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@arcinstitute
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A new scientific institution for curiosity-driven biomedical science and technology.
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The Arc Institute launches today with
@Stanford
@UCBerkeley
@UCSF
, bringing together unconstrained funding for ambitious science, rapid tech development centers, and the scientific excellence of these universities into one physical institute. Join us at
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🧬Introducing a powerful, programmable new mechanism for genome design: DNA recombination with bridge RNAs.
As the first natural RNA-guided DNA recombinase, this system enables insertion, excision, or inversion of any two DNA sequences.
Out today in
@Nature
, led by Arc
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🧬 Turns out, mRNA isn't just a passive genetic courier.
Arc’s Goodarzi lab, in collaboration with
@LukeGilbertSF
’s lab, discovered that mRNA can actively control its own expression using newly discovered "RNA switches." The team found over 200 of these switches in human cells,
Out today from the Goodarzi lab!
@genophoria
SwitchSeeker combines computation and experiment to identify functional RNA structural switches. Applied to the human transcriptome, it identified a novel RNA switch in the 3ʹUTR of RORC, linked to NMD.
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🧬New paper + tool out of
@pdhsu
@skonermann
Labs, led by
@StanfordBioE
Ph.D. student
@JingyiWei4
: a new RNA targeting CRISPR enzyme paired with a convolutional neural network (CNN) model predicting highly efficient guide RNA sequences for transcriptome engineering.
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Today in
@NatureBiotech
, Arc cofounder
@pdhsu
's lab reports the mining and characterization of new genome editing tools for 'gene writing', by integrating large DNA payloads into the human genome.
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A new study
@ScienceMagazine
from the Gilbert lab at Arc Institute (
@LukeGilbertSF
) & the Shokat lab
@UCSF
(
@kevansf
) uncovers how large linked drug molecules enter our cells to reach their targets, expanding possibilities for future therapeutics.
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We're thrilled to announce that Luke Gilbert will be joining Arc as a Core Investigator!
@LukeGilbertSF
is a pioneer in developing CRISPR technology for editing the epigenome, with a particular focus on understanding the genetics & epigenetics of cancer. Welcome to Arc, Luke!
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At Arc, we give early career scientists a springboard for launching their independent careers through our Science Fellow program.
Learn more at our virtual information session next Wednesday, Nov. 15, from 12-1pm PST, hosted by Arc co-founder & Core Investigator
@pdhsu
. 👇
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We’re thrilled to welcome Hani Goodarzi
@genophoria
, Associate Professor of Biochemistry & Biophysics
@UCSF
, as our newest Core Investigator
His groundbreaking research uses machine learning models and experimental frameworks to dig into cancer progression and metastasis.
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🧬A new AI approach featured in
@ScienceMagazine
combines protein 3D structural information with sequence-based large language models to improve our ability to engineer therapeutic antibodies. The pipeline makes it faster and easier to identify rare mutations that improve
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🎉 Today, Arc welcomes our newest Core Investigator, Dr.
@FelixHorns
!
Dr. Horns joins the Arc community as a Core Investigator and
@Stanford
as Assistant Professor of Genetics. The Horns lab works at the interface of synthetic biology and genomics to discover the fundamental
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1 in 8 women in the US will receive a breast cancer diagnosis in their life. Arc Investigator
@genophoria
led a
@TEDTalks
session on applying advanced AI and novel RNA molecules to detect+track breast cancer – changing the future of how cancer is screened
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An exciting update from Arc!
Today, we launched our Scientific Advisory board and welcomed our first Scientific Advisors, Nobel Laureate Dr.
@CarolynBertozzi
and Dr. Aviv Regev, EVP of Genentech Research & Early Development.
Both Drs. Bertozzi and Regev have long careers
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🧠At Arc, we believe great science happens when creative minds can pursue their boldest ideas.
Today, we welcome new researchers to the Arc community to conduct curiosity-driven, collaborative research into complex diseases—from cancer to conditions like autoimmune dysfunction.
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Meet
@LukeGilbertSF
in the first of Arc's Q&A series. Luke is at the forefront of the functional genomics field and an early pioneer of CRISPR-based epigenome editing tools. Luke's lab aims to understand the genetic and epigenetic landscape of cancer.
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☀️It’s a great week at Arc as we welcome our new Core Investigator
@genophoria
and his lab, and our first Science Fellow
@zhou_jingtian
! We’re proud to add these talented minds to our ranks, bringing with them a multidisciplinary approach to human disease research. Welcome, all!
