eLife - the journal
@eLife
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The funder-researcher collaboration and open-access journal for research in the life and biomedical sciences | @eLifeCommunity
Cambridge, UK
Joined September 2011
1/ 🌟 Explore our new Reproductive Health Special Issue 🌟. Research into #ReproductiveHealth has historically been overlooked, while issues shape everything from fertility and pregnancy to demographic trends and healthcare disparities.
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Today, we’re introducing a new model that eliminates accept/reject decisions. By publishing every paper with eLife reviews as a Reviewed Preprint, we plan to restore autonomy to authors, ensuring that they will be judged by what, not where, they publish.
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Reviewer 2 agreed that the ability to determine structures directly within the cellular environment would "transform structural cell biology" #fromthedecisionletter #ResearchAdvance
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A new technique for specifically labelling a rare type of interneuron sheds light on their distribution and connectivity in the brain.
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Novel gene activity regulating neuropeptide precursors in the Drosophila central nervous system.
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PhDs can be challenging and public discourse tends to focus on the negatives. To bring back some balance and positive momentum, this group of students sought to highlight the positive elements of the PhD experience. #AcademicChatter #PhDChat
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A heat-sensitive ion channel known as TRPV4 helps regulate sweating in mice, a finding that offers insights into human sweat disorders.
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How information is processed in the brain when consciousness is lost due to anaesthesia or brain injury.
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This study investigated how cell shape and the motility of individual cells influence how macrophages scan for signs of infection.
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This study investigated how cell shape and the motility of individual cells influence how macrophages scan for signs of infection.
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Cells can pass proteins and RNA to each other through tubes that act as a channel between their membranes.
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Cancer cells hide inside other cancer cells when the immune system attacks, letting the cell inside survive.
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The spike protein of SARS-CoV-2 interacts with cholesterol and ACE2 to induce viral entry and pathological cell-cell fusion. Can cholesterol-lowering statins be used as a treatment for COVID-19?
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ICYMI advanced microscopy with custom software called MaMuT tracked the development of a crustacean over several days of embryogenesis
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💡 Special Issue highlight 💡. Location, location, location: Protein kinase nanoclustering for optimised signalling output. Want to see more like this? Explore the the Special Issue:
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Molecular simulations reveal how membrane pores are formed by gasdermin-D, a protein important in cell death in inflammation and infection.
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Molecular simulations reveal how membrane pores are formed by gasdermin-D, a protein important in cell death in inflammation and infection.
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The spike protein of SARS-CoV-2 interacts with cholesterol and ACE2 to induce viral entry and pathological cell-cell fusion
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The spike protein of SARS-CoV-2 interacts with cholesterol and ACE2 to induce viral entry and pathological cell-cell fusion
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The spike protein of SARS-CoV-2 interacts with cholesterol and ACE2 to induce viral entry and pathological cell-cell fusion
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Molecular simulations reveal how membrane pores are formed by gasdermin-D, a protein important in cell death in inflammation and infection.
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Cells can pass proteins and RNA to each other through tubes that act as a channel between their membranes.
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Cells can pass proteins and RNA to each other through tubes that act as a channel between their membranes.
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Cancer cells hide inside other cancer cells when the immune system attacks, letting the cell inside survive.
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Reviewer 2 agreed that the ability to determine structures directly within the cellular environment "will transform structural cell biology" #ResearchAdvance
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Find yourself jumping between two PDFs when reading a paper?. With our side by side view, you can see the figures and contents next to the main text in your browser window. You can find the "side by side" button on the left side of your screen when viewing an article.
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From today, code can be an integral part of a paper published in eLife. Announcing the Executable Research Article, a new open format for research papers where code can be run directly in the browser
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We are pleased to announce the next advancement in our mission to transform science publishing. From today, we take the next steps towards exclusively reviewing preprints. Learn more about these changes in an Editorial from Editor-in-Chief Mike Eisen .▸
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The entire nervous system circuitry of a sea worm larva that could help us understand how the nervous system evolved.
