Science Immunology
@SciImmunology
Followers
61,649
Following
572
Media
2,127
Statuses
3,091
Official twitter account for the journal Science Immunology. Also find us on Facebook:
Washington, DC
Joined October 2015
Don't wanna be here?
Send us removal request.
Explore trending content on Musk Viewer
بايرن
• 524729 Tweets
موناكو
• 523341 Tweets
Wizkid
• 302438 Tweets
Davido
• 283723 Tweets
Adams
• 124243 Tweets
#BrightestStarBangChan
• 109850 Tweets
#우리의_찬란한_청춘_방찬에게
• 108676 Tweets
Doug Emhoff
• 70881 Tweets
Shakira
• 51548 Tweets
CHAE X JESBIBLE
• 45204 Tweets
Shana Tova
• 41457 Tweets
Centro Carter
• 38258 Tweets
Gago
• 35040 Tweets
KARIME EN HOY
• 34676 Tweets
Cassper
• 34104 Tweets
Rosh Hashanah
• 33218 Tweets
GALA EN HOY
• 32610 Tweets
Lille
• 25515 Tweets
センラさん
• 17156 Tweets
NASCAR
• 16640 Tweets
Girona
• 14784 Tweets
Channie
• 14631 Tweets
Bologna
• 14553 Tweets
Marburg
• 13948 Tweets
ITZY IS THE MOMENT
• 11311 Tweets
Feyenoord
• 10390 Tweets
Camavinga
• 10100 Tweets
Pinned Tweet
Science
#Immunology
's September issue is out!
This month's cover spotlights the unique properties of plasma cells that produce allergy-driving immunoglobulin E (
#IgE
). Other work looks at
#Langerhans
cell development, human
#MAIT
cells, and more.
0
17
104
According to a new Science
#Immunology
study in mice, the
#CD5
receptor limits CAR T cell activation and may contribute to poor outcomes from adoptive
#Tcell
#immunotherapies
.
📄:
1
25
105
A new study from
@VirusesImmunity
,
@YaleMed
,
@kaistpr
, and
@IcahnMountSinai
finds that nasal
#immunization
is superior to injected immunization at producing mucosal lung IgA antibodies, protecting mice from
#influenza
.
8
112
373
“The prospect of achieving [containment of
#SARSCoV2
] with nasal vaccines is high, but will only be possible with dedicated funding, priority, and breaking down of any regulatory hurdles,” write
@EricTopol
and
@VirusesImmunity
in a new Editorial.
8
140
366
Dendritic cells can “self-shape” the chemotactic gradients that help them transport antigens to lymph nodes, finds a new live imaging study from
@Sixt_Lab
@EdouardHannezo
.
📄:
Focus by
@hannahdonnelly_
@EMandrou
@robinsall
:
4
86
297
Studying ~56 million T cells from 55 COVID patients, researchers offer a high-res picture of epitope reactivity and TCR usage in CD8 T cells specific for
#SARSCoV2
, some of which also react to “common cold” coronaviruses.
@RepertoireIM
23
99
281
A 2022 Review by
@EgleKvedaraite
and
@FGinhoux
contextualizes over five decades of research on
#DendriticCells
and their roles in
#cancer
.
Catch up on the work:
#WeekendReads
2
62
281
Human
#DendriticCells
need a unified nomenclature, write
@EgleKvedaraite
and
@FGinhoux
in a Review that summarizes 50 years of dendritic cell research and their functions in
#cancer
.
📎:
2
66
270
We'll be LIVE in less than an hour! In the meantime, check out this video from Sin-Hyeog Im, whose paper on the
#probiotic
Bifidobacterium bifidum appeared in the 19 October issue, and whose research will be discussed in out chat at 11 ET! Full vid here:
1
101
239
The June issue of Science
#Immunology
is out! The cover spotlights two studies that examine how
#RNA
exosomes influence
#Bcell
development and dysfunction.
More here➡️
4
43
244
A Review by
@EgleKvedaraite
and
@FGinhoux
contextualizes over 5 decades of research on
#DendriticCells
and their roles in cancer, which has been propelled forward by single-cell technologies ➡️
1
77
229
A new Editorial by
@EricTopol
and
@VirusesImmunity
calls for an accelerated initiative for nasal vaccination against
#SARSCoV2
to support
#immunity
in the respiratory mucosa.
4
75
224
New work from
@DonnaFarber3
@profshanecrotty
labs shows that
#SARSCoV2
-specific memory T and B cells persist in tissues months after infection and recovery in unvaccinated people—especially in the lungs and associated lymph nodes.
