Excited to share the inaugural lab paper. Thanks to
@AutomneNine
@RDasLab
@ramyarangan
and Twitter-less Marike, Adam and Kathy, also
@NogalesLab
. We not only obtained an atomic structure of human telomerase but also discovered histones bound to telomerase RNA.
The first complete atomic structure of human telomerase has been solved.
@KellyTHD_Nguyen
has worked with
@RDasLab
and Kathleen Collins to determine the enzyme’s structure at 3.4-3.8 Å resolution using cryo-EM.
Read about it here:
#LMBResearch
@LMB_PhD
After a lengthy visa process, having my parents from Vietnam visiting me for the first time and showing them Cambridge and my work
@MRC_LMB
are my happiest moments. Thanks to the vaccines, RNA needs no explanation 😍.
Deeply honored to announce this milestone. 16 years since leaving my tiny hometown in pursuit of better education, I traveled through 4 countries/3 continents. Thanks to my family, friends, colleagues all over the world who have made this possible. Really beyond my imagination.
Very honored to be awarded the Eppendorf Prize. I owe this to my lab, past and present mentors and colleagues, and family/friends. Looking forward to the ceremony. A special shoutout to my family in Vietnam who tried hard but cannot join due to visa issues.
Join the jury in honoring the Eppendorf Award for Young European Investigators
#winner
Dr. Thi Hoang Duong Nguyen on July 5, 2022.🏆
Register now ➡️
#molecularbiology
#awardceremony
Excited to share our latest work and first venture into the chromatin field. We visualized for the first time that shelterin factor TRF1 binds and modulates telomeric nucleosome.
@hongmiao12
@AutomneNine
Great collaboration with the Robinson's group
My lab and I are very honored to be recognized with the Colworth Medal. Wouldn't have been able to do any of this without the amazing lab members, collaborators,
@MRC_LMB
, past and present colleagues and mentors. Looking forward to more exciting science in the future!
Congratulations to Dr Kelly Nguyen
@KellyTHD_Nguyen
as the 2024 recipient of The Colworth Medal! Her research focuses on the molecular mechanism of telomere maintenance and the roles of telomeres in human diseases.
Proud to share our latest work by the talented duo
@AutomneNine
and
@ZalaSekne
on the 2.7 Å structure of telomerase H/ACA RNP with new insights into disease mutations and pseudouridylation. Assisted by the newest lab member during revision.
Super grateful for this opportunity to be to be part of this amazing group of Europe-based scientists! Looking forward to the discussions, trainings and networking for both me and my lab members.
The Nguyen lab is ready to roll and we have exciting opportunities for postdoc(s) to join our team at the
@MRC_LMB
to study large nucleic acid-protein complexes involved in telomere maintenance. Please spread the words.
One-year anniversary of our colleague, Chris Oubridge, and nearly two-year anniversary of Kiyoshi Nagai, the remaining Nagai lab members at the LMB had a bittersweet farewell to the Nagai lab. So proud of their achievements and to have been trained by them.
The past days feel like weeks. Kiyoshi was fearless as a scientist, kind and generous as a person, caring as a mentor and a father-figure to everyone who has been through his lab. He left a big hole that's difficult to fill.
Kiyoshi Nagai (1949-2019), Group Leader at LMB, died on Sept. 27th after a short illness. He had just reached the pinnacle of his long scientific career, unraveling the reaction cycle of the spliceosome. Find out more about his achievements here:
#LMBnews
Very honoured to join this community of
#WomenInSTEM
, following the footsteps of the credible
@voorheeslab
and
@lapassmore
. I would like to dedicate this to the late Kiyoshi Nagai and Chris Oubridge, who played a big role in shaping me as a scientist.
Sit back and count down until the Lunar New Year with goodies from Vietnam. Happy the year of the Tiger 🐯! May the year bring you good health and prosperity! Hopefully will be celebrating with family next time.
Four year lab anniversary marked by the first lab retreat. Feeling so lucky to work side-by-side with such an amazing group of people ☺️. Missing
@AutomneNine
@PatrykLudzia
@hongmiao12
.
Honored to be featured on the RNA Society Spotlight this month. It has been a fun ride in the RNA world and hope for more RNA fun in the future. Thank you
@KeaneLab
for the nice article.
Come and join this amazing group of scientists to work at the cutting edge of structural biology of telomeric complexes. The LMB is a highly collaborative place. Please share!
We have an excellent
#postdoc
position to work with
@KellyTHD_Nguyen
, focusing on the molecular mechanism of telomere maintenance in eukaryotic cells using biochemical & structural approaches.