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This study investigated how cell shape and the motility of individual cells influence how macrophages scan for signs of infection.
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New technology measures the release of dopamine simultaneously from hundreds of release sites at the spatial resolution of a synapse.
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Ten common statistical mistakes to watch out for when writing or reviewing a manuscript
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💡 Special Issue highlight 💡. Recording and classifying MET receptor mutations in cancers: . Want to see more like this? Explore the Special Issue:
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Molecular simulations reveal how membrane pores are formed by gasdermin-D, a protein important in cell death in inflammation and infection.
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The spike protein of SARS-CoV-2 interacts with cholesterol and ACE2 to induce viral entry and pathological cell-cell fusion
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Ten common statistical mistakes to watch out for when writing or reviewing a manuscript
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Multi-view light-sheet microscopy images embryogenesis of the crustacean Parhyale hawaiensis
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First, it eats them from the inside; then, it turns them into zombies. 📽️ Watch how the fungus E. muscae gets fruit flies under its control
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Brainrender is an #OpenSource and user-friendly software for combining any type of anatomically registered data into custom interactive 3D renderings
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Parasites can use extracellular vesicles and cellular projections called cytonemes to communicate with one another.
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Researchers have developed a new single-objective light-sheet microscope and demonstrate its unparalleled resolution on a range of biological phenomena that would usually be challenging or even impossible to image in this way
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Researchers have developed a new single-objective light-sheet microscope and demonstrate its unparalleled resolution on a range of biological phenomena that would usually be challenging or even impossible to image in this way
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Chronic Ca2+ imaging of cortical neurons with long-term expression of GCaMP-X.
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Today we are pleased to announce a new policy that provides a fair and unobtrusive way for authors, editors and reviewers to retroactively change their name in papers published in eLife
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ICYMI an atomic model for an intact bacterial ATP synthase shows how individual amino acids contribute to ATP synthesis
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Ants swap spit to create a colony-wide metabolism, functioning almost like a single organism.
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We’re trying something new!. eLife authors can now freely speculate the meaning and implications of their data in our new section:. 💡 Ideas and Speculation 💡 (1/3).
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This study investigated how cell shape and the motility of individual cells influence how macrophages scan for signs of infection.
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The spike protein of SARS-CoV-2 interacts with cholesterol and ACE2 to induce viral entry and pathological cell-cell fusion. Can cholesterol-lowering statins be used as a treatment for COVID-19?
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These cells are passing proteins and RNA to each other through tubes that act as a channel between their membranes. #12DaysOfeLife
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💡 From a statistical mistakes guide to how to write a lab handbook, this thread compiles some of our most useful guides and advice for academics. 1/n. 🤫 P.S. We’re also building a new resource for neurodivergent scientists with your input. Take a look!
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Brainrender is an #OpenSource and user-friendly software for combining any type of anatomically registered data into custom interactive 3D renderings
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Baby marmosets start making faces in the womb, practising the face and mouth movements they’ll use to communicate with their family before they’re even born.
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The entire nervous system circuitry of a sea worm larva that could help us understand how the nervous system evolved.
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Atomic model for an intact bacterial ATP synthase shows how individual amino acids contribute to ATP synthesis
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We believe that being first should never take priority over doing things right; we offer scoop protection meaning authors are not penalized because another group has recently published similar findings
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Nanoscape is an interactive open-world experience that lets you navigate 3D cellular landscapes like in a video game
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The central region of the fruit fly brain has been fully mapped in 3D for the first time, including roughly 20 million connections between some 25,000 neurons
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Study of 33 three-generation families suggests that each person has, on average, around 70 "de novo" mutations that were not present in their parent’s genetic code
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Researchers have found the possible mechanisms that seem to preserve cognition for a popular model organism later in life with hopes this could translate to human research.
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In cultured cells, mitochondria maintain temperatures of up to 15°C above their environment adjusting their heat production in the face of physiological stresses.
