Alireza Mansouri
@DrAMansouri
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Neurosurgeon, Scientist. Entrepreneur. Focused on clinical trials for brain cancer and ways to simplify the process for patients. Opinions my own
Pennsylvania, USA
Joined May 2018
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In neurosurgery there are days that remind you life can change in an instant, and that one should enjoy every moment.
2
24
213
Finally
@NIH
funded! Took some time and perseverance. Thanks for support of colleagues and mentors.
@gelarehzadeh
@BradZachariaMD
@JamesConnorPhD
@PennStHershey
@PennStNeurosurg
@theNCI
29
7
161
Extremely sad about the loss of Dr. Gentili, a tremendous surgeon, mentor, and kind human being. My sincere condolences 🌹 rest in peace professor.
6
6
116
Happy holidays to everyone. Grateful for these little guys in my life. Hard to convince littlest one to take a pic
8
2
103
Congratulations to Dr. Gelareh Zadeh
@gelarehzadeh
on being elected President of the Society of Neuro-oncology
@NeuroOnc
!
@UHN
@KrembilF
@UofTNeuroSurge
10
10
92
📢 Excited to share our multi-disciplinary, comprehensive review on CSF-based liquid biopsy in brain tumors, which allowed us to outline a potential roadmap to standardizing research done in this realm and optimize the integration of CSF analysis into routine clinical practice.
4
23
83
🚨🚨 our paper is out!
#proteomics
on CSF to diagnose malignant brain tumors, with insights gained into prognostics, using as little as 30uL of sample thanks to cutting edge technology
@KislingerThomas
! Potentially novel markers also identified 🔬🧠
6
11
71
@ProfRScolyerMIA
@Dr_Brindha
@amenzies9
@dralexswarbrick
@PathologyRCPA
@CPC_usyd
@syd_health
@SHPartners
@SydneyResearch
@inespiresilva
@AAHMS_health
Thank you for sharing your journey, the ups and downs, in everyday terms. This is extremely helpful as both clinicians and patients choose their treatment options!
#glioblastoma
#immunotherapy
1
0
71
Dr. Mojgan Hodaie marking an amazing milestone of 1000 cases of trigeminal neuralgia treated! Congrats!
@mhodaie
@KrembilF
@TheJNS
@AANSNeuro
@AANSNeurosurg
@UHN
5
7
67
70s Patient presented with progressive dementia and gait difficulties. Pre and post op MRI below (
#meningioma
). Always amazed at how much the brain can withstand.
#btsm
@PennStNeurosurg
7
6
61
While I am very proud to have contributed to this chapter on epilepsy in brain tumors with Dr. Ruda and Dr. Glantz, the highlight of this post is my 4-year-old saying " This book is kind of boring for kids", and my 6-year-old asking that I kindly "write children's books instead"
1
7
62
Neurosurgery resident after a night of call, wondering "why did I go into this?"
3
4
56
Dr. Zadeh
@gelarehzadeh
presenting lifetime achievement award to the brilliant Dr. Bouffet
@SickKidsNews
@NeuroOnc
#SNO2021
1
5
51
Great start to
#SNO2023
in beautiful Vancouver. Good to meet old friends like
@TheLizArmy
and looking forward to all the great science.
@NBTStweets
@NeuroOnc
@theABTA
@braincancercan
@WeTrialshub
1
3
51
Got to catch up with Rockstar patient advocate (and awesome researcher!)
@TheLizArmy
. Love that I always learn so much from her every time we chat!
#BTSM
#SNO2022
@NeuroOnc
2
4
50
More exciting and encouraging data in the management of low grade gliomas, this time in children.
Most of these tumors have a genetic abnormality called BRAF mutations. Standard chemotherapy is currently not working and is toxic. The authors investigated whether 2 medications
0
9
48
Excited to share our latest collaboration on
#seizures
and connectivity. Longer disease duration = greater cortical thinning. Early surgical referral should be considered.
@DrValiante
@mpmca
@GMI_Canada
@BrijKarmur
@UofTNeuroSurge
@PennStateNSGY
#seizures
4
9
44
Excited to finally get back to in person meetings. The agenda for
#SNO2021
is packed with cutting edge science. Thank you
@gelarehzadeh
@FarshadNassiri
@AlbertHKimMDPhD
Dr. Brastianos and
@NeuroOnc
team!
1
0
44
A short but definitely memorable trip back to
@UofTNeuroSurge
to celebrate 100 years of history and innovation. Great to catch up with
@gelarehzadeh
who continues to lead the way in every regard, Ab Kulkarni my Program Director who played a great part in my training, mentors like
3
4
44
Congratulations to
@debaratibhanja
in winning the SNO
@NeuroOnc
CNS brain metastasis award with her brilliant talk today. Well done!
