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Yuji Uehara, MD Profile
Yuji Uehara, MD

@DrYujiUehara

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341
Following
267
Media
61
Statuses
250

Medical Oncologist (National Cancer Center 🇯🇵)/ Precision medicine, Lung cancer, Early drug development/ JSMO social media committee

Tokyo, Japan
Joined April 2023
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@DrYujiUehara
Yuji Uehara, MD
10 months
Delighted to present my oral presentation on “Pan-Cancer Analysis of 4-1BB Transcriptome Expression and Its Impact on Outcome in Patients Treated with ICIs” in the Developmental and Precision Medicine session at #ESMOAsia23 . Special thanks to @Dr_R_Kurzrock & @myESMO !
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@DrYujiUehara
Yuji Uehara, MD
6 months
2023年の駒込病院 @komagome_tmhp の最優秀英文論文賞を受賞しました。駒込病院、NCCには感謝の気持ちで一杯です。戸井院長のお言葉のように、論文はIF 20辺りに壁があると感じますが、4月以降は、ワクワクして、長期的に患者さんと社会に貢献できる、本質的な研究へシフトしていきたいです!
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@DrYujiUehara
Yuji Uehara, MD
10 months
My mentee’s poster was selected as the best poster. Extremely happy!! @myESMO #ESMOAsia23
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@DrYujiUehara
Yuji Uehara, MD
7 months
🔥 HOT OFF THE PRESS from our study @JTOonline : the timing of ICI infusions may affect survival in locally advanced NSCLC patients. Early infusions lead to better outcomes than late ones. A first look at ICI chrono-modulation in non-metastatic cancers. 🕒
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@DrYujiUehara
Yuji Uehara, MD
5 months
🚀 Exciting news! Building on our research (JAMA Netw Open), National Cancer Center Hospital, Chugai Pharma, Osaka Medical and Pharmaceutical University, & MICIN launched Japan's first company-sponsored Phase I oncology decentralized clinical trial.
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@DrYujiUehara
Yuji Uehara, MD
7 months
Fantastic talk with Dr. @DoctorJSpicer & Dr. Maqueda on preoperative RWD cases in Canada. Incredibly insightful for thoracic surgeons and medical oncologists. Honoured to meet you both! @haigan_geka
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@DrYujiUehara
Yuji Uehara, MD
7 months
中外創薬科学財団の2024年度奨学金を受賞しました。4月からの本庄国際奨学財団 と重複受給になるため、辞退しますが、今までやってきた研究の方向性や努力が認められたことは、とても嬉しいです。国立がん研究センター、駒込病院、医科歯科の関係者には感謝申し上げます。
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@DrYujiUehara
Yuji Uehara, MD
8 months
4月からの本庄国際奨学財団の28期奨学生(日本人国内大学院生)に選ばれました。毎年、60倍程度の倍率で、国立がん研究センター東・中央病院、駒込病院、医科歯科の様々な先生方のご指導とご支援の賜物で、感謝いたします。
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@DrYujiUehara
Yuji Uehara, MD
9 months
@shinkato_unagi @LargeRicefields リード数が少ない場合、splice donor siteに近いhomopolymeric site (TTTT)のエラーが、誤ってex14 skippingのmutationsやindelとcallされたみたいです。先生のご指摘の通り、exon14 skip の偽陽性は珍しい事象なので、肺癌で一番権威のある雑誌に詳細が掲載されています。
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@DrYujiUehara
Yuji Uehara, MD
10 months
🔬 Key Findings on Pathogenic Germline Variants (PGVs) in Lung Cancer: 1. 15% of patients have PGVs. 2. PGV frequency isn't impacted by family or personal history of other cancers. 3. 60% of PGVs are in actionable DNA damage repair genes. @JCO_ASCO #LCSM
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@DrYujiUehara
Yuji Uehara, MD
7 months
腫瘍内科医はこうあるべき!みたいに学生時代は思っていましたが、本当はそうでなくて、がん患者さんのためというマインドセットのもと、色んな道や役割があって、その多様性が腫瘍内科医の魅力であることを本動画で伝えたいです。(この動画で紹介しきれないキャリアも含めて)
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@DrYujiUehara
Yuji Uehara, MD
7 months
Thrilled to announce that I've been awarded a grant by Chugai Pharma as a PhD candidate! It's an honor to receive this prestigious support, and I'm incredibly grateful for the opportunity.
