Dr. Valiante
@DrValiante
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Neurosurgeon & Neuroscientist | Director Surgical Epilepsy Program @neuron2brain @KBI_UHN @C_R_A_N_I_A @mpc_utoronto
Toronto, Canada
Joined August 2010
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Pinned Tweet
Excited to share our new paper in
@CurrentBiology
where we explore single unit responses in the human mesial temporal lobe (MTL) during saccades. Lead by
@chaimNK
@Kramayp
@singleunitgps
in collaboration with
@perpl_lab
@duncanlabUofT
.
🧵 (1/7)
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33
117
Today I say goodbye to my Mom who created change in every sphere of her existence. Grateful for being her son, and the world view she instilled into me - that we all can and should be agents of change:
Happy Mother’s Day - orphaned at 14, leaving civil war, coming to a new country to start life anew, finding her niche as a social worker - the strongest person I know, who made us who we are today with the support of my awesome Dad -
@AliValiante
her “rock”.
8
1
105
59
8
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Lavender - the flower of
#Epilepsy
represents solitude. Individuals with
#Epilepsy
face a disproportionate amount of stigma and social isolation. Through awareness and action we are a singular flourishing global community.
#PurpleDay2020
4
52
161
Honored to receive this letter from
@GermanyInCanada
marking the inauguration of the
@mpc_utoronto
on April 14th 2021 and 50 years of scientific collaboration between 🇨🇦 and 🇩🇪 . So grateful for amazing collaborators and friends
@JoycePoon_
@zpfeng1
@uoftengineering
@AlexM_UT
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19
143
On
#PurpleDay2022
, remembering Dr. Wilder Penfield 🇨🇦 who paved the way to helping those with epilepsy while discovering the mysteries of the brain.
5
18
125
Daily listening to Mozart significantly reduces seizures in people with difficult to treat epilepsy. Check out the findings in our year long study lead by Marjan Rafiee. Supported by
@EpilepsyOntario
in the eclectic
@neuron2brain
lab.
@UHN
@KrembilRI
4
52
123
Love is … a 2-photon microscope?!?
@p5hah
today 😀upon arrival. Thanks to
@moradi_homeira
for the 3 years of admin to make this happen -
@KBI_UHN
’s first 2P with dedicated ephys thanks to
@JoycePoon_
to support
@mpc_utoronto
research + research support from
@paqio
🙏
9
6
121
33 years ago my parents bought me these - 1/5th of my fathers income. Grateful to them for fueling my love of computing!!
4
1
109
Grateful to be able to share this beautiful fall day with my parents (and some Tim Hortons coffee) - at the very end these are the things that sustain us - our families, our communities, our connections.
5
2
106
Happy Mother’s Day - orphaned at 14, leaving civil war, coming to a new country to start life anew, finding her niche as a social worker - the strongest person I know, who made us who we are today with the support of my awesome Dad -
@AliValiante
her “rock”.
8
1
105
It’s a dream coming true - made possible by the huge team
@UHN
@KBI_UHN
@KITE_UHN
and the aweome tech from
@SynaptiveMed
.
@C_R_A_N_I_A
’s 0.5T is in JDMI thanks to the
@CWangTO
and
@DineenConst
teams!
7
10
101
So much to be grateful for. Big thanks to my Dad, Mom, and
@samrasmian
for a wonderful life. Happy Thanksgiving giving everybody.
11
1
101
Happy Father’s Day!!
To my Dad - in his early year showed us the value of hard work, and now in later life the art of ageing gracefully.
Grateful to be able to spend yet another day with you.
4
0
95
Today we celebrate
#Eid
after a month of fasting (my 86 yo father didn’t miss one!!).
We were reminded of the oneness of creation (animate and inanimate), our stewardship of these creations, and the sanctity of life: taking of a single life is like the taking of all humanity 🙏
7
4
95
Its always surreal to remove primary motor and sensory cortex. An emotional tension between “helping”, and “doing no harm” during epilepsy surgery. Grateful for the patient’s trust and the help of amazing colleagues during the surgery
@CA1CA2CA3CA4
@KBI_UHN
@UofTNeuroSurge
9
8
88
Huge congrats to
@chaimNK
for successfully defending his PhD.
