Dr. Zeynep Hülya Gümüş 🕊️
@ZeynepHG
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Associate Prof of Genetics and Genomics @IcahnInstitute & @SinaiImmunol & @TischCancer in NYC. Genetics, cancer, data sci & data viz
New York City
Joined June 2009
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Pinned Tweet
We just published! Germline rare deleterious variant load alters cancer risk, age of onset and tumor immune microenvironment! With
@CmplxGeneticist
,
@EsaiMyvizhi
, Sacha Gnjatic and Ken Onel. Detailed thread to follow.
#germline
#cancer
#genomics
#RDVs
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Give me one good reason to stay in academia. Wrong answers only.
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2/ The drug is called
#Zolgensma
, and it is currently the world’s most expensive drug ever! $2.4 MILLION! .
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I grow old ... I grow old ...
I shall wear the bottoms of my trousers rolled.
No going back ... Associate Professor now...
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Our study just got pubished in
@ScienceMagazine
! An immunogenetic basis for lung cancer risk
#lcsm
#lungcancer
?
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So, just received NOA on our Cancer Moonshot grant! We will be designing an interactive interface for visual exploration of patient immune monitoring datasets. Yeowzy! 🧿🔥🥳
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wow! this is big, but ABSOLUTELY necessary, given the public health significance of
#coronavirus
. One of us gets sick, we all get sick!
BREAKING: I am announcing a new directive requiring NY health insurers to waive cost sharing associated with testing for
#coronavirus
, including emergency room, urgent care and office visits.
We can't let cost be a barrier to access to COVID-19 testing for any New Yorker.
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It is my great honor to receive the
@IcahnMountSinai
"Faculty Council Award for Academic Excellence by a Junior Faculty member"!
@SinaiGenetics
@IcahnInstitute
@SinaiImmunol
#immigrantscience
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7/ Is there a hospital in US or elsewhere that offers
#ZolgenSMA
@ lower cost? PLEASE TELL ME WHERE! but most importantly,
#ScienceTweeps
, please join me in demanding reduced rates from
@Novartis
on
#ZolgenSMA
for little kids without coverage, or with the wrong passport!
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So, my abstract just got rejected from a meeting because of
#plagiarism
. Reason? I had earlier 'published' a
#preprint
of this never-before-presented-in-a-meeting study in
@biorxivpreprint
... Who is in the right here? Thoughts?
@mbeisen
@jchodera
@pollyp1
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Ogretmenlerimiz ve ogrencilerimizin rektore itirazi hakli sebeplere dayaniyor. Bir
@unibogazici_en
mezunu olarak ogrenci ve ogretmenlerimizi destekliyorum.
Melih Bulu "6 ayda biter" demişti, Boğaziçi Üniversitesi'ndeki eylemlerin 180. gününe özel kitapçık hazırlandı: Vazgeçmiyoruz!
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This is too painful to read... I hope they both make a full recovery...!
#COVID19
#coronavirus
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5/
#ZolgenSMA
halts motor neuron and muscle degeneration by replacing the defective or missing
#SMA
-causing gene (SMN1). So, her parents are literally running against the clock to come up w/ the $! They started a
#GoFundMe
- please donate if you can:
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6/ But- this does not solve the problem- the SYSTEMIC problem (see works by
@perterbachmd
). There are many other Mercans around the world. There is a cure for their disease, but the drug company,
@Novartis
, charges an outrageous sum if parents want to use it to save their child!
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8/
@Novartis
also has a lottery, where kids around the world - if they win- get treated for free; so for the majority of SMA sufferers without the funds, who gets to live or die is based on this lottery! Perhaps a lottery is better than a "Sophie's Choice" approach, but still...
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3/ the family has to come up with the cash asap, before Mercan reaches 24 months, because timing is critical: "Infants dosed with
#ZolgenSMA
as soon as possible after diagnosis had better results than those who waited to be treated" (from )
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Today our
@MountSinaiNYC
family showed support for our Black colleagues, family, friends, neighbors; those who are peacefully supporting George Floyd, and so many others before him. Today I was proud to be a part of this family.
