LabAnimal
@LA_NatRes
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Hybrid @SpringerNature journal exploring in vivo science and technology using model organisms of human health & disease
New York / London/ Berlin
Joined March 2016
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✨Our October issue is now live✨
With special content on pig models
On the cover: New method to extend the survival of SCID pigs
Link 👉
0
3
8
Lab Animal is turning 50! To celebrate we have put together a special Anniversary issue. Have a look here:
1
13
44
#ResearchHighlight
| In
@NatMetabolism
, the groups of
@RubenNogueiras
&
@sisi_seoane
(
@cimususc
) show that prolonged breastfeeding in rodents protects offspring against
#obesity
in adulthood via long-lasting effects on the hypothalamus.
#metabolism
Link:👇
1
8
43
Kaska Koltowska
@LymphaticsLab
discusses a paper in
@NatureMedicine
that highlights the role of larval
#zebrafish
in personalized medicine.
Read more:
0
18
39
New online│ News and Views by Eric Lieberman Greer (
@EricGreerLab
) on the study by Takahashi et al. in
@CellCellPress
reporting a new mouse model with directed DNA methylation to study transgenerational epigenetic inheritance in mammals.
1
8
36
#12daysofLabAnimal
🎵
On the fifth day of studies, a plea made loud and free,
Include more female mice in your study!
0
4
34
🌞Our August issue is now live 🌞
On the cover:
A new software package to optimize mouse breeding and reduce animal use (research from
@UniCologne
and
@UZH_en
)
#3Rs
#AnimalResearch
Link 👉
0
10
36
Issue 3 is out online - check out the March TOC here:
And on the cover: Non-invasive drug administration via micropipette
0
11
30
We're all familiar with 'wild types' in our lab experiments. But how much do you know about the wild lives of your model organism?
This month, we've (figuratively) gone to Southeast Asia for a look at
#zebrafish
in the field.
1
12
31
✨September issue is now live✨
On the cover:
@Nuno_H_Franco
and
@VVoikar
give an overview of the
#FELASA2022
meeting and discuss how
#communication
is essential for better
#science
and animal
#welfare
.
Link:👉
0
24
31
✨Our September issue is now live✨
On the cover:
@CarlaBiotech
and colleagues (
@Cresa_r
) provide an overview of the animal models available to study neurological manifestations of the post-COVID-19 condition
#LongCovid
Link 👉
0
9
26
✨Our March issue is now live✨
On the cover:
A mapping review of refinements to laboratory rat housing and husbandry by Neville et al.
Link 👉
0
4
26
‘Good welfare is good science,’ the saying goes. But how do researchers, veterinarians, and animal care staff refine the lives of their laboratory animals?
1
15
26
✨Our December issue is now live✨
On the cover: Gallas-Lopes, M. (
@MatheusGallasL
), et al. analyze the literature on environmental enrichment for zebrafish and find consistent welfare benefits.
Link👉
1
7
24
#ResearchHighlight
| A study in
@NatureNeuro
describes a strategy to generate several recombinant adeno-associated viruses for selective targeting and manipulation of neuronal subtypes, which holds promise for future therapeutic interventions.
0
7
23
New
#Comment
|
@Nuno_H_Franco
and
@VVoikar
summarize the highlights of the
#FELASA2022
meeting 🐟and further explain how
#communication
between all stakeholders is essential to promote better
#science
, education, transparency and animal
#welfare
.
Link: 👇
0
7
22
#ResearchHighlight
| A study from
@TTopilko
and colleagues (
@nicolasrenier
group,
@ParisBrainInst
)
identified that maternal behavior (preparatory nest building) is mediated by peptidergic
#neurons
of a specific
#brain
nucleus in mice🐭. Our highlight here:
1
4
21
#ResearchHighlight
| In
@NatureNeuro
,
@drfadip
,
@drjccruz
and colleagues (
@harvardmed
) report CSF can also exit through skull channels into the skull bone marrow and regulate brain’s
#immunity
in mice🐭.
#neuroscience
#inflammation
.
Our highlight👇
1
3
21
How do you track your animals? Veronica Panadeiro et al. compare 28 freely available animal-tracking software applications, highlighting their strengths and weaknesses from video acquisition to trajectory generation and data analysis.