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It’s not often we catch all of our Core Investigators in one place, standing still, but we did it! Welcome
@FelixHorns
-
@pdhsu
,
@SKonermann
,
@li_lingyin
,
@LukeGilbertSF
,
@genophoria
and Arc Science Fellows
@UcheMedoh
and
@zhou_jingtian
are glad you're here.
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🛠️New CRISPRi tool in
@NatureBiotech
from
@LukeGilbertSF
+ lab!
Until now, scientists have been limited to targeting fewer than 3 genes at a time with CRISPRi. But what about when we want to study more complex combinatorial biology?👇
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This afternoon, Arc’s
@pdhsu
and
@brianhie
welcomed Sir Tony Blair and
@InstituteGC
to Arc to see our institute in action, including the research we’re doing to accelerate biomedical progress with AI foundation models. Thank you Tony and
@BenedictCooney
for visiting
@arcinstitute
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💡Early career scientists explore their most curious + innovative ideas at Arc as Science Fellows.
New Fellow
@UcheMedoh
joins us with a background in investigating the molecular mechanisms of anti-aging metabolites for human health and disease. 🧵
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Big news! We’ve launched an open rank search with
@stanford
Genetics Department. Have a background in basic, translational and/or clinical sciences in the broad areas of genetics, genomics, other “omics” or precision health? Apply now!
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More science at Arc! We are excited to announce the launch of three parallel searches to significantly expand Arc Institute’s scientific community. Applications for Core Investigators, Arc Science Fellows, and Innovation Investigator Awards are now open.
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Exciting collaborations old and new are flourishing at our first Investigator Retreat. Thank you
@genophoria
,
@yimmieg
, Xiaojie Qiu,
@SKonermann
,
@pdhsu
,
@zhou_jingtian
,
@LukeGilbertSF
,
@andcyang
,
@AnnaMolofskyLab
, Nathanael Gray,
@AlannaSchepartz
,
@ishahjain
, and Will Greenleaf
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6
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🎧 Exciting new discovery from
@li_lingyin
and postdoctoral researcher Chris Ritchie on PELI2: a protein that functions like noise-canceling headphones for the cGAS-STING pathway. cGAS-STING is a crucial immune defense mechanism for the human body that’s triggered in response to
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In a second
@Nature
study, led by the
@hnisimasu
and
@pdhsu
labs, the elegant structural mechanism of bridge RNA-guided recombination is revealed across 3 cryo-electron microscopy structures.
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Arc cofounders
@pdhsu
and
@SKonermann
report genome-wide loss-of-function and gain-of-function CRISPR screens mapping pathways that impact SARS-CoV-2 infection in human lung epithelial cells, uncovering an antiviral role for airway mucins.
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Thrilled to gather our investigators for the first Arc Institute Investigator Retreat. Thank you to
@CarolynBertozzi
for launching with an inspiring keynote and to
@zhenanbao
,
@UcheMedoh
,
@li_lingyin
, and Katrin Andreasson, who shared their work and plans. Can’t wait for Day 2!
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@hsiung_chris
in the Gilbert Lab has developed an Acidaminococcus Cas12a variant that can knock down 3+ loci simultaneously – meaning researchers can study complex genetic interactions and map regulatory biology more effectively.
Check it out:
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🤝The new discovery is the result of 2.5 years of collaboration with scientists across disciplines, institutes, and continents – including the Hsu Lab;
@SKonermann
Lab; and
@HNisimasu
Lab at
@UTokyo_News_en
. Read the paper in Nature now:
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@zhou_jingtian
joins as our first Science Fellow. Jingtian is a recent PhD graduate in Bioinformatics & Systems Biology from
@UCSD
and a former Salk Institute scientist.
His pioneering work has developed new algorithms and insights into the epigenetic basis of brain development
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We so enjoyed announcing the growth of our scientific community yesterday, we figured, why not do it all again soon?
Applications for our next Core Investigator and Science Fellows searches are now open!
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In the second installment of our Arc Investigator Profiles, we caught up with Lingyin Li about her lab's work on innate immunity and how joining Arc has transformed her research.
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Breast cancer is 1 of the deadliest cancers for women, but <20% respond well to immunotherapy.
New research in
@PNAS
from Arc Investigator and
@Stanford
Biochem Prof
@li_lingyin
+
@Stanford
grad student Songnan Wang uncovers why. 🧵
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Welcome to our Innovation Investigators!
Zhenan Bao
@zhenanbao
, Iain Clark
@icclarker
, Nathanael Gray, William Greenleaf
@WJGreenleaf
, Brian Hie
@BrianHie
, Isha Jain
@ishahjain
, Anna Molofsky
@AnnaMolofskyLab
, Alanna Schepartz
@AlannaSchepartz
, Jimmie Ye
@yimmieg
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Come join the growing scientific community at Arc! Applications for our Arc Science Fellows program - an early independence program for exceptional recent PhD graduates - are due on Monday, January 9th.
