Carola Vinuesa
@carovinuesa
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MD Scientist interested in autoimmune disease and genomic diagnosis. Views my own.
London, England
Joined November 2014
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Our latest research which we hope will help lupus sufferers - Thanks to Gabriela, Carmen and the many collaborators!
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#LucyLetby
. Regarding the case of Child N, premature twin with hemophilia: a genetic clotting disorder that results in easy bleeding. On the day of the alleged attempted murdered by LL by “trauma to the throat” that was not witnessed, 6 doctors from Countess of Chester Hospital
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#LucyLetby
. Reading between the lines of the doctors’ testimonies at the Thirlwall Inquiry, a pattern of “group think” is emerging - one of the most dangerous unconscious biases. In the absence of any formal investigation and exclusion of the most probable causes (e.g. infection
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#LucyLetby
. Today, more than a year after the first trial and on the day the BBC File on 4 investigation reports that Letby was not working at the hospital when the X-ray with evidence of air in the stomach was taken, nor the previous few days, the main expert for the prosecution
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For me, the most troubling aspect of
#LucyLetby
’s conviction is the argument repeatedly made by the prosecution's main expert witness: He stated that if a doctor has 'ruled out the normal causes of death in a child (infection, haemorrhage, obvious congenital disease)' and there
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The courage of
#LucyLetby
‘s counsellor, Ms de Berger, is refreshing. Despite the pressure that she, like all others called to testify at Thirlwall’s Inquiry, must have been under, this was the last sentence of her witness statement to the Court:
“I feel privileged at being asked
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#LucyLetby
. Regarding baby K, extremely premature, born at 25-weeks gestation, which in itself carries a 20-25% mortality and requires highly specialised neonatal care. Yet again, it was decided Lucy Letby must have been responsible for the baby’s desaturations, despite no one
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What the jury didn’t hear - an important piece on
#LucyLetby
by
@drphilhammond
in this week’s
@PrivateEyeNews
.
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Is it ethical to publish this book when so much evidence is emerging from credible sources that the evidence used to convict Letby was flawed?
Who is the real Lucy Letby? This autumn, the BBC's investigation-leading journalists Jonathan Coffey and
@JudithMoritz
will draw on exclusive access to reveal the psychology behind one of Britain's most notorious serial killers and longest criminal trials.
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I am in the minority in thinking that the Thirlwall Inquiry is doing precisely what it needs to do: thoroughly documenting everything that led up to the detention of Lucy Letby. The opinions of those interviewed regarding her guilt are secondary; what truly matters is that the
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#LucyLetby
. Six of the 7 children allegedly murdered had been found to have recognisable causes of death by the pathologist and/or treating consultant and coroner:
Child C: Acute pneumonia
Child D: pneumonia with acute lung injury
Child E: NEC (necrotising enterocolitis)
Child
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It is important that health journalists correct the 1% figure quoted for expected “extubation rates per shift” (this is an inaccurate unit measure) re: new allegations
#LucyLetby
’s Thirlwall inquiry.
There is extensive literature describing unplanned extubation occurring in 1%
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A meeting of experts hosted by the Royal Statistical Society has heard that the statistical evidence used to convict
#LucyLetby
was “worthless” and there had been no concrete evidence of a spike in deaths at the hospital.
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An amazing article with spectacular results for CAR-T cells targeting CD19+ B cells in lupus… reinforcing the idea that pathogenic B cells are those expressing highest amounts of CD19: ABCs also known as CD11c+ B cells or atypical memory cells.
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#LucyLetby
I would encourage everyone to have faith in this Inquiry. Lady Justice Thirlwall is stating facts that are true: “Lucy Letby speculation is causing families enormous stress” and “Doubts over nurse’s convictions have come ‘entirely from people who were not at the
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From CCRC watch: It has come to light “that the scientific evidence used against Lucy Letby was wrong in virtually every possible respect.”
“[The CoA has effectively] ruled that there is nothing inappropriate about a retired paediatrician modifying the registered cause of death
Lucy Letby – Are the courts not interested in the truth?
