Shoa L. Clarke
@ShoaClarke
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Assistant Professor || Preventive cardiologist for adults, children, and families || 🫀🧬 🖥️ 🤓
Stanford
Joined April 2011
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Pinned Tweet
New Million Veteran Program research out in
#EJPC
@ESC_Journals
! We use 🧬 to examine the relationship between Lipoprotein(a), LDL-C, and coronary plaque severity across the spectrum of disease.
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@DGlaucomflecken
All C suite execs must be practicing MDs with some minimum hospital service requirement.
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Thrilled to announce the official launch of my lab at Stanford in
@StanfordDeptMed
! Our mission is to prevent 🫀 disease. We bring together 🧬, data science, and epidemiology.
We are hiring!
Please share with students, postdocs, & medical trainees!
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Why do we observe a genetic correlation between educational attainment & traits like height or CRP? Because population
#GWAS
is biased by assortative mating & indirect genetic effects!
Nice paper using sib GWAS highlights the issue:
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PEA arrest -> CPR-> Epi -> ROSC -> Cooled & Rewarmed -> Wakes up -> Shakes your hand -> Walks out of ICU-> Returns to work
#medicalgratitude
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Cardiologists love imaging the 🫀. We focus A LOT on cardiac size📏 & function💪. But what about shape?
We used
#AI
🤖 to measure cardiac sphericity in >38K adults with normal hearts. Guess what?
Shape matters!
Paper:
🧵👇
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And the best summary of American medicine goes to
@DGlaucomflecken
(again)
"A handful of ultra rich individuals exploiting the altruistic tendencies of healthcare professionals in order to extract an ungodly amount of wealth from the most vulnerable members of society."
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@DrAlrahmani
Ah yes, online modules to help with workflow. What a surefire way to decrease physician burnout 😐
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@mchonig
@ACLakeMD
@NanditaScott
Nothing
Nothing
Nothing
Aspirin + ticagrelor + rosuvastatin + carvedilol + lisinopril
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My mom & 2 sisters. Being a single mom w/ no HS diploma didn't stop her from getting her son through Med school!
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Just tried to pay a publication fee and my credit card declined it because they thought it seemed suspicious to send Elsevier thousands of dollars. I agree.
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Atherosclerosis starts early in life, particularly for those with high genetic risk. Prevention must start earlier.
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🔥🔥ONLINE NOW🔥🔥
Massive & diverse
#GWAS
of lipid traits with important insights for future genetic studies &
#PrecisionMedicine
. Led by the incredible
@SarahEGraham1
&
@cristenw
💪
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Incredible work led by
@ines_catherine
&
@tassimes
! The first truly DIVERSE large-scale GWAS of coronary disease. This badly needed data will hopefully shift the current trend of precision CV medicine towards a more equitable future.
#preprint
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In this
@CircAHA
letter, we show how aggregating the diverse Hispanic population into a single group for polygenic risk score 🧬 studies masks disparities in PRS performance.
🧵 1/n
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Just got off 1 week of attending on the COVID surge team. Here are a few thoughts 🧵...
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The increasingly popular position of "Instructor" has trapped young physician-scientists in limbo.
Need grants to advance to Assistant Prof.
Need to be Assistant Prof. to get grants.
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What makes a heart left 🫲 or right 🫱 handed?
A simple GWAS of coronary dominance took us on an incredible journey 🛣️, with a look at human fetal 🫀, a 🐁 model, & the intriguing possibility that a developmental decision may impact adult disease 🤯
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💯
"Change is an upsetting possibility to those whose lives remain untouched by — or those who have benefited from — racism."
Those who do not understand racism cannot be in charge of the push to end it: my latest, in
@NBCNewsTHINK
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Continuing my annual tradition of Christmas inpatient service. Happy holidays from
@StanfordHealth
!
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The first cardiac catheterization was done in 1929 by Werner Forssmann... on himself. ON HIMSELF.
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Every pediatrician, every parent, every teacher, anyone who cares about the well being of children should be outraged. Speak up.
#TamirRice
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@Scientist_Rhi
@blacksciblog
WHAT DOES TYROSINE HAVE THAT PHENYLALANINE DOESN'T HAVE!?
🤔
OH...
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macOS has this thing where you sign a white piece of paper and hold it up to the camera, and it will digitize your signature. I was trying to do that, and this is what it gave me...
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First two years as a cardiology attending. ~12 weeks on inpatient services. So many patients. An incredible privilege. Ever grateful.