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A new method allows researchers to analyse the dynamics of immunological synapses while avoiding the limitations of fluorescence microscopy. The approach combines deep learning algorithms and a 3D imaging technique called optical diffraction tomography
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The centrosome decides which branch extending from the body of microglia will successfully engulf and clear away dead neurons.
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Cancer cells hide inside other cancer cells when the immune system attacks, letting the cell inside survive.
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Writing or reviewing a manuscript? Watch out for these ten common statistical mistakes
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R and Python are increasingly used in research. Now you can share your code interactively in your paper when you publish an Executable Research Article.
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As announced late last year, beginning today eLife will only peer review articles posted on a preprint server. You can learn more about these changes in our latest Inside eLife article ⬇️ 1/3
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Researchers investigate the driving forces in the leading edge of a migrating cell.
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The Board of eLife has made the decision to replace our Editor-in-Chief. Read more in the full statement
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Researchers have made an immunofluorescence image map of 456 human kinase proteins representing 85% of the human kinome
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For the first time, scientists analysed the connectome for part of the brain in the common octopus involved in long-term memory. Here, they use #ElectronMicroscopy to trace the length of an axon micron by micron.
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A new method allows researchers to analyse the dynamics of immunological synapses while avoiding the limitations of fluorescence microscopy. The approach combines deep learning algorithms and a 3D imaging technique called optical diffraction tomography
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Writing or reviewing a manuscript? Watch out for these ten common statistical mistakes
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ICYMI multi-view light-sheet microscopy revealed embryogenesis of the crustacean Parhyale hawaiensis
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A structural model of the SARS-CoV-2 spike protein as the virus fuses with host human cells reveals an opportunity to disrupt dynamics and halt transmission
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Super resolution microscopy reveals how B cells form the tight connections needed to trigger the creation of antibodies.
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Researchers present a platform for cardiac tissue cultivation with 3D ring-shaped cardiac tissues generated from human stem cell-derived cardiomyocytes.
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Chronic Ca2+ imaging of cortical neurons with long-term expression of GCaMP-X.
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Researchers track individual cells inside “organoids” to find out whether a tumour can really start from a single faulty cell
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Enhanced single RNA imaging reveals dynamic gene expression in live animals.
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Researchers find a novel mechanism by which an animal cell can move through a 3D extracellular matrix.
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Cancer cells hide inside other cancer cells when the immune system attacks, letting the cell inside survive.
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A structural model of the SARS-CoV-2 spike protein as the virus fuses with host human cells reveals an opportunity to disrupt dynamics and halt transmission
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Part of the nuclear pore protein Nup358 forms a helix which is required for activation of a dynein-dependent transport pathway that is essential for brain development.
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From Arabidopsis to zebrafish, these 12 essays explore what is known about the natural history of a range of model organisms and their wild relatives
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Scientists have developed a technology called G-baToN where cells exchange fluorescent proteins like the baton in a relay race, allowing the physical interactions of cells to be tracked
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Chronic Ca2+ imaging of cortical neurons with long-term expression of GCaMP-X.
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The central region of the fruit fly brain has been fully mapped in 3D for the first time, including roughly 20 million connections between some 25,000 neurons
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Photokinetic bacteria can be arranged into complex and reconfigurable patterns, including portraits, using a digital light projector
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A lab handbook can help with the day-to-day challenges of running a lab and promote a positive culture. Here are in-depth resources, including a template, to help you write your own:
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The 3D structure of kinetochore-fibres in human mitotic spindles.
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Evidence of artefactual calcium microwaves during calcium imaging of neurons in the hippocampus.
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The nucleus acts as a pacemaker for the mitotic cell cycle. Follow up question: what is the advantage for a cell to have the nucleus initiate mitosis?
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pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells.
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The role of a plant peptide in coordinating developmental and immune response signalling.
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A new computational microscopy technique could make it easier to study live cells and human tissues without using fluorescent labels
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Enhanced single RNA imaging reveals dynamic gene expression in live animals.
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With three simple steps and in just 48 hr, EZ Clear effectively renders adult mouse organs optically transparent while preserving signals from fluorescent reporters.
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