Yuan Luo
@yuanhypnosluo
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Chief AI Officer, Professor@NorthwesternU. PhD@MIT. Passionate about equitable, proactive, industrial & collaborative (EPIC) AI for biomed+health. Views my own.
Chicago, IL
Joined February 2014
Excited to share our latest spatial transcriptomics tool "STdGCN: spatial transcriptomic cell-type deconvolution using graph convolutional networks"! 🔬 Spatially resolved transcriptomics is revolutionizing our understanding of cellular organization by integrating high-throughput transcriptome measurements with spatial data. However, many current technologies fall short of achieving single-cell resolution. Enter STdGCN, our innovative graph model that leverages single-cell RNA sequencing (scRNA-seq) as a reference to deconvolute cell types in spatial transcriptomic (ST) data. 💡 What makes STdGCN unique? - It integrates expression profiles from scRNA-seq with spatial localization from ST data. - Extensive benchmarking across multiple datasets shows STdGCN outperforming 17 state-of-the-art models. - In a human breast cancer Visium dataset, STdGCN effectively delineates stroma, lymphocytes, and cancer cells, providing deeper insights into the tumor microenvironment. - In human heart ST data, STdGCN identifies critical changes in endothelial-cardiomyocyte communications during tissue development. Our findings demonstrate the power of STdGCN in enhancing the resolution and accuracy of cell-type deconvolution, paving the way for more precise and insightful spatial transcriptomic analyses. Kudos to Dr. Yawei Li on pushing the boundaries of what's possible in the field of spatial transcriptomics! Paper (no pay wall): Code: #Research #Innovation #SpatialTranscriptomics #GraphConvolutionalNetworks #scRNAseq #Bioinformatics #CancerResearch #HeartDevelopment #DataScience #AIinHealthcare #STdGCN
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My talented PhD student @yikuanli8 is talking to a full house about #transformer based deep #ReinforcementLearning for efficient and fair allocation of health care resources #AMIA2024 #DigitalHealth #HealthcareInnovation #Fairness (PS, he’s on the academic job market!)
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How far can fine tuning take us? @kdpsinghlab puts numbers into concrete use cases. #AMIA2024 #LLMs #Digitalhealth
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RT @JBI_Journal: Apply to JBI Student Editorial Board by 11/20/2024! 3 new positions available, excellent opportunities for getting involve…
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@CatGaoHow @IAIM_NU @IPHAM_CHIP @NM_Lung @NUFeinbergMed Hearty Congratulations Cathy and looking forward to continuing working with you!
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RT @NUCATSInstitute: An #AI model developed by @NUCATSInstitute Chief AI Officer @yuanhypnosluo improved the transformation of EHR data int…
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RT @yuanhypnosluo: I am thrilled to announce our latest publication in @NEJM_AI: "FHIR-GPT Enhances Health Interoperability with Large Lang…
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@dmljmd @BUMedicine @NUPrevMed @NUFeinbergMed Hearty Congratulations Don! You have always been an incredible leader and mentor, not only to me, but also to so many others. Wishing you and your family all the best in this new adventure!
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RT @npjDigitalMed: A ✨ reminder✨ we are still inviting submissions examining the role of Artificial Intelligence (AI) and digital governanc…
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