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My Christmas tradition 8 years and running, being in hospital to take care of the patients! Wearing my Stanford Christmas sweater and got this amazing card from my interns, so holiday cheer is 💯
Happy holidays, all!! 🎄🎅🎄
#CovidChristmas
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This 5th grade level of understanding of medicine/disease is why we need more scientists involved in government.
Take on 4 big diseases that cost the BULK of $$: Cancer, heart disease, Alzheimers, diabetes; find CURES like we did with polio in 50's.
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Not to brag, but...
@StanCVFellows
are rock stars! 🤩
On today's front pages, work from
@JustinParizo
,
@ATSandhu
,
@TheDanGerber
,
@AshishSarraju
!
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These photos do not capture the huge number of physicians, nurses, & other healthcare workers who gathered today at Stanford to proclaim
#BlackLivesMatter
! I was especially heartened to see tremendous showing from faculty & hospital leadership.
#WhiteCoatsForBlackLives
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Congrats to all of the graduating
@StanCVFellows
! I'm extra happy that in a random screen shot of Zoom graduation with >100 guests, there's one that includes me, my mom, and my sister. Couldn't have done any of this without them. Photo credit:
@euanashley
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There is a difference between trying to not do things wrong vs trying to do things RIGHT. The
#pangenome
is trying to avoid egregious mistakes of the past. But I think to do genomics RIGHT requires a much bigger fundamental shift in approach.
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As an early career academic, the lesson that's been hammered into me over and over and over again is don't count your chickens before they hatch. I won't even count my chickens after they hatch. I refuse to look at my chickens. There are no chickens.
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In which
@kph3k
almost gets it but then doesn't.
💫 My new paper, out now in
@NatureRevGenet
, on genetic determinism, essentialism and reductionism:
Non-paywall link here:
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It was a true honor to present at
@StanfordDeptMed
Grand Rounds this week along with colleague and mentor Dr. David Maron. We discussed
#aspirin
for the primary prevention of cardiovascular disease.
#MedTwitter
#CardioTwitter
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The main thing that I want to know coming out of
#AHA20
is
WHY DOES FISH OIL CAUSE ATRIAL FIBRILLATION??
🤔🤔🤔
Any theories?
#cardiotwitter
#EPeeps
#AFib
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How does polygenic risk for 🫀 disease impact women's longterm health? 🤔
We found many expected associations as well as one big surprise!
A thread on the peculiar overlap between the genetics 🧬of
#atherosclerosis
and
#cancer
.
1/
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What an incredible & unified message from the leading experts of Stanford, calling attention to the, "falsehoods and misrepresentations of science recently fostered by Dr. Scott Atlas"
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In past week I've seen two otherwise healthy school age kids present with septic shock due to influenza. Get your
#flu
vaccine!
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This year we've repeatedly seen the systemic racism of our justice system play out. But the case of
#TamirRice
is utterly grotesque.
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Not surprised at all to see my timeline flooded w/ praise for
@DrJoelKatz
, a truly remarkable physician educator & program director. Thank you Joel for making
@BrighamMedRes
the unparalleled program that it is, one that has deeply impacted so many physicians across the globe! 🥲
The incredible
@DrJoelKatz
, longtime IM Program Director
@BrighamMedRes
, is stepping down after 22yrs of wonderful service to generations of
@BrighamWomens
interns and residents.
@DrJoelKatz
, thank you for everything you’ve done for us! We owe so much to you.
We will miss you!
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Lastly, I live in an area with both extreme affluence and homelessness. I saw plenty of wealthy patients and poor patients alike. If all you care about is yourself, the selfish thing to do is care about others. No one is safe from covid until everyone is safe from covid.
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The Lancet: Point-of-care screening for heart failure with reduced ejection fraction using artificial intelligence during ECG-enabled stethoscope examination in London, UK: a prospective, observational, multicentre study.
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Congratulations to Dr. David Maron for this well deserved recognition of the ISCHEMIA Trial! I feel so lucky to have him as my mentor in preventive cardiology since I arrived
@StanfordDeptMed
! cc:
@joshuawknowles
@FaRodriguezMD
@AshishSarraju
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Just when I thought I was done with fellowship... Covering CCU today so that our new chief fellow
@AshishSarraju
can spend the day orienting incoming
@StanCVFellows
. But honestly, can't think of any better way to end fellowship than in the CCU 😁
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Here we go again 🥸
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@CT_Bergstrom
This article would be better received if it were not coming from authors who frequently partake in the very behavior that they criticize. Worse yet, I don't think they acknowledge there own faults whatsoever. They really seem to see themselves as unbiased saints of science.
