SEEN in STEM
@SeenStem
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For sex-realists in STEM who believe reality matters for continuing scientific and technological discoveries. The Enlightenment lives on. SeenInStem @gmail .com
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Joined March 2024
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Pinned Tweet
A point has been reached where those of us who value truth, who value reason, who value material reality and who recognise that the very foundation of how we make sense of the world, the scientific method, is being undermined, take a stand.
@SEENSTEM
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When people demand a metaphysical belief in an innate gendered soul holds more weight that the material reality of biological sex the alarm bells should ring. For every single scientist. We cannot allow a neo-religious belief to continue to destroy reason and rationality.
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When MPs in the House of Commons spend time reading out a growing list of 'gender identities' it is time to wake up and realise we are entering an era of arguing how may angels can fit on a pinhead. These beliefs are unfalsifiable and they are wreaking havoc.
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Thank you to those scientists who are already calling this neo-religion and pseudoscience out for what it is. Take a stand. If not you, who? If not now, when?
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Look at scientific medical journals now demanding that such metaphysical beliefs are embedded in research, or that language is made ambiguous to avoid upsetting a small group of people who subscribe to this ideology. Resistance is everything.
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"please note there is no single, universally agreed-upon set of guidelines for defining sex and gender"..."Sex and gender are often incorrectly portrayed as binary..." This needs to stop.
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A short 🧵on systematic reviews. The Cass Review represents a significant and groundbreaking systematic review in the field of paediatric gender medicine. However it has come under attack for including some studies and not others. Firstly, what is a systematic review?
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A 🧵on the ‘placebo effect’ and why it's relevant to the
#CassReview
. The placebo effect is where a patient responds positively to sham treatment. E.G., in a placebo-controlled randomised trial, patients in the placebo arm improve despite not being on active treatment. 1/n
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Key to effective public health messaging is clarity of messaging & knowing your audience and their concerns. Since ovarian cancer only impacts women, whatever their ‘gender identity’, and the word woman is much clearer than ‘anyone with ovaries’ this is poor ideological messaging
Anyone with ovaries can get ovarian cancer.
Knowing the symptoms can help you spot anything abnormal. If things don't feel normal or if any symptoms get worse, contact your GP.
#OvarianCancerAwarenessMonth
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"We do not understand the underlying mechanisms. We do not even have the figures to know how common this is, and we do not know the follow-up." Lord Winston calling for more scientific research around transgender medicine.
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"the UK employs almost twice as many diversity and inclusion workers per 10,000 employees than any other country. In the public sector, it said there were more than 10,000 public diversity and inclusion jobs, at a cost of £557 million a year."
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“Sex is not defined by chromosomes, nor by anatomy, nor by psychology or sociology, nor by personal inclination, nor by “assignment at birth”, but by gamete size.” Indeed Professor
@RichardDawkins
But this language has infected medical journals (1/4)
This ridiculous article (shame on the once-great Scientific American) ignorantly misunderstands the nature of the sex binary: “Actual research shows that sex is anything but binary”.
Sex is not defined by chromosomes, nor by anatomy, nor by psychology or sociology, nor by
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"Sex is a fundamental feature of the human species; it is a key variable in psychology, sociology, and public policy. Worldwide, men commit the vast majority of homicides; women are far more likely than men to be single parents."
@RichardDawkins
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We are very fortunate to have so many talented people within the sex-realist movement. We approached one such creative woman and asked her for help with a logo for
@SeenStem
. We do however have a tie between 2 of the 3 designs. Please help us choose! (1/2) poll below 👇
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"Dawkins railed against the ‘debauching of language’ and the assault on science and reason. In particular, he took aim at Gender Studies Professor Anne Fausto-Sterling for her nonsensical argument that ‘sex in humans is a non-binary continuum’."
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Hence the fact that Cass criticised the lack of GAT studies that had a control arm should be no surprise. How will we know in such studies (and taking into account points 1-5) whether any improvements seen in patient reported outcomes is down to treatment or the placebo effect? n
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Certain diseases have higher placebo effects than others e.g. pain ( ) and mental health disorders. E.G. up to 41% of people in the placebo arm respond in trials of anxiety despite being on non-active treatment ( ) 2/n
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large long term study on the persistence of gender dysphoria from a Dutch study showing the majority of children who express the desire to be the opposite sex no longer feel that way in adulthood.
