Mikhail Batin
@MikhailBatin
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What do you think is the most underestimated task in life extension? I tried to answer this question in the book Transhumanism. See link below
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A debate titled "How to Defeat Aging" will be held on May 27, 2024, in San Francisco, featuring two distinguished scientists,
@fedichev
and
@aubreydegrey
, both proponents of radical life extension with biotechnology, with opposing views. Fedichev believes aging in humans is
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The main division in life extension is not into “the people who are for” and “the people who are against” life extension. The 2nd group will instantly become the 1st one in the blink of an eye if a cure for old age is developed.
The main devision is between “the people who are
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Since 2007, I have been deeply engaged in researching and developing various life extension strategies. I've employed dozens of scientists, interviewed hundreds, and reviewed thousands of articles and books. I have authored thousands of texts, reaching millions of
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If any good thing has happened recently, it's that many young people have joined the field of cryonics. The community has grown substantially.
It's believed that for a boom in cryonics, a breakthrough result is needed: successful thawing of a mammal or transplantation of a
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Aging is a paradox. A squirrel can live for 20 years, while the rat - only for two years, and we do not know why. Birds and bats live very long for their body sizes. The termite queen can live for many decades, while the worker termite is short-lived while having the same genome.
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Anyone who does not actively support cryonics does not understand the concept of human life extension
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Yesterday at Lifeforce Longevity Connect,
@aubreydegrey
made an important point. One of the reasons for the slow progress toward an anti-aging drug is that many smart people have shifted their focus to AI development.
It might seem that AI holds the greatest promise for radical
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We must pay attention to this fact. Right now the most important initiative is the Dublin Longevity Declaration.
We need money for its distribution and PR. Yes, all of Longevity Biotech will not be able to find 300 thousand dollars to invest in promoting the initiative.
And
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If
@bryan_johnson
does not provide a clear response to the allegations within 72 hours, we will be forced to admit that he is using anti-death rhetoric solely for personal gain.
If his argument boils down to calling the scientific community haters, we will understand that we are
I’ve not checked in with Bryan Johnson for a while (because he blocked me), but now I do—surprise, surprise, he’s monetising Blueprint!
The website that used to show his protocol is now a store…let’s take a look at some of the products.
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Do you understand what XPRIZE Healthspan has done? In fact, they created an alternative FDA for aging.
This is a very cool project and this is what will happen now. There will be a surge in biohacking and patient research.
Now there will be new players in Longevity: half
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The great
@aubreydegrey
yesterday told how an experiment on combination therapy against aging is going. The results are intriguing.
In the control group (blue), 35% of mice are alive. In the group that received all interventions (red), about 80% are still alive.
We are all
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Our task is to turn the signing of the Dublin Longevity Declaration into a political process.
Get involved!
@TheA4li
@TSGlinin
@aubreydegrey
@SayForeverOrg
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I just had a call with Yan Granat
@yangranat
We debated about social capital. I argued that generating data about the social process is the most crucial aspect of transhumanism. He disagreed, finding my arguments insufficient.
Then he said, "Explosions have started around me,
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After four years of dedicated research, we've made significant strides in understanding the complexities of aging. By carefully describing and systematically organizing related facts, we can substantially streamline the process of developing therapies for aging.
We're proud to
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Can we extend human life without major societal shifts? Some might think a tech startup will just invent an anti-aging drug, or even do nothing and hope that advanced AI will solve aging in the next 10 years. However, these approaches seem rash to me.
The issue of aging is
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Why do billionaires fund so little life extension research? Because they are overwhelmed with proposals either to use already developed technologies or to finance technologies that are nearly complete.
The idea of research competes with the idea of improving health right now and
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Skeptics of life extension demand not just theoretical evidence, but practical proof that extending human lifespan is possible. However, they often overlook the significant financial investment needed to achieve such results. This stance is paradoxical; it's akin to requiring
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The first thing that surprised me at
@RAADFest
was how modest, shy, and calm
@bryan_johnson
seemed on stage. You can read most of his ideas on his Twitter, but his answer to one question struck me as brilliant.
Someone asked him about creating a "longevity zone" where people
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Organisms routinely age and die. We often view aging and death as inevitable processes resembling the decay of abandoned houses or neglected cars. However, our body has an amazing regeneration ability. Per lifespan, an average human body produces more than a ton of blood, many
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@elonmusk
@PeterDiamandis
What could be more inhuman than to hope for the death of all people?