@neuron2brain
will miss your presence as you start the next chapter of your life. You have contributed immensely to the science, culture, and social impact of the lab and
@C_R_A_N_I_A
@bme_uoft
@KBI_UHN
🙏
12
8
85
Sensory cortical control of movement | Nature Neuroscience Sensory cortical control of movement | Nature Neuroscience. Great work by
@UofTNeuroSurge
’s
@SpyrosKaradimas
and new PI
@KajanaSatkune
@UHN
@KrembilRI
@DrFehlings
2
30
86
A special Eid prayer on Father’s Day outside on a beautiful day!! We were reminded to be grateful that we can celebrate with loved ones today, and to remember those near and dear to us that are no longer in our lives. Grateful that this guy is still here to party 😀🙏🙏❤️
2
4
84
Implanting the new
#Sentiva
from LivaNova - providing state of the art vagus nerve stimulation (
#VNS
)
#neuromodulation
therapy for those with medically refractory
#epilepsy
1
22
81
Finishing of Epilepsy Surgery Clinic with my awesome surgical fellow Afnan Alkhotani, and
@neuron2brain
indispensable Clinical Research Assistant Victoria Barkley!
@KBI_UHN
@UHN
4
6
79
Many many years in the making supported by our fearless
#Epilepsy
and
#braintumor
patients, an amazing Epilepsy Program, the incredibly hard work of
@moradi_homeira
@RichCompNeuro
and a great collaboration with
@neuronJoy
@CAMHnews
- with support from
@KrembilF
@KBI_UHN
Scientists at
@KBI_UHN
and
@CAMHnews
have used live human brain tissue to identify functionally important features that make human neurons unique. This experimental work is among the first of its kind on live human neurons. Read more ➡
@NatureComms
1
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80
Our first large OR related
@C_R_A_N_I_A
purchase has arrived : the awesome tech developed by
@7DSurgical
- it’s Canadian eh!! Can’t wait to use it!!
@UHN_Research
@KrembilRI
6
6
78
Today I rise with those whose nights awake seem to last forever, those for whom the day seems impossibly painful to rise too, and those whose fear of the future, and regret of the past paralyze them in anxiety and regret.
#CAMHSunriseChallenge
#MentalHealthMatters
1
14
76
Mourning the loss of a fellow human and a wonderful, thoughtful colleague. Our lives are WAY more fragile than we would like to believe. Be gentle and kind to yourself, and those around you.
2
10
78
Happy Canada day everybody - so so proud, and grateful to be Canadian!! Count my blessings everyday especially today!
3
5
71
An exemplar to me and so many others in every sphere of our existences : as citizens of our personal and professional communities, as a teacher, and as the “surgeon’s surgeon”.
We remember and honour the life and career of Dr. Fred Gentili, a world class
@UHN
&
@uoftmedicine
neurosurgeon, who raised the bar for Toronto neurosurgery and 'never hesitated to take on the toughest clinical cases.'
Read more →
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427
3
6
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1/5 🧵 What does diversity mean to you? To us it means resilience!
Twitter-less Jérémie Lefebvre, Axel Hutt and myself conceptualize and then explore this concept in our new
@PNASNews
paper:
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With
@chaim_bell
and Dr. HPK who way back when, fresh out of my PhD and reintegrating to the MD helped me love the art of medicine!! So grateful for these formative encounters and amazed by the indelible mark both continue to make on the field.
@uoftmdphd
@uoftmedicine
5
4
70
0
10
70
Mourning loss of all those on the plane in Iran including Mohammad Asadi Lari - a brilliant
@uoftmdphd
student I knew. Can’t imagine what’s it like for their friends as family. Loss for the world and Canada
0
6
68
Humbled to receive such a generous donation towards my
@neuron2brain
lab’s research raised by Eric, and Mom’s patrons of the Vannoort Flower studio - “research is hope” is what I was told by Eric - wise words. Thank you !!
@KrembilRI
@C_R_A_N_I_A
2
4
68
It is the beginning of
#Epilepsy
Awareness month and
#WorldMusicTherapyDay
-
@neuron2brain
we celebrate the intersection of both by raising epilepsy awareness and studying the healing powers of music
@KBI_UHN
.
1
17
66
Best day of winter - cold, sunny, and frozen!! We are Canadian 🇨🇦 !!
