brom
@therealbrom
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Founding partner at @focalpointlp Investing in frontier healthcare
Los Angeles, CA
Joined November 2010
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🤯 "MDMA therapy = more than twice as effective as placebo"
The results of MAPS second phase 3 trial were published today in Nature. The MDMA group achieved remission of PTSD at more than twice the rate of the placebo group after 3 sessions.
What's next? MAPS will use this data
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Presenting Empath Ventures Psychedelics Industry Map!
We left out some super early stage & stealth companies, but feel free to drop a comment if you think anyone is missing :)
Shoutout to our venture partner Melody (she's too cool for twitter) for putting this together 🍄
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Prediction: over the next few years, data will show that (in most cases) you don't actually need therapy to benefit from psychedelics
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Yesterday I visited a quasi-legal shroom store in Toronto
They sold all sorts of mushroom products and DMT vape cartridges.
In the long run, I wonder what % of people will access psychedelics via the medicalized model (Compass Pathways) vs stores like Fun Guyz?
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the psychedelics industry is "cool"
"cool" industries draw starry-eyed young people who will work for free in exchange for a chance to break in
"cool" industries inevitably end up taking advantage of and abusing this free labor
lets hold psychedelics to a higher standard
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Google search activity for psychedelic related terms is up massively since 2016
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The psychedelics industry needs to admit that some of the substances we promote can have serious negative consequences for society if not used properly.
For example: reckless MDMA use convinced an entire generation that EDM music was good 🙃
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psychedelics' impact on the gut-brain axis will be the subject of some very exciting research over the next 3 years
prepare to have your mind (and gut) blown 👀
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"It’s been a long strange trip for Brom Rector to become one of the few venture capitalists investing exclusively in psychedelic medicine." - Matt Wirz for the Wall Street Journal
Thanks for sharing the story of psychedelics and Empath Ventures, Matt!
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What are the best, lesser-known books about Psychedelics?
(PiHKAL and How to Change Your Mind don't count 😬)
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i wanna do 2 or 3 small angel investments this year in something other than psychedelics . . .
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The War On Drugs and its consequences have been a disaster for the human race
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how sick is a society that considers "recreational" a dirty word?
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If I had to guess, consistently microdosing 🍄 over a long period of time is probably bad for you.
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are there any academic studies that compare the clinical efficacy of psychedelics + integration therapy to psychedelics alone?
trying to understand to what extent the data validates the "formal integration therapy is critical" hypothesis.
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what are the biggest unanswered questions in psychedelic research?
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have you ever "listened to your gut" and later regretted the decision?
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Some interesting tidbits from the study:
1: while MDMA was better than the placebo, the placebo response was very strong
2: prior history of SSRI use was associated with improved efficacy of MDMA
3: women responded better to both the placebo and the MDMA
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Fun Fact! Smoking kills, but tobacco smoke also contains MAO inhibiting β-Carboline alkaloids.
The same class of compounds are the active ingredient in the Ayahuasca vine, and prevent the breakdown of DMT.
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fwiw, I thought "How to Change Your Mind" was well done.
the MDMA episode was particularly compelling
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Like it not, this is another piece of evidence in the “medicalization has the best chance of making psychedelic therapy available” pile
The world ain’t ready for decrim
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if you've struggled to get off Xanax or other benzodiazepines, I'd love to (confidentially) speak with you about your journey. dm's open
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Nurse and single mom facing up to 10 years in prison for daring to grow her own mushrooms.
This is why decriminalization is so important.
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Surprising things you’ll learn when talking with casual users of psychedelics . . .
🧵 (1/n)
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what companies / researchers are working on psychedelics as treatments for chronic pain?
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most "anti Big Pharma" takes are low effort, reactionary, naive contrarianism.
the pharmaceutical industry and modern medical science have improved billions of lives.
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who are the top doctors focused on lifestyle optimization, performance enhancement, longevity and psychedelics?
(obviously huberman and peter attia, but I'm trying to go a bit deeper here)
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Some of our most helpful LPs have been those with relatively small check sizes.
While we normally look for investors that can invest $100k+, I'm opening up 5 slots for value-add "micro-lps" who want to invest between $5k and $25k
If you're interested, DM for more info!
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I love that
@redlightholland
is pushing for expanded access to psilocybin in my home state 🍄
If you're in Washington, make sure to join
@shashkes
&
@iamToddyTickles
in support of Senate Bill 5660
follow
@pma_wa
for more info :)
When studying in the Netherlands I had access to legal Psilocybin that helped me heal my panic attacks.
@Sen_ACleveland
,
@dsfrockt
as a Washington resident I'm asking you to please add bill 5660 to the agenda so everyone in Washington can have the opportunity I had.
#FreeTheMagic
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there are many important topics in psychedelics that are frequently discussed.
what are your favorite "next level" or "under-discussed" topics?
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What are the most important ethical values that the founders of psychedelic startups should have?
Thinking about creating a ‘statement of values’ that any company seeking investment from empath ventures would be required to sign.
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🧪
@samalanascience
and I were lucky enough to visit the legendary Shulgin farm yesterday
this is where "Sasha" discovered 2C-B, synthesized MDMA, and designed, produced and "experienced" thousands of other research chemicals
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I want to go to lunch with someone I don't know next week
DM me if (1) you're in LA, (2) we haven't met before and (3) you have something cool to talk about :)
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Our panel "The Future of Psychedelics: Culture VS Capitalism" brought voices from the non-profit, activist and for-profit worlds together to find common ground.
There's room for all of us in a healthy psychedelic ecosystem💫
@Natalie_Lyla
@Paula_Graciela_
@samalanascience
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for those asking why:
(1) 5ht2b induced cardiotoxicity seems to be a real concern, and most psychedelics are active at 5ht2b.
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psychedelics are actually cool/good and it's good that the world is moving in the direction of increasing acceptance and access
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Feeding mushrooms 5mo-DMT 🤯
Does anyone know if this is real?
"Psilomethoxin is a new and novel tryptamine created in vivo by mushroom mycelium. After inoculation, before the fruiting stage of development, the mushroom substrate is fed 5-MEO-DMT"
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who are the coolest early stage founders raising in fem-tech & female-focused mental health?
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To all deeptech founders in health and bio: we're writing checks.
While Empath was founded as a psychedelic-focused VC fund, we've expanded our scope and are currently considering all companies on the frontier of health and bio.
We've already made two investments in the broader
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the psychedelics industry loves to shit on SSRIs & SNRIs
are we sure that they're actually that bad?
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The Psychedelic Renaissance has a few themes - among them:
ending the war on drugs
treating mental health issues
non-medical, human optimization / enhancement
Which are you most excited about?
ending the war on drugs
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mental health treatments
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human optimization
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