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I'm so cardiology...
If you stare at me, or in my direction, I'm going to ask you about your cholesterol
I’m so Canadian...
If you stare at me, or in my direction, I’m going to say “Sorry”
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For the first time in 10 years, I will not travel home to Maine to spend Thanksgiving with my mom. Every year, I volunteer to work on Christmas, and I take Thanksgiving off for myself. This year I'm staying put, for my mom, for my colleagues, and for my country 🇺🇸
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🚨PREPRINT DROP🚨
Led by stellar student
@milos_ai
& co-supervised w/
@David_Ouyang
, we used
#AI
processing of 🫀 MRIs to conduct the first large-scale study of cardiac sphericity in a normal population.
What does it mean to have a rounder heart? 🤔
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Mount Sinai and Regeneron are building a biobank 🧬 of 1 million New Yorkers
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I'll be presenting
@DLBHATTMD
's REDUCE-IT paper at
@StanCVFellows
journal club next week. As part of my prep, I'm digging back into the history of n-3 fatty acid research, starting with this 1971 observational study in the Lancet.
#omega3
#MedEd
#MedHistory
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Journals, societies, and institutions need to be doing more of this 👇
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Bittersweet feelings as I walk out of the CCU for the last time, having now finished my clinical cardiology training. Seems fitting that my last duty was to hold pressure on a groin 💪💉
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Are we ready to bring PRS into the clinic?
Is DTC 🧬 testing friend or foe?
Check out
#AHA22
session, "Clinical Debates in Cardiovascular Genetics," today at 11am, located at N229.
Looking forward to presenting some thoughts on PRS!
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To not explicitly label the Flint water crisis for what it is, a violent act of systemic racism, is to help preserve that very system.
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I revise my statement. Not just healthcare providers, every adult in America should watch
#BeingMortal
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We've an entire clinic in Boston that's dedicated to caring for kids who's only medical prob is undernutrition. Kids DO go hungry in America
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In college I met Carlos Bustamante. He took me to the 2004 SMBE meeting. Too shy, I hid in the corner. Then a scientist approached me & asked what I was interested in. I said "disease genes" 😂. He encouraged me. It was Svante Paabo. 1st time I felt maybe I could be a scientist🤩
'Introduce young people to science.' A single meeting could change the trajectory of someone's life. I still have the Erlenmeyer flask he gave me when I was around 10 years old. (yes, I realize I was fortunate to meet such a cool scientist) 5/
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The hospital credentialing process
Hosp: Please complete this paperwork
Doc: Done
Hosp: Now the prelim paperwork
Doc: Ok done
Hosp: Now that that’s out of the way, here's the intro paperwork
Doc: Right, done
Hosp: Perfect. Do these modules, & we can send you your paperwork
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⚡️ Cardiology attending achievement unlocked
👂Auscultation of pericardial knock
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Congratulations to
@CHaeffele_MD
, our assistant program director of
@StanCVFellows
, for receiving a DOM teaching award!
Congratulations to the recipients of our
#StanDOM
2019 Teaching Awards, who were honored today for their exemplary commitment to teaching.
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Incredible medicine grand rounds this morning
@StanfordDeptMed
from the visionary
@euanashley
discussing his world record clinical whole-genome sequencing () and stories from The Genome Odyssey.
Genomic medicine is here. MDs need to be ready!
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Right now, I find solace in my profession. Every day, I get to do what I love, put politics aside, and care for people. Thankful for that.
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Yale, Harvard, Berkeley, Georgetown, Columbia, and Stanford have pulled out of the
U.S. News & World Report law school rankings.
Your move med schools.
👀
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This is complete junk, which is hopefully obvious to most. But realize, work like this is fundamentally no different than EA GWAS. These are not real phenotypes. It's clickbait pseudoscience.
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Working tonight. When I get off in the morning, I'll be taking an über straight to my polling station to vote
#HillaryClintonForPresident
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And also an exceptional advocate and program director for
@StanCVFellows
trainees! And a wonderful mentor to me as well 🙏.
Well deserved recognition
@joshuawknowles
!
We are thankful to
@JoshuaWKnowles
for serving as Chief Research Advisor & volunteering his time for
@TheFHFoundation
. Today we honor his commitment to improving the care for all those w/ FH by driving research & understanding of
#genetics
of
#heartdisease
!
#KnowFH
#VolunteerWeek
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We perform lipid screening in children to identify those at high risk of premature heart disease. We should be measuring Lp(a) too!