2
1
65
The fractal beauty of nature - on the right the 🌲 from which the cone dropped.
2
6
59
Our first functional case (
#epilepsy
) with of
@C_R_A_N_I_A
‘s 7D Imaging, Inc.’s machine vision system. Simple work flow from beginning to end! Thanks Adrian Mariampillai for the great support today. University Health Network Krembil Research Institute.…
2
12
59
Ahmad Elsawy just completed his Epilepsy Surgery Fellowship with me (my first fellow)- like the first child I have no idea yet how much I messed him up!! Good luck Ahmad!
@UHN
@KrembilRI
@tgwhf
7
3
60
Some more awesome images from
#PurpleDay
festivities with a celebrity shot with
@mpmca
, a strong showing from
@CAMHnews
and of course the dream team of the
@neuron2brain
@moradi_homeira
@MadeleineFalby
@neuro_ara
@dstania
@thisisNikkkk
@QianBrain
Marco Istasy
1
11
58
Its surreal to remove primary cortex following the mapping of function. Today in somatosensory cortex, its even more surreal to have the patient report they feel no different and display no obvious motor deficit. Thank you
#WilderPenfield
and my mentor Dr. Ojemann.
1
4
58
What makes various cell-types and microcircuits in the brain uniquely human?
@moradi_homeira
,
@MadeleineFalby
@m_depitta
@CAMHnews
@neuronJoy
@keon_arbabi
Jérémie Lefebvre, and I try to answer this question.
@KBI_UHN
@CAMHnews
@uOttawa
1
16
56
Awesome collaborative effort between
@SickKidsNews
@UHN_News
@UofTNeuroSurge
to perform first adult laser ablation for epilepsy in
#TO
2
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56
Grateful these two intrepid explorers made it to Canada.
Happy Canada 🇨🇦 Day everybody!!
2
1
54
It’s been 25 years since being on a plane with this guy. “Dragging” him to beautiful Kelowna
@HelloBC
for
@CLAE_LCCE
meeting. So grateful for these times with him and
@samrasmian
3
0
52
Nostalgic day for me giving my second lecture on oscillations
@CRANIA_Toronto
#CNMI
’s ECE441 - Interfacing & Modulating the Nervous System. It was here where I found this gem of a book the summer before I started my BSc. It transformed how I saw the world.
@eceuoft
1
2
54
My fantastic colleagues Suneil Kalia and Paul Kongkham exercise “laser focus” as they perform Laser Instititial Thermal Therapy
@UHN
@C_R_A_N_I_A
@KrembilRI
#teamwork
0
8
54
Living it up at
#Diwali
@uhnfoundation
@KBI_UHN
@KITE_UHN
@KevinSmithUHN
@kalialabs
@SuganthSuppiah
@MilosRPopovic
@UofTNeuroSurge
@C_R_A_N_I_A
1
2
51
A stellar PhD from a stellar human, to his greatest accomplishment - being chosen as
@GarimaS_18
’s life companion… overjoyed and grateful to share in this special day with
@Kramayp
- wishing them both a life of peace and smiles!!
7
1
51
For trainees and early career researchers who think the path for individuals like myself has been linear and calculated, please tune in (below) where I will hopefully bring that conversation back to “the land of the real”
@KBI_UHN
@eceuoft
@bme_uoft
@uoftmedicine
@UofTNeuroSurge
Join us
@MPI_ae
@mpc_utoronto
on Sept 20 @ 12:00pm EDT for Growing Up In Academia w/
@DrValiante
of
@KBI_UHN
and
@C_R_A_N_I_A
for a
#bts
look at the winding path of Taufik's 'official CV'
1
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4
13
50
Our
@KrembilRI
@UHN
human single unit data is open, and free and in
@NeurodataWB
format. So honored to be part of the
@NIH
@BrainCanada
funded consortium lead by
@UeliRutishauser
. Kudos to
@GomezPalacioA
@chaimNK
@Kramayp
for making this happen!!
0
16
50
In one word:
#courage
. To the many individuals I have met through dealing with their epilepsy - grateful and humbled by your trust in me and the amazing Epilepsy team here
@KBI_UHN
James' story: "It was like a rebirth." From having around 30
#seizures
a day to being seizure-free, hear more about James' experience before and after brain surgery with
@DrValiante
:
0
3
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4
6
48
More exciting
#epilepsy
research out from the
@neuron2brain
and collaborators, lab lead by
@riceasphait
using advanced machine learning approaches to detect when AND where seizures are arising from in individuals undergoing sEEG recordings.