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#Lucyletby
. Yes, there is NO EXCUSE today to not perform a molecular autopsy in cases of unexplained sudden infant deaths before convicting a nurse or mother of murder. There is no such thing as “exclusion of natural causes of death” as claimed by the prosecution’s expert
@carovinuesa
@SusieQ7038
I was in Australia when Roy Meadow’s ‘think dirty’ theory was influencing the prosecution witnesses. He couldn’t be there as he was facing GMC disciplinary proceedings following Sally Clark’s release in January 2003 so telephone calls were made. Despite the huge call for change
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A very good thread that explains why the conviction of
#LucyLetby
is unsafe from a medical and scientific point of view. The bottom line is that the test used to measure insulin (immunoassay) can measure many other proteins because it lacks specificity; proof of exogenous insulin
🧵THE INSULIN CONVICTIONS: A FOUNDATION OF DUST
There's reason to believe the insulin cases of Children 'F' and 'L' were the keystone cases of the entire trial. They have been subject to just as much pounding criticism as the other cases, but they were lethal to Letby's chances
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Lucy Letby: police and CPS handling of case raises new concerns about convictions
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Another baby that was “too unstable” to have a lumbar puncture even when a CNS focus of infection was suspected.
None of these babies were stable, deaths couldn’t possibly be unexplained.
#Lucyletby
.
All hospital notes finally available for public scrutiny thanks to Thirlwall
But..but…but I thought these deaths were meant to be “unexpected” and that babies were all “stable”. Or was that all pure lies? 🤔🤔🤔🤔 You decide!!!!!!!!!!! See just released memo re baby D!!!!
#LucyLetby
@Thirlwall_Inq
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Read the letter published today in the papers signed by nurses, medical professionals and medical researchers, asking for full Royal Commission and forensic review of the evidence used in the Letby case. Still open for signatures.
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Watching channel 5, Lucy Letby, did she do it? Thank you Rachel Aviv and your team for the thorough investigation and great article that made people think twice about the safety of her convictions. A great testament of the value of good investigative journalism. Next: the CCRC.
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Super happy with these news today - a huge THANK YOU to the members of my team and collaborators over the last two decades. It has been exciting times. I feel humbled. Thank you
@Science_Academy
for celebrating this. We will continue to work hard for the benefit of our society.
BREAKING: Our sincere congratulations to Academy Fellows, Profs Carola Vinuesa (
@carovinuesa
),
@Jamie_Rossjohn
, Richard Robson, &
@BobPressey
, on being elected Fellows of the
@RoyalSociety
– the oldest scientific academy in continuous existence.
#RSFellows
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B cells also orchestrate tolerance of developing thymocytes… | Nature
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Regarding today’s Panorama program on
#LucyLetby
. They report uncovering a third case of insulin poisoning. This is seriously problematic from a medical and scientific point of view. Besides immunoassays being unreliable to diagnose facticious insulinemia, that particular baby
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The Countess of Chester Hospital’s spike in neonatal deaths was not an outlier as reported by
@sarahknapton
in
@TheTelegraphUG
on 31st August. Similar spikes were seen at other poorly performing Trusts, yet no one looked for murderers.
“There was a 21% shortfall in nurses
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Today in the French newspaper LE MONDE, an article entitled: “From ‘bad science’ to judicial error”drawing parallels between victims of Meadow’s Law including Robert Roberson (soon to be executed) and Kathleen Folbigg (exonerated last year), and
#LucyLetby
.
It describes “[…]
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Follicular regulatory T cells produce neuritin to regulate B cells
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Multi-prize winning scientist and former Science Advisor to Downing St on
#LucyLetby
: “This was not a fair trial based on the widespread problems in the way scientific evidence was presented at the trial and, just as, or even more importantly, what was not presented to the jury.”
Piece now live. I cover the background to my becoming 'effectively certain' that the Letby conviction is unsafe. This is the piece underlying the pg 1&2 Telegraph article about my views on the Letby trial two weeks ago.
More v soon, covering the specific evidential flaws.
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#LucyLetby
. Regarding the accusations of “insulin poisoning” on the basis of an immunoassay result, Prof O’Rahilly
@stephenORahilly
(expert in insulin metabolism) provided another reason why a high insulin/C-peptide ratio can sometimes be seen in children that did not receive
Private Eye's scoop on the third insulin test of which Hall was not aware. Interested to know if the defence were provided with this material and simply didn't read through it or if the prosecution did not disclose this to the defence.