#BlackLivesMattter
@SinaiGenetics
@IcahnMountSinai
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Wonderful lecture by the distinguished Özlem Tureci, who delivered an exciting lecture on mRNA vaccines against cancers
@SinaiImmunol
#sinaistrong
- photo also with scientist in training
@turhanberk99
🧿💉
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Yarin babamin vefatinin 5. yili dolacak. Babami da iste tam da boyle, benzeri sekilde kaybettik. Yani kaybettiler...
Sosyal medya hesabından yaptığı paylaşımlarda haftalardır hastanelerde yatak bulamadığını yazan Aslı Özkısırlar hayatını kaybetti. Özkısılar'ın ölümüne tepkiler Twitter'da
#Asl
ıölmediöldürüldü etiketiyle paylaşıldı
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Happy to start the day to finally see the publication of our study on pan-cancer characterization of tumor immunity in
@CellCellPress
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4/ In the US, some commercial insurance and
#Medicaid
plans have
#ZolgenSMA
coverage. But... Mercan is not a US citizen!
#ZolgenSMA
is not yet approved in Mercan's native country, Turkey, but she does not have time to wait for approval. She has to come to US for treatment asap!
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9/ In this summer of questioning inequalities and healthcare disparities of haves and have nots, we need to ask: why should families like Mercan’s implore strangers for money, instead of taking care of their sick baby? The drug already exists- HOW MUCH DOES IT COST TO PRODUCE IT?
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Grant awarded... music to my ears... please keep playing... 🙏💕🧿🌸🎈😍
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17/ &
#ScienceTweeps
, are we going to be quiet, or are we going to demand lower prices from
@Novartis
to save Mercan and hundreds of other babies from developing nations who cannot pay these insane prices? Please join me & tell me how we can be their voice! Thank you! ❤️🙏 /end
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15/ On
@Novartis
side, this year Q2
#ZolGenSMA
generated $205 million revenue: So,
@Novartis
, how about a discount on the world's most expensive drug?
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12/ Senators
@BernieSanders
&
@ewarren
urged
@US_FDA
to hold
@AveXisInc
accountable “unconscionable that a drug company would provide manipulated data to federal regulators.. to... charge the highest amount in American history for its medication.”
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@SiemonsLucas
don't forget the flexibility to wake up in the middle of the night, your brain swirling with creative responses to reviewer 3
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insane!
Cases in Denmark: 35 on Monday, 157 yesterday, 514 tonight
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13/ So, why is
#ZolGenSMA
so outrageously expensive? The answer is simply, "why not?", according to
@AveXisInc
CEO Dave Lennon, in this video. The highlight is at min 9:48, when he coyly responds to "WHAT IS YOUR COST?", with "Good try!" & everyone laughs.
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10/ So I researched: "Several US charities, including
@SophiasCure
,
@CureSMA
and Miracle for Madison, raised millions of dollars to advance the research..” that led to
#ZolGenSMA
. Plus,
@NIH
awarded nearly a HALF BILLION USD in grants to SMA research!
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Whoohoo!!! Maybe they did not get the patent but they got the credit! Well deserved! 👍👏
BREAKING NEWS:
The 2020
#NobelPrize
in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
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A recent collaboration just got published: Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions
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/last please help and be the voice of the hundreds of parents in the developing world without a voice, without money, without resources to save their babies!
@charlesornstein
@zeynep
@RVAwonk
@ginakolata
@carlzimmer
@DrSidMukherjee
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Our
#HIPC
collaborators
@SesmaLab
and
@KroganLab
, together with
@kevansf
at the forefront of uncovering
#COVID19
#coronavirus
interacting host proteins & drugs that target them!
