Zach Klaassen
@zklaassen_md
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Uro Onc @GACancerCenter | Assoc Prof, Resident PD, and Ronald W. Lewis, MD Chair of Uro Educ @mcg_urology | #mentalhealth research | @urotoday Contributor
Augusta, GA
Joined July 2013
Honestly, the emails, texts, DMs, etc are what make this recognition so special. I don't know what one has to do to get this award, but I'm grateful to @AmerUrological @SES_AUA for the nomination. All I can say is (in no particular order): 1) Be better each day, 2) Mentor/teach.
Congratulations to the 2023 Young Urologist of the Year Award Winners! Join us in congratulating these early-career urologists and their commitment to advancing the specialty! Read more here β‘οΈ #AUA #Urology #AUAMembers
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mCRPC management is influenced by the treatments received in previous lines . Excellent algorithm from @Ecastromarcos -- likely to change with PSMA RLT. @urotoday #EAU22
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The honesty, thoughtfulness, and wit of @ChrisSweens1 . Phase 3 trials of Immunotherapy in Prostate Cancer -- .A Case Study of "Failed All-Comer Strategy". β‘οΈ8 negative trials.π° >$700 million USD.π¨βπ¦° 7,305 patients. #ESMO24 @urotoday
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Such a humbling honor to take over the @mcg_urology residency program. A program that gave me exceptional training & one that I was fortunate to rejoin after fellowship. Big shoes to fill! @mkterris has done an amazing job the last 15+ years. Yes, @DelaigleKim is INCREDIBLE.
Congratulations to new MCG Urology Residency Program Director, Dr. Zach Klaassen. Along with our extraordinary Program Coordinator Kim Maddox, Dr. Klaassen will keep our program going strong! .@zklaassen_md @DelaigleKim #UroMasters
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Humbled, honored, and extremely grateful to be named the "Ronald W. Lewis, MD Endowed Chair for Urologic Education". Professor Emeritus Dr. Lewis leaves an incredible legacy of resident education that I can only hope to live up to. These pictures will be in my office forever.
Witherington Chair of Urology @mkterris announcing Professor Emeritus Dr. Ron Lewis' "Ronald W. Lewis, MD Endowed Chair in Urologic Education" for @zklaassen_md
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So freaking happy and proud of my friend, colleague, mentor and boss @mkterris on her nomination to the American Association of Genitourinary Surgeons!.ππ»β‘π
π.@mcg_urology @MCG_Surgery @GACancerCenter @AUG_OFS @MCG_AUG @AUG_Health @AUG_JAGWIRE @GA_Urol_Assoc @SES_AUA @SWIUorg
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Going to be an incredible year. The first DEPARTMENT of Urology Residency class 2023-2024. @mcg_urology @MCG_AUG
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Big win for #prostatecancer and #mentalhealth today: still somewhat speechless and incredibly grateful for the @DeptofDefense funding my grant looking at these entities in the national VINCI @DeptVetAffairs system. Great mentorship from @SFreedlandMD & @mkterris !.ππΊπΈ
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Huge congrats to our @mcg_urology Chair, my mentor, and friend @mkterris for an incredibly well deserved @AmerUrological Distinguished Service Award! . @IMRhelpsvets @AUG_OFS @MCG_Surgery
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AMAZING progress in metastatic urothelial carcinoma in the last 17 months!. Beautiful schematics and excellent discussant presentation from @TiansterZhang at #ASCO20 . @urotoday
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First results of RADICALS (biochemical analysis) @PCaParker:. Biochemical PFS: no difference between adjuvant and salvage RT (HR 1.10, 95%CI 0.81-1.49). @urotoday #ESMO2019 #ESMO19
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This is the kind of ingenuity we're lookin for at @mcg_urology . PGY-2 Kyle Cline with a great addition to the Coffee Station
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"When a surgeon designates a tumor βinoperableβ, they do not mean that it is physically impossible to operate. They mean that, with careful analysis, the risks of operating outweigh the benefits". ROI: One of the most important lessons in surgery .#MedEd.