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@DrYujiUehara
Yuji Uehara, MD
7 months
Exploring De Novo EGFR T790M in NSCLC🇨🇳: ・Found in ~1% of NSCLC. ・ Coexists with L858R mutation ➔ 🔽 outcomes with 3rd-gen TKIs. ・Alone, de novo T790M's oncogenicity is limited, but increases with common EGFR mutation. What's its mechanistic role ? 🤔
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@DrYujiUehara
Yuji Uehara, MD
1 year
Key findings on EGFR T790M carriers: ・> 50% diagnosed with lung cancer by 60. ・Lung nodules common in non-cancer patients. ・They often have somatic EGFR mutations. ・Study lacked Asian participants; more research needed. ・EGFR-TKI might be a risk-reducing strategy.
@JCO_ASCO
Journal of Clinical Oncology
1 year
🙌 Germline #EGFR mutations and familial lung cancer 👉 #LungCancer #lcsm
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@DrYujiUehara
Yuji Uehara, MD
1 year
Wow, the NCI is exploring both ImmunoMATCH and ComboMATCH! In my opinion, we should make use of not just in vitro data but also human studies like I-PREDICT or OmniSeq analysis led by @Dr_R_Kurzrock to select drug combinations.
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@NCItreatment
NCI Treatment
1 year
"The New NCI Precision Medicine Trials" - just published in @CCR_AACR on the latest precision medicine efforts @theNCI . You can read about these 2nd generation precision medicine trials - ComboMATCH, iMATCH, and myeloMATCH - here: #CancerResearch #NCTN
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@DrYujiUehara
Yuji Uehara, MD
7 months
@m0370 取り上げて頂き、ありがとうございます。多くの交絡因子や出版バイアスがありますが、今回の結果は自分達も驚いていて、過去の同様の報告や基礎的な面も併せると、免疫治療のchronotherapy を再考する余地は大きいと思っています。同テーマのTR研究は欧米のグループがもうすぐ論文に出すようです。
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@DrYujiUehara
Yuji Uehara, MD
1 year
Our research, published in @JAMANetworkOpen , was featured in The ASCO Post News—a great honor. We found that longer travel times reduced the likelihood of patients participating in genotype-matched trials. via @ascopost
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@DrYujiUehara
Yuji Uehara, MD
8 months
Sotorasib, the Poster Child for Project Optimus: Truths & Fantasies 🧐. Outside the US, given PK, efficacy, cost (national health insurance) & toxicity, opting for 240mg seems a wise choice 💡. A single 960mg ($21,000/mo) prescription could last 4 months.
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@DrYujiUehara
Yuji Uehara, MD
8 months
Very Important research by Dr. @mollylisc from 🇭🇰: Recurrent ILD 🫁 risk higher with Osi rechallenge (63%) vs. erlotinib (11%). Clinically Relevant for 🇯🇵 pts. Erlotinib suggested for Osi-induced ILD. @JTOonline
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@DrYujiUehara
Yuji Uehara, MD
10 months
The cost of 3.5-year recent cancer drugs ($700,000) is approximately half of the average lifetime salary in Japan. It’s unsustainable for our national health care system to provide these novel drugs to all patients. Younger generations will bear the burden.
@JAMANetworkOpen
JAMA Network Open
10 months
Findings of this study indicate that the median annual price of anticancer drugs in the US is not associated with the novelty of their mechanism of action.
