Miha Modic
@paraspeckle
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Uncovering the beauty of embryonic development with functional RNA biology tools. King's Prize Fellow & Assist Prof @KingsCollegeLon / @TheCrick @kemijski
London, England
Joined October 2017
How can cellular signalling swiftly & selectively remodel the transcriptome to drive biological transition? How this switch is orchestrated has been a mystery... 🧵
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And CRG has an outstanding PI, who is another reason you should apply :)
The CRG has an outstanding international PhD programme, do apply!!!
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@IraIosub @KlobucarTajda In case you're at #EESRNA EMBO meeting, find out more about the higher-order transcriptome organisation into distinct smOOPs subnetworks by visiting Jona's poster 210.
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A fantastic work from @OscarWilkins16 on leveraging the delivery of synthetic “cryptic” exons to modulate gene expression only in diseased cells. 👏
Our paper on cryptic splicing-controlled protein expression, which we hope will inspire safer and more adventurous gene therapy approaches for ALS and FTD, has been published in @ScienceMagazine
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What an amazing tour de force to disentangle several cellular regulatory modules through an intertwined network of RBP-RBP interactions.
Delighted to see this study on systematic identification of RBP networks out in @NatureComms! A fun collaboration between the labs of @genophoria, @halfacrocodile, and us! Massive congratulations to @khorms57 and other authors (including Martin)! 🎉
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Thank you @jacob_hanna! It's an honor to be able to read how you brought our recent insights into a bigger concept and am glad that you enjoyed it.
We greatly enjoyed reading and summarizing the important findings of these two new studies on LIN28 regulation of cell fate for @NatureSMB - mechanistic studies at their best! Congrats Miha @paraspeckle and all other authors
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6) If the pluripotency programme is not switched off properly, this leads to complications in development. Watch out for a follow-up study showing what routes the embryos take when the pLIN28A reassembly is disrupted upon embryo implantation. Preview:
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We identify the mRNP assembly hubs at 3’UTR terminal as key determinants of developmental mRNA decay and show how their multivalent RNA signatures interplay with the bound proteins to determine the selectivity and timing of mRNA decay.
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RT @BCI_RNAHUB: We are looking forward to host the London RNA club at @QMBCI on 17 July at 2-6pm in person! Talks by @ericmiska @Seb_Fica…
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