Arye Lipman
@aryelipman
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Following
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Manufacturing critical materials using biotechnology @biosphereio
Los Angeles
Joined November 2013
biotech x manufacturing x anti-doomerism x american dynamism.
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My family is selling 23 acres in Big Sur: ocean views, multiple build sites, great access + water, < $1m. Pop up a few yurts or build something amazing with that crypto/AI $$$ - let me know if you're interested.
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Vaccine sites in LA are empty. The tier system is not working. Open this shit up. Dodger stadium today š
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Iām excited to announce that Biosphere is coming out of stealth today with $8.8m in Seed funding led by @LowerCarbon & VXI Capital, with support from @foundersfund, GS futures, @caffeinatedcap & B37.
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You're reading "The Lean Startup". I'm reading the Ed Merrow classic "Industrial Megaprojects" - we are not the same.
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To all the PhDs out there: building a biotech startup is way cooler than being a biotech VC. Pass it on.
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Starting a thread to track non-academic research organizations that are exploring new models for scientific R&D š¬.
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Bruh, there is a drug called Elelyso approved in 2012 that is made in carrot cells! Check out these carrot bioreactors š„š„š„
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You either die a synbio company, or live long enough to become biopharma.
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Tomorrow you wake up a billionaire - what weird science are you funding!?.
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Quantum Biology is the life sciences' next frontier - .@ClariceDAiello & I propose a new independent research org to build the tools/talent it needs.
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life sciences automation seems to only be working in limited use cases (unless I'm missing it) - companies have burned a lot of cash on robots that sit idle. what's next / where is the opportunity here?.
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Drug targeting is overrated. Living circuits are the future.
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There are surprisingly few scientist investors - funders doing technical due diligence by running experiments in the lab would be a boss move š¬.
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@Noah_Feller @dosnostalgic With a little reformatting, it can be this year's halloween costume
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Weāre expanding our capacity to 1000s of liters in 2025 and are excited to be working with world-class partners in health & nutrition, specialty chemicals, and the military: join us on our quest to build a future of abundance through biology at
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Weāre also announcing a $1.5m contract with the Dept of Defense to scale bioproducts of strategic national interest. Our mission is to unleash the potential of industrial biology.
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2022 will be the year that quantum biology becomes the next frontier of bio - I think we'll see a non-academic QBio R&D institute launch (hopefully in the US).
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Do you have a corn wet mill? Do you have 5-10 acres of adjacent land with rail access? Do you have 10,000 kW of power? My bioreactors wish to grow and flourish.
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If you don't do science, you're officially not allowed to put "labs" in your startup name, OK??.
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The best minds of my generation are (still) optimizing for ad views: how do we get more people working in biotech / deeptech?
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@BrianTHeligman and I started @biosphereio to solve this problem with a ground-up redesign of the bioreactor, enabled by UV sterilization.
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Read @sclarsic's š„ thesis on bioengineering for negative emissions technology. We have barely scratched the surface of biotech climate solutions.
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just sold another $1m of domestically made bioproducts šŗšø
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Quorn just installed another 150,000L 10 story air lift fermenter at their plant in the UK - THIS is biomanufacturing at scale. Legends.
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A microbiologist coined the term "fission" for the splitting of the atom. It's biologists all the way down folks.
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First big institutional raise in Desci - well done @Molecule_dao team š„.
Decentralized science platform Molecule raises $13 million in seed funding. By @_tommatsuda .
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Incredible podcast with @drmichaellevin: .-ion channels as transistors.-all intelligence is collective intelligence.-gap junctions & consciousness.-regen med as somatic psychiatry.-expanding our def of cognition.-the anatomical compiler.
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hi folks - we're getting a lot of inbound on this so please be patient as we triage.
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Staggering innovation is taking place in the use of biotech to make products that are more performant, sustainable, and resilient, but the sector is littered with failed companies who ignored this industryās key challenge: the capital intensity of biomanufacturing infrastructure.
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New vaccines with modified Spike (to handle new variants) would only require immunological trials (~400 patients), could be done rapidly via Peter Marks @FDACBER (see 24min in this video).
@Noahpinion Yes.
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Tues Apr 5th is our next #DeSci meetup in LA hosted by @goodworkDAO, @Science_stanley, & @lab_dao in Venice Beach - web3+science, it's a thing folks. LFG.
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The synbio revolution is a biomanufacturing revolution: my attempt to classify different types including gas, electro, solid state, and biocatalysis.
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These are the heady early days of a paradigm shift - we'll look back and be amazed that the DeSci ecosystem fit on a single slide.
The Decentralized Science movement is picking up speed. Presenting an updated map of projects across biotech, publishing, organization, funding, data management, and community. This is the #DeSci Landscape: .#web3 #dao
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@SexyLikeMeiosis time for some new blood on the mountain. and have new family projects in the works :).