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@DrYujiUehara
Yuji Uehara, MD
7 months
本日、私が今年の主幹事を務める筑駒医師の会の引き継ぎがありました。大学、がんセンター、海外どこ行っても、活躍しているOBが沢山います!創立20周年かつ1000人近いコミュニティになっていますが、もっと内部の繋がりを強くして、ITやバイオ系とのコミュニティとも繋がってもいければと思います。
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@DrYujiUehara
Yuji Uehara, MD
10 months
@yusuke_mazda 強く同意します。日本臨床腫瘍学会のsns委員会をやっているのですが、そこの違いが大きな根底にあって「学会の写真解禁、SNS投稿」もなかなか進まなかったり、海外学会同様のことを行う障壁になっている感じています(投稿の責任の所在と連絡先が不明)。
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@DrYujiUehara
Yuji Uehara, MD
5 months
とてもまとまっていて、勉強になります。本邦の学会でもSNS投稿解禁が増えてきて、必読と思います!学会のSNS-WGに複数関わっていますが、学会が色々細かいルールを決めるより、会員一人一人が自身の責任で著作権を勉強することが大事に思います。
@GtoDr
GoTO
5 months
研究と著作権についてまとめました。基本的事項からブログやSNSでの論文紹介など、弁護士にも聞いて作成しましたが、明瞭な線引きはありません。AI時代だからこそ、著作権を改めて知ることは大事です。 研究と著作権:SNSやブログ、学会で困らないために @GtoDr #note
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@DrYujiUehara
Yuji Uehara, MD
7 months
@DrewMoghanaki @dramycummings @n8pennell @DoctorJSpicer @FordePatrick @charlesrudin @JieDengMDPhD @StephenVLiu Thank you so much for taking an interest in our study! Despite confounding factors and potential publication bias, the consistent findings from basic and clinical research make exploring the mechanism of ICI chronotherapy a worthwhile endeavor.🔍🕰️
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@DrYujiUehara
Yuji Uehara, MD
1 year
The abstract, "Pan-cancer analysis of 4-1BB transcriptome expression and its impact on outcomes with ICIs," was chosen for a mini-oral and ESMO Asia travel grant. Thrilled! Huge thanks for the incredible opportunity and support @Dr_R_Kurzrock @OmniSeq @zacksurg @jacobadashek
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@DrYujiUehara
Yuji Uehara, MD
8 months
A new WHO🌍 report reveals lung cancer as the top global cancer (2.5M new cases 📈) & leading in deaths (1.8M📈). Notably, it's the 2nd most common cancer among women👩 in both cases & deaths. A lesser-known fact many are unaware of. #lungcancer #LCSM
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@DrYujiUehara
Yuji Uehara, MD
7 months
🔍 The cfDNA & multitarget stool DNA tests in NEJM are buzzing topics! While sensitivity for precancerous lesions is low, tech brilliance 🧠 will solve this challenge. Should this breakthrough hit lung cancers, how to intervene with premalignancy becomes crucial for patients.🫁
@drgandara
David Gandara
7 months
Hot off the press! “Multi-omics” approach (genomics, epigenomics, proteomics) to plasma testing proves effective in colorectal cancer screening. Hoping same will be seen in other cancer types @NEJM @ASCO @isliquidbiopsy
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@DrYujiUehara
Yuji Uehara, MD
8 months
490 NSCLC pts in NGS Testing at Tempus Labs.🧬 Variant Concordance: 66%. Unique variants: 29% found in tissue, 5% in ctDNA➡️Most assay-unique variants (>70%) detected by tissue testing. 📌Tissue is Still the issue in NSCLC! @JAMANetworkOpen
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@DrYujiUehara
Yuji Uehara, MD
8 months
My colleague, Dr. Kato from National Cancer Center Hospital East, will discuss the efficacy of ICI+chemo doublet vs. chemo for HER2-mutant NSCLC (268 pts) at LC-SCRUM Asia (15,251 pts). He'll address a crucial question 🤔: the optimal 1st-line Tx for HER2-mutant NSCLC. #JSMO2024
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@DrYujiUehara
Yuji Uehara, MD
8 months
🎉 Excited to share I've been selected for the Honjo International Scholarship Foundation's 28th cohort!! With a 1 in 60 acceptance rate, it's a prestigious honor. Huge thanks to the National Cancer Center, Komagome Hospital, and TMDU for their support.