6
93
222
Memory B cells (mostly IgM+IgD+ and IgG1+) for
#SARSCoV2
S and N proteins are more stable in blood than
#antibody
levels for up to 8 mos. after
#COVID19
. New
#Bmem
tetramer data from
#vanZelmlab
@ImmunologyMU
@CCSMonash
@emmye1984
#openaccess
Link:
3
74
219
Intracellular complement signaling in human and mouse
#macrophages
controls inflammatory response in
#atherosclerosis
models, a new study reports.
0
65
213
The April cover of Science
#Immunology
is out!
This month, a study describes the developmental lineage of T follicular regulatory cells isolated from human tonsils. Other pieces examine macrophages behind fibrosis and neoantigens for cancer vaccines.
1
50
206
The new October issue of Science
#Immunology
is out! In this issue, researchers find that pre-existing killer T cells may enhance checkpoint blockade
#cancer
#immunotherapy
; and that targeting white fat macrophages prevents
#obesity
in mice. More to come:
1
34
209
A 2022 Review characterizes the ways TGF-β interacts with regulatory T cells, especially in the context of disease.
Learn more:
#WeekendReads
2
47
203
Short-lived Ly6G+
#macrophages
help repair lung damage after
#flu
infections in mice.
Learn more in Science
#Immunology
:
2
33
110
Intracellular complement signaling in human and mouse
#macrophages
controls inflammatory response in
#atherosclerosis
models, a 2021 study reported.
📄:
#WeekendReads
3
60
199
Tumor draining lymph nodes actively remodel in response to tumor growth to directly contribute to immunosuppression and metastasis, argued
@theLundLab
@nyugrossman
@nyulangone
in a 2021 Review.
#WeekendReads
0
63
197
The May cover of Science
#Immunology
is out!
This month, a study explores how crosstalk between myeloid cells and lung epithelial cells could prevent asthma in people with allergies. Other pieces explore STING-agonist nanoparticles for immunotherapy.
5
44
194
Targeting pathogenic CD4
#Tcells
with CAR T cell therapy reverses the progression of multiple sclerosis-like disease in mice, finds new research from
@WUSTL
@MS_ResearchDoc
.
📄:
4
60
195
A new Review explores the role of CD4+ resident memory
#Tcells
in protection against and pathology of disease, exploring the population’s influence during
#infection
and
#cancer
🔀
1
59
191
During treatments to deplete regulatory T cells, conventional T cells that express IL-10 can step in and assume immunosuppressive qualities that continue to obstruct immunotherapeutic success, finds a new study in mice.
@SarahKWhiteside
0
46
187
The July issue of Science
#Immunology
is out!
This month's cover explores how chromatin topology aids memory recall by human memory T helper 2 cells. Other work features antigen presenting tumor cells and assesses immunosuppression from radiotherapy.
5
107
185
A new study in mice suggests that a majority of IgA in the gut is selected to recognize and react to distinct gut bacterial species instead of demonstrating polyspecificity.
@IcahnMountSinai
@jeremiahfaith1
5
48
181
.
@ljiresearch
scientists uncover the origins of powerful and mysterious cells that fight
#dengue
,
#HIV
and more...
1
123
173
Patrolling resident memory T cells generate their own biophysical forces that help them travel to pathogenic intruders in the salivary glands of mice, a new study by
@joseimmuno
and colleagues finds.
@unifr
📄:
1
40
174
A study finds a lack of neutralizing antibodies,
#Bcells
, and
#Tcells
against
#SARSCoV2
variants of concern, such as BA1.1, in vaccinated people’s lungs, showing intranasal boosters in mice induce lung immunity.
@Jie_Immunology
@ImmunologyTang
@ShanLuLiu1
5
55
178
The new May cover of
#Science
#Immunology
is out! In this issue, read about gut repair programs and how inflammasomes may promote the success of radiation therapy for
#cancer
. More to come here ...
0
26
172
The April issue of Science
#Immunology
is out! The cover article defines how
#Tcell
proximity can influence
#cancer
#immunotherapy
outcomes in
#melanoma
tumors. Other work explores how T cells recruit
#Bcells
in such contexts. Read more ➡️
2
30
173
Urinary tract infections (UTIs) reoccur easily, in part, because resident memory T (TRM) cells are slow to establish immune memory, finds a new study in mice.
@ImmunoBladder
@institutpasteur
0
41
175
Science
#Immunology
's September issue is out!
