Caetano Reis e Sousa
@ReiseSousaLab
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The Immunobiology Lab @TheCrick studies how the body detects and responds to infection, cancer and tissue damage.
London, England
Joined July 2021
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Pinned Tweet
Check out our latest paper . Congratulations to
@giampazolias
who led the work. Thanks to very many who helped. Great collaboration with Tine Jess and
@RominaGoldszmid
labs. Tweetorial will follow soon.
Scientists at the Crick,
@theNCI
and
@aalborg_uni
found that vitamin D encourages the growth of a type of gut bacteria in mice that improves cancer immunity.
The
@CR_UK
-funded work includes Crick researchers
@ReiseSousaLab
and (formerly)
@giampazolias
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This is a blatant misrepresentation of our work . Our study does not in any way suggest that the application of SPF50 sunscreen “blocks our natural defences” or is detrimental to health.
Vitamin D regulates cancer immunity via microbiome- another reason to stop using SPF 50 all year round which blocks our natural defences
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After years of hesitation, the Immunobiology Laboratory
@TheCrick
finally joins the Twitter community. With some trepidation…
#Immunology
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Read this. Worth 5 minutes of your time.
It matters who does science
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With everyone doubly vaccinated and weekly PCR tested, we can finally resume in-person lab meetings. With cake. Yippee!
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Anyone who wants to read the actual paper, download an open access author manuscript at
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We are very pleased to share our latest work on emergency cDCpoiesis during influenza infection
@SciImmunology
! A join effort from
@CabezaCabrerizo
@CarlosMMinutti
and
@MarianaPdCosta
@TheCrick
🥳
1/11
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Check out our latest paper just out on antiviral RNAi in stem cells. Congrats to
@EnzoZ_P
and colleagues!
@TheCrick
@ScienceMagazine
#RNAi
#virus
#immunesystem
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My surname was born 136 years today. My dad’s family comes from Goa, India. Forcibly converted to Catholicism in 16thC, they took the name of the priest, Souza. My grandfather was born on 6 Jan 1886, Dia de Reis (Epiphany). He became Reis e Sousa.
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Today marks the 25th anniversary of the
@ReiseSousaLab
🎂. An appropriate time to reflect on success🎇. But what counts as success?
A thread 🧵
(1/6)
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Delighted to report that we have passed our quinquennial evaluation with flying colours! 🥳👏
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Opening of our lab retreat in Portugal. Looking forward to 3 days of exciting science and comradeship.
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Nice start to the year by arriving in my office to find a package containing a medal from
@EFIS_Immunology
to commemorate the virtual lecture I gave
#sfi2021
joint session
@sfiimmunologie
@britsocimm
in December. Thanks!
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Check out our new paper
@NatImmunol
on trying to make sense of the complexity of the dendritic cell family from an ontogenetic perspective. Spearheaded by
@CarlosMMinutti
who has posted a helpful thread. Thanks to all our collaborators and helpful reviewers.
Delighted to share our latest work, out in
@NatImmunol
, tackling the seemingly inordinate complexity of
#cDC2s
.
@ReiseSousaLab
@TheCrick
, we found that distinct ontogenetic lineages dictate cDC2 heterogeneity, rather than cell states imposed by the tissue microenvironment 🧵(1/x)
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It’s great to see politicians so excited by science that they want to do experiments. But perhaps they should start with smaller scale ones…
The world has its eyes on the UK where the government plans to drop nearly all measures for mitigating the spread of COVID–19 across England in less than a week.
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This year we celebrate the 25th anniversary of our lab. Nothing better than a boat trip at the end of our retreat in Portugal. With dolphins as guard of honour.
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True commitment to experimental science! Not only does
#UKGovernment
make £20M available for research into
#LongCovid
but it lifts restrictions 24h later to ensure there will be plenty of subjects to study!
People experiencing
#LongCovid
will benefit from a comprehensive package of new
#NIHRfunded
research that will help improve diagnosis, treatment, rehabilitation and recovery. Read more:
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Very happy that our latest paper on regulation of DNGR-1-mediated cross-presentation is out in Cell Reports
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This week, we welcome a new postdoctoral fellow
@AdiBiram
to the lab and to London. Looking forward to working together on exciting science!
