Nicholas Perry
@ntperry13
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PhD Candidate, Hsu Lab UCB-UCSF Bioengineering Arc Institute Genome design and bridge recombinases
Berkeley, CA
Joined August 2018
Our work on bridge recombination is out in @Nature today. We are especially excited to share our structural work in collaboration with @hnisimasu. We show that this enzyme makes and breaks a Holliday junction, using more (!) RNA-DNA base-pairing to drive the reaction forward 🧵
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RT @Gabogonzalez515: me with deepresearch: “find obscure biochemistry papers from the 1960s and 70s that have very weird but intriguing res…
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Congratulations Alison! Looking forward to seeing what people do with your engineered integrases in stem cells and T cells. Check out @AlisonFanton exciting thesis work here:
Super proud of the fearless @AlisonFanton for her PhD defense yesterday! Alison is a super talented bioengineer and molecular biologist who has done pioneering work on DNA recombinases for human genome insertion. Congratulations, Dr. Fanton!
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RT @mgdurrant: Hey folks, I know most deadlines are fast approaching, but I am applying for assistant professor positions this cycle, and I…
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RT @yaireinhorn: A recent & exciting scientific discovery is Bridge RNA - a new class of guide RNAs that could recombine, insert, delete, o…
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RT @shsternberg: Did you see the bridge RNA papers yesterday? Bacterial transposons promote programmable, RNA-guided DNA recombination. Re…
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RT @shsternberg: On the topic of RNA-guided biology emerging from transposons, you won't want to miss this one! In published work led by th…
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@ebetica definitely incredible! it seems unlikely that humans, given the task to make a programmable recombinase, would design a similar mechanism
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RT @connorjtou: Congrats to @mgdurrant @ntperry13 @pdhsu @hnisimasu and colleagues on their bridge recombinase works! Excited to see how th…
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RT @patrickc: This morning, Nature published two papers on bridge editing, the new genome engineering technology from @ArcInstitute: https:…
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Finally, plasmids will be @Addgene soon: Please reach out with any questions on applying bridge recombination to anything you are interested in!
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Excited for our papers out in @Nature today! Please read this excellent thread by @pdhsu. Incredible teamwork was required for all this work to come together. Especially thankful to my co-lead @mgdurrant, and our collaborators at University of Tokyo @hnisimasu and @somturn20
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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RT @mgdurrant: Our 2 bridge RNA papers are finally published in @Nature! Check out the incredible CryoEM structures, they're truly beautifu…
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RT @JKeithJoung: Excited to share a new preprint ( describing Precision Editing of Regulatory Sequences to Induce S…
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