New online│ News and Views by Eric Lieberman Greer (
@EricGreerLab
) on the study by Takahashi et al. in
@CellCellPress
reporting a new mouse model with directed DNA methylation to study transgenerational epigenetic inheritance in mammals.
🌞Our August issue is now live 🌞
On the cover:
A new software package to optimize mouse breeding and reduce animal use (research from
@UniCologne
and
@UZH_en
)
#3Rs
#AnimalResearch
Link 👉
We're all familiar with 'wild types' in our lab experiments. But how much do you know about the wild lives of your model organism?
This month, we've (figuratively) gone to Southeast Asia for a look at
#zebrafish
in the field.
✨Our September issue is now live✨
On the cover:
@CarlaBiotech
and colleagues (
@Cresa_r
) provide an overview of the animal models available to study neurological manifestations of the post-COVID-19 condition
#LongCovid
Link 👉
‘Good welfare is good science,’ the saying goes. But how do researchers, veterinarians, and animal care staff refine the lives of their laboratory animals?
✨Our December issue is now live✨
On the cover: Gallas-Lopes, M. (
@MatheusGallasL
), et al. analyze the literature on environmental enrichment for zebrafish and find consistent welfare benefits.
Link👉
#ResearchHighlight
| A study in
@NatureNeuro
describes a strategy to generate several recombinant adeno-associated viruses for selective targeting and manipulation of neuronal subtypes, which holds promise for future therapeutic interventions.
How do you track your animals? Veronica Panadeiro et al. compare 28 freely available animal-tracking software applications, highlighting their strengths and weaknesses from video acquisition to trajectory generation and data analysis.
Full text here:
✨Our May issue is now live✨
On the cover: a N&V discusses recent findings challenging the assumption that female mice should be excluded from research because of their hormonal cycle.
Link👉
We are thrilled to be at the
#Felasa2022
meeting🐟 in Marseille. Looking forward to exciting talks. Find us in person or DM us if you want to chat !
#Felasa
#Congress
Genetically engineered mouse models are advancing.
In a new News & Views, Kirsteen Campbell and
@kblyth1
@CRUK_BI
describe somatic base editing to model oncogenic drivers in
#breastcancer
:
🎃 Our October issue is now live 🎃
On the cover: Two new bioluminescent mouse strains that incorporate bright luciferases allow in vivo imaging with consumer-grade cameras! Nakashiba et al. from
@RIKEN_JP
Link👉
#ResearchHighlight
| In a new study in
@NatureAging
,
@MGodinhoFerr
shows that restoring telomerase in the gut of mutant zebrafish reverses premature aging and increases lifespan. Targeting one organ reverses aging in the whole body!
#Aging
🐠🧬
Highlight👇:
Do you use DREADDS? New research suggests you could replace those IP injections with a micropipette.
Read more in the article: Oral application of clozapine-N-oxide using the micropipette-guided drug administration (MDA) method in mouse DREADD systems
✨Our April issue is now live✨
On the cover:
Medetomidine/midazolam/fentanyl narcosis alters cardiac autonomic tone leading to conduction disorders and arrhythmias in mice by Tomsits et al.
Link 👉
��Our November issue is now live✨
On the cover:
Varshney &
@varshneylab
discuss the use of DNA base editors for human disease modeling in zebrafish.
Link👉
Working with sea urchins and need to sort your females from your males?
@Estef_Paredes
and Damian Costas
@CIM_Uvigo
describe their non-lethal method for sex determination.
#ResearchHighlight
: Recent papers in
@nature
and
@NatureNeuro
are taking a closer look at the brain circuits responsible for mouse behaviors, like fight-or-flight and male aggression.
✨Our February issue is now live✨
On the cover:
Zhang et al. show that transcription factor Egr2 in the medial prefrontal cortex regulates mouse social and cooperative behaviors.
Link👉
Our June issue is now live
On the cover: Zevnik, Jerchow and Buch provide recommendations to implement the 3Rs in every step during the generation of genetically modified rodents.
In a new Perspective, Cassandra Backes
@dan_martimarti
, and
@Cabreiro_Lab
discuss what makes C. elegans a supreme model for the study of microbe–host interactions.