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Nice to gather the lab to celebrate with bubbles our various papers published this year. A ritual that was sadly disrupted by the pandemic. Better late than never!
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Delighted to share our latest work on the molecular signals that drive steady-state and emergency bone marrow exit of
#DendriticCell
progenitors, led by
@MarianaPdCosta
, out now in
@CellReports
! A 🧵... (1/x)
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Today we celebrate the revolution that marked the birth of Portuguese democracy. I was on the streets with my parents 50 years, not quite understanding what was going on. Let’s remember our gained freedoms and not take democracy for granted.
#25deAbril
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Many congratulations to our talented first year PhD student
@MarianaPdCosta
on being awarded a very competitive and prestigious BIF fellowship!
#BoehringerIngelheimFonds
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Wonderful to be be at a symposium honouring the career of my great friend and colleague Alan Sher.
#alanshersymposium
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A new and exciting adventure to translate our work into patient benefit: ATP Launches Adendra Therapeutics, a New Kind of Immunotherapy Company Deploying Novel Insights into Dendritic Cell Biology, with $53M Series A
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Many congratulations to our newly-minted Dr. Piot
@Cecilepiot1
who successfully defended her PhD thesis this afternoon! Thanks to
@StridLab
and
@ClatworthyLab
for acting as examiners.
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The
@Crick
PhD programme is now open for applications. Deadline: 11th November. One position available in the Immunobiology Laboratory to start in 2022.
#Immunology
#CancerResearch
#findaphd
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It is all downhill after you win the Nobel prize…
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Check out our review
@ImmunityCP
together with
@gordon_d_brown
and Sho Yamasaki on
Myeloid C-type lectin receptors in innate immune recognition. Part of a whole collection of reviews on innate immunity.
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Amazing one-day Masterclass in Immunology
@TheCrick
yesterday by the incomparable Abul Abbas from
@UCSF
! Very grateful that Abul so graciously gave up a whole day of his holiday in London to enlighten us. Thanks to
@cjohansson_lab
for co-organising.
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Dhilan Bartlett, a 6th form (12th grade) student, is spending the week with us to see how a lab works. Dhilan is the son of Shivanthi Manickasingham, one of the first postdocs to join the lab. And a contemporary of Oliver Schulz who is mentoring Dhilan!
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Many congratulations to
@DrJonLim
who successfully defended his PhD thesis today. Thanks to the examiners
@squezadd
@QuezadaLab
and
@alanmelchericr
@ICR_London
who put Jon through his paces. He is now a Dr. Dr!
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Lovely to meet beautiful Olivia today! Daughter of our two lab members
@gasparrinif
@brunoagf
. Born to be an immunologist?
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The start of our yearly lab retreat in Portugal 🇵🇹. Looking forward to a week of exiting science, discussion and camaraderie.
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Tonight we say goodbye to
@EnzoZ_P
. He leaves us to start his own lab
@institut_curie
. We wish him well and look forward to hearing about his future successes.
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Very pleased to see our paper on inhibition of
#cancerimmunity
by secreted gelsolin out in print
@CellCellPress
! Congratulations to the fantastic team of
@giampazolias
, Oliver Schulz and
@DrJonLim
@TheCrick
for bringing it all together. 🧵... 1/8
📎
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Delighted to have hosted Uğur Șahin
@BioNTech_Group
for a Crick Lecture today
@TheCrick
. Wonderful overview of the power of mRNA vaccination in personalised cancer vaccination.
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Great to have Christmas lunch… cheese fondue in January as is the lab tradition!
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Today
@TheCrick
we celebrated
#bringyourculturetoworkday
. Wonderful foods from all around the world and evening performances of music from different cultures. Proud to be part of such a diverse community!
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Vaccines have made COVID a preventable disease. They are a triumph of global science, bringing together experts from all corners of the globe. Our failure to distribute vaccines equitably around that same globe is shameful and criminal.
Despite the repeated warnings of health leaders, our failure to put vaccines into the arms of people in the developing world is now coming back to haunt us.
We were forewarned – and yet here we are.