Full text here:
2
11
21
Sure that your Cre system is working as intended? A new tool published in
@NatureCommunications
can help check.
0
8
17
✨Our May issue is now live✨
On the cover: a N&V discusses recent findings challenging the assumption that female mice should be excluded from research because of their hormonal cycle.
Link👉
3
9
19
We are thrilled to be at the
#Felasa2022
meeting🐟 in Marseille. Looking forward to exciting talks. Find us in person or DM us if you want to chat !
#Felasa
#Congress
0
5
19
#ResearchHighlight
: Floxed fish from Darius Balciunas & colleagues add to the
#zebrafish
toolbox
0
11
20
#12daysofLabAnimal
🎵
On the sixth day of studies, a fact that's plain to see,
Cage size matters as ammonia is smelly!
0
3
19
Genetically engineered mouse models are advancing.
In a new News & Views, Kirsteen Campbell and
@kblyth1
@CRUK_BI
describe somatic base editing to model oncogenic drivers in
#breastcancer
:
0
11
19
🎃 Our October issue is now live 🎃
On the cover: Two new bioluminescent mouse strains that incorporate bright luciferases allow in vivo imaging with consumer-grade cameras! Nakashiba et al. from
@RIKEN_JP
Link👉
0
1
16
#ResearchHighlight
| In a new study in
@NatureAging
,
@MGodinhoFerr
shows that restoring telomerase in the gut of mutant zebrafish reverses premature aging and increases lifespan. Targeting one organ reverses aging in the whole body!
#Aging
🐠🧬
Highlight👇:
1
3
19
#12daysofLabAnimal
🎵
On the third day of studies, refinement for rats came to be,
better husbandry in the laboratory!
0
2
18
New online | Technology features are back in Lab Animal and with an open science theme.
Sharing is caring and we bring the insider's view of many researchers & projects.
@DeepLabCut
@giorgiogilestro
@TReNDinAfrica
@maximoprado
@PRIMatE_RE
@AlikWidge
👇
0
4
16
Do you use DREADDS? New research suggests you could replace those IP injections with a micropipette.
Read more in the article: Oral application of clozapine-N-oxide using the micropipette-guided drug administration (MDA) method in mouse DREADD systems
0
7
17
✨Our April issue is now live✨
On the cover:
Medetomidine/midazolam/fentanyl narcosis alters cardiac autonomic tone leading to conduction disorders and arrhythmias in mice by Tomsits et al.
Link 👉
0
4
15
The results of the
@NC3Rs
cage aggression survey - encompassing 44 facilities and 137,580 mice - have been published in
@SciReports
0
6
16
#12daysofLabAnimal
🎵
On the eighth day of studies, planning brought glee,
A new calculator making breeding easy!
0
4
15
��Our November issue is now live✨
On the cover:
Varshney &
@varshneylab
discuss the use of DNA base editors for human disease modeling in zebrafish.
Link👉
1
5
13
Working with sea urchins and need to sort your females from your males?
@Estef_Paredes
and Damian Costas
@CIM_Uvigo
describe their non-lethal method for sex determination.
0
6
15
#ResearchHighlight
: Recent papers in
@nature
and
@NatureNeuro
are taking a closer look at the brain circuits responsible for mouse behaviors, like fight-or-flight and male aggression.
0
4
15
Can animal models inform us about human models of fear (and vice versa)? Read more in a new Viewpoint from
@NatureNeuro
0
2
15
✨Our February issue is now live✨
On the cover:
Zhang et al. show that transcription factor Egr2 in the medial prefrontal cortex regulates mouse social and cooperative behaviors.
Link👉
0
0
15
Our June issue is now live
On the cover: Zevnik, Jerchow and Buch provide recommendations to implement the 3Rs in every step during the generation of genetically modified rodents.
0
6
15
The February issue is live!
On the cover:
* Making a coral model:
* Microglia, from man to mouse:
* Two model organisms, one lab:
0
6
15
In a new Perspective, Cassandra Backes
@dan_martimarti
, and
@Cabreiro_Lab
discuss what makes C. elegans a supreme model for the study of microbe–host interactions.
0
7
15
New online│ News and Views by
@ana_marta_capaz
&
@nicolasrenier
on the study by
@LoogerL
in
@Nature
showing that GCaMPs keep getting better with unprecedented speed and precision!