@PennStNeurosurg
@BrainTumorDoc
@BaptistHealthSF
4
4
45
Wrapped up a productive meeting on brain metastases.
🧠Got to present our latest work on CSF liquid biopsy for brain metastases.
🧠 Learned about work other colleagues are doing in this realm.
🧠 Got a sneak peak at the concept of tumor treating fields and laser interstitial
2
2
44
Excited to share our review on Blood-Brain Barrier Disruption for
#brain
#tumors
. Despite decades of research, many challenges remain.
@DrNirLipsman
@BradZachariaMD
@BrijKarmur
@PennStHershey
@HopkinsNsurg
@UCSF
@UofTNeuroSurge
1
7
43
Can drug repurposing work in
#glioblastoma
? Our Phase 0 Clinical Trial will try to figure that out!
@gelarehzadeh
@NeuroOnc
@NSTumorSection
@PennStNeurosurg
@BradZachariaMD
2
7
41
Excited to be Co-Editing a Special Edition in "Cancers" focusing on Functional Neuro-Oncology, with
@SolmazSahebjam
. Please disseminate to intereested colleagues.
@HerveyJumper
@michelle_monje
@NeurosurgUCSF
@Ricardokomotar
@DrValiante
@SunnyD_UT
6
8
41
Glioma in SMA region, with enhancing component encroaching on FAT. Patient in 20s, otherwise healthy and intact. What is your approach to lesion and patient counseling?
@EKNduom
@BradZachariaMD
@HerveyJumper
@carvelhn
@hadjiMDPhD
@pascalzinn
@NSTumorSection
6
2
41
Check out our review on minimally-invasive approaches for mTLE
#epilepsy
& our discussion on going too minimalistic, too fast. kudos to Ryan Wang
@uoftmedicine
& thx to
@v_padmanaban
@UsmanBeg1
@tjabeluw
@DrNirLipsman
@GMI_Canada
@PennStNeurosurg
3
8
41
On this first ever
#GBMDay
, the goal is to increase awareness for this deadly disease and to find better solutions. There has been little surgical innovation,
#survival
has not changed in ~15 years.
#patientexperience
matters!
2
21
41
🚨🚨My team is
#HIRINGNOW
a Post Doc for Neurosurgery research. Looking for a motivated individual to lead our translational and early phase Clinical Trial efforts.
🧠🔬
@NSTumorSection
@NeuroOnc
@PennStNeurosurg
1
16
40
Great CNS tumor section meeting, many thanks to the organizers
@CNS_Update
@NSTumorSection
@gelarehzadeh
and Drs. Galanis, Bettegowda, and Recinos. Great opportunity to learn about progress in the field, showcase our research, and enjoy great times with the team
@debaratibhanja
0
2
40
Excited to be launching GSUMIT, our pilot Phase II trial looking at feasibility and safety of a supramarginal resection of glioblastoma!
#glioblastoma
#surgery
#rct
4
3
40
@ProfRScolyerMIA
@JWilmott38
@inespiresilva
@amenzies9
@MattCarlino
@syd_health
@CPC_usyd
@SHPartners
@SydneyResearch
@SydneyCatalyst
@PathologyRCPA
Fantastic news!! Rooting for you and the prospect of immunotherapy for glioblastoma.
1
0
39
CSF liquid biopsy for classification of
#BrainCancer
. Great example of team science.
@PennStNeurosurg
@uoftmedicine
#btsm
Honored to see our CSF methylome-based malignant brain tumor classification work on the current cover of Neuro-Oncology
@gelarehzadeh
@DrAMansouri
@decarvalho_lab
@PatilVikas1010
@MansouriSheila
@FarshadNassiri
@UHN
@NeuroOnc
1
5
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1
7
38
Pleased to be an editor for
@FrontOncology
and share the impact (6.24) our journal has achieved publishing high-quality research that is open to all. Find out more:
4
1
37
Typical surgeon thinking they've got a "routine" case today
2
4
38
On this
#WorldCancerDay
I would like to express my deepest gratitude to self-less patients who participate in clinical trials and my colleagues working hard to improve our therapies.
#clinicaltrials
#btsm
#lcsm
#bcsm
@NeuroOnc
@ASCO
0
9
36
When you hear your Neurosurgery colleague get so excited about a post op scan that you can hear them from 3 doors down: priceless!