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@DrYujiUehara
Yuji Uehara, MD
8 months
⭐️JSMO2024 Early Career Oncologist Lounge @JSMO_official 📣You can meet Dr. Lynn M. Schuchter @ASCOPres , President ASCO @ASCO , to ask questions, network, and receive career advice in the field of oncology. 🗓️Feb 23, 11:30~12:30 #JSMO2024
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@DrYujiUehara
Yuji Uehara, MD
8 months
@shinkato_unagi De novo, Acquired共にMET AMPに関しては1.有効性の問題と2.MET AMPのcut off がはっきしてない問題だと思います。MET exon 14 skippingはORR 40-60%あるのに、MET AMPは1st lineからORR 20-30%程度ですので、1・2共にまだ改善の余地が大きいと思います。
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@DrYujiUehara
Yuji Uehara, MD
7 months
My twin brother, a researcher in Dr. Aviv Regev's Lab at Genentech (gRED) 🧬, is seeking a summer research intern. 🌟 There are numerous opportunities for top journal publications, combining AI with biology/medicine for drug discovery 🧪
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@DrYujiUehara
Yuji Uehara, MD
8 months
🔬Research from the Breast TRACERx study on TNBC 🎀reveals that chromosomal instability🧬 (marked by a high frequency of LOH and WGD) leads to diverse subclones and immune evasion through mechanisms like HLA LOH and ecDNA-driven immune suppression. @AACR
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@DrYujiUehara
Yuji Uehara, MD
1 year
The RAGNAR study underscores the clinical benefits of selective FGFR inhibitors in a tumor-agnostic context, yet the ORR remains at 30%. Our findings @Dr_R_Kurzrock @jacobadashek suggest that targeting co-alterations, such as FGFR and CDK4/6, could potentially enhance efficacy.
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@TheLancetOncol
The Lancet Oncology
1 year
NEW: In the RAGNAR single-arm ph2 trial of erdafitinib in pts w/ adv solid tumours with FGFR alterations, an objective response was seen in 64 (30% [95% CI 24–36]) of 217 patients across 16 distinct tumour types (median FU 17·9 months [IQR 13·6–23·9]).
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@DrYujiUehara
Yuji Uehara, MD
8 months
JSMOのメンバーとして、参加しましたが、とても良いイベントでした!日頃、交流の少ない地域や他分野の先生方から色々なアイディアやアドバイスを頂き、夜は理事長達や一線で活躍されている研究者と、夜遅くまで語り合う熱いイベントでした🔥これからも続いてほしいです。 @JSMO_official @jcaopl
@JSMO_official
日本臨床腫瘍学会(JSMO)
8 months
日本癌学会様( @jcaopl )より「💫がん関連三学会Rising Starネットワーキング💫」のご報告記事が紹介されております。 このイベントは日本癌学会,日本癌治療学会,日本臨床腫瘍学会の3学会合同で開催されました。 ぜひぜひご覧ください✨⭐️🌟 #JSMO
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@DrYujiUehara
Yuji Uehara, MD
1 year
Abstract titles for #ASCO23 released @ASCO Will be presenting a poster on our data from @NccriOfficial on "Impact of patient travel time on disparities in precision oncology clinical trials." I'm excited to attend the annual meeting in Chicago!
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@DrYujiUehara
Yuji Uehara, MD
1 year
I just rewatched Chris Abbosh's keynote lecture on Molecular Minimal Residual Disease and Early Detection. The concept of combo of ctDNA and pCR status, as well as TNM(B) staging, is very insightful. #ASCOBT23
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@DrYujiUehara
Yuji Uehara, MD
8 months
@m0370 FDA は患者さんに早く薬を届けるために、1. Phase 1/2有効性でaccelerated approva l→ 2. Phase 3 or 長期フォローで後にtraditional approvalなので、逆に後者の承認を受けた希少ドライバーへの分子標的薬は今までRETぐらいで、殆ど無いと思います!(それにMETが加わった)
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@DrYujiUehara
Yuji Uehara, MD
8 months
@shinkato_unagi @LTK81872901 横から失礼します。連携施設からCGP紹介後(国がん中央の我々の研究)では、「併存疾患、治療中、PS不良」が治験を提案できない理由になります。 その前の段階では、ご指摘のとおり、病勢進行・地理的要因がより上位にランクすると考えており、後者は大きな課題だと思います。
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@DrYujiUehara
Yuji Uehara, MD
1 year
Methylation subtypes reveal cell origin and tumor phenotype. Using them as MRD markers, we could pinpoint SCLC transformation or recurrence sites.
