Mikhail Shugay
@antigenomics
Followers
1K
Following
951
Statuses
563
Bioinformatics, immunogenetics, high-throughput immune repertoire sequencing. Decoding adaptive immunity.
3rd Rome
Joined May 2014
RT @andimscience: Our work on contrastive learning of T cell receptor representations is now out in Cell Systems! Give SCEPTR embeddings…
0
21
0
RT @Dushek: Our new work! The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect…
0
12
0
"Age-Related Dynamics and Spectral Characteristics of the TCRβ Repertoire in Healthy Children: Implications for Immune Aging" in Aging Cell
0
7
56
RT @mourisl: Great news before starting 2025. TRUST4 is highly recommended in this benchmark evaluating TCR reconstruction method from scRN…
0
10
0
RT @myphysicsvoyage: Excited to share my final preprint of 2024, “Direct estimates of irreversibility from time series,” with Gianluca Teza…
0
5
0
RT @amirshanehsaz: We @abscibio are excited to open source the code and datasets for IgDesign, with over 1,000 SPR datapoints against 7 tar…
0
27
0
RT @andimscience: How to learn generalizable rules across complex sequence-function maps? 💡In our new preprint we propose a framework for l…
0
14
0
RT @UlrikStervbo: A new paper, led by @kerry_mullan from Pieter Meysman’s (@chevaliersf) group, advocates for a TCR-centric approach to ana…
0
6
0
@chevaliersf Great job! Based on my experience, I would definitely say that one would need different substitution matrices for contacting vs non-contacting residues and CDR3 center/flanks) Ideally depending on pMHC context.
1
0
5
RT @GurYaari: Check out our new publication: An unbiased comparison of immunoglobulin sequence aligners
0
15
0
RT @UlrikStervbo: Statistical analysis of repertoire data demonstrates the influence of microhomology in V(D)J recombination
0
3
0
@AMikelov Тут одна цель - развести на эмоции. Игнор и шэдоубан это самое страшное наказание) Ты вроде как в преферанс гораздо лучше меня играешь))
1
0
1
RT @pierce_lab: Happy to share an update to our TCR structure database, TCR3d, now online at @NAR_Open! More structures of TCR complexes, a…
0
21
0
RT @NatComputSci: 📢Out now! Mikhail Shugay and colleagues leverage protein structural data to predict T-cell receptor–peptide interactions…
0
4
0
@jamimmunology @chevaliersf @CederD @NatMachIntell Sure, access to dex(-) data is critical. What is available right now is cluster multi-dextramer single cell based on tag expressions and select specific clusters that are far apart. Yet the real accuracy of such staining is not studied enough when it comes to individual clones.
1
0
1
@jamimmunology @chevaliersf @CederD @NatMachIntell The problem is the lack of data actually, one could maintain a "-" version of VDJdb. Anyways actual "+" set diversity is negligible compared to "-". The only solution right now IMHO is to provide enough evidence like in GO enrichment analysis.
1
0
6
RT @TcellResearch: Great effort from the team on this study published in Cell today! Hard work pays off - well done everyone 👏🏻 Exciting…
0
75
0