@hipcProject
@ImmuneRegulate
@IcahnMountSinai
👏👏👏
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So proud to be a part of this community of Turkish Female Scientists
@Bilimkadinlari
🙃🔥🧿💪
#TurkishWomenInSTEM
#WomenInSTEM
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5 years today since I lost my dad to a yet unidentified lung infection that led to a heart attack; multi organ failure; sepsis; death in 33 hrs. We scrambled, unseccesfully, to find an ICU bed. There were no
#ventilators
. Here we are at my
#Princeton
graduation. RIP
#AliGumus
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My longest running collaboration is finally (provisionally) accepted for publication after 9 years or so (who is counting) and I am now officially ready to retire in peace. 🎉🍾🎊🥂🧿😀
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14/ For every child like Mercan, who ‘may’ have a chance, hundreds of others may never collect the $
@Novartis
asks for, or collect it too late. My friend, a scientist, is in constant agony- the family is devastated. Will they collect enough $? Will Mercan be alive until then?
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Met one of my idols today, the scientist and CEO of Biontech, Dr. Uğur Şahin 😃
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All in-person large group lectures, events, and meetings across
@IcahnMountSinai
are cancelled. Small meetings are encouraged to be virtual.
#coronavirus
#COVID19
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@say_cem
Hocam erkek ya da kadın olması hangi kriterlere göre acaba? Yani pozisyon açmadan o pozisyona en uygun kişinin cinsiyetine nasıl karar veriliyor? ABD’de genelde pozisyona en uygun kişi işe alınır cinsiyet ayırımı kanunen yasaktır da merakımdan soruyorum. Teşekkürler
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11/ Preclinical work leading to
@US_FDA
approval was done by researchers from
@nationwidekids
&
@ohiostatemed
. A lead researcher then became the
#CSO
of
@AveXisInc
, the producer of
#ZolGenSMA
, but was pushed out after a data manipulation scandal:
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Happy to present our work to
#Turkish
students! Come join! :)
18-20 Mart 2022 tarihlerinde online olarak gerçekleştireceğimiz
#BIOINFOCONGRESS
II organizasyonumuzun ilk afişini sizlere heyecan ile sunuyoruz.
Katılım ücretsizdir ve kayıt için başvurularımız başlamıştır.
Tüm bilimseverleri davet ediyoruz.
Kayıt için:
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Humbled to be celebrated among this remarkable group of strong, independent
#Turkish
women scientists on this
#WomenInScience
day! There are so many brilliant women scientists and trainees from
#Turkiye
! 🇹🇷
Bilimsel etkinliklerimize katılarak bilim paylaşımı adına bizlere destek olan ve bilimsel çalışmaları ile bilime önemli katkılar sunan değerli bilim kadınları başta olmak üzere tüm kadınların ve çocukların 11 Şubat Uluslararası Bilimde Kadın ve Kız Çocukları Günü'nü kutlarız.
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16/
@Novartis
, this is consistent w/ your community statement: “We reaffirm our commitment to creating multiple access pathways so that as many children as possible around the world can benefit from Zolgensma… & sustainable access solutions in low- and middle-income countries.”
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@ItaiYanai
Itai, hard to take this seriously when > a million humans (half children) are displaced in Gaza. Many cannot relocate because they are too sick or elderly or disabled or injured. As faculty in medical schools it is our responsibility to be on the side of all victims.
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A beautiful soul left this world, a student of genetics who battled cancer until the very end... Here is a lovely photo of her with her bf, who shaved his head in support for her, with him she later married.. RIP Cemre... 💜
Bana destek olmak için benle kadın kuaföründe saçını kazıtan erkek arkadaşımla neydik, ne olduk
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Thrilled that our study with
@LiamHoltLab
@EsaiMyvizhi
@jchodera
that uses ancestral reconstruction to understand the mechanisms of
#ERK
regulatory
#evolution
got out today at my favorite open access journal in the world,
@elife
!
@mbeisen
yay!