#PatientCare
#Neurosurgeon
1
0
36
Check out our study on
#mentalhealth
diagnosis (MHD) and
#lowgradeglioma
. Using a health insurance database review,
@debaratibhanja
found 61% prevalence of new MHD in LGG. 16% were new within 12 mos of dx. Seizures associated with highest risk!
1
7
35
A good friend who is highly qualified for program director position was told to focus on family for time being instead (she is pregnant). Aren't we living in 2021? 🤔
7
1
36
Happy
#CanadaDay2019
! My time as a
@UofTNeuroSurge
trainee has ended. Many thanks to
@DrValiante
, a great mentor, colleague, and friend.
@C_R_A_N_I_A
@UHN
. On to next adventure
@PennState
!
5
0
36
Our paper on CSF methylome-based liquid biopsies for classific'n of brain tumors is out! Grateful to
@gelarehzadeh
,
@JeffreyZuccato
and co-authors for this great work.
@NeuroOnc
@UofTNeuroSurge
@PennStNeurosurg
@MansouriSheila
@BradZachariaMD
#BTSM
0
2
36
Incredibly proud of Hannah Wilding
@PennStNeurosurg
presenting our work on predictors of
#brain
#metastases
from non small cell lung ca at
@NeuroOnc
@ASCO
joint meeting. Look out for her and her accomplishments in the years to come
3
2
35
Had the distinct pleasure of presenting on our surgical clinical trials and some of the nuances at the Ottawa neuroscience rounds with Dr.
@JahaniArezu
as a gracious host. I was fortunate that this coincided with the day Dr.
@gelarehzadeh
was giving her
#Gairdner
lecture where
1
2
36
Outstanding op-ed, advocating for an end on price gouging on lomustine, one of the few effective brain cancer drugs👉
@NeuroOnc
@theABTA
@NSTumorSection
@NBTStweets
@AANSNeuro
#glioblastoma
#btsm
4
15
34
Great talk on the molecular hallmarks of pain in
#schwannomatosis
by
@MansouriSheila
.
@gelarehzadeh
@ChildrensTumor
@NeuroOnc
#Neurofibromatosis
0
3
34
Incredibly happy for those who matched today to Neurosurgery. You should be proud of all your hard work and perseverance!
#neurosurgery
#matchday
#residency
1
2
35
End of a great trip to
#Toronto
. Great catching up w family & great friends. Fantastic conference
@NeuroOnc
. Looking Fwd 2 future collaborations.
@MKhasraw
@cnsmender
@DrSadhanaJ
@SahgalArjun
@debaratibhanja
@PennStNeurosurg
1
2
34
Back in the lab to start the bench work for our microdialysis- based clinical trial for brain tumors. Wish us luck!
#clinicaltrials
#Glioblastoma
#phase0
@PennStateNSGY
@PennStHershey
1
0
34
Standing room only on session dedicated to Innovative Technologies and Modern Systemic Approaches to glioblastoma, delivered by
@BrainTumorDoc
@StevenBremMD
and Michelle Kim.
@MiamiCancerInst
@NeuroOnc
#SNO2023
0
2
34
My 4 year old has been having temper tantrums lately about many life challenges, but her shadow not leaving her alone today was by far the most entertaining.
1
0
33
Best team ever! Happy
#DoctorsDay
to all my amazing colleagues especially in these difficult times.
@PennStHershey
@DrValiante
@gelarehzadeh
@mhodaie
@JamesRutka
@GMI_Canada
@BradZachariaMD
@cwitiw
@justinzw
@NWarsi
1
3
33
Rough start to the holiday with very sad injuries. Constant reminder to be grateful for our health and well-being. Stay safe everyone.
1
1
32
Superstar Ahmad Ozair
@NeuroAhmad
presenting safety and feasibility of ruxolitinib in high grade gliomas
@CNS_Update
. Looking forward to the phase 2 trial launching in 2024.
Congrats to all team members
@BrainTumorDoc
@yasmeenrauf
3
2
33
Wishing everyone a
#HappyNewYear2023
. I am hopeful that 2023 will be a year of health, peace, and prosperity.
#Iran
#Ukraine
️
#World
2
0
32
Photodynamic therapy for
#glioblastoma
, initiated! Thanks
@leonardomacedo
for getting this project off the ground. Looking forward to positive results. Huge thanks to 4 diamonds
@penn_state
for funding this study.
