes to face the right direction!
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In all seriousness, I am most genuinely concerned about what will happen to
@biorxivpreprint
if Twitter goes down. BioRXiv has done so much for open-source science, disseminating research, and democratizing access. Many of us owe our careers to it. I know I do.
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So thrilled to begin our journey at
@DukeBME
! We’re hitting the ground sprinting, our first major equipment delivery just arrived, and the team will all be here within a matter of weeks!
Overwhelmed with joy to be joining this amazing community
#NewBeginnings
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Who wants to bet they’re just using shit Taq
This is the first description I’ve seen of what’s actually amiss with the CDC’s test.
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Dearest sciencetwitter friends, I have a hobby.
It's not quite as cool as lizards, haikus, breadmaking, and puns but I make cocktail-shaped squeaky dog toys and it makes me smile so thought I'd share w you 🧶🐶🍹
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I like science Twitter a lot better when we talk about good mentors doing great science so could we maybe do that today? You go first
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@bessbell
Respectfully, Bess (disclaimer big fan of yours generally), MDs and DOs take almost all the same classes and pass the same boards and do the same residencies. 25% of graduating doctors are DOs. The degree has no bearing on the fact that Trump's doctor is absolute garbage.
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My first review is out in this week's issue of Science (!) on the past, present & future of chemical dimerizers in biology and medicine. Amazing experience writing with Ben Stanton. We hope you'll read, share & enjoy!
@sciencemag
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Holy cow! So honored,
@SLAS_Org
! I'm absolutely blown away by this award and all the amazing talks this year at
#SLAS2022
. What an awesome end to a few crazy weeks.
Shout out to
@kesvelt
@erika_alden_d
@gretton_dana
@stefanmgolas
@medialab
! 🤖
Just announced at
#SLAS2022
: Congratulations to this year's $10,000 Innovation Award winner Emma Chory, Ph.D. (
@MIT
) for her presentation, "Phage and Robotics-Assisted Directed Evolution." Thanks again to
@HighResBio
for sponsoring the award.
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As much as the CDC test has issues this is not responsible representation. The test is qPCR based and there's no reason to assume that those bonus bands would appear with Taqman without seeing the data.
Additional proof that the CDC primers for
#SARSCoV2
have a lot of background. Science done by
@BenjaminNilsson
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You've been in lab for too long when you click on a mattress ad thinking it's a really pretty 384 well plate
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Getting a fellowship but then doubling your health insurance, quadrupling dental permiums, and losing 401k benefits is the most postdoc thing to ever happen.
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I recently learned that scientists are the lowest paid employees across all roles in biotech (usually), bc the jobs pay more in intrinsic value.
Yes, we are so fortunate to have jobs we love, but this is also a form of institutionalized gatekeeping to STEM.
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I think all of my MIT friends are just using me for my Elsevier access and it feels dirty and wrong.
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Hold on.
@EMBLHeidelberg
, are you telling me that people get to live, study, AND do science here?!!
#EMBLEvoEco2022
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So grateful to
@HarmitMalik
for the nomination and the Hypothesis Fund for the
@ChoryLab
’s first grant!
This is a huge milestone for our lab. The entire team, robots included, is eager to get to work!
#phagebabies
🦾
@DukeU
@DukeUBME
@DukeCAGT
2/ Awardee
@chorye
uses a novel high-throughput system to understand how proteins evolve along different trajectories🔀. Her project has important implications on future studies of protein evolution.
🍾Congrats Dr. Chory!
@DukeU
🙏
#HFScout
@HarmitMalik
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That photo where someone’s girlfriend is pulling their arm towards an exotic location, but I’m the someone and my girlfriend is a croissant.
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Boston is a thriving biotech paradise because Massachusetts invested in its roads, bridges, and public transportation 40 years ago w the Big Dig even though it was unpopular and expensive. Many other cities had the chance to do so, made the wrong choice, and missed out.
#Ivoted
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Apparently no one in
@CityOfBoston
thought to check if the train stations had functioning escalators before they shut down sumner tunnel for a month and gave free
@MBTA
blue line passes to everyone coming from the airport with multiple suitcases.
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Dunno about you all but new-PI-announcement-twitter is my favorite kind of Twitter. The future of science is in great hands.
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Most people who know me know that I’ll go to great lengths to talk about my love of
@Northeastern
, it’s students, the co-op program, and the value of experiential learning. This is prob one of my proudest accomplishments.
❤️
@NU_ChemE
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"Figure out who you are, and do it on purpose"- Winky, the Bichon Frise
One day, I hope to have half the confidence of Winky.
One of our favorite moments from yesterday's Masters Agility Championship Preliminaries, Winky the Bichon Frise!
#WKCDogShow
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I have claimed, for Professional development purposes, faculty positions at MIT (which won't allow me to skip a postdoc), Stanford, and the University of Harvard, each of which have a BIG Chory lead. Additionally, I hereby claim an R01 grant from the NIH if, in fact....
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AlphaFold2 has done it again!
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I guarantee journals could pay postdocs $200 to get reviews done in two days and faculty would gladly pay for turn around time. Too bad we're not allowed to consult.
I and most academics I know get ~14 days for a review and usually do it in the last 2 days before it's due, or ask for an extension and do it last 2 days before the extension's up. This may be a bonkers idea, but why don't journals just tell potential reviewers they have 3 days?