@Cancer_Cell
Cancer Cell
1 year
Online Now: Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
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@DrYujiUehara
Yuji Uehara, MD
10 months
Great summary of MCED: Over half of the patients with positive results in recent studies had no discernible cancer, yet they faced numerous risks of diagnostic procedures. This highlights a significant unmet need in MCED. @ASCO Daily News
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@DrYujiUehara
Yuji Uehara, MD
1 year
Must read for young physician-scientist. "Young investigators in particular might have the greatest impact probing deeply Check for updates nature cancerTurning points where there is space to grow. Even graveyards, left fallow, can be fertile fields."
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@DrYujiUehara
Yuji Uehara, MD
5 months
Why Osaka Medical and Pharmaceutical University (OMPU) is chosen as a satellite🏥? Find out in our prior paper. With a travel time of over 2 hours from OMPU (Osaka) to NCCH (Tokyo), Decentralized Clinical Trials could significantly reduce travel burdens.
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@DrYujiUehara
Yuji Uehara, MD
7 months
@StephenVLiu Thank you so much for tweeting about our study! Although there are many confounding factors and potential publication bias, it's worthwhile to investigate the mechanism of ICI chronotherapy.
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@DrYujiUehara
Yuji Uehara, MD
1 year
Our new @ASCO #ASCO23 abstract released today asks an important question in the era of precision oncology: "Do regional disparities create inequities in precision oncology?" → YES. DCT (decentralization of clinical trials) is needed. to solve the problem.
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@DrYujiUehara
Yuji Uehara, MD
6 months
@GtoDr 勉強になります。楽しみにしています。ありがとうございます!
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@DrYujiUehara
Yuji Uehara, MD
1 year
Check out our editorial on ICI therapy for fusion-positive NSCLC (IMMUNOTARGET registry). It highlights the ineffectiveness of ICI in ALK/RET/ROS1 fusions and emphasizes the importance of accurate diagnostic methods for these rare subsets to avoid false positives by IHC or FISH.
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@DrYujiUehara
Yuji Uehara, MD
7 months
Reflex testing has boosted the success rate of DNA tissue-based molecular testing 🫁. Japan lacks such a system, requiring oncologists to manually order tests via paperwork each time. We need the system to ensure Right drug-Right patient-Right time. #LCSM
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@DrYujiUehara
Yuji Uehara, MD
1 year
🔥🚨Hot off the press👉Increased travel time was associated with a reduced chance of genotype-matched trial participation after CGP testing. 👉Regional disparities in precision oncology👉Need for solutions like DCT to ease the travel burden.
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@JAMANetworkOpen
JAMA Network Open
1 year
Longer travel times were associated with a decreased likelihood of participation in genotype-matched trials. Regional disparities perpetuate inequities in #PrecisionOncology . @DrYujiUehara @NccriOfficial
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@DrYujiUehara
Yuji Uehara, MD
1 year
In the upcoming NCI-ComboMATCH trial, combinations are limited to 'targeted therapies'. While I concur with the importance of exploring combinations with immunotherapies, I'm concerned about potential toxicity variations across different tumor types.
@ArndtVogel
Arndt Vogel
1 year
The NCI-MATCH trial: lessons for precision oncology @NatureMedicine 👏Very innovative 👉1,593/6,000 pts assigned to 38 subtrials 👍pos. signal in 7/27 subtrials 👉Proof of concept > we need to continue this pass to improve outcome & tackle 💊resistance
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@DrYujiUehara
Yuji Uehara, MD
8 months
@slimshady__7 ですよね。グローバルへのインパクトもないでしょうし。。最近、中国も髄膜転移に対して、オシメルチニブ倍量をretrospectiveでまとめたstudyを出していましたよね。日本は用量を下げる試験は進む一方、用量を上げるような試験は聞いたことないんですが、何かありましたっけ?
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@DrYujiUehara
Yuji Uehara, MD
1 year
Due to a high treatment-related death rate (7.4%, n = 11/148) in an early-terminated trial, Japanese oncologists are wary of using the 9LA regimen (platinum-doublet 2 cycles with nivolumab + ipilimumab) for metastatic lung cancer.