#Letby
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From today’s article
@guardian
:
A superbug, doctor shortages and a neonatal unit ‘out of its depth’: failures at Lucy Letby hospital revealed
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Very grateful to
@wellcometrust
, my collaborator
@AnisurRahman60
, my superb team, patients, collaborators, and
@TheCrick
technical platforms- this grant will allow us to better understand and treat lupus.
Congratulations to
@carovinuesa
and Peter Ratcliffe, who were awarded a combined £5.5 million in
@Wellcometrust
Discovery Grants 🥳
Read more about each of their projects and collaborators ⬇️
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There is this misconception that neonatal deaths (those that occur in the first 28 days of life) are so rare that a spike in deaths must involve foul play.
In 2022, there were 1,924 neonatal deaths in the UK, out of 4,604 total baby deaths. The majority of neonatal deaths (79%)
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Dr Matthew Orde disagrees with the conclusions of the main expert in
#LucyLetby
’s prosecution. He is someone to be taken seriously. Dr Orde’s forensic review of Kathleen Folbigg’s children pathology was crucial for the inquiry into her convictions - she was convicted of
Dr Evans said he had invited experts who disagreed with him to get in touch. "Give them my email and we can have a chat about it. I'm not holding my breath."
I have messaged Dr Evans, and look forward to discussing this matter with him.
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An important and well-sourced article by Anouk Curry and
@Sarahknapton
that puts a nail in the coffin of murder convictions by insulin poisoning on the basis of immunoassay results. Prof Alan Wayne Jones, Prof Chase, Prof Johll and Dr Ismail - NHS consultant in clinical chemistry
Insulin tests used to convict Lucy Letby cannot be relied upon, scientists say
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#LucyLetby
: A hospital takes a review seriously and says sorry. Spike of deaths Derby and Burton hospital trust included 56 neonatal baby deaths - in the first 28 days of life - and 13 “late fetal losses”. The hospital admits poor care.
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MP Sir David Davis demands retrial for
#LucyLetby
- 'There is a 90 odd percent she is not guilty'.
"I'm not gonna make a judgment of her innocence or guilt by looking at her," Sir David Davis told
@GBNEWS
. "I'm judging on the evidence."
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#LucyLetby
. This post concerns the alleged murder of Child A by air embolism. A premature twin born at 31-weeks gestation from a mother with antiphospholipid syndrome (APS). Born by emergency cesarean -section due to maternal high blood pressure and risk of pre-eclampsia.
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This is the paper describing the pathogenic mutation in Kathleen’s Folbigg daughters, who died suddenly. Sadly she remains in jail. 435 days waiting for an announcement from
@MarkSpeakman
on the petition to release her, supported by 150 eminent scientists.
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It is not irrelevant that the mother of a premature twin baby that dies within 24 hours of birth has antiphospholipid antibody Sd. Thromboembolism related to maternal autoantibodies, aggravated by failed catheterisations and dehydration must be more probable than murder by Letby.
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#LucyLetby
. If the Thirlwall Inquiry could produce a single piece of data, it would be worth the £££:
A complete table with ALL the infant deaths at CoCH in the relevant 2015-2016 period (not only the “selected” 7), and all the data suggested by Prof Hutton/Royal Statistical
Words of statistician Prof Hutton, regarding some of the flaws of how the shift data was compiled:
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#LucyLetby
. This post concerns the case of one of the insulin babies, Baby F. I would like the opinion of my immunology colleagues and clinical laboratory-based immunologists.
Does anyone know the immunoassay used by Liverpool Hospital lab to measure insulin in 2015? In assays
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More than 1/5 of sick neonates are found to suffer from genetic conditions. Before accusing nurses (like Lucy Letby) or mothers of murder, genetic causes should be investigated. It is important to cast a wide net on rare gene variants, including those of uncertain significance.
#lucyletby
I cannot stress enough how easy it is to muddy the waters in medico legal cases involving the highly complex needs of sick neonates. These cases stretch even the best legal minds, let alone a jury. I despair that we have learnt nothing from the Cannings & Clark cases.
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Spectacular results of CAR-T cell therapy in lupus, myositis and systemic sclerosis… .)