Here,
@makhoury
and I describe why:
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@DrJCoftheDC
Nice. Let me get in on this. I'm no
#TikTokDoc
, but I used to get down 🕺🏽
Me in med school 👇🏽
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Congratulations
@FaRodriguezMD
! 🎉🎉 Such an incredible leader and role model!
@StanfordDeptMed
is so lucky to have you!
Join us in congratulating the 2022 recipients of
#ClinicalScientistDevelopmentAwards
! We look forward to following the important contributions of these
#physicianscientists
to
#clinicalresearch
. Learn more about the awardees and their exciting projects:
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@mbeisen
If you want to bang your head against your desk repeatedly after spending hours on Google finding incorrect and nonsensical answers to your very simple question, then you are doing R right. That is R.
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@genome_gov
Totally agree. So....
|￣￣￣￣￣￣ |
| NIH |
| needs to |
| fund diverse |
| PI who have |
| BEEN trying |
| to do the. |
| work. |
| ＿＿＿＿＿__|
(\__/) ||
(•ㅅ•) ||
/ づ
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There are many great cardiology divisions around the country, but nothing beats Stanford. Happy holidays from all of us, and here's to heart health in 2019!
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Totally amazed at the response to my piece on VIP patients! 2nd most emailed NYT article!
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Excited to share our preprint where we show that even after considering extensive longitudinal LDL data, genetic testing for FH variants improves risk stratification for CAD.
#KnowFH
#FindFH
@tassimes
@ines_catherine
@joshuawknowles
@VAResearch
1/8
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Dear California,
This is not the deal we had. I'm going to let this slide because the week has otherwise been off to a good start. But I don't want to have this conversation again.
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Week 5 of
@StanCVFellows
fitness and still going strong! Keeping ourselves healthy so we can have a long career keeping our patients healthy! 💪♥️
#GetUpAndMove
#PracticeWhatYouPreach
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We have a stellar team of
@JuneWRhee
,
@HanZhuMD
,
@Paul_P_Cheng
, and
@SeanM_Wu
presenting on CV complications of
#COVID19
at cardiology grand rounds. Thrilled to see clinicians & researchers joining from all over the country, from Alaska to Maine!
@ajrogers_md
@StanCVFellows
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We've seen this time & time again. Familial Hypercholesterolemia 🧬 variants ⬆️ risk for coronary disease, independent of observed LDL. Screening for FH using arbitrary thresholds of LDL falls short. Is it time for universal 🧬 screening?
#KnowFH
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Check out
@vnparikh
! She's a Stanford cardiologist, scientist, educator, and expert in inherited cardiomyopathies
#ThisWomanRocks
1. Pick a female colleague
2. Describe why she’s awesome
3. Use the hashtag
#ThisWomanRocks
Let’s hear about a ton of cool women!
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It's 93 degrees & driving home I saw a small group of white senior citizens 👴👵 standing outside waiving
#BlackLivesMatter
signs. I'm ashamed I have not marched yet. Tomorrow, I will be joining other
#Stanford
physicians to rally outside the hospital. Join me.
#BlackLivesMatter
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Look at this incredible decline in heart attacks and strokes in Sweden among both diabetics and controls! In fact, diabetics who got their risk factors to target had similar risk as controls 🤩!
Heart attacks CAN be prevented!
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Way to go
@TheMahaf
& Marco Perez, Stanford CV faculty being recognized for their innovation & leadership in clinical trials research!
cc:
@StanCVFellows
@HeartBobH
@EldrinL
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Merry Christmas from the VA hospital! A salute to all the veterans and everyone working on this Christmas day 🙏
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The fact remains:
#FreddieGray
died in police custody, and he died of a violent injury. The police are at fault. This is unambiguous.
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Another garbage headline courtesy of behavioral geneticists
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In my opinion, this is the most important problem facing all of biomedical science.
#Genomics
#diversitymatters
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This is an incredible tour de force from
@Paul_P_Cheng
. From
#GWAS
to mechanism of disease! CAD risk via plaque vulnerability! ZEB2, yet another link between 🫀 disease and
#cancer
pathophysiology! 🤯
#OriginalResearch
: ZEB2 affects features of plaque vulnerability through direct effects on the epigenome
@Paul_P_Cheng
@shoaclarke
@dishasharmaaa
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🚨PREPRINT UP🚨
New work w/
@tassimes
& led by
@JoannaLankester
. We used
@WHIStudy
,
@uk_biobank
, & other cohorts to examine the causal relationship between ♀️ age of menopause & risk for adverse health outcomes using 🧬 Mendelian randomization.
👇
🧵1/
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