@KBI_UHN
Published!✨🎉
We train a GNN to detect epileptic seizures from brain networks and show that its internal attention layer predicts the seizure onset zone in human subjects.
Exciting collab from my time
@neuron2brain
w/
@DrValiante
R Wennberg
@GMLG_Lugano
1
5
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1
5
49
My awesome team hard at work explaining closed-loop epilepsy clinical trial, and human hippocampal responses to eye movements and image onset’s.
@Kramayp
@chaimNK
@C_R_A_N_I_A
@UHN
@KrembilRI
#SFN2018
2
7
47
At
@KBI_UHN
@UHN
we are celebrating
#PurpleDay
today. The
@neuron2brain
lab has been working closely with all those providing support/care for those with
#Epilepsy
within and outside of the hospital to help raise awareness. Please show your support with a RT and joining in!!
1
14
44
Spending quality time on line with my long term community partner in crime
@CynthiaMilburn
@EpilepsySCO
- check it out on May 11th.
2
18
48
#BellLetsTalk
- amongst the most powerful pieces of advice that helped me - if you’re struggling with a mental health problem try to pull down the wall of shame and self expectation and reach out and talk, if you know somebody struggling - reach out to them and help them talk.
1
15
46
Very proud of this
@KBI_UHN
and
#KCNI
collaboration lead by CAMH team and
@neuron2brain
lab’s
@moradi_homeira
. A beautiful example of building human inspired computational models to study human disease. Impossible without the amazing team and generous epilepsy patients. 🙏🙏
Exciting work from
@Kant_Yao
,
@AlexGuetMcC
, Etay Hay and collaborators
#KrembilNeuroinformatics
@CAMHnews
. This is the first data-driven human cortical L2/3 microcircuit model and is used to predict circuit response properties in health and depression.
0
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1
10
44
So grateful it’s not only installed and operational but that it’s lives in the Joint Department of Medical Imaging!! 🙏🙏
@CWangTO
@bradwouters
@KevinSmithUHN
for helping us realize this.
@SynaptiveMed
We are excited to unveiled our new a state-of-the-art 0.5 Tesla MRI scanner.
It is the first time a 0.5 T MRI scanner will be used in an Ontario hospital setting, and first in the world for clinical neuromodulation.
Learn more about it here:
0
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0
4
45
Today is
@epilepsytoronto
's purple walk. The
@neuron2brain
lab challenged one another to do a 100 of something in recognition that about 1 in 100 individuals have epilepsy. My personal challenge is here - please RT to help raise
#Epilepsy
awareness.
1
23
45
A
@UHN
@UHN_Research
surgical epilepsy fellows
@DrAMansouri
and Harish Babu assisting Suneil Kalia on steroEEG case. Proud signs of growth of our clinic and basic science epilepsy programs, and collaboration in
@UofTNeuroSurge
@KrembilRI
2
8
43
For memory/hippocampus aficionados - saccades and image onset responses are very different - something to keep in mind when designing visual memory tasks. Great work by
@chaimNK
@Kramayp
@OmidTalakoub
@dmgroppe
in collaboration with
@perpl_lab
@KrembilRI
1
16
45
An old photo (when Michael won at Gallie day) to celebrate a new COVID style milestone with Dad - Michael Chang’s successful PhD defense
@IMSMagazine
- which he accomplished with flying colors. Big congrats, and shout out to
@neuron2brain
@KrembilRI
for their support.
4
6
46
The path is anything but linear …
#PurpleDay2023
A tragedy in his youth and a classroom epiphany combined turned A&S alum Dr. Taufik Valiante into a neurosurgeon and researcher studying the relationship between music and epilepsy.
#PurpleDay
Learn more:
1
7
19
1
5
43
Big shout out to
@Kramayp
@chaimNK
on this 🤯 result showing volitional control of neurons in the limbic system. Great collaboration in
@C_R_A_N_I_A
@MilosRPopovic
and Dr Suneil Kalia.