Learn more and submit your application:
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Core Investigators are pivotal to Arc’s mission – they’re scientific leaders who are empowered to tackle curiosity driven research. Today, we’re proud to announce a new call for applications in partnership with
@StanfordDBDS
.
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Katrin Andreasson, Faranak Fattahi
@FaranakFattahi
, Michael Fischbach
@mfgrp
, Martin Kampmann
@MartinUCSF
, Calvin Kuo, Alexander Marson
@MarsonLab
, Alex Pollen
@brainevodevo
, Xiaojie Qiu
@Xiaojie_Qiu
, Julia Salzman, Robert Saxton
@rsaxton_
, Andrew Yang
@andcyang
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Emerging technologies at the nexus of AI and health have the potential to augment our understanding of how to treat human diseases. We’re honored by the
@BiswasFamilyFdn
's gift, which will help support important computation-driven research. Thank you!
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Science thrives within a physical environment that fosters curiosity-driven research and enables a high collision frequency of ideas. Recently, we celebrated the grand opening of Arc’s headquarters - a state-of-the-art lab and office that was carefully designed to do just that.
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4
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Congrats
@JingyiWei4
on the new study and notable contribution to transcriptome engineering. A great
@arcinstitute
collaboration between
@SKonermann
and
@pdhsu
labs.
Excited to share our latest work 'Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting'! Posted as an update but greatly expanded our previous story - we identified a new Cas13d ortholog with low toxicity and collateral effects!
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🔎How does it work? The recombinase enzyme relies on a noncoding bridge RNA with two loops. One loop binds the donor DNA and the other loop binds the target DNA – the first example of a bispecific guide RNA
The two loops can be independently programmed to control the
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⚡After discovering the role of the ENPP1 enzyme in masking cancer from the immune system,
@Lingyin_Lab
has found a new enzyme, ENPP3, that also inhibits cGAMP-STING signal + anti-tumor immune response, preventing immunotherapies like Keytruda from working effectively.
🧵⬇️
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The recent ENPP1 study from Arc Investigator
@li_lingyin
and
@Stanford
grad student Songnan Wang shows us the importance of seeking out opportunities for collaboration and multidisciplinary exploration. 🧵
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This new work expands a gene editing platform technology, known as large serine recombinases, by over 100-fold to accelerate functional genomics and genetic medicines.
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🔬Uche will drive important subcellular metabolism and aging exploration to develop treatments for age-related diseases (e.g. Alzheimer’s) in a dynamic, collaborative, and interdisciplinary community of scientists tackling complex disease.
Welcome to Arc, Uche! 🎉
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We're thrilled to have been able to partner with
@StanfordEng
ChemE and
@StanfordData
to bring Brian on board! Looking forward to the great science to come.
Delighted to share that I will be starting a research laboratory as a professor at
@StanfordEng
ChemE and
@StanfordData
, in collaboration with
@arcinstitute
. The lab will work on aligning biological AI with human good.
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🌐 The new Cas13d guide design tool out of
@skonermann
and
@pdhsu
Labs is just one step in the technological development happening at Arc. We’re proud to launch the Arc Tools Portal, a one-stop shop for computational tools to support discovery within the scientific community. 🧵
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Learn how we're expanding Arc’s community by recruiting new Core Investigators, launching the Arc Science Fellows early independence program, and funding bold research directions through Innovation Investigator Awards
@Stanford
@UCSF
@UCBerkeley
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A key pillar of the Arc Institute model is our Technology Centers - innovative technology development hubs with an industry mindset collaborating closely with our core labs to accelerate biomedical science. Learn more:
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Interested in how
@li_lingyin
and postdoctoral researcher Chris Ritchie unlocked the secrets of PELI2, a new player in autoimmunity? Learn more at the Arc blog:
🎧 Exciting new discovery from
@li_lingyin
and postdoctoral researcher Chris Ritchie on PELI2: a protein that functions like noise-canceling headphones for the cGAS-STING pathway. cGAS-STING is a crucial immune defense mechanism for the human body that’s triggered in response to
2
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50
0
1
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🪡CRISPR has revolutionized gene editing. But for true large-scale genome design, scientists need a precise and programmable way to rearrange large segments of DNA. The bridge recombinase - discovered in mobile genetic elements - joins any two DNA molecules in a modular way.