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Why is the idea of radical life extension gaining support so slowly? Which of these reasons do you agree with?
1. People don't believe they will live to see life-extending technologies.
2. People don't value their lives enough to want to live longer.
3. People have been given
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The realm of life extension and anti-aging is a diverse landscape, teeming with a myriad of projects, companies, and initiatives, each distinct in its approach and focus. Let's delve into these varied domains:
Universe number one is the largest.
At the forefront is the vast
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Why are there so many Russians in the field of life extension? I think it is because of the language. In Russian, nouns use cases, which change the noun depending on the context of the situation. This gives the noun a greater sense of meaning. For the same reason, there are many
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If we want to be effective in Longevity, we must learn to ask the right questions. For example:
1. Why hasn't evolution eliminated aging?
2. What can we do that even the founders of Google, Amazon, and OpenAI can't do to extend life?
3. How do we search for mechanisms of
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The youth movement Singularity Squad held a Say Forever event on the beach in Miami.
It turned out very cool! And here's an idea. If you are in favor of immortality, then you can start asking people at any conference how long they want to live. If a person does not want to die,
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Aging is a monstrously complex and tangled process. At the biochemical level, the main issue seems to be feedback loops. An initial issue leads to a second, the second causes a third, and the third intensifies the first. Due to these loops, some scientists believe it's impossible
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If six people get into the elevator with me, then seven transhumanists will come out of the elevator.
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How does the battle against aging and death truly function?
Life extension is an immensely controversial field. Wellness, Longevity Biotech, biohacking, developing aging theories, utilizing AI, organ replacement, and societal shifts favoring life extension are profoundly
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There is a project in life extension that requires the utmost attention: "Open Problems in Longevity."
It's an absolutely brilliant idea
@jpsenescence
to transform the entire fight against aging into a clear and comprehensive list of questions and seek answers to them.
If you
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Renaming the National Institute on Aging to the National Institute on Dementia is an affront to the entire field of Longevity.
Some might argue, "But that's the reality; most of the NIA's budget already goes to cognitive disorders." Yes, the current situation is far from ideal,
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Let's critically examine our main theses:
1. More proponents for life extension are needed.
2. We require significantly more data on aging.
3. More interventions and their combinations should be tested on various organisms.
4. Greater openness, more information exchange, and
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What are all our conferences, conversations, plans worth if the Longevity community cannot unite? Matt Kaeberlein is a scientist with an impeccable reputation, doing incredibly important projects, including studying the lifespan of dogs. Now his project has been deprived of
Help save the Dog Aging Project.
Despite being one of the most influential, productive and impactful NIH supported projects over the past 5 years, the National Institute on Aging has inexplicably chosen to withdraw support for the Dog Aging Project. For now, I’m won't get into
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@lexfridman
@sama
1. What is your strategy for achieving immortality?
2. Which projects in the Longevity field seem to you the most promising?
3. Why aren't you funding Aubrey?
4. Which billionaire is ready to create life extension together with you?
5. Are you ready to become a promoter of
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@aubreydegrey
and I will come to the Ferry Building on Saturday, October 7th at 12:00 pm in San Francisco to support the Dublin Longevity Declaration. You too come, it is important to continue to act in favor of prolonging life.
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I think the most intriguing investment in life extension is Gero's $6 million Series A. Clearly, applying generative models to clinical trials is the only viable path to finding therapies for aging. We are talking about creating virtual patients and searching for new targets
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We don't know what forces are opposing the idea of life extension. Nor do we understand the mistakes being made by the Longevity community.
The paradox is that we continue to repeat what we've done for many years, without trying to understand the true picture of reality.
When
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The spread of the idea of life extension contradicts the laws of physics. Or rather, its lack of spread does.
Look. There are thousands of people working in the field of longevity science. There are millions of people doing something to extend their own lives. There are hundreds
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What, in your opinion, is the most feasible experiment in the field of life extension that could also have the broadest impact?
I'd like to offer my perspective.
Let’s begin with philosophy. What exactly suggests that life extension is possible? Primarily, the fact that human
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@GeroMaxim
Indeed, why is there such a low percentage of smart people who are ready to fight death? It's puzzling that no Nobel laureates have signed the Dublin Declaration of Longevity. It's curious to note the absence of seminars at institutions like Princeton, led by mathematicians and
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Why is the battle against death and aging research not mainstream in modern society? It stems from a lack of clear purpose in life for many. Caught in the claws of mundanity, people scarcely find time to ponder the very reason for their existence. And when they do find an answer,
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Transposon Inhibition and Its Impact on Longevity
In recent years, multiple studies have shed light on the correlation between transposons and the aging process, revealing intriguing insights into longevity. In the initial study by M. Harrison et al., transposons emerged as
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The answer to the question of who is the most target audience for the idea of immortality, and who is not, is not at all obvious.