A new review in
@NatureNeuro
this week discusses rodent models of neurodegenerative diseases, with strategies to improve translation and thoughts about the future. Read more:
The
@LA_NatRes
team would like to welcome our newest editor, Ioannis Bakoyiannis!
Ioannis (aka John) is joining us after a PhD at
@univbordeaux
in the field of neuroscience and nutrition. He is based in our Berlin office.
You can follow him at:
@IBakoyiannis
✨Our November issue is now live✨
On the cover:
Anderson et al. compared the metabolic profile of non-fasted vs. fasted plasma samples in the Nile rat model for type 2 diabetes.
Link 👉
Half way through the year! Check out the June issue:
On the cover:
Making the COVID-19 model:
What happens to whistleblowers?:
Pondering the parent trap:
Reminder: Rats *are not* just big mice.
Our August feature covers some of the advantages of rats over their murine cousins and shares resources for those interested in learning more about working with the larger rodent.
☀️August issue is now live☀️
On the cover:
McLeod et al. recorded sound levels and other variables in a nonhuman primate (NHP) animal facility at
@VUMChealth
to describe environmental conditions and best practices for NHP research.
✨Our June issue is now live✨
On the cover: Cage size matters for ammonia levels inside individually ventilated cages. Smaller cages result in higher ammonia levels!
Link👉
MODs in need | Following funding cuts, several model organism databases and the larger efforts that rely on their data are left facing uncertain futures.
Research│New online: Jaric et al. show that heterogenization of study populations by using mice from different breeding sites fails to improve the replicability of results from single-laboratory studies.
Review|
@k_stag
,
@tjsharpton
and Karen Guillemin-
@uoregon
, discuss the strengths of the
#zebrafish
model for
#microbiome
research, and highlight important insights gleaned from observational and manipulative microbiome studies in zebrafish🐠.
#Tbt
Link:👇
#ResearchHighlight
: A new study shows that the mouse cortex is organized in large-scale gradients of structural properties, a hierarchical specialization also observed in primates. Free read here:
Called for duty | Zebrafish and fruit flies can be made quickly and in large numbers. With technologies
that enable the animals to be personalized to a given cancer patient, avatar armies may be rising in the
future.
February is live and the Table of Contents is here:
On the cover: A practical guide to setting up pig models for cardiovascular catheterization, electrophysiological assessment and heart disease research
Do you use isoflurane to anesthetize your mice? Why or why not?
While you're thinking about it, don't miss a revisit of its effect on cardiovascular function:
In a new study,
@FrederikDenorme
et al.
@UUtah
showed that platelet-derived high-mobility group box 1 (HMGB1) protein induces neutrophil extracellular traps formation during
#stroke
in mice🐭. 🧵4/4.
👉
What's the best animal to study
#COVID19
? There likely won't be just one, with different species each contributing in their own way as researchers work to beat the ongoing pandemic.
Our editor Ioannis Bakogiannis (John)
@IBakoyiannis
will be attending the
@FENSorg
Forum 2022 from 9 to 13 of July. Find him in person or DM him/us if you want to chat!🧠
#FENS2022
#Congress
Looking into neuronal activity? A new generation of array-based probes is giving scientists a powerful new tool for addressing tough but essential neuroscience questions.
We have an award-winning
#3Minute3Rs
for June, highlight the recipients of the 2020 3Rs prize. Take a listen to hear about the winning research:
@NC3Rs
@NA3RsC
#KnowYourModel
| There’s growing evidence that sex-based differences can influence phenotypes beyond those directly related to the reproductive system; to fully understand a gene’s function, researchers should consider both male and female subjects.
In a new Review,
@LauraLopezCruzz
and colleagues discuss using touchscreen-delivered cognitive assessments to address the principles of the
#3Rs
in behavioral neuroscience:
April went to the bats!
On
#BatAppreciationDay
, read about the scientists studying bat biology:
And don't miss our latest podcast to hear more about
@bat1kgenomes
:
New research from researchers
@jacksonlab
: Shared and distinctive features of the gut microbiome of C57BL/6 mice from different vendors and production sites, and in response to a new vivarium
February is live and the Table of Contents is here:
Don't miss the cover story, which could you help skip the snip and save the GMs when you have to induce pseudopregnancy in your female mice: