MRC Laboratory of Molecular Biology
@MRC_LMB
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MRC Laboratory of Molecular Biology aims to understand biological processes at the molecular level to help tackle human health problems and disease.
Cambridge, UK
Joined January 2010
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Pinned Tweet
Poppy Marriott was recently appointed Scientific Services and Sustainability Manager at the LMB.
Read more about how she supports LMB research and champions green initiatives here:
#LMBNews
#GreenLMB
#TechniciansMakeItHappen
0
1
5
The first complete atomic structure of human telomerase has been solved.
@KellyTHD_Nguyen
has worked with
@RDasLab
and Kathleen Collins to determine the enzyme’s structure at 3.4-3.8 Å resolution using cryo-EM.
Read about it here:
#LMBResearch
@LMB_PhD
9
116
396
Catching the ribosome in the act of scanning mRNA: Venki Ramakrishnan’s group have solved the structure of the 48S translation initiation complex, shedding light on the processes by which the ribosome finds start codons
#LMBresearch
6
96
349
Atomic advance for
#cryoEM
:
@SjorsScheres
’ and
@RaduAricescu
’s groups break resolution records to visualise individual atoms with single-particle cryo-EM
#LMBresearch
4
89
315
Congratulations to Lori Passmore (
@lapassmore
), Group Leader in the LMB’s Structural Studies Division, who is elected Fellow of the
@royalsociety
, alongside
#LMBAlumni
@m_madan_babu
!
Read more on the announcement here:
#LMBNews
#royalsociety
33
26
306
Filmed in a single shot, we flew a drone around the inside of the MRC Laboratory of Molecular Biology to share a snippet of everyday life in our institute.
Check out the full video on our YouTube channel:
9
36
266
Congratulations to Chris Tate and
@SjorsScheres
, Group Leaders in our Structural Studies division, who have both been elected Fellows of the
@royalsociety
!
Read more about them and their research here:
#LMBNews
#royalsociety
6
30
244
Congratulations to Andrew Carter (
@Carter_Lab
), Group Leader in the LMB’s Structural Studies Division, who is the 2023 recipient of the Hooke Medal from
@Official_BSCB
!
Read more about Andrew and his research on cytoplasmic dynein here:
#LMBNews
12
10
210
The 2021 John Kendrew Lecture will be given by
@demishassabis
& John Jumper of
@DeepMind
at 2:30PM & 4PM (BST) on 13th OCT.
They will discuss the scientific benefits of
#AI
and how
#AlphaFold
predicts protein folding.
More info:
#LMBNews
#LMBseminar
(1/3)
7
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204
It is with great sadness that the LMB has to report the death of Kiyoshi Nagai. Kiyoshi had just reached the pinnacle of his scientific career, unravelling the reaction cycle of the complex spliceosome. More about his career will appear on our website shortly.
12
122
205
#OTD
in 1977 Sanger, Nicklen & Coulson published the DNA dideoxy sequencing method. Day 335 of
#LMB365
shows a sequence gel of bacteriophage phiX174. Fred Sanger was awarded the 1980
@NobelPrize
for Chemistry for this, the only Briton to have been awarded 2 Nobel prizes
1
63
202
Congratulations to Andrew Carter (
@Carter_lab
), Group Leader in the LMB’s Structural Studies Division, who is elected Fellow of the
@royalsociety
.
Read more here:
#LMBNews
#royalsociety
(1/2)
14
17
182
Are you interested in the structural biology of
#ribosomes
and translation?
We are looking for a Postdoctoral Scientist to join Venki Ramakrishnan’s group to study this!
Click here to apply (closes 30 MAY):
Please RT!
#ScienceJobs
#PostDocJobs
#PostDoc
4
109
173
Congratulations to Greg Jefferis (
@gsxej
) newly appointed Joint Head of the LMB’s Neurobiology Division, alongside
@Bertolotti_lab
.
An LMB Group Leader since 2008, Greg investigates neural circuits and behaviour in Drosophila.
Read more:
#LMBNews
24
19
167
13
24
171
On
@DNAday
we celebrate Fred Sanger, who pioneered the dideoxy method for sequencing DNA. This revolutionised the field of genomics and was crucial to the Human Genome Project.
Read more about Fred’s
#NobelPrize
winning work on DNA here:
#DNADay2021
#DNA
1
35
151
Huge congratulations to Greg Winter on being awarded a share of the 2018
#NobelPrize
in Chemistry, for his work on the phage display of peptides and antibodies!
BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the
#NobelPrize
in Chemistry 2018 with one half to Frances H. Arnold and the other half jointly to George P. Smith and Sir Gregory P. Winter.