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Excited to share our fun collaborative pre-print on high-throughput combinatorial synergy analysis in AML.
A combo of open-source automation + data viz + epigenetics with the Stanton lab
@nationwidekids
.
A quick🧵...
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Excited to share our recent paper in ACS
@chemicalbiology
from my graduate work in the Crabtree lab on drug combination synergy between ATR and SWI/SNF inhibitors in cancer!
@Stanford_ChEMH
@StanfordEng
@HHMINEWS
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If youre interested in robots, directed evolution and protein engineering, check out my talk tomorrow at
#slas2022
and
@stefanmgolas
' poster this afternoon. Pumped for keynote by incomparable
@CarolynBertozzi
!
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Designed and built a DIY double helix mobile for the office!
#SculptingEvolution
#RightHanded
@kesvelt
@medialab
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And even with rush shipping it’s more affordable/better quality than a paper poster and they last forever. $40 total with 2 day shipping.
Conference life hack: Print a fabric poster for $15 from
@Spoonflower
. It’s super cheap and easy to travel with!
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Sure, I've got a PhD in Chemical Engineering... but what's more impressive is that I just finished these two bottles of shampoo and conditioner at the exact same time
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The final version of our paper is now out! Big thanks to all the authors who contributed over many years.
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That feeling when your summer undergrad generates some of the best data of your postdoc 🥰
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Oh cool! My first paper from my postdoc is finally online at
@MolSystBio
! "Enabling high‐throughput biology with flexible open‐source automation"
Thread below 👇
Bonus: Tip shortage?
#Pyhamilton
enables easy asynchronous tip reuse and sterilization
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To anyone who received an "ND" on their F31/F32s and is feeling super down: I was there 6 months ago. It's the absolute worst feeling. But I churned some data and reapplied.....
"Research proposal weaknesses: None noted."
Keep at it!!
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First, references. I've used EVERY ref manager.
@paperpile
is the best. You don't need a massive pdf library compiled over 30yr. Add refs from your library, current paper, and search directly in Google scholar/pubmed, with autoformat for every journal with shift + cmd + p
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Here’s some fresh science from my postdoc work with 🤖🦠+ Python package by
@gretton_dana
...introducing Pyhamilton!!
"Flexible open-source automation for robotic bioengineering"
@erika_alden_d
@kesvelt
@HamiltonRobotic
Here goes… (thread) 1/n
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1) Flight gets cancelled & no other avail until tomorrow
2) 3 min emotional meltdown then initiate plan B
3) Pay sympathetic Uber driver cash to get you to Amtrak as fast as humanly possible
4) Buy ticket mid-Uber
5) Make train with 3 min to spare
6) Wine
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🥳Amazing news to share! I'm thrilled and so humbled to announce that Ryan Boileau
@bffswithbiology
will be joining the
@ChoryLab
as our first postdoc! 🧬Looking forward to pushing the boundaries of synthetic chromatin biology together!
Also check out his great paper🧵below!👇
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@jonepstein1
It's unbelievably hard to take a private zoom call during the day as a trainee (especially telehealth calls). Even a few small meeting rooms per floor would make an incredible difference. This is more important now than ever.
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Contrary to popular belief, it's actually pronounced "fai-ay"
#phage
SO excited for this! 🦠🤖🧬
Our
#PennBioengineering
seminar series continues on Oct 21 with Dr. Emma Chory of
@MIT
: "“Phage and Robotics-Assisted Biomolecular Evolution”
#bioengineering
#research
#chemicalengineering
#robotics
#evolution
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Quite literally
@hpsacredtext
got me through some of the most emotionally trying days of grad school. So lovely to finally experience their charm in person back in Cambridge
@MIT
. If you haven't listened to their podcast, DO. You won't regret it.
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Guys I knit a thing
#DogSaveAmerica
Leo says thank you for the sweater,
@chorye
! He's a little unsure about the snug fit, but will wear it with pride.
#DogSaveAmerica
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PSA: thank your parents for those art classes you took as a kid.
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Would men still behave this way if my twitter bio said “professor” rather than “postdoc”? Asking for my sanity.
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@fjsanchezrivera
The trick is you actually have to push the lit one and the other arrow one at once to get to the 6th floor but NOT the second 6
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Yesterday, an engineer fixed a problem as part of his normal job of 35+ years. That fix was to a
@Sikorsky
helicopter which hours later rescued 31 sailors & that engineer was my dad!
@ChoryTony
Thanks to all the unsung engineering heroes out there.
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Unpopular opinion: the green line is the *most Boston* T line. The red line is just a vehicle for getting from Boston to Cambridge/Southie. I will not taking questions at this time.
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@SGRodriques
Not to splash cold water on your hot take, but this is just categorically untrue...
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Y'ALL IT'S FRIDAY WATCH THIS ROBOT DO MY WORK FOR ME WHILE I GO TO THE BAR.
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On my way to
@EMBLHeidelberg
, home of Homo heidelbergensis (!!), to celebrate the ancient genomes
#NobelPrize
with a bunch of evolution biologists!!
What phenomenal news!
#MolecularMechanismsInEvolutionAndEcology2022
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OMG I taught a graduate level class at MIT today how cool is that
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