#VaccinEquity
@guardian
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Nothing brightens my Sunday evening quite like learning I have a fan club…
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Lab dinner to celebrate our quinquennial review. Even though we do not know the outcome yet…
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Let’s remember these lists give a distorted view. But I am honoured to continue to be listed. Testament to all the talented people who have worked in my lab over the years and my great colleagues and collaborators
@TheCrick
and elsewhere.
Congratulations to Crick group leaders Caetano
@ReiseSousaLab
and
@CharlesSwanton
, and visiting scientist
@NickyMcGranahan
! They have all been named as one of
@Clarivate
's highly cited researchers in recognition of their and their teams’ work 🎉
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Pleased to share our just-published review on an underexplored interface of cell biology and immunology.
@TheCrick
team work from
@ekchilds_
@Dr_Condor
@CantonJohnathan
.
#endosome
#phagosome
#antigenpresentation
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First retreat of
@IMMolecular
and meeting of the Advisory Board since the pandemic. Opening remarks by
@MariaMMota2
on the achievements of the Institute in the last 2 years, including major contribution to SARS-CoV-2 testing in Portugal.
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Just in case Brexit was not enough to debilitate UK science, shoot yourself in the other foot.
New analysis from the
@royalsociety
shows just how high UK visa costs for researchers are compared to upfront costs for similar visa routes in 13 other countries.
Here, we take a look at how the UK compares to countries in the G7 included in the analysis 🔍⤵️ 1/5
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Many congratulations to
@ekchilds_
who defended her PhD thesis today. Well done Dr. Childs! Thank you very much to
@ActonLab
and
@patrycja_kozik
for acting as examiners!
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Very nice to have a long overdue lab social: treasure hunt across London followed by drinks and dinner. And bright sunshine!
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Lovely to be able to have a lab retreat again after 2 years without. Alas, not in Portugal this time so no pool photo.
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End of the first day of our lab retreat. Intense discussions filled by a well-deserved dinner al fresco.
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Thanks you again to the organisers
@KC_DC_01
@MartinGuilliams
@bart_lambrecht
@MiriamMerad
for a an exciting meeting full of insights into DCs and Macs.
#EMDS2023
in beautiful Ghent.
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Banff is one of my favourite spots for
@KeystoneSymp
. Even when it is -20 degrees Celsius.
#KScelltherapy23
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All’s well that ends well. 3.5 days of intense discussion at our lab retreat, punctuated by social interactions. And the obligatory pool photo!
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Brilliant piece from Paul Nurse at a time when science often feels like it is drowning in data.
"Don’t get me wrong. We need data produced from new technologies to advance understanding. But this is only the first step."
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Welcome to Estelle Wu, a new PhD student starting in our lab this week. Looking forward to 4 years of great science.
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Happy to share our latest paper on how secreted gelsolin acts as a barrier to immunogenic cancer therapies in a pre-clinical model. Great work led by
@DrJonLim
.
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Here is a photo of the new Professor looking happy with the news. Many congrats!
Very happy to have been promoted to Professor of Mucosal Immunology at
@imperialcollege
@ImperialNHLI
Huge thanks to current and past group members, colleagues, collaborators, mentors, supervisors, funders, friends and family.🥂
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Opening of
#DC2022
in Cairns by Jose Villadangos. Looking forward to some wonderful dendritic cell science. And meeting old and new friends!
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Absolutely brilliant!
Why is science a core subject? Our animation aimed at students aged 14 to 16 explains the key transferable skills gained from studying science and the relevance of science to all future careers.
#NationalCareersWeek
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@ThurstonLab
Very sad. Even if the funds are matched by UKRI, loss of association with Horizon Europe is a serious blow to UK science.
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Proud to deliver the EFIS-IL lecture at the
@SImunologia
#SPIannualmeeting
#50years
this morning. And get a nice plaque for my office!
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It’s one year since the Immunobiology Laboratory joined the Twitter-sphere. Still trying to figure out the balance between usefulness and distraction but nice to be part of a large community of colleagues and friends.
#MyTwitterAnniversary
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Farewell dinner for
@DrJonLim
, clinical PhD student, last night. He leaves us to go back to the clinic. It has been a privilege to host him in our lab. Our loss is his patients gain!
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A belated welcome to
@Victor_Bosteels
who joined us a few weeks ago as a postdoctoral fellow. Looking forward to some great science together!
