Nikolas Plevris
@PlevrisN
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Specialist GI Registrar IBD Clinical Research Fellow, Western General Hospital
Edinburgh, Scotland
Joined November 2012
@ShahidaDin1 @CrohnsColitisUK @CrohnsColitisFn @southasianIBD @Y_ECCO_IBD @BritSocGastro @NIHRresearch Great work! I do wonder about IBD heterogeneity. No one person is the same. Placebo trials may allow us to bring new drugs to market that on an IBD population level may not be superior to 'standard tx' but work really well for a sub-set of patients. How do we navigate this?
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RT @Bealoquebea: 📢 Thrilled to share our latest study in @JCC_IBD Tofacitinib vs vedolizumab as first-line advanced therapies in #UC ➡️…
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@JosephHabibi_MD @laura_tee_mdgi @Jonathansegal85 @ibddoctor @ibdseb For me it's reduced risk of immunogenicity. Albeit in CD, PANTS extension did show that full dose / AZA at time or before IFX initiation was protective for future immunogenocity
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@JonnyBlackwell @Bealoquebea @DrRosenIBD @drkeithsiau @MondayNightIBD @DCharabaty @abbvie @JanssenUS @ign76 @AshkanRA @AngusWorthing @rheumecraig @IBDPharmacist @IBDPharmD @SchairerIBDMD @DrPujaMehta1 @RestelliniS @JosephHabibi_MD @ColmanMD Exactly. Especially for ADA. I think if you start developing any immunogenicity against ADA it is the real deal. Even with low level immunogenicity (10-50) we found sig lower drug levels.
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RT @FrontGastro_BMJ: Check out latest study by Elford et al. on the real-world effectiveness of Upadacitinib in Crohn's disease. Their find…
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RT @charlie_lees: Upadacitinib for Crohn's disease • data from Edinburgh and Exeter • n=93 with median 25w follow-up • effective in highly…
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RT @Gastro_GRJ: I’ve been working with the British Society for Immunology (BSI) to develop a new online training course on IBD immunology i…
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@DisneyBen @ibdseb @ibddoctor @DCharabaty @Jonathansegal85 @UKGastroDr @ShahidaDin1 High dose thiamine or modafinil
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@chershiong @Bealoquebea @IBDNathan @Gastro_GRJ Thanks for all your help with the work throughout the years!
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