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#LucyLeby
According to a pathologist, Child A (twin premature baby, born by emergency C-section from mother with anti-phospholipid Sd) had crossed pulmonary arteries (CPA), a rare malformation. Over 60% of CPA patients have rare genetic diseases (PMID: 35491976) including Noonan
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@drphilhammond
@PrivateEyeNews
I can recommend eminent UK neonatologists and toxicologists but, like you, I have not yet met one that believes murders have been proven.
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Great article today by
@lawrencefelic
in
@guardian
describing the concerns of highly qualified and courageous experts on the Letby case. An important read.
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The Lucy Letby case. A thoughtful very accessible article worth a read. I particularly liked Part 2: broader remarks.
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"Remember this Kenyan runner Abel Mutai who was just a few feet from the finish line, but became confused with the signage and stopped, thinking he had completed the race. A Spanish runner, Ivan Fernandez, was right behind him and, realizing what was happening, started shouting
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Words of statistician Prof Hutton, regarding some of the flaws of how the shift data was compiled:
@Telegraph
A doctor being present for a high number of incidents is not notable in itself.
What is notable is that the shift pattern for the doctors was excluded from the data that was presented to senior management—leaving only the nurses' shifts for them to scrutinise.
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From this article:
“So: juries are an essential check against the professional criminal justice apparatus, but they are not the only such check. Another essential check is the ability of people in the broader public sphere to question the outcome of court processes, including
The Lucy Letby case. A thoughtful very accessible article worth a read. I particularly liked Part 2: broader remarks.
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The UK charges exorbitant fees to access court transcripts (£100k in the case of Lucy Letby), compared to Australia, Canada, and most other countries. Yet credible experts coming forward with more plausible causes for the spike in neonatal deaths at the CoC Hospital are being
It costs £100k to obtain the transcripts relating to the trial of nurse
#LucyLetby
.
Journalist
@NewYorker
@RachelAviv
has obtained the material and written a 13000 word article exposing why so many have grave concerns regarding the safety of the trial.
It’s geoblocked in the
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Media reporting around the Letby case was restricted over the last 10 months, but restrictions are now lifted as per a recent BBC article. This article from the New Yorker by
@RachelAviv
can presumably now be read
Source:
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#LucyLetby
Insulin babies. In this article, parents were suspected of injecting insulin to a baby due to an insulin:C-peptide ratio on immunoassay, then shown to be a false result by insulin LC assay, due to interference by heterophilic antibodies.
Source
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I would like to correct my previous post: an expert neonatologist that had provided a report to
#LucyLetby
’s defence and criticised the medical evidence presented at the trial, had indeed been present at the trial, as reported today in
@guardian
(extract below).
The main message
#LucyLetby
I would encourage everyone to have faith in this Inquiry. Lady Justice Thirlwall is stating facts that are true: “Lucy Letby speculation is causing families enormous stress” and “Doubts over nurse’s convictions have come ‘entirely from people who were not at the
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Celebrating Cynthia Turbull’s and Pablo Canete’s superb effort with this story out today.
DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency | Science Advances
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A beautiful piece of work
@sciencemagazine
led by my wonderful and longstanding collaborator Nan Shen on the important role of ZEB2 for pathogenic B cells (ABCs) in lupus.
Excited for my former colleague Nan Shen and his collaborators:
@carovinuesa
@Kottyan_Lab
@ScienceMagazine
ZEB2 is essential for age-associated B cell differentiation in mice and humans and contributes to autoimmune disorders
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Thank you for answering re: the insulin test used in Child F (
#LucyLetby
): a Roche Elecsys/E170 immunoassay.
This is the same sandwich immunoassay that gave a falsely high insulin/c-peptide ratio (due to interference by heterophile antibodies) in the paper I posted below,
In the case of
#LucyLetby
, the essential insulin LC-MS test to exclude a possibly false high insulin/C-peptide ratio obtained by immunoassay before convicting a nurse, was not performed. Why was this evidence allowed in the trial?
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B cell-driven inflammatory bowel disease, responding to B cell depletion:
Neutralizing Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease | New England Journal of Medicine
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The public has a right to investigate possible miscarriages of justice (MoJ) because juries can get it wrong: ~400 MoJ have occurred in England and Wales since 1970. For the Crown to quote £100,000 to obtain the
#LucyLetby
court transcripts is a terrible denial of justice. This
It would cost £100,000 to get full transcripts of the
#lucyletby
trial. We should be able to get these for free in a country with open justice.