Surprisingly, doctors are not the target audience for the idea of life extension. Even those who work in preventive medicine will say that quality of
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People do not want to live strongly enough. They want to, but not to the extent that they would leave their current affairs and seriously engage in prolonging life.
This is the very problem that we must address first and foremost. To actualize the desire to live in people.
This
This week in Dubai is buzzing with crypto conferences, and we've kicked off SayForever!
We're engaging attendees on their desired lifespan, advocating for the importance of extending life. At Blockchain Life, we polled 108 people, with 67 stating they want to live Forever!
We
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Do you agree that life extension is a political issue?
Then why are we wasting time?
Join The U.S. Transhumanist Party.
I myself have joined. You can do this no matter where you live on the globe.
We must defend our right to life. There are no alternatives to political tools
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We at Open Longevity have one idea - to create a “Wish to Live Clock”. Look here. In biology, there is the concept of the clock of aging. And at the level of society there may also be a clock that measures how much time we have left until the cure for old age.
This is a set of
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The central effort in promoting life extension revolves around broadcasting scientific achievements in this field.
The battle against aging often boils down to a newsfeed of scientific discoveries.
Thousands of people, across various platforms like Twitter, review articles,
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What's the strangest aspect of fighting death? It's the reluctance of many intelligent people to oppose death. If you aren't aware of a more paradoxical issue in this struggle, it suggests that this problem alone deserves our focus. How can we engage very smart people in the
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Between today and the day we achieve the escape velocity from aging, a series of events must surely unfold.
The march toward technology will provoke a societal response, and in turn, public sentiment will influence when the hour of reckoning arrives.
So, what exactly will
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I really liked the reaction of New Yorkers to our small performance. Unfortunately it was very short and now I want it for a long time. Who wants to rally with me in San Francisco? I am here again
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Extending life is the realization of the idea of being needed. If you need yourself, then you want to stay alive. If the people close to you need you, then they want you to stay alive. If society needs you, it is trying to save your life.
Apathy and loneliness are the opposite
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We present AgeMeta, a database of aging transcriptomics that is based on a meta-analysis of 122 publicly available datasets from various tissues of humans, mice and rats. The database presents a visual interface to the 7 signatures of aging identified in our previous work, that
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Aging and Regeneration: Salamanders Unveil Nature's Lessons
In the realm of regenerative abilities, salamanders hold a unique and exceptional position. Unlike simpler nonvertebrates like hydra, jellyfish, or tardigrades, salamanders are complex vertebrates, making their
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Perhaps this is the central question in life extension strategy:
Does the activity of selling supplements with poor evidence base lead to useful work in the fight against death?
The arguments in favor of this position are as follows.
People are interested in health
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You may have a brilliant philosophical concept and a comprehensive worldview, but if you don't take simple actions to realize it, it's just a dead theory.
When it comes to extending life, there are several global approaches:
Wait: This is Ray Kurzweil's idea. He believes that
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The smartest policy in the fight against aging is to help
@aubreydegrey
Here's a 90-second video about our unprecedentedly ambitious mouse lifespan study. We desperately want to kick off the next such study as soon as possible in 2024. Please consider helping us to do so, with a donation to LEVF. Thank you so much!
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Why do we find ourselves at a point where we must justify that extending life is a good thing? It is an utterly absurd situation. In everyday life, only a madman advocates for death. Why is that so?
We are faced with mundanity. The discussion about life extension is outside the
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The discussion about the fight against death is schizophrenic in nature in 99% of cases. Almost every time, the topic of fighting death is replaced with another topic.
When you assert that death is bad and urgent action is needed, the response is usually: a) people start arguing
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Why is human cloning more important than aging research for life extension?
This assertion might seem odd since we age ourselves, and clones cannot transfer their youth to us. If you had a clone, it would likely be your closest companion.
However, the point is that cloning
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The multinational corporation LBF has presented a global plan to defeat aging in Silicon Valley.
Our agency is increasing its assessment of the chances of developing life extension products in the next 20 years.