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Just over a week to go before the deadline to apply for a PhD student position
@TheCrick
@ReiseSousaLab
starting in 2023. Don’t miss out. Apply now!
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I am proud that
@ReiseSousaLab
has trained over 70 PhD students, postdocs, research assistants in its 25 year history. Only 3 have left science or medicine!
(4/6)
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Our traditional post-Christmas Xmas lunch. Complete with cheese fondue and Secret Santa!
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Very fortunate to work
@TheCrick
. A regular series of wonderful evening concerts to enrich our life beyond science.
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A nice article in The Scientist highlighting our recent work.
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An unexpected chance visit from the President of Portugal helping celebrate the 50th anniversary of
@SImunologia
.
#SPIannualmeeting
#50years
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Delighted to have attended the wedding of two lab members
@gasparrinif
and
@brunoagf
and christening of their beautiful daughter Olivia. Wonderful ceremony and party in Algarve. Many congrats to the happy couple!
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Thanks to Sonia Lee in our lab for ensuring that we achieved a Bronze award in this year’s LEAF Awards
@TheCrick
for
#LabSustainability
. Will be going for Silver next year!
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Wonderful visit
@TheCrick
today by
@PichlmairL
. Remembering the old days of 5’PPP-RNA.
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Wonderful to work
@TheCrick
and have an evening of chamber music. Last night, French composers from the first half of the 20C. Punctuated with an arrangement of a piece by Sibelius for sheer diversity.
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Our lab is represented
@bsicongress
in Liverpool
#BSI22
. Don’t miss Bright Sparks PhD talk today by
@MarianaPdCosta
. Longer version tomorrow in the Immune cell interactions in tissues (part 2). And check out poster P-197 by
@CarlosMMinutti
.
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Trip down memory lane. Remembering great times back at NIH learning from Ron Germain and Alan Sher.
#alanshersymposium
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Very nice paper from
@RominaGoldszmid
in latest issue of
@CellCellPress
! Among other findings, shows that microbiota-derived STING agonists can drive the NK cell-XCL1/2/CCL5-cDC1 axis to promote anti-cancer immunity (dear to our heart).
Now online! Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment
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And more than 20 former lab members are leading their own academic labs around the world and passing on the message.
#trainscientists
(5/6)
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Great talks yesterday at the Medical Research Club
@TheCrick
by
@Dr_James_Lee
@FranzeProgatzky
and Jan Rehwinkel. Nice to sit at dinner between Sandra Diebold and Jan Rehwinkel remembering old days in
@ReiseSousaLab
.
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Posting this somewhat belatedly. Last week I popped over to Boston to give the Benacerraf Lecture at Harvard Medical School.
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Dinner at the Portuguese Embassy with Marcelo Rebelo de Sousa, Portuguese president, to celebrate the Day of Portugal.
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Couldn’t agree more! Fundamental research is the foundation upon which we build science and its applications.
Proud to contribute to this article and thx to
@emboreports
for making space for topics of general interest to science.
"The mission is to foster and fund vibrant, basic
#research
for the benefit of society and future generations"🫶
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Couldn’t agree more!
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Wonderful to see Adendra Therapeutics shortlisted in the category of New Startup of the Year!
Breaking news: The shortlist for our
#IEAwards22
is here!
Congratulations to everyone who made the shortlist, we can't wait to celebrate with you at our Awards Ceremony on 6 December! 🥂
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Today, we commemorate the Portuguese poet, Camões, the Day of Portugal and the Portuguese Communities around the world (of which I am proud to be part!).
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Absolutely delighted that Adendra Therapeutics has just won the New Startup of the Year award! Congratulations to the entire Adendra team, including CEO
@RajM968
.
#AdendraTherapeutics
Up next is our New
#Startup
of the Year category, recognising a company’s potential, including its ground-breaking
#technology
and potential impact in the
#cancer
sector.
The winner is…
#Adendra
Therapeutics Ltd! Congratulations.
#IEAwards22
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Accompanied by a nice perspective piece by Shahrudin and Shou-Wei Ding.
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One of the great pleasures of science is to meet colleagues all over the world and discuss science. And to catch-up with old friends such as now Twitterless Facundo Batista from the Ragon Institute!
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