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Delighted to see Arc Innovation Investigator and
@Stanford
Professor
@zhenanbao
inducted into
@theNASciences
. Her lab works to treat neurological disorders through skin-inspired bioelectronics – the kind of bold research Arc was created to fuel. Congratulations to Dr. Bao!"
We are thrilled to announce the election of 120 members and 24 international members to the National Academy of Sciences in recognition of their distinguished and continued achievements in original research.
Congratulations to our new
#NASmembers
and welcome to the Academy!
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The Hsu lab (
@pdhsu
) and Konermann lab (
@SKonermann
) at Arc are looking for a Senior Scientist with expertise in RNA-protein biochemistry, structural biology, and protein engineering to work on genome engineering effector development. Apply now at
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Want to start your own lab out of grad school? Our Science Fellow program gives you a springboard to launch your independent career! Make sure to apply by December 4th to ensure full consideration:
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A chance conversation with incoming Arc Core Investigator
@genophoria
gave Li access to new clinical data, revealing that ENPP1 levels were highest in Stage 4 cancer patients with lots of metastasis – a foundational piece of the team’s discovery.
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As Lingyin explains, “This research was highly interdisciplinary, combining “hardcore” biochemistry with immunology, genetics, and computation, but likely would not have received funding under traditional models. It’s the kind of curiosity-driven, interdisciplinary work that
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Don't miss out on your chance to join us at Arc as a Core Investigator, or to receive support from Arc for bold ideas in your
@UCBerkeley
@UCSF
or
@Stanford
lab through our Innovation Investigators program!
Applications for both due Tuesday, Jan 31.
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Full announcement here:
Meet the scientists! 👇
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New from
@CellChemBiol
: Arc Core Investigator and
@Stanford
Biochem Prof
@li_lingyin
explores the future of cancer therapy using cGAMP-STING
The perspective piece from Dr. Li highlights pros & cons of cGAMP and its analogs as STING agonists and how to boost STING signaling while
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The results were black and white: patients with low ENPP1 responded to Keytruda and had no metastasis, while 12% of patients with high ENPP1 relapsed and their cancer metastasized.
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Together, we’re looking for a talented computational biologist to step into an Assistant Professor role at Stanford and lead their own lab as a Core Investigator at Arc.
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“Without Songnan’s work of assembling the puzzle pieces and seeking collaboration with researchers in our scientific community, we wouldn’t have gotten to this critical discovery,” said Li. Check out our blog post for the full story:
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The growth in our flagship programs sets us up to ask and answer some of the important questions behind complex human disease.
Read more about how today’s announcement advances our mission to accelerate discovery!
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Lingyin is well known across the
@Stanford_ChEMH
community for her outstanding mentorship of graduate students. In our Q&A, she reveals her mentorship philosophy and why it's so critical to the success of her lab.
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We're looking for a stem cell and organoid expert with management experience to build a fully-funded team and develop new cellular models of neurodegeneration and other complex diseases. Apply now to lead our Cellular Models Technology Center!
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Do you have expertise in computational biology? Apply to join Arc as a Core Investigator and
@StanfordDBDS
as an Assistant Professor. Submit your application by Friday to ensure full consideration:
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5. Lastly, if you’re an early-career scientist looking to jumpstart your independent career, apply to our Science Fellows program.
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The scientists used this knowledge to develop two new linked drugs that offer similar potency and superior specificity compared to their unlinked counterparts, even though they violate traditional drug design rules.
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Congratulations to Sita Chandrasekaran
@sitaritapita
from the Hsu lab on being selected as a 2024 Siebel Scholar!
Thrilled that our star PhD student, Sita Chandrasekaran
@sitaritapita
, has been selected as a 2024 Siebel Scholar, which recognizes the top grad students from 27 partner programs across the US, China, France, Italy, and Japan!
@UCBerkeley
@arcinstitute
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If you’re interested in playing a key role in both the Arc and the Stanford communities – apply now – or retweet for a colleague!
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Are you a PhD/MD with a passion for researching genetics, genomics, other "omics" or precision health? Apply to join Arc as a Core Investigator and
@stanford
Genetics Department as faculty. Submit your application by Friday to ensure full consideration:
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Innovation Investigator Awards: We invite applications from faculty at our partner universities
@Stanford
@UCBerkeley
@UCSF
to receive 5 years of funding from Arc to tackle a visionary idea and join our network of curiosity-driven innovators.
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Do you want to build and manage Arc's fully-funded, cutting-edge Genome Engineering Technology Center team? Leaders with management experience and a proven track record in functional genomics and/or CRISPR effector development are encouraged to apply!