@PennStNeurosurg
3
6
33
Excited for 2nd annual CNS Clinical Trials & Brain Metastases, an interdisciplinary conference for primary/metastatic
#CNS
#cancer
Joint effort bw
@ASCO
&
@NeuroOnc
. Submit Abstract:
#clinicaltrial
#brain
@MKhasraw
@gelarehzadeh
#PriscillaBrastianos
1
12
32
Excited to share our network meta-analysis, comparing the efficacy of treatments for non-small cell lung cancer brain metastases without an EGFR or Alk mutation. Threat 🧵
2
5
32
0
9
32
A relatively large retrospective paper showing that in patients withGrade 2 astrocytoma and the favorable prognostic marker of IDH mutation, chemotherapy and radiation can be spared until there's evidence of recurrence, in most cases. Specifically, this applies to patients who
Thank you to Sapienza group for publishing our experience in patients with adult-type diffuse IDH-mutant grade 2 gliomas: Long-term treatment outcomes of temozolomide-based chemoradiation in patients with adult-type diffuse IDH-mutant gr…
1
4
15
2
4
32
First attempt at making Persian food. Thanks
@MansouriSheila
and parents for guidance.
@gelarehzadeh
@mhodaie
#betterlatethannever
7
0
32
Upfront
#WBRT
becoming less necessary:
#radiosurgery
for 11
#metastases
to the brain from renal primary, together with
#immunotherapy
, VEGF antagonists and denosumab. Top panel is 8 months post SRS.
#btsm
#bcsm
#lcsm
#kcsm
@AANSNeuro
@ASCO
@ASTRO_org
@PennStHershey
0
3
30
Wishing everyone who celebrates Persian New year a happy
#Nowruz
. As this day also coincides with the official arrival of spring, I hope to see a year of health, peace and prosperity for humanity.
1
2
30
Please check out this exciting clinical trial by my brilliant friend and colleague
@NIH
Dr. Jackson, for patients with high grade glioma or diffuse mid line glioma.
#btsm
@DrSadhanaJ
2
7
29
Check out our systematic review and our take on the necessary approaches to combining immunotherapy regimens for glioblastoma
@NeuroOnc
@NSTumorSection
Great to see this published; Thanks to
@platten_michael
@wick_wolfgang
@DrAMansouri
@HeimbergerAmy
@VPuduvalli
@SolmazSahebjam
and all other coauthors who are not on Twitter!
0
1
12
0
1
29
Rapid malignant progression of lower grade glioma: 50s male presents in status with top panel of images. Biopsy shows Gr 2 IDHwt Astro. Presents 2 mos later with speech deficits and bottom panel of images. Pathology GBM.
#BTSM
@PennStNeurosurg
@NSTumorSection
4
2
29
Status update on "boot camp"
2
3
29
Dr. Zadeh giving a beautiful presidential address.
@gelarehzadeh
#resilience
#tenacity
#pandemicpresident
#Antifragile
@NeuroOnc
#SNO2021
0
0
28
Exciting to have
@AaronCohenGadol
here in Toronto and taking part in the annual
#keith
lectureship and
@UofTNeuroSurge
graduation.
@UofTSurgery
@AANSNeurosurg
0
2
29
Our review on health
#economics
of
#radiosurgery
for brain
#metastasis
@NeurosurgeryCNS
. Radiosurgery is cost-effective, particularly in high functioning individuals.
@PennStHershey
@UofTNeuroSurge
@nyuniversity
@Fymoraes
@detsang
@BrijKarmur
@NWarsi
#btsm
1
5
28
Great to kick back with the team, celebrating accomplishments and looking forward to future work!
@debaratibhanja
@leonardomacedo
#Hannah_Wilding
@PennStNeurosurg
@penn_state
0
0
28
Congrats to my amazing sister
@MansouriSheila
and
@gelarehzadeh
lab on this fantastic study delineating epigenetic landscape of schwannomatosis
@NSTumorSection
@NBTStweets
@theABTA
@AANSNeuro
@EANOassociation
@NeuroOnc
Congratulations to
@MansouriSheila
& Co. from
@PMResearch_UHN
@KrembilRI
1st comprehensive Genomic & Epigeneomic-Landscape of
@schwannomatosis
@nfnetwork
@nfopensci
Thanks to
@ChildrensTumor
Acta Neuropathologica
5
9
47
1
0
29
Check out our open access paper on lesion network mapping in
#LGG
to identify potential resting state networks engaged by epileptogenic lesions:
@DrValiante
@gelarehzadeh
@GMI_Canada
@mpmca
@KarimMithaniMD
@BrijKarmur
2
10
27
What is your approach to motor mapping in brain tumor surgery? Proud to share our survey. Great work by rising star
@Ornate_Brute
and thx to colleagues
@carvelhn
@NeuroRaquisHUMV
Lorenzo Bello, Juan Martino
@PennStNeurosurg
2
4
28
Happy International Women's Day to all the amazing mothers, sisters, daughters, role models, and super Heroes of the world.