Who knows what we haven’t heard? Remember that journalists were only giving us snippets of information!!
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“Immunoassay [which was the only test used to infer insulin poisoning in the Letby case] entails an inherently high error rate and, therefore, has the potential for inaccurate and misleading results susceptible to misinterpretation and/or diagnostic misapplication by clinicians.”
"The error rate in immunoassay tests is variable, random, insidious and unpredictable and may occur in any immunoassay test irrespective of its nature and/or format." Adel AA Ismail (2017), When laboratory tests can mislead even when they appear plausible.
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The spike in deaths at Letby hospital ‘could be explained by how small and premature babies were’. There had been “higher activity and lower admission birthweight than average during the period corresponding to the increase in mortality”.
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In the case of
#LucyLetby
, the essential insulin LC-MS test to exclude a possibly false high insulin/C-peptide ratio obtained by immunoassay before convicting a nurse, was not performed. Why was this evidence allowed in the trial?
#LucyLetby
Insulin babies. In this article, parents were suspected of injecting insulin to a baby due to an insulin:C-peptide ratio on immunoassay, then shown to be a false result by insulin LC assay, due to interference by heterophilic antibodies.
Source
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The fact that Dr Garstang has been called to give evidence at the Thirlwall Inquiry is very encouraging and points to an effort to understand how some babies might have died.
Dr Garstang is indeed a highly credible paediatrician and SUDI expert that provided expert testimony
@carovinuesa
It's interesting that Dr Joanna Garstang, is taking part in today's hearing for the Thirlwall Inquiry.
Dr Joanna Garstang has expertise in SUDI and SUDIC, and has been an expert witness for the Inquiry into the convictions of Kathleen Megan Folbigg.
@carovinuesa
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Thanks to Merck for the superb award ceremony, and to Amy Kao
@EMDSerono
, Anne Davidson
@NorthwellHealth
,
Annemarie Sluijmers
@LupusEurope
, Christof Specker, Edward Vital
@edvital
BILAG and
@LupusForum
and Jan Klatt,
@MerckHealthcare
for their time & fantastic panel discussion.
Congratulations to Carola Vinuesa
@carovinuesa
, Principal Group Leader and Assistant Research Director at
@TheCrick
for winning the €30k Johann Anton Merck Award.
#JAMA2023
#Lupus
@merckgroup
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Blood samples from twins Child E and F were sent together for biochemistry analysis, including insulin. Child F had received an insulin injection and child E an insulin infusion. The jury heard that the recipient laboratory at Liverpool hospital had labelled the samples as “twin
Worth adding that Baby E was premature and weighed less than 1.4kg (3lbs). Twin of baby F, who LL allegedly “poisoned” with insulin. Both twins had problems with glycemic control and were treated with insulin.
The consultant ascribed baby E’s death to necrotising enterocolitis
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A superbug, doctor shortages and a neonatal unit ‘out of its depth’: failures at Lucy Letby hospital revealed
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A news feature in this week’s issue of Nature on this tragic case and it’s broader implications. ——- “She was convicted of killing her four children. Could a gene mutation set her free?”
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The article by
@RachelAviv
in the
@NewYorker
was a great reminder of the importance of solid statistics and seeking advice from
@RoyalStatSoc
- United Kingdom ·
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#LucyLetby
.
A probability question:
What is more likely when looking for the cause of a high insulin/C-peptide ratio amongst hundreds of medical notes from babies that were discharged from the hospital?
1. Attempted murder by any means - Probability of 1:50,000 newborns
Regarding today’s Panorama program on
#LucyLetby
. They report uncovering a third case of insulin poisoning. This is seriously problematic from a medical and scientific point of view. Besides immunoassays being unreliable to diagnose facticious insulinemia, that particular baby
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@LucyLetbyTrials
#LucyLetby
was convicted for the attempted murder of child K: the endotraqueal tube of this 25 week-gestation premature baby was found dislodged. Today the Thirlwall inquiry heard that the prevalence of dislodgement of endotraqueal tubes is “not at all common”.
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It is reassuring that the Inquiry reviewing the events at the Countess of Chester Hospital at the wake of Letby’s conviction is led by Lady Justice Thirlwall, who previously cleared another nurse of murder after identifying systemic deficiencies at another hospital.