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$2,000,000 is very little money for research into the biology of aging, but huge for lobbying for research into the biology of aging. At the same time, lobbying is the path to billions of dollars for aging research.
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The purpose of my Twitter account is to ensure the restoration of vital functions in the event of my death. How am I going to come alive?
My personality arises from the connections between brain cells, from a certain position of molecules in space, and this situation is
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At the European Parliament elections on June 9th, the Party for Biomedical Rejuvenation Research suffered a devastating defeat, securing a mere 0.05% of the votes.
While not absolving our German colleagues of responsibility for this colossal failure and their inability to
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Today, I overcame existential dread. For years, I feared using apps that determine biological age. To me, opening them seemed like staring into the eyes of death, and death staring back at me.
I always thought that determining biological age was akin to the detrimental observer
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A cure for old age will not be created in Silicon Valley. There is no such pain here. Venture capital cannot comprehend the problem of death. Venture capital builds a pyramid scheme where the primary goal is to resell investments to the next round of investors. There is no
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I admire
@kaimicahmills
and
@jpsenescence
' work individually, but when they do a jpsenesproject together, it seems to me that the project is flawless:
"Project Molecular Profiling and Computational Modeling for Novel Cryoprotectants
Cryopreservation is a vanguard discipline
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An interview with me was published on
@LifespanIO
Thank you
@ArkadyMazin
I would like to add something. The field of life extension needs dramatic changes. If we accept the current pace, we will all simply die. There will be no cure for old age.
The statement that people do
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There is one thing I would really like to do. This is to organize a debate in San Francisco about ideas for life extension. I think we need to raise the intellectual level of the discussion about the fight against death. Write to me if you want to do the same.
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A random attendee of the RAAD conference answers questions from SAY FOREVER. Fill out a short survey yourself. This will help us change society.
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I think the simplest and most useful thing in our business: a declaration of commitment to the idea of life extension.
We must protect our interests in the public sphere.
And it's not that difficult. We can convince everyone that death is terrible, and the idea of saving
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The value of life cannot be logically derived from any other values. Asserting that life is needed for a specific purpose diminishes its intrinsic worth. Life is not only necessary for known objectives but also for the unknown, and its primary value is inherent.
At first glance,
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Say Forever today in Paris. 14 out of 120 people would like to live forever. Say Forever is a very simple promotion. Anyone can go out into the street and ask passers-by how long they want to live. Do this too! Say Forever!
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How can we best describe what we're doing? Vitalism, transhumanism, immortalism, longevity? All of these are accurate, but there's a more precise term.
We're fighting for survival.
Safe AGI, anti-aging medicine, organ replacement, longevity policy, peace movement — it's all a
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If we do not engage in discussions about bottlenecks in life extension, we are doomed.
We will face an overwhelming number of tasks that are impossible to tackle. Moreover, the solutions to most of these will not lead to anything revolutionary.
The most popular answer to why
This report is the months-long culmination of some of the brightest young leaders in the longevity field coming together to prioritize and detail the field’s top bottlenecks:
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Guys, there's a matter of utmost importance.
In our quest to reshape society, making it more attuned to the idea of life extension, we cannot grow blindly in the dark.
We urgently need objective data on people's attitudes towards death and the concept of extending life. We
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I don't think it's correct to say 'We lack a Manhattan Project.'
What we lack are steps that lead to a 'Manhattan Project.'
Obviously, there are people who could make such a decision. This could be a significant group of Congressmen or Tech Entrepreneurs.
Currently, such a
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An incredibly cool open letter has been published: “Dublin Longevity Declaration”, prepared by
@BKennedy_aging
,
@aubreydegrey
and Martin O'Dea
Consensus Recommendation to Immediately Expand Research on Extending Healthy Human Lifespans.
I strongly
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On August 13, 2023, I wrote in a message to
@GriffinBrumley
"How do you like the growth of our network? By the end of the year, we will be the most influential life extension group in the world."
At Open Longevity, we are only interested in exponential growth. Where there is
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@PeterDiamandis
My aim is to exponentially increase advocates for radical life extension.
But how to achieve this? I believe we should actively support and highlight those who challenge the inevitability of death and present feasible methods to combat it.
Though few globally view death as an
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From the thesis "we have nothing in life extension" it follows that "we must start all over again."
Why do we have nothing?
1. We do not understand aging as a phenomenon.
2. We do not understand the evolution of aging (this remark alone is enough to assert that we are at
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Today at Edge Esmeralda,
@Replacing_Aging
Jean Hébert defeated
@ydeigin
Yuri Deigin in the debate "How to Defeat Death?" with a score of 5:3.
