Jon Brestoff
@BrestoffLab
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Associate Professor MD/PhD @WUSTLmed who studies #immunometabolism, intercellular #mitochondria transfer, and metabolic diseases like #obesity.
St Louis, MO
Joined July 2019
Curious about #mitochondria transfer? Check out our latest #MitoTransfer review with the @theHumanBorch in @Nature Feel free to post your thoughts, ideas, and questions below. Please RT to help grow this blossoming field.
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@MitoPsychoBio Not all cytokines promote inflammation. Most famously, IL-10 strongly suppresses immune responses. For many of them, their functional effects depend on context, abundance, microenvironment, cell types involved, and other factors
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@MitoPsychoBio @NBoydGibbins I would think so but i am not aware of compelling evidence showing that definitively. It stands to reason though that once in the acceptor cell’s cytoplasm, nuclear genome-encoded mito genes would ultimately modify transferred or transplanted mito.
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Bidirectional #mitochondria transfer swaps T cell mitochondria with those from cancer cells to impair anti-tumor immunity. Check out my News & Views in @Nature summarizing this incredible paper by Ikeda et al. Nature 2025
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5/ #MitoWorld hosted a 30-day public commenting period so we could solicit feedback from the community before peer review. Nature Metabolism kindly published this an open paper to maximize accessibility (kudos and thanks!). Let me know if you have issues accessing the PDF.
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Glad to be part of this study! Thanks Hannah and Chris for allowing our mouse skills to come alive in a clinical paper. It’s a great way to establish a clinically relevant model for future studies.
Elevated cTnI in diabetics may signal early heart trouble. @hbrownphd & others find a link between #glucose control and #cardiac biomarkers. Could routine screening help? Read the article here: @wusm_pathology @farnsworthcw @nickspies13 @brestofflab
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RT @NatMetabolism: RESEARCH | R Nakai, T Yokota, J Brestoff et al. (Osaka Univ, JPN; @washu_pathology) Administration of exogenous #mitoch…
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RT @ChenUltrasound: Our lab is hiring a postdoc or staff scientist to join our NIH Pioneer Award-funded project on artificial hibernation.…
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RT @immunometlab: CENCAT; an immunometabolic profiling tool that blends the @SCENITHmetab approach with BONCAT click chemistry to measure m…
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Had an amazing trip to Prague for the 1st International #mitochondria transfer meeting! Thanks for the invitation Jiri Neutzil. Made many new friends and great to see old ones. Excited for Paris 2026! Off to Barcelona for @CellSymposia Multifaceted Mitochondria
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@CaicedoLab @CesarZbrn @aencalada1 @MantillaGonzalo @palsqito @Alejo_bermeo @USFQ_COCIBA @USFQPRESS @edicionmedEC Very exciting Andres and well deserved recognition!
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Of course also very appreciative of our many collaborators, colleagues and friends. Especially the ones who welcome my crazy ideas, of which there are many. And Richard Cote (Chair), Gautam Dantas (Chief), and Ann Gronowski (Chief) for supporting my career in so many ways!
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RT @nieminm: Interested in BNIP3/NIX-mediated mitophagy? Check out our new review, written with @LabFriedman, about recent advances in the…
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