Judith Moritz was in a position to know how to cover the Letby case responsibly. She'd previously reported on a nurse who died after being wrongfully accused of murder.
Interestingly, the inquiry that cleared nurse Anne Griggs-Booth of murder was led by Lady Justice Thirlwall.
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A comprehensive review of why an insulin/C-peptide ratio determined by immunoassay should have never been used as evidence to convict
#LucyLetby
for the attempted murder of two infants (Child L and Child F), who both actually survived.
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A great article by
@Docstockk
“Hence, given the stakes are so high, and the evidence of faulty process is now so suggestive, both those who insist Letby is guilty and those who insist she is innocent should demand her lawyers be given another chance to establish the facts”
“The
The public inquiry into the Letby murders has begun in the strangest of circumstances: serious doubt that there were ever any murders at all. My latest in
@unherd
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Courageous medical experts say that Thirlwall Inquiry on the Letby case should be changed or postponed because “the inquiry’s narrow terms could prevent lessons being learned about “possible negligent deaths that were presumed to be murders” in the neonatal ward of the Countess
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#LucyLetby
| Interesting 16 minute documentary I had missed - The other 15 infants, the compensations to parents in cases of neonatal deaths, the sewage evidence…
via
@YouTube
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Indeed. Lack of statistical and scientific rigor, circumstantial evidence, and poor medical expert testimony have led to many erroneous convictions including Australian Kathleen Folbigg’s. She spent 20 years in jail before we could overturn it with genetic evidence.
As the co-author of a book calling for scientific rigour & competent defence in criminal trials, I can only concur with this article about the
#LucyLetby
case from
@Forensic_Sci_
@BBCr4today
- please look beyond the superficial.
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An insightful piece by John Ashton
@Johnrashton47
, a former Public Health Director describing the
#LucyLetby
case as: “the ‘Gruyère Cheese’ phenomenon, whereby all the risk factor holes are lined up and as a result, in retrospect, something was inevitably going to happen.”
🔴 Lucy Letby: The Thirlwall Inquiry and the Truth About the Countess of Chester Neonatal Deaths Scandal
The inquiry has dismissed the increasing body of concern around the legitimacy of the verdicts as “noise”. It is anything but, says
@Johnrashton47
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Worth adding that Baby E was premature and weighed less than 1.4kg (3lbs). Twin of baby F, who LL allegedly “poisoned” with insulin. Both twins had problems with glycemic control and were treated with insulin.
The consultant ascribed baby E’s death to necrotising enterocolitis
Baby E - a classic post event revision.
The senior consultant present at the time believed the death of the "high risk" baby was due to gastro-intestinal disorder.
So who and when and how, long after the event, came up with the idea that in fact it was result of air injection?
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I am being asked whether the evidence that Child A, allegedly murdered by
#LucyLetby
by air embolism, had crossed pulmonary arteries (see post below), was presented at the trial. The answer is yes.
The members of the jury were read a “statement of agreed pathology facts” that
#LucyLetby
. This post concerns the alleged murder of Child A by air embolism. A premature twin born at 31-weeks gestation from a mother with antiphospholipid syndrome (APS). Born by emergency cesarean -section due to maternal high blood pressure and risk of pre-eclampsia.
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This time it is a junior doctor that has the courage to write in her statement to the Inquiry that she has great doubts that Letby committed the crimes that she denies.
🤯 Dr Jiraskova, a GP trainee who worked in the paediatric team at the Countess between August 2015 and February 2016, said she had "great doubts" that Letby "has committed the crimes that she denies."
Dr Jiraskova was one of several junior doctors whose statements were read out
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Thank you Brian. It has given me and my team at ANU an enormous satisfaction to be able to do this work.
thank you to
@ourANU
Prof Carola Vinuesa for her efforts to right this miscarriage of justice
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Here is advertisement for Early career group leaders at The Crick, a fabulous place to work. Please apply if you’re interested!
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Feeling blessed to have such an extraordinary team of researchers and such a supportive environment at
@TheCrick
with wonderful mentors and colleagues, and superb scientific technical platforms.