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Is there really a brain microbiome? Huge implications, but rather skeptical of a single SfN poster w/a claim of this magnitude. cc @Neuro_Skeptic
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#munger: recommends A Man for All Markets, about Ed Thorp, mathematician, beat the dealers in Vegas. Then went into stock market & made $4b.
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Accelerator programs & tech transfer offices should have their own version of the Hippocratic Oath: "First, do no harm." š¤¬ You know who you are!.
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Can someone start tweeting about all the unannounced synbio layoffs or does it have to be me ?
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Our factories are lower cost, more productive, and rapidly scalable - weāre laser focused on going big and going fast, to strengthen the domestic supply of critical materials.
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The rise of new scientific institutions + IP NFTs could revolutionize the way we do deeptech R&D
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The next few years will be really tough for synbio (layoffs and failures coming), but those that scale (and sell) will reap the rewards.
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In light of the White House's recent executive order, I wrote up some thoughts about how the government can effectively invest in the bioeconomy.
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I didn't know much about #AndyGrove before his death, but this is a nice video from @bhorowitz about his leadership.
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I, for one, would like to try the DARPA light activated adderall.
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Oh you like lab grown meat? How about lab grown Sonoran Desert Toad to make 5-MeO-DMT??
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oh me? I work on "picks and shovels" for nascent industries with no economically viable products.
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@theallinpod Let's get @friedberg's take on famine and food scarcity post Ukraine, where are we headed over next 5y ?.
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you (a gassy simpleton): consumer biotech products are years away!!.me (a man of class):
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With the death of Amyris (+ Zymergen before it), does the Bay make bad industrial biotech cos, or is this just because the risk capital is there to take that 1:1000 chance?.
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Folks we've really made it now - featuring @jrkelly @rob_carlson @DrewEndy @jaykeasling @francesarnold @vijaypande & data from @SynBioBeta.
Synthetic biology makes it possible to engineer organisms and redesign life. That could change everything. Our cover this week
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Synbio students should be required to take chemical engineering.
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the key ingredient in Listerine Breath Strips is bio-produced?!? let's gooo
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A big milestone for us @MarsBio_VC closing LA County's commitment to our fund. Thanks to everyone at the County, @mridleythomas's office, and @BioscienceLA for seeing this through. Excited to fund many more #biotech startups!
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Agtech 1.0 was GM Crops. Agtech 2.0 was software+Ag. Agtech 3.0 is biomanufacturing. Climate resilient, scalable, and US is uniquely positioned to lead.
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$100m for a bat biology company (Paratus Sciences) announced today - LFG š¦.
@seemaychou @mattkrisiloff Would love to study bat immune systems - they harbor tons of deadly viruses without flinching. Could be a treasure trove of interesting immunology.
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Food $200.Data $150.Rent $800.McMaster-Carr $14,811.Utility $150.someone who is good at the economy please help me budget this. my hardware startup is dying.
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#munger: I'm a specialist in stupid ideas and turning corn into Ethanol is one of the stupidest of all time - that's what politics can do.
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.@Erowid is an invaluable resource for clear, fact based information on drugs & psychoactive chemicals, used by 1000's of people every day: they're running a $250k matching challenge - please give if you can
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I'll intro you to pretty much anyone. as long as you send me a smoking hot blurb. No blurb, no dice.
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What are some of the most promising biotech solutions to our climate crisis? Fermentation, biomaterials, bioremediation, and new plants. to name a few.
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It's time to build. An independent Quantum Biology research organization.
Upon graduating everyone I need,I am ready to leave academia and try our luck in the private sector. #QuantumBiology will not happen thru institutions/govt funds. Truly -- I did try to play by the rules.We need a home for our groundbreaking work,surrounded by people who value us.
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Top ideas for govt bio $billions:. 1) Open access (public) bio labs.2) Large scale biomanuf infrastructure.3) Talent training.4) Standards, frameworks, databases.5) Raw materials & inputs.6) Offtake / govt procurement commits.7) Media, communications, & art.
How would you spend $2b earmarked for the bioeconomy?.
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The most important part of the whole White House Biomanufacturing treatise:
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Why purify, just sip on one of these bad boys. More info here
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A truckload of hand sanitizer made by our friends at @solugen in Texas just arrived here in LA for distribution to our public hospitals! Thanks to our logistics partner @OperationUSA, @GaurabC, @LabLaunch & @MayorOfLA.
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We're getting closer to "Yamanaka Factors" for limb regeneration by @drmichaellevin & team. 5 sm mol produced by a wearable bioreactor regenerate and maintain a frog's leg for > 1 year.
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