Apply by 21 AUG
#PostdocJobs
#ScienceJobs
Lab summer picnic at the Cambridge Shakespeare festival in the
almost nice weather except 5 mins of downpour and thunder. Can’t get any more British than this.
Proud PI moment when your first student
@ZalaSekne
attending her first conference and won a talk prize 🥳🎊🎉. Thanks to the lab neighbours
@lapassmore
for keeping her companied.
Last split of the year. Looking ahead to 2021 with more exciting plans than numerous lockdowns. Fingers crossed it’ll be brighter. Happy New Year and stay safe and healthy everyone!
Hosted the first in-person seminar since the pandemic started. It was great to have
@ZhongingAlong
visit us today and gave us exciting new updates on CryoDRGN. Here is Ellen in front of the Nobel hall of fame.
Beautiful morning run in Boston after a stimulating week of catching up on all the exciting science going on at MIT and Harvard and many reunions with friends and former colleagues. Thanks to
@seyvos
and
@fischerlab1
for hosting.
What a great week of a lot of exciting science at the first in-person
@MRC_LMB
symposium since 2019. Congratulations to our postdoc
@AutomneNine
on being awarded the Joan Steitz Prize! So well-deserved George.
On November 17, we are honoring the lives and careers of my PhD mentor, Kiyoshi Nagai and dear colleague, Chris Oubridge. Attendance can be either in person with limited numbers or on Zoom. See below for the registration details.
On Friday 17th November, we’re hosting a memorial symposium in honour of
#LMBAlumni
Kiyoshi Nagai and Chris Oubridge, whose pioneering research helped unravel the mysteries of the spliceosome.
Click here for more on the event & to register to attend:
Leaving is always the hardest thing for me to do. Thank you everyone in Berkeley who has made my stay in the Bay Area so much fun and memorable. Will really miss you all. Especially the
@NogalesLab
, Collins labs and
@UCB_MillerInst
for all the support.
We are looking for two postdoctoral scientists to join us on exciting projects on telomere biology. The LMB is an amazing place for science and these scientists are great fun to work with. Please pass the words or RT 🙏. This is an updated tweet of the job advert.
Happy International Women’s Day! Thankful to have the privilege to work with this group of amazing women in my lab in the past 4 years. 💐🎉👩🏻🔬🧑🔬
@ZalaSekne
@HochheiserInga
@_helenyan_
(with picture this time)
On the bright side of the pandemic, I end 2021 with 1173 miles running packed in. Looking forward to 2022 with more exciting goals, 2022 miles may be too ambitious but never know 🏃♀️ . Happy 2022 everyone!
For the EM enthusiasts who are curious about the near-
@NogalesLab
carbon standard, this is the first piece I made in my own lab that didn’t get tossed and ended up giving us that telomerase structure last year.
@IsraelF96135088
Socially distancing welcome to our new PhD student Zala Sekne and happy birthday Adam! With cocktails from
@AutomneNine
. (It’s really not E. coli we are drinking)
Frank Bürmann, from Jan Löwe’s group, has determined the most complete structure of an SMC complex to date, and revealed how two DNA helices can be entrapped simultaneously.
Read more here:
#LMBresearch
#cryoEM
@MolecularCell
@The_MRC
@UKRI_News
This hits close to home, just as I am trying to get a Schengen visa to travel for seminars for the summer. Prepared nearly 3 months early and yet still stressful.
📢'The World Is Your Oyster' is for those who are born in global north countries--don't experience visa bureaucracy & emotional burden that non-white global south scholars do. Citizenship is a privilege that we need to recognize in the academe. 1/n
Two exciting 3-year postdoc opportunities are available with Kelly Nguyen's group in the LMB’s Structural Studies Division to study
#telomere
maintenance in mammalian cells.
Deadline: 16 Jan 2023
#sciencejobs
#postdocjobs
#cryoEM
Happy International Women’s day! What an amazing honour and experience to be surrounded by these incredible
#WomenInScience
at this symposium last year.
To mark
#InternationalWomensDay
, we’ve released the first day of talks from our ‘Ahead of the Curve: Women Scientists at the LMB’ symposium.
Find them on our YouTube channel:
And make sure you’re subscribed so you don’t miss the rest of the talks!
#IWD2023
Congratulations to the nine
#Cambridge
scientists announced as Fellows of the
@RoyalSociety
today!
This honour recognises their exceptional contributions to science.
Join the LMB as a PhD student working on exciting projects:
A great lab
@KellyTHD_Nguyen
, amazing facilities and the exceptional environment of
@MRC_LMB
Learn more about our fully funded PhD places:
#cryoEM
#PhDposition
Wonderful visit to
@EMBLGrenoble
. A lot of great and simulating questions. Also nice time exploring the beautiful surroundings. Thanks my ex-lab sibling
@WojtekGalej
for hosting.