The cover features insights into dendritic cells' chemotactic migration, while other work parses the ins-and-outs of T cell exhaustion.
Read more:
1
51
168
“Apart from the acute illness caused by
#SARSCoV2
, it is now clear that a substantial proportion of patients develop long-term sequelae [damage] after
#COVID19
,” say the authors of a 2022 Review.
Learn more on
#LongCovidAwarenessDay
:
#LongCOVID
2
72
169
Scientists identified a macrophage target in white fat that, when deleted in mice, stunted weight gain, reduced inflammation, and overall protected the animals against
#obesity
and associated health conditions.
@nyugrossman
@ufrj
📄:
#WeekendReads
4
53
166
T cell exhaustion is an immunological state that can appear during cancer.
ICYMI: This recent Review described recent findings on how exhausted T cells develop and insights into how the state might be treated.
#WorldCancerResearchDay
A new Review contextualizes what is known about the developmental trajectory of T cell exhaustion—a state that arises during cancer and chronic infections.
@lan_xlan7
@CaitlinZebley
@StJudeResearch
1
42
123
0
47
165
Inflammatory
#cytokines
help increase the efficiency of human
#fibroblast
to
#DendriticCell
reprogramming by 190-fold.
Check out the 2022 study:
#WeekendReads
0
32
160
A new study describes how some CD4 T cells can exhibit killer behavior against melanoma, more closely resembling their cousins, CD8 T cells.
@egbawden
Learn more:
0
39
160
In a new review, researchers look for ways to uncouple anti-tumor and autoimmunity effects of PD-1
#CheckpointBlockadeTherapy
.
1
57
157
Scientists mapped the different stages of maturation for human T follicular helper and T follicular regulatory cells, which aid B cell development:
#WeekendReads
@medicina_lisboa
@ULisboa_
@immolecular
1
43
157
Cerebrospinal fluid
#macrophages
are a distinct population from
#microglia
and border associated macrophages, proposes a new Review.
1
54
154
By mapping interactions with chromatin loops in mice, scientists from
@harvardmed
showed how the transcription factor FoxP3 directly regulates the expression of key regulatory T cell genes.
Check out the 2022 study:
#WeekendReads
1
47
154
The December issue of Science
#Immunology
is out!
The cover study spotlights an IL-2 mutein that is more tolerant of the acidic tumor environment, improving immunotherapy in mice with melanoma. Other work presents a mRNA flu vaccine strategy.
9
21
75
The new August issue of Science
#Immunology
is out! Check out new research on differences of the caspase enzyme among dogs, cats, and humans, and how virtual memory T cells act as a bridge between innate and adaptive
#immune
systems:
2
34
144
Tcf1, a “master regulator” of T cell development and
#immune
responses, may hold the key to new treatments of diseases, from
#autoimmunity
to
#cancer
.
Learn more in this 2020 Review:
@BrighamWomens
0
39
152
Scientists have found that autoantibodies that neutralize type I interferons accounted for ~20% of critical
#COVID19
cases in individuals >80 years old, as well as more than 20% of deaths in infected patients of all ages.
@InstitutImagine
@RockefellerUniv
0
62
145
Tissue resident memory
#Tcells
changed the understanding of adaptive
#immunology
when they were first discovered. Scientists from
@ColumbiaMed
,
@CCTI_NYC
provide an extensive review of what we know so far about these elusive cells:
2
59
146
What’s preventing T cells from entering “cold” tumors?
In a new study, researchers find that the
#PLA2G10
protein prevents
#Tcell
infiltration in mouse tumors, suggesting a new
#immunotherapy
target.
2
37
142
Monocyte-derived Ly6G+
#macrophages
promote
#epithelial
repair following
#influenza
virus-triggered lung injury.
Read this research and more in the August issue of Science
#Immunology
:
2
30
141
A single mutation in the
#spike
protein receptor-binding domain enabled the SARS-CoV-2 JN.1 variant to escape neutralizing antibodies.
Read more in Science
#Immunology
:
6
59
134
BioNTech/Pfizer’s mRNA vaccine induced long-lived memory T cell response for 6 months in 71 vaccinated Italian adults, according to recent research.
10
45
135
ICYMI:
@WUSTLmed
scientists showed that an
#immune
cell subset in the gut, called group 3 innate lymphoid cells, requires the
#circadian
clock to better sense and interact with surrounding gut
#microbes
:
0
57
139
#Tcells
aren’t necessary for
#Bcells
as they initiate cyclic re-entry in the
#GerminalCenter
, signaling a paradigm shift for understanding affinity maturation.