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May have to fact check this, but pretty sure this is the first time @Eminem has been referenced at an @ASCO sanctioned event. Well done @ChrisSweens1 ! #GU18
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Dropped off my oldest at school this morning on her 13th birthday . Can't believe THAT just happened π³. So proud of her - 7th grader doing 9th grade math and 8th grade pretty much everything else. Kind, loving, caring. Days are long and the weeks are short. (π·: a few weeks ago)
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#ESMO24 Congress Highlights - Prostate Cancer.@UrsulaVogl . Looking at the nuances: characteristics of the two phase 3 trials (SPLASH and PSMAfore) in the mCRPC taxane naive setting. @urotoday
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Congrats ππΌ to @spsutkaMD -- Clinical decision aid to support treatment selection for patients with cT1 renal masses. 5-Yr CSM, OCM & 90-d Clavien 3-5 complications for pts selecting between RNx, PNx, thermal ablation & AS. #GU20 @urotoday
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Moving into summer, traditional sub-I season.Applicants:.- Get on Twitter, be active.- Attend as many residency virtual open houses as you can. Many programs doing this across πΊπΈ, s/o to a few in the @SES_AUA : @mcg_urology @emory_urology @VUMCurology @UNCurology @UF_Urology.
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Optimal Dissemination of Scientific Manuscripts via SoMe: A Prospective Trial Comparing Visual Abstracts Versus Key Figures in Consecutive Original Manuscripts Published in @EUplatinum . πTwitter impressions > for VAs vs KFs (8385 vs 6882, p = 0.006)
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Summary of PRECISION, MRI FIRST, and 4M studies from @mrsprostate -- @Uroweb #ESOU19 debate: mpMRI for all men with elevated PSA. Standard of care in the UK
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Results of TITAN released for @asco #ASCO19 :.Apa + ADT vs ADT alone for mCSPC. OS benefit for Apa: HR 0.67, 95%CI 0.51-0.89.11% of pts with prior docetaxel. Landscape is changing meeting to meeting .#prostatecancer.
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Proud of my man @rksayyid matching in @UroOnc @UofTUrology today! π. Coming full circle: we met in Toronto 2016 when I was a fellow and Rashid was a Masters student with @FleshnerNeil . (Second pic, circa Jan '17 in T.O. - @AmerUrological match day for Rashid into @mcg_urology )
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Here we go - #TipsForNewDocs .1) Don't "Doctor" your colleagues: Introduce yourself using first & last name, your service.2) Be humble .3) Own your mistakes - you'll make them. plenty of them .4) Teach the med students .5) Never cause your patient to lose hope.
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Really appreciate everyone joining us for our first @mcg_urology Virtual Open House! .Peaked at 65 participants ππ».Happy Memorial Day everyone πΊπΈ.@Uro_Res
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Phase 3 Adjuvant Chemo for UTUC -- first presented at GU @ASCO '18, now published in @TheLancet. Adjuvant chemotherapy significantly improved DFS (HR 0.45, 95% CI 0.30β0.68; p=0.0001) at a median follow-up of 30.3 months.
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Thank you π. But, more importantly, thank you for resurrecting this sweet pic from Movember 2019 π€£.
The @AmerUrological has named @Zklaassen_md as a Young Urologist of the Year award winner!. π Read more:
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One of my old partners is retiring and cleaning out his office -- he found a stack of these scrub cap relics. I feel more blood flow going to my head already π³
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Lots of data upcoming in the oligometastatic mHSPC space . Trials from @ChrisSweens1 . #EAU24 @urotoday
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Absolutely phenomenal lecture from @DrChoueiri in the @myESMO On Demand Educational Session discussing 1L treatment for mRCC. Attached algorithm: what he uses in the clinic when deciding 1L treatment approach for mRCC patients . Summary available soon on @urotoday #ESMO21
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So incredibly happy for and proud of @mkterris -- this has been overdue and in the making for a loooong time now. Tremendous persistence! . There's been 4 Division Chiefs over the 60+ years of our program, but only 1 Department of Urology Chair ππ.
Announcement! We are grateful for the support and encouragement of our institution in attaining the goal of Department of Urology!
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Applicants applying to this year's @AmerUrological Residency Match: please encourage those applying that aren't on social media to join. Hard to reach applicants these days during #COVID19 that aren't on SM. brainstorming ideas #UroSoMe.@Uro_Res @mcg_urology @SES_AUA @mkterris.
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School assignment for my 8 year old son - "Write something about #COVID19 ". This is COVID positivity
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What are the biggest intraop fallacy statements in Urology?. Here's one:. "You're MILES away from the rectum". #UroTwitter.
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We are recruiting a Uro Onc to join our team at @mcg_urology @GACancerCenter. Augusta, GA and the CSRA: great place to live, raise a family, work w/ phenomenal partners & residents . If you're attending #SUO22 in San Diego and would like to meet to discuss, shoot me a DM!
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Hi, I'm a urologic oncologist. You may know me from my hits "that PSA of 3.9 at age 75 is not concerning", "no, the robot doesn't actually do the procedure", and the chart-topping "please drop your pants, place your chest flat on the table, and spread your legs slightly apart".