The idea of brain tissue replacement won over partial epigenetics.
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Why does cryonics fail year after year?
To begin with, we need to recognize the fact that cryonics, despite decades of efforts by many people, has not become popular. And also admit that there has been no scientific research to explain the current state of affairs.
We can only
Today is Cryonics Day, aka Bedford Day!
Congratulations everyone!
I'm curious to know, how many of you remembered it's today? And how many are actually aware of what this day signifies?
It's been 57 years since we began the practice of cryonically preserving humans. What's
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The three worst ideas in life extension:
1. We need to demonstrate results in extending human life, and then we will get funding for research.
This is an absurd idea. Money is needed first to achieve results. Those who create the cure for aging will control the world, and they
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How to age a hydra?
The longevity of hydras hinges on three critical pillars: the safeguarding of their genome from transposons via piwiRNA, the preservation of stem cell function, and efficient DNA repair mechanisms.
However, intriguingly, it is possible to expedite the aging
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An article was published in Nature Aging that once again confirms that we are right that we need to develop combination therapies for aging. The article is called “Combinatorial interventions in aging.”
Actually, the question of combating aging is a question of how to find a
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What is the Say Forever Network?
First and foremost, it's the strengthening of the foundation for all life-extension projects. We answer the question: why are they necessary? We don't want to die.
The Say Forever Network offers an opportunity for everyone to participate in the
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If there is no cure for old age, then we are doing something wrong.
What exactly are we doing wrong and what should we be doing? Just good projects in life extension are not enough for us; we need to find the best action.
The best action can only be found in a large open
You might have noticed that I often ask for likes and reposts on my tweets, referring to the struggle between kind and wicked memes in our longevity community. In the field of anti-aging medicine, there are at least three particularly detrimental narratives:
* Aging is solved:
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Why is slowing down aging the most difficult task?
1. Imperfection of biological reactions:
Biochemical processes in the body always produce harmful byproducts. Even the most effective repair systems cannot eliminate all damage, which accumulates and affects aging. Evolutionary
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I haven't seen a better anti-aging project this year. The main thing is that everyone can take part. I pray to the gods that other laboratory animals will appear in the project
Mr. Wormboto selects colchicine as the Million Molecule Challenge intervention of the week at the advice of
@BradStanfieldMD
. Can't wait to see the first edition of the longevity leaderboard!
Help support the Million Molecule Challenge:
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Discussing life extension is essentially a conversation about money. Millions of experiments remain theoretical simply due to lack of funding.
There's also insufficient funding to lobby Congress for life extension initiatives.
Even funding for advocating the necessity of such
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When we find ourselves surrounded by a significant number of people who do not support life extension or notice that numerous life extension projects lack funding, we must recognize that there is a reason for this.
The primary reason is that we have not accomplished crucial
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@elonmusk
needs to stop justifying death. No need to look for reasons to say that death is useful. Death is unacceptable under any circumstances
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If the battle against death is a war, where is the front line?
The front line exists where we reject the acceptability of death.
Who are the combatants in this war against death? Those who identify death as the ultimate enemy. On the other hand, those who do not see death as a
deathism is the most potent of all human ideologies
the acceptance of death is deeply ingrained into each of us from a young age
we are taught that it is natural, inevitable, and even desired
this is why there can be no room for compromise in the fight against death
any
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How can one truly contribute to the life extension movement? You wouldn't believe how many people have sought an answer to this question and how much effort we at
@OpenLongevity
have put into testing various options.
I believe I have found a universal answer: data generation.
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Good article about increasing the lifespan of mice. And a new target
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Under what conditions do you think 1,000 highly skilled individuals could significantly impact the fight against death?
In my opinion, they/we should commit to acting in unison.
The Longevity Community's goal is to elicit a maximum response from society through its actions, to
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Money invested in social changes in favor of life extension is more effective than money invested in the science of life extension. I’ll explain myself. A thread:
(1) Currently, budgets in longevity social changes vs. sciences are 1:100. All the books, videos, and political
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If we hold 12 similar battles over the course of a year, the Longevity field will change dramatically. We need to understand exactly where our differences lie and find the best solutions for creating life extension technologies.
Clash of the Titans: high stakes debate on how to defeat
#aging
Two titans of aging research – Aubrey de Grey and Peter Fedichev – set to take to the floor in landmark debate.
@economy
#longevity
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