@KrembilRI
@uoftengineering
@uoftmedicine
funding from
@BrainCanada
@NIH
Learning to control individual neurons in the brain. Check out our preprint where we use intracranial human single unit recordings, and neurofeedback. Mind boggling that the brain can exert such fine grained control.
2
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2
11
44
Thanks for the shout out
@UofTNeuroSurge
. If you like this topic of diversity check these out from us:
Read
@DrValiante
’s new paper on his exciting research into the importance of cell-to-cell biophysical diversity!
0
6
32
3
9
45
A wonderful friend, colleague, and person - Frank Vidic of
@KrembilRI
. I would joke as PhD student (almost 30 years ago!!) in Peter Carlen’s lab that Frank knows all the answers to the problems we are trying to solve, he just doesn’t tell us so we have something to do.
@UHN
2
0
43
Mission accomplished- we had the best ice cream in Canada at a great meeting! Thanks
#PEI
and
@CLAE_LCCE
. Stole these guys from their task master
@GMI_Canada
@UofTNeuroSurge
for some carbohydrate extravagance!!
6
1
43
We have kicked of the
#CRANIAConf2023
@CRANIA_Toronto
with a moving, engaging and insightful talk about
@Neuronologist1
’s (Ben Stecher) journey as a patient with Pakinson’s. Many shout outs to
@DrAlfonsoFasano
for his care, support and friendship.
@KBI_UHN
0
8
42
Celebrating Vandana Prasad’s and
@MadeleineFalby
MSc defences through
@eceuoft
and
@IMSMagazine
respectively. Vandana will stay on for her PhD and Madeleine is of to
@uoftmedicine
!!
Congrats to both and grateful to the whole
@neuron2brain
for making these achievements possible
3
3
42
Wonderful talk by Andreea Diaconescu
@CAMH_KCNI
scientist and
@mpc_utoronto
faculty member on computational network modeling in psychiatric conditions at Krembil² retreat.
@KBI_UHN
@CAMHnews
@wake_sleep
@1791_mew
@gelarehzadeh
0
7
40
Beside myself presenting our (
@moradi_homeira
@RichCompNeuro
) human cell-type work (experiments and modeling) at
@BlueBrainPjt
workshop to such a distinguished group of scientist including one of my scientific hero’s
@Segev_Lab
.
@NZulaica
@KrembilRI
0
2
41
A big thanks to my lab and all the awesome summer students for a productive summer filled with science, epilepsy outreach, and good times!! Also thanks
@KrembilRI
@UHN
for the support.
#epilepsy
@C_R_A_N_I_A
0
7
39
Proud to present another human focused poster by
@moradi_homeira
’s on human neurons recorded in vitro. A great collaboration between
@KrembilRI
@neuronJoy
#SfN19
@KrembilRI
@UHN
@RichCompNeuro
@francesskinner
3
5
40
Valiante Lab getting ready for
#purplewalk
#paintTOpurple
@UHN_News
@KrembilRI
... what an awesome team!!
4
18
38
Nobody better in the world to kick of
@C_R_A_N_I_A
’s Neuromodualtion Intitute (CNMI) “Electroencephalography: from the clinic to wearable devices” workshop than
@KBI_UHN
very own Dr. Richard Wennberg. Kudos to
@neurodidact
and
@SindhuM56548494
for making this workshop!!
2
5
37
Enjoying the beauty of fall in the rolling hills of
@MulmurTownship
- so much to explore in our beautiful province of
@ONresources
2
0
38
Good morning
@Toronto
- leaden clouds give the illusion of mountains on a beautiful fall morning!!
0
0
37
Sharing in the fun of being with current and future
@C_R_A_N_I_A
team members after panel discussion on
#neuromodulation
organized by
@MilosRPopovic
during
#Rehabweek2019
@DrAlfonsoFasano
@KrembilRI
0
11
36
It’s unequivocal we need to wear masks: advice to the contrary is nonsensical.
1
8
38
Big shout out to the iEEG team in the
@neuron2brain
for making this amazing science happen!!
Delighted to announce our latest paper. We discovered single-cell correlate of theta-gamma PAC. Hippocampal PAC cells participate in control of WM through information-enhancing noise correlations and long-range frontal interactions.
