Nick Borcherding
@theHumanBorch
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Assistant Professor @wusm_pathology | MD/PhD Pathologist using computers for oncology and immunology | Former Marine Corp Sgt
St Louis, MO
Joined November 2019
RT @SmithImmunology: We developed a 3-gene signature to identify tumor-specific CD8 TIL, i.e. the cells targeted by #immunotherapy, from #s…
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RT @rust_ruslan: Single-cell profiling of the immune landscape across the entire human lifespan, very useful resource! @NatImmunol Paper:…
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Coolest paper of the year so far!! With a great summary from @BrestoffLab
Bidirectional #mitochondria transfer swaps T cell mitochondria with those from cancer cells to impair anti-tumor immunity. Check out my News & Views in @Nature summarizing this incredible paper by Ikeda et al. Nature 2025
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RT @Francesca_Fin_: Many thanks to @tangming2005 for highlighting our work! In a joint effort with @itisalist lab, we have developed 2 ad…
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RT @BrestoffLab: Bidirectional #mitochondria transfer swaps T cell mitochondria with those from cancer cells to impair anti-tumor immunity.…
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RT @LabWaggoner: 191 children with diverse solid tumors, immune variation with age and tumor type provide a reference for future precision…
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RT @andimscience: Our work on contrastive learning of T cell receptor representations is now out in Cell Systems! Give SCEPTR embeddings…
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RT @MiLaboratories: There are many tools out there for analyzing T and B cell repertoires, but 𝗵𝘂𝗻𝗱𝗿𝗲𝗱𝘀 of scientists across academia, phar…
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If you are interested in HLA, adaptive immunity, or viral infections, please see the special issue I am guest editor for:
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RT @karthik_varanas: With great joy! I want to share with you our recent work on how Bile acid synthesis impedes tumor-specific T cell resp…
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RT @antigenomics: "Age-Related Dynamics and Spectral Characteristics of the TCRβ Repertoire in Healthy Children: Implications for Immune Ag…
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Pseudobulk VDJ feature space used to estimate pseudotime in T cell development. Cool vignette for DandelionR with scRepertoire.
So i'm very happy to say that my very talented honours student has reimplemented the entire trajectory workflow in R, intersecting with @theHumanBorch's scRepetoire! Code is now live but lacking vignette; will be up shortly!)
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RT @mourisl: Great news before starting 2025. TRUST4 is highly recommended in this benchmark evaluating TCR reconstruction method from scRN…
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Just in time for the new year: scRepertoire 2: Enhanced and Efficient Toolkit for Single-Cell Immune Profiling
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RT @tangming2005: TLS_Finder: An algorithm for Identifying Tertiary Lymphoid Structures Using Immune Cell Spatial Coordinates https://t.co/…
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I created a @quarto_pub markdown file that reproduces the figures of our PNS atlas manuscript. It's fully automated. It downloads all necessary data from @ZENODO_ORG and can be run in the respective Docker container.
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