Michele Frison. follow me on BlueSky
@mkfrison92
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Postdoc in @Cam_mito @MRC_MBU. Lover of mitophagy. Fervid European. Obsessive environmentalist. Way too excited. Curator of Mitophagy @Bims_BiomedNews
Cambridge, England
Joined May 2013
RT @mpids: Dear community Due to the current developments, we have decided to discontinue our activities on X. We look forward to staying i…
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Red meat was a strong driver of omnivore microbiomes [..] negatively correlated with host cardiometabolic health. Conversely, vegan signature microbes were correlated with favourable cardiometabolic markers and were enriched in omnivores consuming more plant-based foods.
OUT NOW - Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals @fackelmeister @nsegata @cibiocm @Join_ZOE @timspector #microbiome #metagenomics #vegan
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A novel function of the mitophagy receptor BNIP3! Adapting mitochondrial metabolism to the DNA damage response and mediating senescence 🧨
"DNA damage response (DDR) signaling to mitochondria triggers senescence" Mitochondrial fatty acid oxidation drives senescence | Science Advances
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RT @AbellJonny: So often with similar papers I find the imaging just isn’t good enough for me to actually see if the tagging has worked, su…
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RT @MitoPsychoBio: If we look at thousands of proteins (i.e., signals) in the human blood, the protein most associated with chronic physica…
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@JankauskasPhd Therefore it seems unlikely that all the compartments of mitochondria are recycled in the same manner with age. In my opinion, this calls for more attention to detail in describing mitochondrial quality control pathways in ageing, to avoid creating apparent contradictions.
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RT @mitopinionated: New study from us: High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtD…
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RT @FrezzaLab: "Cellular ATP demand creates metabolically distinct subpopulations of mitochondria"
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@JankauskasPhd There are other systems (MDVs, VDIMs) that deliver mitochondra OMM for destruction. It would be interesting to see whether they compensate for decreased autophagy in ageing, or whether mitophagy truly follows this trend.
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RT @ShorterLab: Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates | The EMBO Journal https://t…
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Congratulations @KeshriSwati! So interesting 🤓
USP7 protects TFEB from proteasome-mediated degradation: Cell Reports
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