Hi, Iβm a pediatric urologist. You may know me from my hits βthatβs not actually a UTIβ, βno we donβt need an ultrasound to find your kidβs testisβ, and the chart-topping βyouβre symptoms are probably due to constipationβ.
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Proton beam therapy for PCa?.
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BCG Unresponsive Cancer in 2024 @UroDocAsh at the #SUO24 Bladder Cancer Course. Bladder-sparing therapy for BCR-UR NMBIC: @IBCG_BladderCA Recommendations for Optimal Sequencing and Patient Selection. @urotoday
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.@DrRanaMcKay 's practical approach to treating 1L clear cell mRCC in 2024. An effective clinic triage algorithm! . @urotoday #SoCalGU24
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#Urology colleagues in the Southeast: if you, your family, or patients need lodging this week during #HurricaneDorian our house is open and I'm on call for @mcg_urology at @AUG_Health all week.DM me.@SES_AUA @GA_Urol_Assoc.
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A lot of moving parts in BCG-unresponsive NMIBC!. Updated table from @MarkTysonMD after presenting initial results of BOND-003. #SUO23 @urotoday
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#ASCO22 just around the corner, starting this Friday!. @urotoday with full coverage: A sample of the excellent research to presented this week π. @asco @WallisCJD
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π¨Impressive results: Ph3 BCG + IL-15RΞ±Fc superagonist N-803 in BCG-unresp NMIBC. @UroCancerMD et al. #GU22 . CIS Cohort.β¦οΈ CR rate: 71%.β¦οΈ12-mo CR rate: 62%.β¦οΈ24-mo CR rate: 52%. Papillary Cohort.β¦οΈ12-mo DF rate: 57%.β¦οΈ18-mo DF rate: 53%. Very favorable safety profile.@urotoday
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How to Best Use Current Drugs: Treatment Sequencing and Combinations for mCRPC @Silke_Gillessen . Outstanding possible treatment algorithms based on previous therapies received. #GU23 @urotoday
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Final OS analysis 2yr f/u in CheckMate 9ER: Nivo + Cabo v Sun in aRCC.@tompowles1 et al #GU22 . Benefit of Nivo + Cabo:.πOS: HR 0.70 95%CI 0.55β0.90.πPFS: HR 0.56 95%CI 0.46β0.68.πORR: 55.7% v 28.4%.πβ¬οΈ % β₯30% β¬οΈ baseline π― lesion (kidney, liver, lung, LN, bone).@urotoday
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Don't "doctor" anybody on the phone when talking to other services, nurses, SW, etc. we know you've worked hard to get to this point and are DYING to say it. But "Hi, I'm Zach from Urology" goes a long way. We know you're a doctor, trust us.#TipsForNewDocs.
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AE profile for IO agents vs chemo in solid organ tumors: A SR and MA of RCTs - @Annals_Oncology. Take π :.- 10,598 abstracts screened, 22 RCTs included, 12,727 pts: 16.5% IO AE>=3 vs 41.1% chemo. Great work @d_magee22.& @AHirdMD (future @UroOnc fellows).
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First pop-level study accounting for psych comorbidities prior to #Cancer dx - confirming a cancer dx increases suicide risk compared to the gen pop, specifically in first 50 mos (60% β¬οΈ) @JournalCancer. Many thanks to @GSK_UofT @WallisCJD @KurdyakP et al.
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#ASCO24 . PSMAfore: the latest RLT therapy in #prostatecancer to show improved HRQoL and improved pain control. @Cpaller @urotoday
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β‘οΈ LBA β‘οΈ- ARANOTE: Efficacy & safety of Daro + ADT in mHSPC @urotoday #ESMO24 @BayerOncMed . Daro + ADT vs PBO + ADT:. πn=669; 446 Daro vs 223 PBO.πPrim EP, rPFS: HR 0.54, 95% CI 0.41β0.71.πOS: HR 0.81, 95% CI 0.59β1.12.πTT CRPC: HR 0.40, 95% CI 0.32β0.51.πTT PSA Prog: HR
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Nice paper in @urogoldjournal, good info. @MCG_AUG with the 4th highest (n = 29) absolute number of med students entering Urology and graduating from @AmerUrological residency programs from 2016-2021.
Just out @urogoldjournal-Characteristics of Medical Schools in US Associated w Successful Match into Urology Residency Programs-Analysis of 2016-2021 Resident Cohort @julianakim04 @isaackimjr @eric_facs @DrDaniVelez @saumyg @TomJangUroOnc #UroSoMe @UroAcademic @AmerUrological π.