141
7K
8K
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Breakthrough from
@cjrlab
promises a new era in resolving biological structures. Latest proof-of-principle paper demonstrates that reducing electron energy to 100 keV improves imaging while making these microscopes 10 times cheaper.👉
@IUCrJ
#lmbresearch
2
70
151
Kiyoshi Nagai (1949-2019), Group Leader at LMB, died on Sept. 27th after a short illness. He had just reached the pinnacle of his long scientific career, unraveling the reaction cycle of the spliceosome. Find out more about his achievements here:
#LMBnews
1
70
144
David Baker, Director of the Institute for Protein Design (
@UWproteindesign
), University of Washington will deliver the 2021 Max Perutz Lecture: The coming of age of de novo protein design on Tuesday 27th April at 4pm on Zoom
More details:
#LMBseminar
0
45
141
Unravelling the replisome: how a molecular machine overcomes obstacles to DNA replication. Joe Yeeles' group have produced the most complete structure of the
#replisome
to date, providing insight into how DNA is unwound before replication:
#LMBresearch
3
50
144
#ICYMI
David Baker, director of
@UWproteindesign
, gave the 2021 Max Perutz Lecture on Tuesday. His talk 'the coming of age of de novo protein design' is now available to watch online here:
#LMBseminar
#LMBzoominar
0
42
138
Huge congratulations to Richard Henderson of
@MRC_LMB
, Jacques Dubochet and Joachim Frank for their
#NobelPrize
in Chemistry!
1
75
135
Kelly Nguyen
@KellyTHD_Nguyen
recognised with Suffrage Science award curated by
@MRC_LMS
that celebrates the scientific achievements of women in STEM & their ability to inspire others
#SuffrageScience
#WomenInSTEM
#LMBnews
8
22
138
Two new group leaders at the LMB: Kate McDole and Marta Shahbazi
#LMBnews
@Marta_Shahbazi
#womeninscience
#cellbiology
2
16
136
New
#CryoEM
structure of the outer kinetochore bound to microtubules by David Barford’s group
@centromuir
reveals how phosphorylation regulates mitotic spindle chromosome attachment errors.
Read more:
#LMBResearch
@The_MRC
@UKRI_News
0
35
132
Linda Amos, former Group Leader in the LMB’s Structural Studies Division, died on Sunday 21st February 2021. Linda was an excellent electron microscopist, at the forefront of image analysis and reconstruction.
#LMBnews
4
27
133
Cyrus Chothia, pioneer of the use of computational methods to study the structure and function of proteins, and the evolution of genomes, died on 26th November 2019. His work led to the birth of structural bioinformatics and computational genomics
#LMBnews
2
75
131
Congratulations to
@SjorsScheres
, whose methodological innovations in image analysis in
#cryoEM
have been recognised with the Leeuwenhoek Medal and Lecture from the
@royalsociety
!
Read more about Sjors and his research here:
#LMBNews
#Awards
3
19
128
Congratulations to
@laupellegrini
, a postdoc in
@MadLancaster
’s group in
@CellBiol_MRCLMB
, who is starting her own research group at King’s College London!
Best of luck to you Laura!
#LMBAlumni
5
9
129
Frank Bürmann, from Jan Löwe’s group, has determined the most complete structure of an SMC complex to date, and revealed how two DNA helices can be entrapped simultaneously.
Read more here:
#LMBresearch
#cryoEM
@MolecularCell
@The_MRC
@UKRI_News
2
25
127
We have an amazing opportunity for someone to lead their own research group in
@CellBiol_MRCLMB
, supported by the LMB’s exceptional scientific facilities, core funding and enthusiastic colleagues!
Apply by 01 NOV
#ScienceJobs
0
82
127
First complete atomic model of condensin: Jan Lowe’s group lays the foundation for an improved understanding of chromosome assembly
#LMBresearch
1
27
127
First structure of a fungal GPCR: Work by
@LMB_PhD
student
@VaithishVela
in Chris Tate’s group sheds light on how GPCR dimerisation can occur and provides the template for future understanding of other fungal GPCRs
#LMBResearch
2
16
125
New
#ModelAngelo
software builds atomic models quickly and accurately, and is able to identify previously unknown proteins from
#cryoEM
maps.
Read more about the programme, developed by
@jamaliki1998
,
@LMB_PhD
student in
@SjorsScheres
group:
#LMBResearch
1
27
123
Congratulations to Lalita Ramakrishnan (
@RamakrishnanLab
), who has been awarded the 2024 Robert Koch Prize in recognition of her pioneering research into tuberculosis!