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In 2022 a paper was published specifically on the placebo effect and gender medicine (). This has several important points:
1) The treatment response measured in GAT (gender affirming treatment) and trials is mainly based on patient-reported outcomes 3/n
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Whenever the word 'cisheternormative' is used in a derogatory way in a paper about healthcare then 1) it is clear the paper will be ideologically focussed and we suggest 2) replace 'cisheteronormative' with 'evidence-based medicine' 🧵
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A new publication is out about the Cass Review entitled "The Cass Review: Cis-supremacy in the UK’s approach to healthcare for trans children" in the Journal International Journal of Transgender Health (mini 🧵)
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4) Repeated claims are made that gender distressed youth are at high suicide risk and that GAT reduces this risk
5) There is a lack of control arm used in studies examining GAT 5/n
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"Cass review found professionals in the field are scared to discuss views amid risk of reputational damage & online abuse. Her conclusion was echoed by doctors, academic researchers & scientists, who said this climate has had a chilling effect on research"
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2) Some clinicians, enthusiastically promote GAT, including on the media, social media & alongside celebrity patients
3) Alternative psychosocial treatment approaches are sometimes denigrated as harmful and unethical conversion practices or as “doing nothing.” 4/n
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The work to undermine The Cass Review is underway. All children deserve the highest standards of care and that needs to be based on evidence. The review should not be swayed by activist's ideological leanings which would ultimately destroy the tenets of modern medicine,
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One key point - the search plan & inclusion/exclusion criteria are decided in advance (unlike a narrative review). This reduces bias. Imagine a researcher is looking to support a specific answer. If they can cherry pick post-hoc which studies to include they can bias the outcome
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@Broma07983148
We were all busy being in the various feminist groups. Then there comes a moment. An event. A contact. A conversation. Like when you seed a solution and suddenly you get beautiful crystals. (Perhaps 😉)
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"Jane Symons, vice-chair of the Medical Journalists’ Association, said: “It’s the first time I have ever attended a medical conference requiring police protection. Healthcare should be driven by evidence not ideology.”"
This is the Streisand effect in action on the media. These protests at the
@CanSG_org
conference have done more to garner press attention than panel members or discussion topics. This is the
@Telegraph
front page.
Footage
@bindelj
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The steps are laid out in this paper 1) Formulate the review question 2) Define inclusion and exclusion criteria 3) Develop search strategy and locate studies 4) Select studies (translation may be required) 5) Extract data 6) Assess study quality 7) Analyze and interpret results
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A 🧵on the ‘placebo effect’ and why it's relevant to the
#CassReview
. The placebo effect is where a patient responds positively to sham treatment. E.G., in a placebo-controlled randomised trial, patients in the placebo arm improve despite not being on active treatment. 1/n
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Given concern about the placebo effect, especially since many study results relied on patient important outcomes for example, then specifying studies should have a control arm may be one such criteria for inclusion. See previous thread on placebo effect.
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“Cervical cancer affects thousands of people in the United States (U.S.) annually, including cis-gendered, transgender, and nonbinary individuals assigned female at birth.”
Journal = Cancer Causes & Control
The word is woman. (2/4)
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8) Disseminate findings. See:
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Listen to
@sapinker
describe what’s wrong with our universities. “You can’t get at the truth if there are some things you can’t say. We’re a fallible species riddled with bias and fallacies.”(1/6)
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In the case of the Cass Review most of the criticism has fallen on which studies were included in the analysis. This falls under point 2 - Define inclusion and exclusion criteria see more detail here around this point:
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Welcome to a new SEEN!
@SEENinHealth
Welcome to SEEN in Health, the Sex Equality and Equity Network for NHS staff. We focus on the protected characteristic of sex. We're open to anyone who works in the NHS who shares our aims and values. Find out more or sign up for updates here
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"I heard of endocrinologists at one Russell Group institution being forced to disavow binary theories of biological sex" How universities killed the academic Flamboyant brilliance has been purged
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The academic who authored this paper is not a clinician, a statistician, a scientist. He works at the Centre for diversity, research, Policy and Practice, Oxford Brooks. Since 2020 his published research has focussed on transgender children and medicine:
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@garylfrancione
@billybragg
The side of those who burn books. The side of those who refuse to let films be screened or to let audiences view them. The side of those who promote and threaten physical violence due to hearing words and ideas they object to. The totalitarians vs the liberals.
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"The very willingness to make certain indisputable statements about biological sex is the crime, because gender activists have rendered the debate landscape so toxic and chilling that truth has become an emblem of defiance rather than clarity."
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“in general the assumption can be made that the term women refers to cis-gender women (i.e., women whose gender is consistent with their sex assigned at birth)” Am. J. of Phys. Heart & Circ. Physiology
Clarity is important - the word woman is taken 3/4
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“Self-report” their “gender”…
Researchers submitting original research to Nature over the past year will have noticed an extra question, asking them to self-report their gender
Nature publishes too few papers from women researchers — that must change
#InternationalWomensDay
#IWD2024
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The author's PhD from Goldsmiths was about "cisnormativity, minority stress and the rights and wellbeing of socially transitioned trans children under 12."
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"spurious results were produced by a flawed question, which originated with a transgender campaigning organization. The question evidently confused a substantial number of respondents...overrepresentation of people lacking English proficiency"
#DataMatters
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Mind the funding gap! Overall
@UKRI_News
grant awards are higher for male awardees than female awardees with male researchers being awarded £150K more on average than females. See below for some individual funding bodies.
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The NICE reviews, the gold standard of evidence based decision-making in healthcare, are criticised including how the information is communicated to a 'non-specialist audience.' It really is worth reading this paper in full to understand how captured some academics are.