@Nature
@CedarsSinai
9
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273
0
6
38
Spectacular work by
@Kramayp
, using a
#BMI
, a cool experimental design, and some nice computational techniques to show humans can learn to control the firing rate of one out of their 80 billion or so neurons 🤯
@KBI_UHN
@C_R_A_N_I_A
@uoftengineering
@uoftmdphd
Excited to share our paper in
@Brain1878
where we show that humans can learn to control individual neurons in various memory structures of their brains! Exciting implications for
#learning
,
#memory
and
#neuromodulation
!
@OUPAcademic
@KBI_UHN
@C_R_A_N_I_A
5
27
87
1
7
37
My clinical mentor and good friend Dr. Ho Ping Kong - who redefined medicine for me when I returned back from my PhD.
#PurpleDayUHN
@UHN
1
2
37
Excited to be part of consortium to study declarative memory using single unit recordings in patients with
#epilepsy
. Big thanks to
@NIHFunding
, and the individuals with epilepsy that consent to being part of such studies.
@KrembilRI
@UHN
@UHN_Research
3
8
36
Wightman-Berris Academy teaching awards ceremony. Incredible mentors & great times!! Reminiscing about my 12 weeks of GIM with Chaim Bell and Dr.HPK my senior resident and staff who reintegrated me back into medicine after my PhD.
@uoftmedicine
@UHN
@MountSinai
@KrembilRI
0
3
37
In 2016
@MilosRPopovic
and myself presented to engineers on the evolving field of neuromodulation, just prior to submitting our
@CRANIA_Toronto
@InnovationCA
which was funded in 2017. Yesterdays townhall - How CRANIA has grown in number and disciplines!!
@bme_uoft
1
5
36
Great time hanging out with friends and colleagues
@DrDaniAndrade
@Esther_Bui
@CLAE_LCCE
2022 in a relaxed and beautiful venue!! Really enjoyed this meeting!!
3
4
36
Sad to say good bye to an awesome colleague Harish Babu who has finished his fellowship with me and on to greener pastures. Thanks
@KrembilRI
and
@UHN
for creating a fertile environment for both clinical and scientific growth both for mentors and mentees.
1
2
36
Excited to present with my colleague
@UofTNeurology
’s Peter Tai a on a very fascinating case of insular epilepsy - diagnosis, management, and new technologies
@UHN
@KrembilRI
for epilepsy treatment. He is the consummate clinician and a great colleague!!
0
4
36
So proud of all
@neuron2brain
lab members for their
#Epilepsy
advocacy !!
@moradi_homeira
@MadeleineFalby
@thisisNikkkk
@integerard
Big thanks
@UHN
@KBI_UHN
for highlighting
#PurpleDay2023
In this month's UHN on the Go, we highlight the in-person Purple Day event💜, showcase Operation Green collecting for earthquake relief♻️, and release UHN's COVID-19 Pandemic After Action Report.
Read more →
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For many years we have been the only Canadian lab at this amazing meeting on characterizing human cells and circuits. This year fellow 🇨🇦 Larissa Kraus represented the 💯
@MarkCembrowski
lab!!
We presented on neuronal heterogeneity as a fundamental design feature of the brain.
Meanwhile in Amsterdam...
@DrValiante
and
@moradi_homeira
presented at the 2024 Human Neuron and Circuit Meeting, Amsterdam!
@VUamsterdam
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Super fun 80k ride with
@Kineticneuron
and
@CA1CA2CA3CA4
in the rolling hills of
@MulmurTownship
. Photo cred
@CA1CA2CA3CA4
. The
#outdoor_research
component of the functional fellowship
@UofTNeuroSurge
@UHN
@KBI_UHN
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Members of my lab presenting to
@epilepsytoronto
on Research in the lab and implications for ET staff and clients. Community service can’t be underestimated. Thanks team, and thanks ET for being such a great partner.
@KrembilRI
@UHN_News
@Flowergirlrprs
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Looking great team
@neuron2brain
. Thanks
@KBI_UHN
@hsherm117
@twayner_
for the amazing support!! I couldn’t make it today, but for good reason - 2 epilepsy surgeries today!!
Recognizing
@PurpleDay
with our talented clinical and research staff
@UHN
's Epilepsy Department. Staff, patients and visitors had a chance to learn about our clinical care programs and cutting edge research.
We also had a concert from our friends at the Lullaby Project.
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