Read the full news story here:
#LMBNews
0
19
121
We are thrilled to welcome Tanmay Bharat (
@TBharat_lab
) back to the LMB, this time as a Group Leader in our Structural Studies Division!
Tanmay’s group will research cell surfaces of prokaryotes.
Read more about Tanmay and his research here:
#LMBNews
5
9
120
Discovery of a chaperone for membrane proteins: Patrick Chitwood and Manu Hegde, in the Cell Biology Division (
@CellBiol_MRCLMB
), have identified a new complex that helps membrane proteins assemble correctly
#LMBresearch
0
36
116
Congratulations to
@KellyTHD_Nguyen
, Group Leader in the LMB’s Structural Studies Division, who has been awarded the 2024 Colworth Medal from
@BiochemSoc
.
Read more about the award & Kelly’s telomerase research here:
#LMBNews
#BiochemAwards
4
11
114
Our new LMB VisLab is looking for a Scientific Illustrator () and a Scientific Graphic Designer () to help visualise and communicate our exciting science.
Apply by 4th Aug. Please RT!
#SciViz
#SciComm
#CambridgeJobs
@Na_y_ak
2
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112
Are you interested in mRNA & how a ribosome translates it?
We’re looking for a Research Support Officer to join Venki Ramakrishnan’s group, using varied biochemical techniques to research the structure and function of ribosomes:
Closes 23 AUG
Please RT!
5
55
113
Congratulations to Richard Henderson from
@MRC_LMB
on being made a Companion of Honour in the Queen’s Birthday Honours
0
40
114
A new study from Joe Yeeles’ group, in the LMB’s PNAC Division, demonstrates the first reconstitution of a functional human
#replisome
.
Read more about the work, led by
@LMB_PhD
student
@YaseminBaris_
here:
#LMBResearch
6
23
112
The LMB welcomes Juliette Fedry, who is starting her research group in
@CellBiol_MRCLMB
, where she will study cellular proteostasis networks in physiology and diseases.
Read more:
#LMBNews
9
16
114
Exciting
#postdoc
opportunity with
@lapassmore
to study transcription and mRNA processing using cryo-electron tomography and single particle cryoEM:
Deadline: 15 SEP
#PostdocJobs
#ScienceJobs
Please RT!
0
85
110
How do cells know what to become?
@Marta_Shahbazi
, who joins the LMB today, aims to understand the molecular mechanisms that govern cell identity, a fundamental question that involves multiple levels of biological organisation. Welcome to the LMB!
#stemcells
4
13
111
Congratulations to
@m_madan_babu
, former group leader in the LMB’s Structural Studies Division (and former
@LMB_PhD
student), who has been elected a Fellow of
@acmedsci
!
Click here to read more about Madan and his research:
#LMBNews
#Fellowship
11
9
110
Congratulations!
@Mad_Lancaster
- Group Leader in
@CellBiol_MRCLMB
- has been honoured in the 2022
@BlavatnikAwards
for Young Scientists in the UK as Laureate in Life Sciences.
Read the full news story here:
#LMBNews
1
11
111
The
@royalsociety
Biographical Memoir of Kiyoshi Nagai by Andy Newman and Ben Luisi has been published.
Kiyoshi was a preeminent researcher at the LMB for 30+ years where he worked alongside Chris Oubridge researching the spliceosome.
#LMBAlumni
1
40
106
Chris Russo
@cjrLab
and Katerina Naydenova share a novel optimisation method to scale-up manufacture of
#cryoEM
grids to ease the bottleneck from increased global demand.
Read more here:
#LMBresearch
2
25
109
Packaging a molecular motor for delivery -
@Carter_Lab
discovers a novel protein, Shulin, that binds and inactivates outer dynein arm motors for delivery into cilia
#LMBResearch
1
23
107
On day 244 of
#LMB365
is Richard Henderson who
#OTD
in 1974 started his group at LMB. Pictured here in the 1970s with the X-ray camera rotating anode, he used electron microscopy for his work on membrane proteins and received
@NobelPrize
in Chemistry for developing cryoEM
1
19
106
Congratulations to Jason Chin, joint Head of the LMB’s PNAC Division, who is elected Fellow of the
@royalsociety
!
Read more on the announcement here:
#LMBNews
#royalsociety
1
12
108
New
#LMBResearch
from
@AbsmeierEva
in
@lapassmore
’s group & Viswanathan Chandrasekaran has revealed mammalian CCR4-NOT complex specifically recognises and ubiquitinates ribosomes which are stalled during translation elongation.