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My mom wishes everyone a happy, healthy, peaceful and fun new year! 🎊🎆🎈🥂🎂🎉🌸🥳
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Two manuscripts accepted in one day... New president elect... COVID19 vaccine on the way... Life is good.. :)
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The unbearable lightness of your grant being funded... 🙃🍺
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Me, waking up with Turkish brain, working on a manuscript: oh, these % signs are all wrong, let me fix them (spends inordinate time reverting each number% to %number - e.g. 3% to %3).
Me, after coffee: Oh wait, why are all these % signs BEFORE the number?
#bilingualproblems
👩🎤
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I am a cancer genomics expert - not virus. Yet,
#COVID19
is too close to home. Lost my aunt to
#Influenza
; lost my dad to an unknown lung infection which rapidly progressed to sepsis. Both could maybe be saved had there been beds in the
#ICU
- there weren't.
#StayAtHome
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If true, this is absolutely irresponsible! Either way, please tweeps, help support
#CloseCUNY
All my CUNY professors tell me that if we get the coronavirus at our age we’ll make a full recovery and I get that 100% but I live at home with a grandma who is 72 years old who has a heart disease, lung problems, diabetes, HBP... she won’t.
#CloseCuny
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It was a great pleasure to present our
#genomics
research at the
#Turkish
Medical World Congress organized by
@tusebgovtr
in
#Istanbul
, attended by colleagues around the world as well as ministers of health from multiple counties.
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Oh well, this arrived in the mail so I guess it is on... distant and digitally this year... so please allow me to blur the lines between work and life even more... happy birthday to me! 🙃🎊🎉🌸🥂
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@AmbassadeChine
That bridge is thousands of miles away and even glass houses have not collapsed in the area. Stop the lies please!
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Can I please just submit a recommendation letter and be done with it? Please grad schools, save me some time. These extra questions that pop up just at the time of submission are torture. 😭
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As an
#immigrantscientist
, during
#COVID19
#pandemic
I strived to balance parental care with tenure-track life. I describe my experiences at
@NatureProtocols
community:
#Parentalcare
is an important discussion we should have!
@IcahnMountSinai
@hipcProject
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Gencler, yarin sandiga! Saglikta nasil bir ulkede yasamak istediginizi dusunun; yurtdisina giden doktorlar geri gelmiyor; yandaslarin ozel hastanelerinin yogun bakimlarinda yer bulunamiyor; standartlar kotu; BABAMI boyle kaybettim ben. Yarin icin, lutfen!
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To quickly query regulators of your fav genes in 43K genotyped individuals; 51K experiments; 220 million eQTLs (cis & trans); 14 million TF-binding hits, we built: Now published
@NAR_Open
:
@hipcProject
@ImmuneRegulate
@ImmuneSpace
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At
#ISMBECCB2023
in person and could not attend a single session due to packed rooms.Very disappointing because being here in person is a waste od my time at the moment.
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Happy
#WomenInScience
day! Big shout out to the brilliant women who are doing amazing science at
@IcahnMountSinai
! What a privilege to work with you!
@EsaiMyvizhi
@petra_fra
@SesmaLab
@MiriamMerad
@PeiMSSM2016
@NLTignor
@DataDrivenMayte
@astocheva
@LauraHuckins
@KamphorstAlice
✊
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Packed zoom seminar by
@florian_krammer
on antibody responses to SARS-CoV-2 spike... more than 200 attendees as I type after taking this photo... 👍💪
@SinaiImmunol
@MountSinaiNYC
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Please RT:
#postdoc
position available in my group at
@IcahnInstitute
in NYC for a
#CSPhD
on
#datavis
in
#genetics
. Please email me
#infovis
#datascience
#genomics
#compbio
#AcademicTwitter
@AcademicChatter
#PhDChat
#phdjobs
#csjobs
#computerscience
#cscareers
#programmer
#coder
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Please RT! Expanding our team! We have
#postdoc
and
#staff
positions for
#fullstackdevelopers
to lead the development of
#dataviz
projects in my lab at
@SinaiGenetics
in
#NYC
! We will develop interactive web interfaces and/or data visualization tools. Please DM me if interested!