@StephenVLiu
Stephen V Liu, MD
1 year
Interesting letter to the editor @Annals_Oncology reports high rate of cytokine release syndrome #CRS and irAEs with nivolumab + ipilimumab for NSCLC in Japan. JCOG2007 trial stopped for high rate of treatment-related deaths. Pharmacogenomic differences?
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@DrYujiUehara
Yuji Uehara, MD
1 year
Read our editorial on BRAF RNA expression in lung adenocarcinoma. Approximately 75% of LUAD patients displayed 🔼 BRAF RNA expression, correlating with 🔽 prognosis to platinum doublet therapy. A deeper grasp of RNA expression beyond DNA is needed.
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@DrYujiUehara
Yuji Uehara, MD
8 months
@mollylisc @JTOonline In our institution, we frequently transition from Osi to Afa or Gefi because we experience a higher incidence of severe ILD associated with the Osi rechallenge. This anecdotal evidence is confirmed in your paper!!
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@DrYujiUehara
Yuji Uehara, MD
11 months
@nextommysuke @slimshady__7 約60%のプロトコール内のクロスオーバーに加えて、15%はプロトコール外で、selective RET inhibitorをtrial外で使ってる記載があるので、68人の中で75% (51人くらい?)と比較的高いクロスオーバー割合だと思います。残りは先生方のおっしゃる通り、有害事象や脳転移によるPS低下とかでしょうか。
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@DrYujiUehara
Yuji Uehara, MD
1 year
Just out! We reported the successful treatment of ALK+ LCNEC with sequential ALK inhibitors. Emphasizing the importance of NGS for LCNEC patients, especially younger patients. #LCSM @JTOonline
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@DrYujiUehara
Yuji Uehara, MD
1 year
Kudos to our department for this exceptional research demonstrating the importance of the genomic screening project in Asia (LC-SCRUM Asia).
@StephenVLiu
Stephen V Liu, MD
1 year
Data from LC-SCRUM-Asia @JTOonline describes #BRAF mutant NSCLC. Overall, 3.5% had a BRAF mutation (30% of which were class 1: V600E). mPFS with chemotherapy 11.5m and mOS 34.8m. Non-V600E mutations were more common in this Asian cohort.
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@DrYujiUehara
Yuji Uehara, MD
1 year
Physician motivation and knowledge gaps between referring and early drug development doctors are significant barriers to enrollment. We need a system to identify and prioritize patients for referral.
@JAMAOnc
JAMA Oncology
1 year
Molecular targeted trial w/identified potentially eligible patients within feasible distance failed to enroll; findings raise the hypothesis that the biggest barrier to enrollment is motivation of treating physicians.
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@DrYujiUehara
Yuji Uehara, MD
8 months
4月からは国立がん研究センターがん進展研究分野の吉田健一先生のLabで、肺の前がん病変〜正常組織の研究を行います。将来的には、非喫煙者の肺がん根治を目指して、前がん病変段階からの個別化介入を目指したいと考えています。(腫瘍内科専門医のトレーニングは継続します)
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@DrYujiUehara
Yuji Uehara, MD
8 months
@akihiro_ohba @MamMa_mimumemo 大場先生 ありがとうございます。勝手ながら、いつも国際的なご活躍拝見してて、尊敬してて、やる気をもらっています。JSMOがアジアで一番の学会を目指すには、ASCO/ESMO同様のSNS活動盛り上げが必須と考えています。よろしくお願いします!
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@DrYujiUehara
Yuji Uehara, MD
7 months
🔍 Interesting study: The number of ctDNA mutations, plasma DNA concentration, and clinical factors can predict outcomes in RRMM. TP53 mutation has different meanings between BMPC and ctDNA. We may say the same thing in the lung cancer space. 🫁
@kataoka_lab
Keisuke Kataoka Laboratory(片岡 圭亮 研究室)
7 months
Happy to share our latest paper from @BloodJournal . @yasunori_kogure and colleagues analyzed relapsed/refractory #multiple_myeloma (RRMM) and found that molecular profiling with #ctDNA mutations can enhance patient management strategies for RRMM.
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@DrYujiUehara
Yuji Uehara, MD
8 months
@M_Torasawa @waraonc23jp 楽しみです☺ ぜひお願いします!!