Read more:
2
21
108
The LMB welcomes
@albertcardona
as a new Group Leader, joining the LMB to continue his research into the structure-function relationship of neural circuits
#LMBNews
2
14
107
ICYMI, yesterday we reported that
@RaduAricescu
’s and
@SjorsScheres
’ groups have visualised individual protein atoms for the first time in a 3D
#cryoEM
image
Video, by
@AbhayKot
, showing cryo-EM map of mouse apoferritin
#LMBresearch
2
24
105
Science is about success and failure as many experiments fail. Dealing with failure constructively is a vital skill scientists develop in their career. On day 357 of
#LMB365
a postdoc lost his purified protein due to a machine malfunction but his sense of humour saw him through
1
21
97
Congratulations to
@KellyTHD_Nguyen
,
@bwfalcon
and LMB alumni,
@BolandLab_GE
and
@M_Hospenthal
, for being elected
@EMBO_YIP
!
Read the full news story here:
#LMBNews
#LMBAlumni
#telomeres
#DNAreplication
#neurodegenerative
#diseases
6
6
99
This is not a Zoom meeting. These are some of LMB staff/ students who are working hard to fight the pandemic. As scientists, volunteers, donor coordinators and conscientious citizens, many LMB members are doing all they can.
Story:
#COVID19
#coronavirus
4
26
100
Wanda Kukulski awarded the Royal Microscopical Society’s Alan Agar Medal
#LMBnews
@RoyalMicroSoc
2
23
94
"Fred Sanger at the LMB - From DNA sequencing to the advent of genomics" - double Nobel Laureate in
#Chemistry
born 100 years ago
#OnThisDay
#LMBNews
#NobelPrize
0
47
94
Exciting postdoc opportunity with Venki Ramakrishnan’s group to investigate initiation of translation, mitochondrial protein synthesis and ribosomal quality control mechanisms:
Deadline: 14 Mar
#ScienceJobs
#Ribosome
#StructuralBiology
Please RT!
0
58
95
First structures of alpha-synuclein filaments from human brain -
@MichelGoed
's and
@SjorsScheres
' groups have determined
#cryoEM
structures that may benefit diagnosis and treatment of neurodegenerative synucleinopathies
#LMBresearch
0
27
94
Richard Henderson was born
#OnThisDay
in 1945, in Edinburgh. Day 200 of
#LMB365
shows Richard overlooking the atrium of the LMB building, plans for which were started during his Directorship of LMB. Richard was awarded the 2017
@Nobel
Prize for Chemistry
1
11
92
A map to show the way to sense odours, temperature, and humidity:
@gsxej
’s group have presented the first full map of olfactory, thermosensory, and hygrosensory projection neurons in the fly brain
#LMBresearch
#connectomics
#drosophila
0
33
92
Researchers from Chris Tate’s group in Structural Studies Division, and others, have solved the first high-resolution structure of a GPCR-arrestin complex.
@JGarciaNafria
@leetle_yang
@arshukla
#LMBresearch
#GPCR
#arrestin
1
25
90
Congratulations to M. Madan Babu for the
@EMBO
gold medal.🥇
Read more about his work in computational biology here:
The award was announced in June.
Paola
#Picotti
and M. Madan Babu received their
@EMBO
Gold Medals last night at the
#EMBOMembersMtg19
!
6
15
152
1
15
91
Congratulations to LMB Group Leaders Chris Tate and Marta Zlatic, and LMB alumnus Sascha Martens, for their election to
@EMBO
membership!
#LMBNews
#LMBAlumni
#EMBO
2
10
91
Ribosomal rescue in our mitochondria:
@_nirupa_desai
,
@Hanting_Yang
, and
@vishy_chandra
lead work in Venki Ramakrishnan’s group, in collaboration with
@mito_gene
@MRC_MBU
, to discover a novel pathway to rescue stalled mitoribosomes
#LMBresearch
2
20
90
Revolutionary microscopy technique sees individual atoms for first time:
@SjorsScheres
’ and
@RaduAricescu
’s groups have pushed the boundaries of cryo-EM. Radu commented, “It was like peeling off a blur over your eyes”
#LMBinthenews
1
29
90
You can also read profiles of some of our other fantastic
#WomenInScience
here:
#AdaLovelaceDay
#ALD20
1
16
89
#LMBseminar
#LMBZoominar
TOMORROW (20th April), 11 AM (BST):
"Molecular views into cellular functions by in-cell cryo-electron tomography"
By Julia Mahamid
Group Leader at
@embl
, Heidelberg
Facebook event:
Zoom link:
1
18
87
Felix Randow elected Fellow of the Academy of Medical Sciences
#LMBnews
@FelixRandow
@acmedsci
#FMedSci
8
6
87
Wow! 🤩
0
1
20
0
7
86
New
#LMBresearch
led by
@TBharat_lab
(LMB’s Structural Studies Division) reports the structure of the s-layer of the archaeon N. maritimus, crucial to the global nitrogen cycle:
@Vikram_Alva
@pstansfeld
@CKeithCassidy
@sofie_dot_rec
#cryoET
#teamtomo
0
17
86
We're launching a new Rising Talent Fellowship for Black heritage scientists.