#Neuroscience
#Brain
🧠🔬
Link: 👇
0
2
15
A new review in
@NatureNeuro
this week discusses rodent models of neurodegenerative diseases, with strategies to improve translation and thoughts about the future. Read more:
0
5
15
The
@LA_NatRes
team would like to welcome our newest editor, Ioannis Bakoyiannis!
Ioannis (aka John) is joining us after a PhD at
@univbordeaux
in the field of neuroscience and nutrition. He is based in our Berlin office.
You can follow him at:
@IBakoyiannis
1
2
14
#ResearchHighlight
| Karen Crawford
@StMarysMD
has spent 26 summers working with squid
@MBLScience
- those efforts have now led to first CRISPR'd cephalopod.
2
7
14
⭐️April issue is now live⭐️
On the cover: Ober, Ho et al. (
@DrHasanAlam
,
@NorthwesternU
) provide key recommendations to promote
#collaboration
between
#clinician
-
#scientists
and
#veterinary
specialists in translational sciences👩🔬👨🔬
0
4
13
#ResearchHighlight
| In
@Nature
,
@rachelkratofil
from the
@Kubes_Lab
discovered a monocyte-mediated pathway that is critical for wound repair following bacterial
#infection
in mice🐭.
#immunology
@SnyderInstitute
,
@UCalgaryMed
,
@UCalgary
Our highlight 👇
1
1
13
#ResearchHighlight
: Silicon is making its way into biological applications, from Bozhi Tian's lab
@UChiChemistry
@natBME
0
6
12
Our first issue of 2022 is now live! Check out what’s in the January issue here:
And on the cover…a survey on translational research:
0
3
12
✨Our November issue is now live✨
On the cover:
Anderson et al. compared the metabolic profile of non-fasted vs. fasted plasma samples in the Nile rat model for type 2 diabetes.
Link 👉
0
0
13
Half way through the year! Check out the June issue:
On the cover:
Making the COVID-19 model:
What happens to whistleblowers?:
Pondering the parent trap:
0
6
13
Reminder: Rats *are not* just big mice.
Our August feature covers some of the advantages of rats over their murine cousins and shares resources for those interested in learning more about working with the larger rodent.
0
9
13
#ResearchHighlight
|
@dsboothacosta
@BioBoothLab
and
@Choano_Lab
establish a CRISPR approach for genome editing
#choanoflagellates
0
6
12
☀️August issue is now live☀️
On the cover:
McLeod et al. recorded sound levels and other variables in a nonhuman primate (NHP) animal facility at
@VUMChealth
to describe environmental conditions and best practices for NHP research.
0
5
13
✨Our June issue is now live✨
On the cover: Cage size matters for ammonia levels inside individually ventilated cages. Smaller cages result in higher ammonia levels!
Link👉
0
5
12
Our September issue is live:
This month, we are keeping track of animals on the move:
0
1
12
Hello, December (at last?)!
Our next issue will be January 2021 - starting Lab Animal's big 5-0! - but in the meantime, take a look back at 2020:
1
2
12
🌞Our July issue is now live 🌞
On the cover:
A new Protocol for generating the NeoThy humanized mouse model 🐭for
#immune
system studies
Link 👉
0
1
12
MODs in need | Following funding cuts, several model organism databases and the larger efforts that rely on their data are left facing uncertain futures.
0
11
12
Research│New online: Jaric et al. show that heterogenization of study populations by using mice from different breeding sites fails to improve the replicability of results from single-laboratory studies.
0
3
12
Review|
@k_stag
,
@tjsharpton
and Karen Guillemin-
@uoregon
, discuss the strengths of the
#zebrafish
model for
#microbiome
research, and highlight important insights gleaned from observational and manipulative microbiome studies in zebrafish🐠.
#Tbt
Link:👇
0
4
12
#12daysofLabAnimal
🎵
On the twelfth day of studies, joy for all to see,
Environmental enrichment impacts zebrafish, beneficially.
0
2
12
#ResearchHighlight
: A new study shows that the mouse cortex is organized in large-scale gradients of structural properties, a hierarchical specialization also observed in primates. Free read here:
0
9
12
Called for duty | Zebrafish and fruit flies can be made quickly and in large numbers. With technologies
that enable the animals to be personalized to a given cancer patient, avatar armies may be rising in the
future.
