Science #Immunology's February issue is out! The cover depicts hotspots of tumor-immune cell interactions within #BreakoutLesions in patients with #MultipleMyeloma, which could contribute to disease progression. Learn more in this month's issue:

Scientists have identified bone marrow #BreakoutLesions as hotspots for tumor-immune cell interactions, which could contribute to disease progression in patients with #MultipleMyeloma. @haas_lab @HDMyeloma @hi_stem_lab Read more in Science #Immunology:

A new Science #Immunology study in mice and human cells shows that the transmembrane domain of proteins determines whether they can be transferred between TCells in a process known as #trogocytosis, which could inform future #CARTcell immunotherapies.

A Science #Immunology from last year highlights how LIPSTIC, a proximity-based labeling method, can identify antigen-presenting #DendriticCells that activate CD4+ #TCells in tumors and tumor-draining lymph nodes in mice. #WorldCancerDay

A Science #Immunology study from last year describes an antibody-based alternative treatment for B cell non-Hodgkin #lymphoma that boosts #NaturalKillerCell antitumor activity in preclinical models without causing serious toxicities. #WorldCancerDay

A new Science #Immunology study in mice highlights ID3+ #StemLike #TCells that arise during acute infection and can form precursors of exhausted T cells in mice.

Researchers have demonstrated that #CARTcells can transfer tumor-specific receptors to T cells in mice via #trogocytosis, endowing recipient cells with antitumor immunity. @UU_University Read more in Science #Immunology:

Scientists have identified #ID3 as marker for #StemLike T cells that sustain immune responses to chronic infection and cancer. @JohnstoneRicky @KalliesLab @UniMelb Read more in Science #Immunology:

A new Science #Immunology study identifies a subset of cytotoxic ZNF683+ T cells that engage in diverse immune cell interactions in the bone marrow and drives responsiveness to immunotherapy in patients with relapsed #leukemia.

RT @Miguel_Marin_R: New in @ScienceImmunology! 🧠✨ We explored how the brain maintains equilibrium with the immune system. Our focus? The ke…

Researchers in Science #Immunology have found that humans have naïve #antibodies that can recognize and neutralize highly pathogenic strains of the #BirdFlu virus, potentially offering protection against infection. @IcahnMountSinai @ragoninstitute

New research suggests that the bone marrow microenvironment in patients with relapsed acute myeloid #leukemia can affect response to donor lymphocyte infusion therapy. @DanaFarber @elhamazizi @Dr_KatieM @Columbia Learn more in Science #Immunology:

A new Science #Immunology study finds that humans without known exposure to bird flu have #antibodies that can recognize H5-specific hemagglutinin and neutralize highly pathogenic #H5N1. @gogo_science @SchmidtLabHMS

A new Science #Immunology Review highlights the role of #DendriticCells in shaping T cell antitumor responses and explores how this interplay could be harnessed for cancer #vaccines.

A new Science #Immunology study describes how repeated #HIV immunizations generates antibodies against immune complexes formed by anti-HIV antibodies in rhesus macaques, which could inform future #vaccine strategies.

A new Science #Immunology Review discusses the mechanisms through which #DendriticCells influence cytotoxic CD8+ #TCell responses against cancer. @viditbhandarkar @stefanispranger

Repeated #HIV immunizations in rabbits and rhesus macaques can induce anti-idiotypic #antibodies that target anti-HIV antibodies generated by previous immunizations. @WardLab1 @SharidanBrown @scrippsresearch Read more in Science #Immunology:

A new Science #Immunology study in mice describes how the #allergy-promoting cytokine #TSLP maintains immune balance by enabling regulatory T cells to suppress allergic inflammation in the airway.

A new Science #Immunology study in mice describes how the cholesterol regulator #Srebf2 controls accumulation of regulatory T cells in visceral fat, impacting #obesity-related pathology. @EmoryMicrobio

A new Science #Immunology study describes the distinct and shared signatures of human RAG immunodeficiencies such as #SCID and #OmennSyndrome, based on multiomics analysis of 157 patients.