Wonderful review our work and the Feigon lab's work by Michael Stone. To hear more about it, please tune in for George Ghanim
@AutomneNine
's talk tomorrow at
#RNA2021
. First talk in the
#RNPAssembly
session.
This scheme will potentially create inequality as it discriminates students who may not have the means to go to this list. Graduates should be assessed by their individual potential rather than which university they go to.
Graduates from these 37 top-ranked universities will be able to apply to come to the UK under a new "high potential individual" visa scheme. None from Africa, Latin America or South Asia. That’s a big problem.
World's top graduates get new UK visa option
Our lab is very grateful to our kind talented and fun postdocs
@AutomneNine
and Hongmiao Hu. Thank you for putting up with us all and always doing it with a smile.
#PostdocAppreciationWeek
Chris Oubridge senior scientist in Kiyoshi Nagai’s group at the LMB for over 30 years, who made essential contributions to deciphering of the full reaction mechanism of pre-mRNA splicing, died on Tuesday 25th August
#LMBnews
The LMB postgraduate students are a truly international and diverse community. Every year 20-30 new graduates from the UK and all over the world join the
@LMB_PhD
programme. This photo for day 284 of
#LMB365
shows this year’s intake on their first day in the Lab.
Beautiful piece about the scientific journey of Kiyoshi Nagai and Chris Oubridge by Andy Newman and Ben Luisi. Very grateful to have been mentored by them.
The
@royalsociety
Biographical Memoir of Kiyoshi Nagai by Andy Newman and Ben Luisi has been published.
Kiyoshi was a preeminent researcher at the LMB for 30+ years where he worked alongside Chris Oubridge researching the spliceosome.
#LMBAlumni
Amazing weekend at my last
@UCB_MillerInst
Symposium with 7 great speakers with a diverse range of science. Finally met my hero
@francesarnold
whose work I followed since my first year of undergrad (doing directed evolution during two summers).
My mind still can't comprehend the fact that the lives of million innocent civilians are hanging by a thread, all to satisfy the greed of one evil man
#StandWithUkraine
.
One of the many lab Christmas events and secret Santa! So grateful to work with these amazing scientists. Also congratulations to our postdoc
@hongmiao12
on being awarded an EMBO fellowship! We are so proud of you!
Some acknowledgement of how less well-off countries like Vietnam handled this to avoid thousands from dying and the collapse of the healthcare system. This was the same 2002 with SARS.
First day back at work. Thanks to the
@MRC_LMB
Christmas raffle for bringing us Kylie in 2022. We say goodbye to Kylie and hello to Tom. Their smiles will keep us motivated through difficult experiments. Bring on 2023.
Delighted to share a review, in which
@hongmiao12
,
@_helenyan_
and I discussed the current state of shelterin structural biology and the links between shelterin and chromatin. Happy reading!
“While science can be a challenge… All that pales in comparison to the thrill of the questions to be asked, of seeing them answered one day.”
Prof. Eva Nogales’ acceptance speech at 2023
#ShawPrize
Award Presentation Ceremony.
@NogalesLab
@UCBerkeley
Which PI purifies the protein, collects the cryo-EM data, and processes the images, all by oneself? Nigel Unwin has been doing this in the past 45 years! He just published another single-author research article.
It was such a pleasure to be joined by
@KellyTHD_Nguyen
(
@MRC_LMB
) who gave us an amazing talk about the visualisation of human telomeric complexes by cryo-EM last week.
The raw data of human telomerase with recruitment factors by
@AutomneNine
and
@ZalaSekne
are out. The dataset is a great example for extreme conformational heterogeneity (Sekne,Ghanim et al., 2022; Ghanim,Sekne et al., 2024).
I remember seeing the first micrographs of these by
@BJ_Greber
. Amazing to see this beautiful structure in its final state! Congratulations
@paulvictorsauer
@BJ_Greber
and everyone involved.
Our complete 2.7A structure of a cyanobacterial phycobilisome reveals unexpected conformational changes, the position of the quencher and even a completely new protein! Great collaboration with
@TinaDomnguez
at the Kerfeld lab. Preprints below!
#CryoEM
@UCBerkeley
@LBNLBioSci
@WojtekGalej
@maxewilkinson
and I found a new spliceosome intermediate. Featuring heroic SPA analysis and model building by
@maxewilkinson
and fun biochemistry by me, we explain how the spliceosome achieves equilibrium between the two catalytic steps. 1/n
We have ~£5000 worth of
@IBALifesciences
resins which we have data to show they don’t work as well as previous batches. Without showing any data, the company insisted that their resins were fine and offered no replacement or refund. Anyone with similar experience or any advice?