Quintin Frerichs
@quintinfrerichs
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raising the baseline | co-founder @Nudge , founding team @ArcadiaMed
Joined April 2024
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First human study on non-neurotoxic MDMA isomer?
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So excited to be sharing more about what we’re building
@nudge
- we see huge potential for ultrasound to both improve mental health and enhance everyday life.
We’re making great progress on the science and engineering to make the technology a reality. If you’re an exceptional
I founded
@nudge
with
@quintinfrerichs
.
We’re building an ultrasound headset to enhance human experience. Press a button to shift your brain state: go to sleep, boost focus, break habits, elevate mood, etc. We believe this device has the potential to improve people’s daily lives
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We’ve got a lot of hard engineering problems and are moving beyond the edge of the known science - reach out!
Want to join a small but growing and mighty team of engineers and scientists building a neuromodulation device that unlocks the potential of the human mind? Email info at nudge dot com.
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There’s been a long-standing debate about MDMA neurotoxicity, and although it is a complex issue, but there’s clear evidence of risk (). And now there’s an exciting result on what appears to be a much safer isomer of MDMA in humans from a publication that
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Writing up thoughts on NDK (thanks to
@AEStudioLA
@MWCvitkovic
@SumnerLN
!). Still way too few opportunities for software engineers to contribute to neurotech…
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seeing spacex catch a rocket makes me think how the 2020s are the 1960s pt 2.
we have a space race, a psychedelic revolution, a new era in computing (LLMs vs the mother of all demos), and both a cold war and a hot proxy war between the superpowers. main difference is this time
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One 40-minute ultrasound session decreases chronic pain by an average of 60%, lasts for ~1 week
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In 2017, Curry et. Al. published a study (colorfully titled “Separating the agony from the ecstasy” ) on how one of the MDMA enantiomers, r-MDMA (typically MDMA comes in a 50:50 ratio of r-MDMA and s-MDMA), may provide the positive therapeutic effects
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Fast-forward a few years and a study just out in Nature from Liechti et. Al. () shows that in a randomized-controlled trial of r-MDMA in 24 humans, 250mg of r-MDMA seems to feel extremely similar to sr-MDMA, although a touch less intense.
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There still remains some work to be done to definitely prove the safety profile is also improved in humans, but the metabolic data collected is a promising sign in that direction. Stay tuned :)
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Researchers showed that even a dose that (scaled assuming a 30g mouse and 75kg human) was comparable to the doses used in human clinical trials there was immunoactivity on a reactive astrogliosis panel in the slices of rodent brains, a marker of damage to the central nervous
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The paper also showed that the behavior of the mice implied r-MDMA may still be as effective as a therapeutic as rs-MDMA if used in humans, since it showed similar “prosocial” effects. It suggested a dose of 267mg could be effective in humans.
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who knew the most annoying outcome was the most likely
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The design first tested the stimulation parameters in an MRI, where the params were selected based on which regions produced the largest subjective reduction in pain in a given participant (the reduction in pain was immediate, so could be used as a feedback signal)
fMRI was
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Overall, it’s both really exciting to see this technology helping people suffering from pain and to see the impact of better hardware and study designs on understanding how ultrasound impacts the brain. Congrats to the team at University of Utah on an excellent paper, full
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They study was conducted in n=20 participants (with a variety of different forms of chronic pain, all of which were about equally impacted by the treatment), and showed the single 40 minute session reduced chronic pain substantially for ~7 days
Critically, they also showed that
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Along with that excitement the field is, imo for the first time, starting to publish high quality human studies -
In this case, it was a randomized, well controlled trial with clear effects and large effect sizes, in 10s of subjects, with hardware that allows for precise
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There’s a lot of excitement around ultrasound right now as a brain stimulation technology - one that can uniquely target deep brain regions safely and non-invasively, in a simple form factor.
There’s been some recent press coverage showing that it can be powerful as a therapy
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@Mackenzie_then
@dwarkesh_sp
@fchollet
@fchollet
is the only skeptic I’m aware of who’s posited and implemented a benchmark that’s easy for humans and hard for AIs, including LLMs. Talk about ARC!
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