PPIを使��と免疫療法の効果が落ちる、特に免疫療法単剤だと顕著なので、PPI使用者には化学療法と免疫療法の併用が良いかも、と言うデータでした(肺癌).
日本からの報告
Proton Pump Inhibitor Use With Immune Checkpoint Inhibitor Therapies for NSCLC
腎癌でニボルマブを使ってirAEがでると予後が良いかも, と言う論文
副作用後のステロイドは大丈夫の様ですが、治療前10mg以上のステロイドは効を落とすかもと肺癌で既報あり
Corticosteroids and Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma
英語のルール: Patient-first language
Cancer patient (x) 癌患者
Patient with cancer (o) 癌を持つ患者
診断以前にその人を優先し、その人が「何であるか」を主張するのではなく、その人がどのような状態を「持っている」かを説明する表現法
例 monster patient vs. patient with monster
前立腺癌に対する放射線治療後の再発定義 はPSA>nadir+2.0でしたが、PSMA PETによりその時点で既に84%で転移陽性、という事が判明。基準が変わる可能性大。手術の再発は>0.2 ng/mL
According to the Phoenix criteria, 84% had positive lesion on PSMA-PET at nadir +2.0. It might be too late.
Accepted !
Effects of apalutamide dose reduction on skin-related adverse events in patients with advanced prostate cancer
APA減量すると体格の小さい患者さんの皮疹は減り制癌も標準量と同等であった、という短期成績。詳細はpublish 後に。ENZやABIとの比較は今後の課題ですね。
PSA進展しないでCRPCになる前立腺癌ってヤバいよね、という発表。表がとても分かりにくいのでわかりやすく改変させて頂きました。もちろん自己研鑽です
Radiographic progression in the absence of PSA progression in patients with mHSPC: Post hoc analysis of ARCHES
ADT and risk of dementia in pts w/
#ProstateCancer
📌 627,025 ADT PS-match to 73,933 no ADT
📌 ADT: assoc w/ dementia: HR 1.60, 95%CI 1.49, 1.73
📌 ADT: inc risk of dementia White men (78.6% vs 77.7%, p<0.001); no diff AA men
📌 Highest risk: GnRH antag (HR 1.92, 95%CI
Published!
Pts with testicular tumor are aging. What are the reasons for this phenomenon?
Trends of incidence and age in adults with testicular germ cell tumors: a two-decade multicenter retrospective study
Accepted. Coming soon.
Comparison of Neoadjuvant Chemohormonal Therapy vs. Extended Pelvic Lymph-node Dissection in High-risk Prostate Cancer Treated with Robot-assisted Radical Prostatectomy
Neoadjuvant 2nd generation AR inhibiter might be an option in future in high risk PC.
Really interesting paper in Nature Immunology today (Broquet et al.)
They found that people who recover from sepsis have a reduced cancer risk in the years that follow (vs. matched people with non-septic infections):
This was recapitulated in a controlled setting in mice - mice