This 3-year fully-funded fellowship, based in Cambridge, is suitable for early career researchers with a passion for molecular biology.
For full details check here:
2
80
86
Freezing molecules completely still for cryo-EM:
@cjrlab
has designed new hexagonal
#cryoEM
grids that eliminate beam-induced specimen movement during imaging, allowing better quality data generation and higher throughput data collection
#LMBresearch
0
19
85
New
#LMBresearch
led by
@TBharat_lab
in the LMB’s Structural Studies Division reports the cryo-EM structure of the surface layer of Deinococcus radiodurans, the “toughest bacterium known”.
Read more here:
@Vikram_Alva
@ElitzaTocheva
@LMB_PhD
#cryoET
1
18
84
First wireless neuropeptide signalling network of a whole animal, C. elegans, mapped by
@Lidia_Ripoll_S
@LabSchafer
in the LMB’s Neurobiology Division and collaborators
@isabelbeets
@petra_vertes
.
Read more:
#LMBResearch
1
29
85
The first atomic structures of amyloid-beta 42 filaments from the brains of
#Alzheimers
patients have been determined through
#cryoEM
analysis.
Read more here:
#LMBResearch
2
18
83
We’re deeply saddened to hear of the passing of HRH Queen Elizabeth II.
Her Majesty Queen Elizabeth visited the LMB twice to officially open our buildings, first in 1962 (pictured) and again in 2013.
0
6
84
Perutz and Brenner Prizes recognise outstanding work by
@LMB_PhD
students and postdocs
Congratulations Takanori Nakane,
@laupellegrini
, Katerina Naydenova,
@FrancesCryoEM
, and
@DrPJChitwood
!
#LMBnews
0
14
84
Congratulations to Emmanuel Derivery (
@DeriveryLab
), Group Leader in
@CellBiol_MRCLMB
, who is the 2024 recipient of the Hooke Medal from
@Official_BSCB
!
Read more about Emmanuel and his research on asymmetric cell division here:
#LMBNews
7
13
83
This month’s
@RNASociety
Spotlight has a feature on LMB Group Leader
@KellyTHD_Nguyen
. Kelly describes the inspirations that led her to RNA structural biology, her experience of starting her group, and her advice for younger scientists:
#LMBintheNews
0
9
82
Unexpected matrix protein rearrangements seen in structures from intact HIV-1 virus -
@BriggsGroup
and collaborators provide the first descriptions of HIV-1 MA structures within both immature and mature authentic virus particles:
#LMBResearch
1
16
80
#LMBSeminar
#LMBZoominar
:
4 pm (BST) tomorrow: "Base Editing and Prime Editing: Genome Editing Without Double-Strand Breaks"
By
@davidrliu
, Richard Merkin Professor and Director of the Merkin Institute of Transformative Technologies in Healthcare
Join:
0
24
79
Development of
#cryoEM
at the LMB is allowing high resolution structure determination of many more proteins, including
#tau
.
@SjorsScheres
explains how his group’s work fits into this in this clip from our upcoming film:
#WorldAlzheimersDay
0
24
78
We are delighted to announce that
@Matteoffm
will be joining our Structural Studies Division as a new Group Leader!
His group will investigate the macromolecular basis of nucleus remodelling.
Click here to read more about Matteo and his research:
#LMBNews
11
7
79
The LMB welcomes Marta Zlatic as a new Group Leader. She will continue working to advance our understanding of how the structure and organisation of the central nervous system relates to its function in learning and decision making
#LMBNews
1
19
77
Some fantastic mid-week news!
Many congratulations to William Schafer (
@LabSchafer
), group leader, for being elected a Fellow of the
@royalsociety
. Also to LMB alumna Sarah Teichmann,
@sangerinstitute
.
#LMBnews
#RSFellows
Read the story here:
1
13
78
Congratulations to Michel Goedert, Chris Tate & Sjors Scheres - all named in
@webofscience
2019 Highly Cited Researchers list, recognising the world's most influential researchers!
#HighlyCited2019
@SjorsScheres
@MichelGoed
See the full list 👉
0
9
77