0
50
138
A 2022 study from researchers at
@UniOslo
suggests the
#IgG3
subclass of
#immunoglobulin
G
#antibody
is especially good at targeting viruses because of its distinctive hinge region.
Read more:
#WeekendReads
3
40
140
Unexpected findings in wildling mice challenge a popular idea that allergies emerge from overreactive and bored immune systems without sufficient exposure to microbiota, due to today’s strict hygienic practices.
@SRosshart
6
53
138
A 2022 Research Resource identifies more than 300 disease risk
#gene
variants dependent on activated CD4
#TCells
.
Learn more:
#WeekendReads
2
37
140
Deficiency of IgA antibodies influences how well the immune system can maintain control of intestinal bacteria, finds new study involving pediatric patients with varying IgA levels.
@henricksonlab
@LabSilverman
3
40
135
By mapping interactions with chromatin loops in mice, scientists from
@harvardmed
show how the transcription factor FoxP3 directly regulates the expression of key regulatory T cell genes.
0
49
136
Growing evidence shows tuft cells are important producers of leukotrienes, lipid moderators of type 2 immune responses.
Read more in this Focus article from 2022:
#WeekendReads
0
31
131
A new Review by
@MoreauJoshua
,
@Treg_Mike
and
@Zihai
characterizes the ways TGF-β interacts with regulatory T cells, especially in the context of disease.
0
34
132
A 2022 Research Resource identifies more than 300 disease risk
#gene
variants dependent on activated CD4 T cells.
Learn more:
#WeekendReads
0
33
133
Tumor cells are infamously skilled masters of immune disguise, but research from
@CellReproLab
shows that forcing them to present antigens can boost anti-cancer immune activity.
@lunduniversity
0
42
130
ICYMI: A study of
#Tcells
from patients infected with
#HIV
shows that a transcription factor known to drive T cell exhaustion in mice might not play the same role in humans. From
@marcus_buggert
and colleagues at
@CIM_Sweden
,
@karolinskainst
:
#immunology
1
44
126
The June issue of Science
#Immunology
is out!
This month's cover features an analysis of tumor TRM cell characteristics in mice. Other studies looked at GAS-responsive T cells and psoriasis, as well as immune cell “neighborhoods” in the skin:
0
28
127
The new November issue of Science
#Immunology
is out!
In this issue, researchers report loss of XIAP impairs Paneth cells leading to IBD; and show how lung cDC progenitors are recruited during flu. More to come:
0
16
124
Researchers found that CD4 T cells from mouse and human infants show enhanced TCR signaling in response to low antigen doses, supporting induction of early life immunity to viral infection.
Read the 2021 paper:
@DonnaFarber3
@ColumbiaMed
#WeekendReads
2
23
130
IL-9 contributes to
#asthma
and
#airway_inflammation
by promoting interstitial
#macrophage
responses that support recruitment of
#eosinophils
according to new research.
0
36
128
In a new Review, scientists discuss how resident tissue
#macrophages
go beyond immunity to keep organs thriving.
@ragoninstitute
@HHMINEWS
1
36
131
A rare group of epithelial cells in the gut provides a reservoir for norovirus infection by resisting local killer T cell activity, finds a new study in mice.
3
30
131
Science
#Immunology
is thrilled to welcome Seth Scanlon (
@ImmunoEditor
) as Editor.
Seth comes to the journal from
@ScienceMagazine
, where he handled the journal’s immunology research content.
7
6
130
.
@TheDohertyInst
,
@AlfredHealth
,
@MonashUni
scientists now have a clearer picture of how T cells discriminate between self-antigen and foreign antigens, highlighting the role of NK cell receptors in helping T cells fight
#viruses
and prevent
#autoimmunity
:
2
50
127
The February issue of Science
#Immunology
is now out!
The cover depicts
#CRISPR
-Cas9 technology repairing faulty memory
#TCells
as seen in a disease called hemophagocytic lymphohistiocytosis. Other work includes mapping nasal
#TuftCells
, and more.
2
40
126
Anti-PD-L1 therapy may have limited success in certain cancers because it unleashes the immunosuppressive capacity of regulatory T cells, a new study from
@erasmusmcintl
finds in mice.
0
34
124
By identifying the “origins” of stem-like cancer-killing T cells, a 2021
@YaleMed
study may help inform efforts to convert cold tumors into hot tumors that are more responsive to checkpoint blockade immunotherapy.
#WeekendReads
1
26
126
New studies explore how systemic lupus erythematosus pathology develops, revealing how mutations in human UNC93B1 lead to TLR7 hyperactivation and autoimmunity.