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Looking forward to delivering this lecture to
#Turkish
science students... 🇹🇷♥️
19 Mart 2022 tarihinde 18.15-19.15 saatleri arasında
#BIOINFOCONGRESS
II kapsamında, Sayın Dr. Zeynep Hülya Gümüş (
@ZeynepHG
) hocamız 'Akciğer Kanserinde Doğuştan Gelen Genetik Riskler' konulu konuşmasını gerçekleştirecektir.
Kayıt:
#bilimlekalal
ım
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My only strong opinion on peer-reviews: journals should PAY the reviewers.
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We are still
#hiring
!!! If you would like to work on
#dataviz
for
#cancer
and
#Immunotherapy
multi-omics datasets, join us! Postdoc positions open! DM or email me if interested.
#Datavisualization
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Bugun, en buyuk bayramdir! Kutlu olsun! Yasasin
#Turkiye
#Cumhuriyeti
100 yasinda! 🇹🇷🇹🇷🇹🇷❤️❤️❤️
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It is quite telling that the new Pfizer-BioNTech
#COVID19
#vaccine
is developed by
#Turkish
#immigrant
scientists to Germany...
#immigrantscience
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We are hiring on an
#NIH
#NCI
supported grant! Are you interested in
#DataVisualization
? Do you have a
#computerscience
PhD (or are you a very strong MS degree individual)? Do you have any training in biology or are you open to learn? Please reach out to me!
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As I work on a grant, I think about the times when as little girl growing up in Istanbul, I would dream about my future professorial life: discussing science with my students while drinking sherry by the fireplace on fine snowy afternoons... And then I laugh and laugh.
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@mbeisen
@biorxivpreprint
@jchodera
@pollyp1
Thank you for kind offers of help! Were it not for earlier twitter debates on preprints & current encouragement from researchers and editors, I would probably give up. However, times are INDEED changing! I just received a +ive response to my 2nd appeal! YAY! PLAGIARIST NO MORE!!!
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Our most recent international study on
#glioblastomas
, with colleagues at
@kocuniversity
is out: Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization 👇
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Forget it. I can't focus on science.
#hatayyardimbekliyor
#Kahramanmarasyard
ım
#sanliurfayardim
#antepyard
ımbekliyor
#AdiyamanYardimBekliyor
#osmaniyeyard
ımbekliyor
#Diyarbak
ıryardımbekliyor
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@notSoJunkDNA
I thought the 'h' had to do with work-life balance so I am going to go with homewrecker. Higher the h-index, more likely that something had to give.
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So, what is the latest research? Angiotensin inhibitors for hypertension are good or bad for
#coronavirus
#COVID19
patients? I am reading conflicting results...
@florian_krammer
@marklewismd
?
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Our review out in
@JTOonline
: "Small Cell Lung Cancer: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening and Early Detection."
#LCSM
#SCLC
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@BeckyCNN
@RTErdogan
Becky, why don't you invite his challenger, Kilicdaroglu, who more than 80% of Turkish-Americans support? Could go a long way in understanding your fellow US residents.
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I was in high-school when I first arrived at
#BogaziciUniversity
; sat by the canteen & took in the gardens, Bosphorus & Asia beyond. A magical place. Worked hard to be admitted & study with the best & brightest. Today faculty protest the new rector by turning their backs to him😟
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Want to explore
#COVID19
#phosphoproteomics
#network
from recent
@CellCellPress
study by
@KroganLab
@pedrobeltrao
@VirusPathways
? Here is an interface for that! Feedback welcome as we develop the tool!
@SesmaLab
@florian_krammer
@MiriamMerad
@SinaiImmunol
3
9
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Our latest work in
@CellCellPress
! Integrated proteogenomic characterization of clear cell renal cell carcinoma
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