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We’re planning to hire 1-2 new Fellows this application cycle, and we’ll review applications starting Dec. 4 until the position is filled. Learn more here:
We look forward to seeing you next Wednesday!
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Learn what's on Luke's biotechnology wish list, the best advice he's received for persevering in science, and how his hobbies outside the lab keep his creative juices flowing.
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Arc’s Core Investigators are appointed for eight-year terms and set the direction for the science happening at the Institute.
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The recent ENPP1 study from Arc Investigator
@li_lingyin
and
@Stanford
grad student Songnan Wang shows us the importance of seeking out opportunities for collaboration and multidisciplinary exploration. 🧵
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We’re excited for the scientific community to use this tool for their own work! Check out the paper
@CellSystemsCP
and our blog post to learn more
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They enjoy:
💸Unrestricted funding to support their research and a team of 2-4 people
🧪Freedom to pursue curiosity-driven research
🤝Opportunities for cross-discipline collaboration
🔬Robust scientific infrastructure and cutting edge Technology Centers
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Keep those applications coming!
🗓️DEADLINE REMINDER: the Arc Science Fellows applications are due January 9, 2023, while our Core Investigators and Innovation Investigators applications are due January 31, 2023.
Learn more about all three programs:
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New Core Labs: We are seeking applications for Arc Core Investigators in the areas of Neurobiology, Immunology, and Computational Science, to be based at our headquarters in Palo Alto, California. Learn more and apply here:
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@pdhsu
@SKonermann
The Konermann (
@SKonermann
) and Hsu (
@pdhsu
) labs at Arc are also hiring a Senior Scientist with expertise in functional genomics and cell and molecular biology to work on cellular models of neurodegenerative disease. Learn more and apply today!
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In the future, we’ll expand the Portal to include cutting-edge protocols, datasets, open-source software, and other resources—so other labs can adopt and build on our emerging technologies and drive new avenues of discovery.
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There’s still time for prospective Science Fellows to register for our virtual Information Session and Q&A, happening tomorrow, November 15, from 12-1pm PST!
Arc co-founder and Core Investigator
@pdhsu
will share all about the program and answer any questions you have.
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To learn more about Arc's Technology Centers and how they help us blend the best features of academia and industry to drive innovative technology development, read our recent blog post:
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Independent Science Fellows: Arc is launching a program to enable brilliant early-career scientists to launch an independent lab following their doctoral training. Learn more at
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In addition to the Cas13d guide design tool, a new tool, ScreenPro2, out of the Gilbert Lab enables users interested in pooled CRISPR screens to easily analyze experiments performed with widely used standard or custom single and dual sgRNA library designs.
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The study, reported in Nature Genetics, is the first of its kind conducted in cells resembling the primary cellular targets of SARS-CoV-2, and represents the first gain-of-function screen identifying antiviral pathways protecting us from SARS-CoV-2.
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Interested in working at Arc and/or the Gilbert Lab? Check out our open positions at .
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A bit more on the program:
Science Fellows are recent or soon-to-be MD and/or PhD graduates conducting research in Neurobiology, Immunology, Computational Science, Human Genetics, Chemical Biology, and Technology Development.
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Do you aspire to groundbreaking research in immunology and/or neuroscience? Don't miss out on the opportunity to join Arc as a Core Investigator and
@StanfordPath
as faculty. Apply by Wednesday to ensure full consideration:
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What does it mean to lead a lab at Arc?
💸 Guaranteed, annual, no-strings attached funding for you and your lab over 8 years.
🔓 Autonomy to pursue your boldest research
🔬 Access to cutting-edge equipment and technologies
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Luke told us about his fascination with genetic interactions: "One of the grand challenges of modern human biology is understanding how a limited set of genes can produce the complexity of the cell types within the human brain."
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In contrast to earlier Cas13-based tools for RNA targeting, it also exhibits no observable negative impact on cellular proliferation, even in highly sensitive human cell types (e.g., human embryonic stem cells, neurons and hematopoietic progenitor cells).
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Eleven partner university faculty members have received Arc’s inaugural Ignite Award. With this one-year, $100K funding opportunity, Ignite Awardees will strengthen Arc’s connections with our academic partners. Join us in congratulating the Ignite Award recipients!
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We’re also thrilled to partner with
@stanford
’s Department of Pathology for a Core Investigator search.
(Stay tuned for news about more joint searches with partner universities coming soon!)
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“Without Songnan’s work of assembling the puzzle pieces and seeking collaboration with researchers in our scientific community, we wouldn’t have gotten to this critical discovery,” said Li. Check out our blog post for the full story:
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