1
6
11
February is live and the Table of Contents is here:
On the cover: A practical guide to setting up pig models for cardiovascular catheterization, electrophysiological assessment and heart disease research
0
3
10
May is out and we've got microbes! Check out what's in the issue:
And on the cover: C. elegans to study host-microbe interactions.
0
3
11
Ever onward...April is out!
On the cover:
* Creating cancer avatars:
* Hit the wheel running:
* Research and rehab:
0
3
11
✨Our February issue is now live✨
On the cover: 3D printing of a murine MRI platform
Link:
0
2
11
Our freely available web collection "Focus on
#DiseaseModels
:
#Reproducibility
and Translation" is now live.
0
12
7
Do you use isoflurane to anesthetize your mice? Why or why not?
While you're thinking about it, don't miss a revisit of its effect on cardiovascular function:
0
6
10
Make some time for our January 3-minute 3Rs podcast to learn the latest in 3Rs science and technology. Produced with .
@NC3Rs
0
6
10
#ResearchHighlight
on .
@NatureNeuro
paper: Shaping up 2-photon imaging in vivo Na Ji's lab .
@HHMIJanelia
0
5
8
In a new study,
@FrederikDenorme
et al.
@UUtah
showed that platelet-derived high-mobility group box 1 (HMGB1) protein induces neutrophil extracellular traps formation during
#stroke
in mice🐭. 🧵4/4.
👉
1
4
10
#ResearchHighlight
| Non-spatial cues precede spatial attributes in memory retrieval! Using two-photon imaging in mice,
@hr_chang
@mohajerani77
and colleagues shed light on neocortex-hippocampus dynamics. 🧠🐭
#Memory
Highlight👇:
1
1
9
What's the best animal to study
#COVID19
? There likely won't be just one, with different species each contributing in their own way as researchers work to beat the ongoing pandemic.
0
4
10
#12daysofLabAnimal
🎵
On the first day of studies, Labanimal showed to me,
a mouse with a septic knee!
0
0
10
Our editor Ioannis Bakogiannis (John)
@IBakoyiannis
will be attending the
@FENSorg
Forum 2022 from 9 to 13 of July. Find him in person or DM him/us if you want to chat!🧠
#FENS2022
#Congress
0
0
10
#ResearchHighlight
on .
@doudna_lab
.
@NatureBiotech
work: Cas9 complex for direct gene editing in adult neurons
0
9
10
Looking into neuronal activity? A new generation of array-based probes is giving scientists a powerful new tool for addressing tough but essential neuroscience questions.
0
4
9
#ResearchHighlight
Do your
#labanimals
move too much under your microscope? Dirk Albrecht's lab has a new approach for keeping them still, published in
@CommsBio
0
8
9
0
3
9
0
5
9
We have an award-winning
#3Minute3Rs
for June, highlight the recipients of the 2020 3Rs prize. Take a listen to hear about the winning research:
@NC3Rs
@NA3RsC
0
3
9
#KnowYourModel
| There’s growing evidence that sex-based differences can influence phenotypes beyond those directly related to the reproductive system; to fully understand a gene’s function, researchers should consider both male and female subjects.
0
5
9
#12daysofLabAnimal
🎵
On the fourth day of studies, mouse insights were gained, you see,
Anesthesia impacts heart electrophysiology!
0
1
9
In a new Review,
@LauraLopezCruzz
and colleagues discuss using touchscreen-delivered cognitive assessments to address the principles of the
#3Rs
in behavioral neuroscience:
0
5
8
#12daysofLabAnimal
🎵
On the ninth day of studies, for studying post-covid we guarantee,
Animal models are the key!
0
4
9
April went to the bats!
On
#BatAppreciationDay
, read about the scientists studying bat biology:
And don't miss our latest podcast to hear more about
@bat1kgenomes
:
0
5
9
And we are on to August! Check out what's in the issue:
And on the cover, Automated recording in the home cage:
0
2
9
0
6
9
New research from researchers
@jacksonlab
: Shared and distinctive features of the gut microbiome of C57BL/6 mice from different vendors and production sites, and in response to a new vivarium
0
2
9
February is live and the Table of Contents is here:
Don't miss the cover story, which could you help skip the snip and save the GMs when you have to induce pseudopregnancy in your female mice:
0
3
8