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Bear in mind The Cass Review is an independent review of gender identity services for children and young people. It will look at the evidence behind various treatments and care pathways. It is due to be published soon; it seems that some academics are determined to undermine it
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The author concludes: "The Cass Review itself can be understood as an example of cis-supremacy, within a cis-dominant healthcare system lacking accountability to trans communities." Ideological standpoint when Cass is trying to establish what the evidence base is for children
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“Participants included 11,622 youth (ages 9-13; 47.6% assigned female at birth) from the Adolescent Brain Cognitive Development (ABCD) Study.”
Journal of the American Academy of Child & Adolescent Psychiatry
'assigned at birth' again. Cut it out. (4/4)
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The paper cites four issues: "Four concerns are presented and explored: (1) prejudice; (2) cisnormative bias; (3) pathologization; and (4) inconsistent standards of evidence." However all these points are about bias in the review which the author attributes to ideological reasons
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“the Cass review is concerned not only with the low certainty of the reported benefits due to poor study designs, but also with the possibility that the small improvements may be short-lived and due to the potential placebo effect” (SEGM)
A 🧵on the ‘placebo effect’ and why it's relevant to the
#CassReview
. The placebo effect is where a patient responds positively to sham treatment. E.G., in a placebo-controlled randomised trial, patients in the placebo arm improve despite not being on active treatment. 1/n
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is ‘the people on my side are self-evidently right and the people who are on the other side are spreading dangerous falsehoods therefore for the good of society we have to shut up the people who are obviously incorrect and immoral.’” (6/6)
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One concern the author has is with 'non-affirmative care' and the concept of a 'trans child' is presumed, hence the author has an issue with non-affirmative care which he elides with conversion "non-affirmative or conversive clinical practice"
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"This is very carefully worded, but is questionably using the absence of evidence to imply evidence of absence, and at the same time pushing the lack of data onto the child to make an informed choice about." Important article highlighting the echo chambers
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@ 26 mins 40 s further defence of free speech. “Free speech is cognitively very unnatural…it needs constant defence otherwise we back slide into orthodoxy. Because what is natural – this is well established in cognitive psychology - (5/6)
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The DNA clipped to look like an 'X' (reference to X chromosome) or the molecule with a female symbol incorporated.
DNA logo
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Molecule logo
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Essentially this paper treats whatever TGNB patients ask for medically as that is what they should get and any barrier is either cis- or transnormative rather than medical decisions being based on evidence-based medicine and the principle of
#FirstDoNoHarm
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"placebo response rates are often greater (in some conditions almost double) in children than in adults...in adult migraine trials, placebo effects have been estimated around 35% whereas pediatric migraine trials suggest placebo response rates of 50%" .
A 🧵on the ‘placebo effect’ and why it's relevant to the
#CassReview
. The placebo effect is where a patient responds positively to sham treatment. E.G., in a placebo-controlled randomised trial, patients in the placebo arm improve despite not being on active treatment. 1/n
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"We have been drilled into the belief that “you can’t make a child trans”, but apart from the fact that an innate state of transness is unlikely and unprovable, you can definitely make a child “confused”
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@JuraMurphyRules
"Placebo response rates are often greater (in some conditions almost double) in children than in adults..in adult migraine trials, placebo effects have been estimated around 35% whereas pediatric migraine trials suggest placebo response rates of 50%+." .
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"research had shown that such training often failed to result in a “meaningful or durable improvement in organisational culture and workplace morale”, did not increase collaboration and failed to improve hiring, retention or promotion of diverse candidates."
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Article on the study here:
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Then this paper discusses that maternity care is...women-centric "This is especially the case for TGNB people navigating reproductive and sexual healthcare settings that are normatively women-centric or stereotypically feminized." Is there an expectation that women are erased??
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Our first substack piece. This builds out our previous thread on The Placebo Effect and its relevance to gender medicine.
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Another "Cisnormativity is enforced through medicine that often discounts TGNB patients’ care needs and experiences" "Evidence-based medicine is enforced through medicine and often discounts TGNB patient's care needs" (needs or desire/want/paraphilia?)
#FirstDoNoHarm
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Of course it is possible for midwives to provide individualised care without having to destroy the experience for others. Only females can get pregnant, - no matter how transgender people wish the world to be & in order to provide good healthcare the sex of the patient is salient
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@MayaSia1543004
@sapinker
Yes. There is a lot of discussion about what is going wrong including the fact Harvard ranked dead last in terms of free speech. He also discusses what they’re trying to do about this.
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*Pronoun usage - FYI I have just been informed that the author is a female who identifies as NB..........
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Another "sociological examination of ways that medical institutions and authorities...enforce cisnormativity in medicine" "sociological examination of ways that medical institutions and authorities...enforce evidence-based medicine in medicine"
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The paper then goes on to discuss 'transnormative' issues as a barrier to people basically being allowed to get whatever surgery they like around their gentialia and chest/breasts
#PeopleAreNotLego
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E.G. from following sentence: "In this article, I demonstrate how TGNB patients are held accountable to the institutional and interpersonal maintenance of (a) cisnormativity" (TGNB = transgender & non-binary); change 'cisnormativity' to evidence-based medicine shows the ideology
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visit their new website here:
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Despite the title of the review, it isn't actually a systematic review. It's a narrative review. It needs a Community Note.
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