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π Finally here! π @urotoday. Prostate Cancer Patient Voices:. An incredible resource for patients: A one stop shop of patient testimonials and written articles explaining the #prostatecancer journey at the patient level. A huge thank you to my patients
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#EAU24 PEACE V-STORM: Ph 2 RCT of salvage MDT + 6 mo ADT +/- ENRT for Oligorecurrent nodal PCa: 24-mo toxicity results @ZilliThomas .@urotoday . n=97, MDT vs n=93, ENRT.πWorst late Gr β₯ 2 GI AEs: 5.3% vs 6.6% (p=0.94).πWorst late GU β₯ 2 GU AEs: 22.2% vs 26.5% (p=0.61)
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Every surgeon has a "coffin in the recesses of their brain" that we carry with us for pts that pass post operatively . Make sure you have a colleague to talk to/grieve with about these patients . We learn, move on, help others, but we carry a piece of them forever .#medtwitter.
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#AUA24 @yawnyame State-of-the-Art Lecture: Prostate Cancer Screening High-risk Groups. New @PCFnews Screening Guidelines for Black Men in πΊπΈ. Guideline statements π @NEJMEvidence @urotoday
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#ESMO24 Congress Highlights - Prostate Cancer @UrsulaVogl . Randomized Phase 2/3 trials investigating metformin in prostate cancer. @urotoday
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Had a lot of fun being co-guest editor with @WallisCJD for the Mental Health in Urology issue of @EurUrolFocus .Important topic and great contributions from @daviesbj @qdtrinh @gorejohn @crisbergerot @montypal @Drkelvinmoses06 @yawnyame @DrShariat @siemensr @CaPsurvivorship et al
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We will not be using @SignalTokens here at @mcg_urology . As PD, all applications are reviewed in detail -- if you are invited to an interview, we think you have the potential to be a resident at our program. We hope this alleviates anxiety during this challenging year.
.@UroAcademic please consider making an official statement on @SignalTokens and related entities. although many PDβs have indicated that they will not be participating, applicants are still apprehensive and may buy-in out of an abundance of caution . @UroResidency @Uro_Stream.
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Forever indebted to my wife @urowife_designs family, friends and the hundreds of folks along the way that have shaped my career over the last 17 year's of school and training. The end of the beginning @goUFV @SFU @StGeorgesU @SaintBarnabasNJ @mcg_urology @UofTUrology @ihpmeuoft.
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#SUO24 Bladder Cancer Course - Emerging Perioperative Systemic Therapy @jackiebrown_MD . Summary of adjuvant immunotherapy monotherapy phase 3 trials. @urotoday
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For those (like me) having trouble keeping up with the timeline of FDA movement in the 1L mUC setting for CPIs, great summary from @apolo_andrea in #GU23 discussion .π 4/21: Atezo keeps indication.π 8/21: Remove pembro indication for cis-ineligible PD-L1 β¬οΈ; cont for
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If you find Gleason 6 #prostatecancer in men >70 years of age, please ONLY offer active surveillance:.1) It's the right thing for the patient.2) It'll save Medicare ~$320 million.@corp_UNC @JAMAOnc.
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Phenomenal weekend having @FleshnerNeil down to Augusta as our keynote speaker for the 48th annual Rinker-Witherington Urologic Symposium . Keeping the Toronto-Augusta connection strong: @rksayyid heading north next year for @UroOnc fellowship
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Discussing starting active surveillance with a patient in clinic today for low volume GG1 #prostatecancer . "Doc, so what your saying is: the house ain't on fire, but we have the fire extinguisher near by". EXACTLY.
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We're excited to get the band back together for another set of @mcg_urology virtual open houses this summer leading into Fall's interview season. Mark your π!. Thurs, July 15: 7PM EST.Sat, Aug 21: 1PM EST.Sat, Sept 18: 1PM EST. @Uro_Res @UroAcademic @MCG_AUG . Details to follow.
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This is what happens when TSA kindly tells you at airport security that your driver's license expired 4 days ago (had no idea) and you get to rock #movember every day for the next 5 years on your new licenseπ₯π₯ Don't forget to donate to our Movember team. for the next 5 yrs
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So proud of our @MCG_AUG medical students in today's @AmerUrological #uromatch . 8 out of 9 matched!. Incredibly proud that 2 will be joining @mcg_urology too ππ». @AUG_Health @MCG_Surgery.