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@DrYujiUehara
Yuji Uehara, MD
1 year
@waraonc23jp I'm also attending ASCO. Let's connect and catch up in person!
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@DrYujiUehara
Yuji Uehara, MD
1 year
Insightful summary on cancer screening status. PATHFINDER study shows MCED test detected cancer in 1.4% of 6,621 people, but only 38% of positives were confirmed - a high false-positive rate. Much work needed for clinical implementation."
@NatureMedicine
Nature Medicine
1 year
Clinical trials assess a precision-medicine approach to cancer screening. News feature from @sofiamoutinhoBR , part of our focus on Building Healthy Populations.
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@DrYujiUehara
Yuji Uehara, MD
1 year
Just found out my high school classmate authored this paper. Incredible!
@NatureMedicine
Nature Medicine
1 year
News and Views: @masakanai explains how fine-scale population structures can unveil crucial insights into healthcare disparities. Part of our focus on Building Healthy Populations. @broadinstitute @MGH_RI
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@DrYujiUehara
Yuji Uehara, MD
10 months
@waraonc23jp @TheLancetOncol 凄いです。とても貴重なstudy ですね。おめでとうございます!
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@DrYujiUehara
Yuji Uehara, MD
1 year
Early-Stage Lung Cancer: Using Circulating Tumor DNA to Get Personal. . ・Two ways: Tumor-informed (NGS) vs. Tumor-agnostic (DNA methylation, cfDNA fragmentation). ・ Most NSCLC studies used the former way. ・ Main issue: Low negative predictive value.
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@DrYujiUehara
Yuji Uehara, MD
7 months
大きく分けてDBの信頼性は1. 治験統合DB>2. 臨床試験統合DB/薬事承認レジストリー>3. 前向きレジストリー>4. カルテデータで、自分が使用しているDBは1.はCSDR、2.は日本肺癌学会のJIDB、3. LC-SCRUMですが、解析実務者と解析立案者のブラインドが正しいのか?ジレンマは常に感じます。
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@DrYujiUehara
Yuji Uehara, MD
1 year
Must read on the integration of AI and conventional statistical methods. Many formats of protocols focus solely on conventional stats, which can be frustrating sometimes. 'Where Medical Statistics Meets Artificial Intelligence' | NEJM "
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@DrYujiUehara
Yuji Uehara, MD
8 months
@mollylisc @JTOonline Kudos to you!! I hope we can collaborate in the future. Please let me know if you need a cohort from Japan!
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@DrYujiUehara
Yuji Uehara, MD
1 year
Facing hurdles in MCED🩸: 1️⃣ Blood sampling skews towards hematologic cancer signals. 2️⃣ Most detected solid tumors: late-stage or recurrent. 3️⃣ Many positive results, but no identified cancer. 4️⃣ Only <1/3 of cancers diagnosed were detected by MCED.
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@DrYujiUehara
Yuji Uehara, MD
7 months
@M_Torasawa 言及、ありがとうございます。これは知らなかったです。皆、自分の詳しくない研究分野があると思いますので、スクリーニングやインプットスピードを上げることに、とても役立ちますね!
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@DrYujiUehara
Yuji Uehara, MD
8 months
Men face a higher risk of lung cancer from household PM2.5 exposure than women, including in Asia. Last year, @CharlesSwanton reported the link between PM2.5 and EGFRm NSCLC. Yet, unknown factors may increase women's risk for this cancer @JTOonline #LCSM
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@DrYujiUehara
Yuji Uehara, MD
10 months
@stephanieplsaw @danieltanmd Congratulations on your paper! The focus on not only MRD but also accessibility is excellent, and the findings are highly relevant to many Asian countries!! Is monitoring tumor markers a common practice in SG? (It's a standard in Japan.)