#InternationalWomensDay
#8March
#ChooseToChallenge
#8M2021
#WomensDay
@MansouriSheila
@gelarehzadeh
@mhodaie
@clairekarekezi
@sparklingcsf
and many more!
3
4
27
Sex differences in
#glioma
#metabolism
. Enlightening talk by Dr. Sponagel
@NeuroOnc
#SNO2020
@JamesConnorPhD
@JustinLathia
@JBarnholtzSloan
2
2
27
Fantastic presentation by
@debaratibhanja
on role of dual agent immunotherapy in prevention of melanoma brain metastases!
@PennStNeurosurg
@NeuroOnc
@BrainTumorDoc
@HTawbi_MD
#BTSM
#SNO2022
3
2
26
Evidence favoring upfront max safe resection of LGG vs biopsy is accumulating. But does this = higher risk and cost to patients? We set out to study this 🧵
Great work by
@KyleTuohyMD
@debaratibhanja
and
@PennState
colleagues.
@PennStNeurosurg
#btsm
1
4
27
Excellent review on brain
#radiation
with consideration of the
#connectome
. Time to redefine organs at risk in the brain.
@NeuroOnc
#btsm
@ASTRO_org
@AANSNeuro
@TheJNS
1
15
27
Kicking off soon: clinical trials workshop!
@NeuroOnc
@NSTumorSection
@PennStHershey
@gelarehzadeh
@MKhasraw
#clinicaltrials
1
3
26
Happy
#InternationalWomensDay
to all of the wonderful women in the world who are working to make it a better place!
@AlinejadMasih
@NazaninAJ
@NazaninBoniadi
@SafaiDarya
1
1
26
Great catching up with
@GSholler
. Looking forward to many exciting and innovative collaborations!
#clinicaltrials
#precisionmedicine
@chadtough
@DefeatDIPG
@AbbiesArmy
@PennStNeurosurg
@ASCO
0
2
26
Exciting residency interview day. Remarkable how each year the caliber of candidates just keeps getting better. Impressed by intelligence, hard work, and humanitarianism of this future generation!
#residency
#neurosurgery
#MedTwitter
0
1
25
May is
#BrainTumorAwarenessMonth
. Now more than ever it is important to advocate for people with 🧠tumors. Join me Tuesday May 5 at 5pm EST for an interactive webinar 👇on things to know about
#BrainTumor
and
#COVID
ー19. DM to register.
1
7
23
Excited to co-edit a special topic issue
@FrontiersIn
focused on LITT for neurosurgical applications, with great colleagues
@BorgheiRazaviMD
and
@TaylorAbelMD
. Link:
#laser
#brain
#neuroscience
@PennStHershey
@ClevelandClinic
@UPMC
0
2
23
@EladLevyMD
@DrTobiasFunky
Not sure if you'd want to be in a program that "tests" you. Authenticity and genuineness with your future colleagues should be a key part of the decision
0
0
25
#GBMDay
reminds us of how devastating these tumors are and the need for better answers. As members of the neuro-oncology community and beyond, we need to continue multi-disciplinary
#collaboration
,
#research
, and
#advocacy
.
@BradZachariaMD
@DrSadhanaJ
@NeuroOnc
@NBTStweets
#btsm
0
4
25
A great example of thinking outside the box to push the envelope for this terrible disease. Clearly the classic approaches that we have been trying have not been working. Thank you
@johnboockvar
for your innovation!
@BTSMchat
#btsm
Omentum is the fatty blanket that covers our intestines. It also is a rich source of immune cells that are needed to fight infection and cancers. Here we use it as a source of cancer fighting cells and to create new blood vessels that lack a blood brain barrier. Learn how we are
8
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248
2
4
23
Not sure what I was thinking when I decided to start sleep training my youngest as I work on a paper before an OR day 🤷♂️🤔
1
0
24
We are
#hiring
! Exciting opportunity for a research manager to lead the clinical research portfolio at
@PennStHershey
#Neuroscience
institute 🧠🧠🧑🔬🔬. Please retweet. DM for more details. Link
@eliasbrizkmd
@PennStNeurosurg
0
6
24
Continuing excitement from day 1. New therapies on horizon. Novel designs for Her3+ BrCa
@MKhasraw
. Genomic drivers of 🧠mets. Updates on
#Alliance
trial.
@CareyAnders1
@HTawbi_MD
@NeuroOnc
@ASCO
#btsm
#bcsm
#LCSM
0
1
23