📄:
@tudresden_de
📄:
@_HarshitaMishra
@MajerOlivia
@mpiib_berlin
1
34
124
New research in mice finds that neonatal CD8+ T cells can undergo rapid chromatin remodeling, which supports their innate-like functions.
Read more:
@Cornell
@CornellCFI
1
31
127
The new April issue of Science
#Immunology
is out! Learn about the adaptability of tissue resident memory
#Tcells
, and more to come. Wondering what's on the cover? Read more in the online cover caption here:
4
39
121
A new study describes why newborn mice—and, possibly, newborn mammals in general—are more susceptible to viral infections in their central nervous systems.
@gou_koh
📄:
2
37
126
A new Review contextualizes what is known about the developmental trajectory of T cell exhaustion—a state that arises during cancer and chronic infections.
@lan_xlan7
@CaitlinZebley
@StJudeResearch
1
42
123
The ability to produce Interleukin-2 (IL-2) contributes to an increase in effector CD8
#TCells
’ protective powers.
Learn more in the 2022 study:
#WeekendReads
3
26
124
T cells aren’t necessary for B cells as they initiate cyclic re-entry in the
#GerminalCenter
, signaling a paradigm shift for understanding affinity maturation.
Check out the study from 2022:
#WeekendReads
1
29
124
The February issue of Science
#Immunology
is out!
The cover features insights from two new studies that explore how recurrent TE-exon splicing junctions could be potentially used to improve
#cancer
immunotherapies:
3
28
121
Researchers from
@UofT
discovered three subsets of macrophages in mice with unique life cycles and origins residing in multiple tissues.
Check out the 2022 study:
#WeekendReads
5
37
123
Manipulating the way TGF-β interacts with regulatory T cells to develop disease therapies will be a goal for future research, predict
@MoreauJoshua
,
@Treg_Mike
and
@Zihai
in a new Review.
1
39
120
A new
#nanoparticle
design selectively activates the innate
#DNA
-sensing
#cGAS
-
#STING
pathway in conventional type I
#DendriticCells
to boost anti-
#tumor
activity.
@JinmingGaoLab
Learn more:
0
22
120
A new method developed by
@DanaFarber
,
@broadinstitute
scientists
@meyersonlab
,
@mnleeee
identifies specific
#antigen
parts, or epitopes, among peptide pools – akin to finding needles in a haystack:
#immunology
0
56
117
A 2022 Review explores the role of CD4+ resident memory
#Tcells
in protection against and pathology of disease, exploring the population’s influence during
#infection
and
#cancer
.
Check it out here:
#WeekendReads
2
29
120
During immune homeostasis, dendritic cells become tolerogenic in the spleen by consuming cholesterol from apoptotic cells or lipid nanoparticles, new research by
@Victor_Bosteels
@JanssensLab
in mice finds.
Read more:
2
40
117
New study finds 24% of 42 doubly mRNA vaccinated patients with breakthrough
#COVID19
with severe pneumonia had autoantibodies neutralizing type I IFN, suggesting these autoantibodies are a key player in life-threatening breakthroughs.
@casanova_lab
1
54
119
Examining 1,202 male patients with critical
#COVID19
#pneumonia
, many of which were fatal cases, researchers have identified sex-linked genetic mutations in TLR7 that may contribute to male-biased prevalence of severe
#COVID19
.
@INSERM
@RockefellerUniv
1
49
119
In two 2021 studies,
@UniSpitalBasel
@MayoClinicSOM
researchers identified a hybrid T cell subset in the lungs of mice that shows how bodies could protect against new
#flu
strains after experiencing one.
Learn more:
#WeekendReads
0
31
115
A subset of natural killer cells—innate immune cells once thought to lack immune memory—can, in fact, remember and react to antigens from HIV-1 and influenza viruses in humans.
@BIDMChealth
@DukeMedSchool
📄:
1
27
115
A new study of human gamma delta
#Tcells
demonstrates their diversity across tissues over the lifespan.
@JoshGray12
@ColumbiaMed
#HumanImmunology
2
24
115
For the weekend, read how
@KessenbrockLab
at
@UCIrvine
used mouse models of breast
#cancer
to uncover new biomarkers and detect an elusive type of cell used by cancer cells to undermine immune responses.
➡️
0
37
116
A new Review highlights how circadian rhythms control
#immunity
, spotlighting circadian control of
#macrophages
,
#neutrophils
, and cells of the
#adaptive
immune system:
0
35
115