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@DrYujiUehara
Yuji Uehara, MD
7 months
@waraonc23jp 全然、先生には及ばないですが、ありがとうございます。全体的な日本の研究環境や研究の価値の低下は止まらないと思うので、自分の領域では 1. 国際的に、2. 重要かつ面白いクエッション、3. スピード感で工夫していけたらと思っています!また色々ご指導頂けると幸いです。
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@DrYujiUehara
Yuji Uehara, MD
8 months
@slimshady__7 まとめ、ありがとうございます。ALINAの日本人subsetはdose reductionが多かったとの噂も聞きましたが、こういう研究見ると、日本だけadjuvant settingでは600 mg BID, metastatic settingでは300 mg BIDみたいな逆バージョンの良く分からない状態になることを懸念しています。。
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@DrYujiUehara
Yuji Uehara, MD
1 year
🔬Outstanding paper: In allogeneic CAR T cells, 3 genes were silenced via base editing: 1. T-cell receptor β chain: Reduces T-cell receptor expression & graft-versus-host effect. 2. CD52: Enables anti-CD52 immunosuppression. 3. CD7: Targets only tumors, not CAR T cells themselves
@NEJM
NEJM
1 year
Original Article: Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia Science behind the Study: Engineering CAR T Cells for Off-the-Shelf Use
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@DrYujiUehara
Yuji Uehara, MD
7 months
@M_Torasawa 二極化は駒込とNCCEもそうですね!NCCEは別の独自ファクターを提供できる気もします笑 同時発表は、先生ならすぐだと思うのですが、そのお気持ち分かります😆 一方で、ASCOで採択されて、その反響も含めて、より良い雑誌に引っ掛かったということもありそうですよね🤔
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@DrYujiUehara
Yuji Uehara, MD
1 year
@waraonc23 Sure. Looking forward to seeing your IDO1 poster!! Actually, I'm working on a similar project targeting 4-1BB with Dr.Kato.
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@DrYujiUehara
Yuji Uehara, MD
8 months
@shinkato_unagi ご指摘のように、EGFR患者のTKI後のMET AMPに対するMET inhibitorsがORR 30-40%で、現状は一番可能性あると思います!といっても、肺がん領域で単armで承認するほどの有効性とは言えず、mPFSも5ヶ月程度で標準療法のプラチナ併用療法に勝てるか怪しく、有効性・カットオフ共に課題ありだと思います。
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@DrYujiUehara
Yuji Uehara, MD
7 months
@herbloong @JSMO_official @ToshioShim1025 @apoddc Thanks a lot for your excellent talk!! It was a pleasure meeting you, and I'm so happy to see you enjoying the misonikomi udon😆. Let’s keep in touch.
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@DrYujiUehara
Yuji Uehara, MD
1 year
@waraonc23jp 外来通院する体力がない患者さんは、抗がん剤の適応がないのが原則だと思いますので、本来はそうあるべきですよね��普通に入院でもできるとなると、通院や介護負担の面で患者/家族には良い面もあると思いますが、最初の前提が疎かな状態で抗がん剤が使用されてるのではと感じるときもあります。
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@DrYujiUehara
Yuji Uehara, MD
8 months
@m0370 そのaccelerated とtraditional approvalsの線引きは、恣意的な部分とも思います。肺癌の分子標的薬��accelerated approvalsを企業が撤回する/FDAにさせられる例は少なそうですが、武田のEGFR exon20挿入mobocertinibみたいな撤回例もあり、皆保険制度では難しそうですよね。
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@DrYujiUehara
Yuji Uehara, MD
7 months
今日は本セミナーを聴講しました。薬事利用のDB活用に当たり、臨床家/統計家/規制当局かの第一人者から、統計から実務的な話まで詳細に聞けて、非常に勉強になりました。私も詳細は知らなかったのですが、身近に先進的な取り組みをやってる機会に触れられるのが国がん研修の魅力だと思います。
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@DrYujiUehara
Yuji Uehara, MD
8 months
@waraonc23jp ありがとうございます。先生のご投稿、とても勉強になると共に刺激になっています。今年のASCOも出したので、もし採択されたらまた直接お会いしたいです!よろしくお願いします。
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@DrYujiUehara
Yuji Uehara, MD
7 months
@RIHigashiyama それはOKなはずですが、それすら日本の学会はグレーな雰囲気ですよね。著作権、肖像権、抄録/スライド権利承諾の問題、問題が起こった時の責任所在など、細かい点で色々詰めるところはあるのですが、今やってるJSMO SNS-WGとしてはASCO/ESMO同様の全面解禁に全力で動いてます!
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