Brilliant
@TheCrick
Lecture by
@carovinuesa
, sharing her work over the years exploring B cells and their many roles in autoimmunity
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Sharing our latest paper by
@AMedhavy
&
@VickiAthanasop1
. Underscores the value of: i) discovery of rare gene variants in children with ambiguous diagnoses of autoimmunity; ii) collaboration between
@TheCrick
,
@JCSMR
, & Shanghai Renji Hospital - Nan Shen
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Well done Phil Hammond and all the courageous professionals speaking out.
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Great interview in which
@KevinWNg
and
@CarlosMMinutti
explain how this series at
@TheCrick
“was also a great indication of how many people are actually LGBTQ+ in immunology”. A good reason to celebrate
@TheCrick
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#LucyLetby
. Regarding post below, it is also important to remember that maternal antiphospholipid antibodies can cross the placenta and cause neonatal stroke due to cerebrovascular thrombosis, which is difficult to diagnose clinically in neonates and requires dedicated
#LucyLeby
According to a pathologist, Child A (twin premature baby, born by emergency C-section from mother with anti-phospholipid Sd) had crossed pulmonary arteries (CPA), a rare malformation. Over 60% of CPA patients have rare genetic diseases (PMID: 35491976) including Noonan
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Another case of parents falsely accused of harming (shaking) their babies aired yesterday in Australia: medical ignorance of how rare genetic diseases can present, denial of genetic testing, biased police investigation. Michael Nott: great legal defence.
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Exciting prospects with low dose IL-2 therapy in type 1 Diabetes from Chu Jin Wang
@LucyWalkerlab
#BSI22
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This response re:
#LucyLetby
insulin accusation is from Cambridge Professor Stephen O’Rahilly, a world authority in insulin resistance.
LC/MS has the additional advantage of being able to distinguish between endogenous insulin and any of the many insulin analogues some only differ ring by one amino acid that are routinely used in clinical practice. This can provide direct objective evidence that the insulin/
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An important podcast to listen for those that want to understand the flaws behind the shift data incriminating
#LucyLetby
by a world expert: how interpreting data can lead to confirmatory bias if done by someone that is not independent to the criminal investigation.
Excellent interview with William C. Thompson halfway through today's episode of
@thetimes
' podcast The Story [his interview starts at 19:50]:
(The first half of the episode, as has come to be expected from The Times, betrays an annoyance on the part of
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Pseudomonas aeruginosa and Dr/nurses understaffing are serious problems when dealing with premature, very low birth weight, and sick babies.
#LucyLetby
.
Probably the tip of the iceberg. Latest document released Pseudomonas infesting the ward & not enough nurses or doctors to care for those poor premature babies. How could the hospital dare to accept these super vulnerable premature babies with not enough staff!!😡😡😡
#LucyLetby
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This is the amazing work of a great team - thanking in particular Grant Brown, Vicki Athanasopoulos and Yuke He; my long term CPI collaborators; Matt Cook and Nan Shen. Plus all past & current lab members, patients like Gabriela and their families. Together we will get there!
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Thank you
@VinuesaLab
current and previous lab members. This prize recognises everyone’s extraordinary work and superb team effort. 🥳👏❤️
This week we celebrated the accomplishments of the Crick scientists, including the 2023 Johann Anton Merck Award that
@carovinuesa
received for outstanding scientific preclinical research accomplishments. Join us in congratulating her and other brilliant scientists at
@TheCrick
!
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It is important that the mainstream media disseminates these voices.
Overwhelmingly none of the nurses had any concerns or suspicions about the conduct of Letby while working on the NNU - contrary to consultants most nurses felt capable and empowered to raise concerns about members of staff. Many of the nurses described June 2015 to June 2016 as a
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What a great meeting and scientific community!
We had a fantastic time at the
#EMBOlymphaticTissues
& Germinal Centers workshop in Galway! Lots of exciting and brilliant research, some gaelic games, and many nice discussions with old and new friends ☘️
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Thank you again for this honour and warm reception. I enjoyed hearing the cutting edge science taking place at MPIB - brilliant scientists working on the most fundamental processes that underpin totipotency, photosynthesis, severe skin diseases, and the protein aggregates that
Yesterday,
@carovinuesa
was awarded the Axel Ullrich Medal. In an inspiring
#lecture
she presented her findings on using
#genomics
to understand
#autoimmunity
as well as her contributions to the case of a mother wrongly convicted of killing her children. Thank you,
@carovinuesa
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