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#AUA24 @UrogerliMD MoonRISe-1: Ph 3 study of TAR-210 vs intravesical chemo in pts with IR NMIBC with susceptible FGFR alt @urotoday . πn=540, randomized 1:1 to TAR-210 vs choice of intravesical chemotherapy (MMC or Gem).π1L EP: DFS.πEnrollment opened April 10, 2024: planned at
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Excellent summary of the current landscape in June 2022 for metastatic urothelial carcinoma . @shilpaonc discussant presentation today during the kidney/bladder oral abstract session -- awaiting results of EV302 (EV + pembro in 1L treatment). @urotoday #ASCO22
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So excited for these phenomenal new urologists joining us at @mcg_urology π₯π». Congratulations and welcome to Chen Jiang, @EdwardMachen7 and @Drewology!. #AUAMatch.
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Brilliant RCC discussant in oral abstracts for RCC by @PBarataMD . Summary of the phase 3 adjuvant ICI RCTs in RCC. #GU24 @urotoday
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Evidence of 'triplet therapy' (ADT + doce + additional systemic Rx) in mHSPC from @Prof_IanD #APCCC21. Best evidence in ENZAMET (ADT + doce + enza): no OS benefit yet (50% of events), but strong PFS signal for triplet. @urotoday @APCCC_Lugano @ANZUPtrials.
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Undetectable ctDNA Before RC Predicts πΌ Outcomes @urotoday #IBCN2024 @DrJohnSfakianos @IBCN1997 . π¨πn=134.π¨πn=85 (63.4%) pts had MIBC, 25 (29.4%) had NAC .- Med F/U 10 mos: 40 (29.9%) pts had dx relapse.π¨πUndetect vs Detect ctDNA, 12 mo RFS rate: 93% vs 40%.π¨πUndetect ctDNA: πΌ
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1-line Treatment of mRCC: A Systematic Review and NMA. ITT pop:.PFS - Cabo (SUCRA 84%), avelumab + axi (SUCRA 68%), pembro + axi (SUCRA 82%).OS - Pembro + axi (SUCRA 95%).Lower AEs - Atezo (SUCRA 100%). Similar for int/poor risk pts. @EurUrolOncol.
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ADT and risk of dementia in pts w/ #ProstateCancer . π 627,025 ADT PS-match to 73,933 no ADT.π ADT: assoc w/ dementia: HR 1.60, 95%CI 1.49, 1.73.π ADT: inc risk of dementia White men (78.6% vs 77.7%, p<0.001); no diff AA men.π Highest risk: GnRH antag (HR 1.92, 95%CI
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Decades of progress in 1L clear cell mRCC treatment @DrRanaMcKay . From an OS benefit of 10 mos in 1992 (cytokine era) to 56 mos in 2018 (ICB + targeted therapy). @urotoday #SoCalGU24
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Giving a presentation "What is Urology?" to my daughter's 5th grade Horizons class tomorrow. Other than focusing on stones rather than penile/testis cancer, any other words of wisdom from #UroSoMe ? Prop ideas (no IPPs)?.π³π.
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Missed #GU22 @ASCO ?. Check out the 309 talk summaries posted @urotoday - @WallisCJD @DrJonesNauseef @aloktewar @jberchuck.
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I know we all have these from grateful patients, but there's something about a hand written note from a patient (17 cm renal mass s/p nephrectomy) in your mail box after a long clinic day.ππ #KidneyCancerAwarenessMonth
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Amen @UroDocAsh . Was told by my med school to not bother applying to #urology because "you won't have a chance" (despite 256/264 USMLE 1/2 and 25 pubs). Forever grateful to @mcg_urology , @mkterris , and Dr. Ron Lewis for taking a flier on an IMG from π¨π¦.π.
#ThisIsReal.Lost track of the number of times I was told to βnot botherβ when applying for residency as an #IMG . But remember - and will be eternally grateful to - the two (Don Lamm and Stan Kandzari) who said βwe will take a chance on youβ.
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Algorithm from Dr. Morey @UTSWUrology for calculating level of resident involvement in a case ππΌππΌ.Cc: @UroOncMD .#SAU2020
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Contagious Enthusiasm in PSMA-Driven Therapeutics by @EfstathiouEleni #APCCC21. π177Lu-PSMA trials earlier in the disease. Stay tuned for upcoming:.πPSMA-targeted bispecific T-cell engager (BiTE) immunother.πPSMA-targeted CAR-T. @urotoday @APCCC_Lugano.
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At @mcg_urology mentorship is like recruiting for big time College Football programs: year round. Zoom call today with the newly matched M4s discussing their experience with the M3s applying next year #AUAMatch . More excellent @MCG_AUG Urology candidates coming next year!
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