@johnhawks They say they remap the "raw" reads, but the links suggest that they are remapping the reads that were already aligned to hg19?

@joe_pickrell @AlexTISYoung @vagheesh I don't think there's any (? certainly not much) aDNA from Finland from the last few thousand years. Definitely not enough data to estimate those sorts of allele frequencies.

@vagheesh @AlexTISYoung @joe_pickrell @genesandhealth Well but the effective selection coefficient is only 0.01 (actually 0.005, since it has no effect in males) here - it will still take a long time to be removed, compared to, say, an additive variant with s=0.1.

@AlexTISYoung @vagheesh @joe_pickrell Exactly, the expected frequency change is ~ 1e-4 per generation, so once the bottleneck pushes the frequency up, it will take a long time to remove it.

@iosif_lazaridis @ChrisStringer65 Find one and I'll buy it :-)

@iosif_lazaridis @ChrisStringer65 Where are they living, then?

@AlexTISYoung @moveincircles And Queen Victoria!

@vagheesh No, I think it is pretty clearly (W Eurasias, (E, Eurasias, Papuan)).

@WiringTheBrain Just a tiny bit

@Graham_Coop @A_A_Zaidi 😢

@dortega_delv @johnhawks @valenomics @mashaals @emiliahsc Agreed. It seems like there shouldn't really be any difference between predicting in ancient and contemporary populations.

@vsbuffalo @alexbilz That was an excellent article, which made it very clear to me why my initial reaction that it could not possibly be true, was incorrect. Thanks!

@pastramimachine @DocEdge85 @jgschraiber False advertising!

@SashaGusevPosts @DavidEnard @Graham_Coop To be fair you would expect things that are strongly selected to be found in more constrained regions.

@apragsdale @SashaGusevPosts There are lots of methods for fitting the wright-fisher model to time series data but the problem is controlling for changes in ancestry. In e.g. Holocene Europe the variance coming from admixture is >> drift so you prefer to control ancestry rather than drift.

@MathSRIsh @vsbuffalo @pastramimachine They fixed that by renaming the genes (and you can turn off that feature in Excel).

@vsbuffalo @pastramimachine Excel has built-in data integrity; you can see when people faked data because they left in the formulas they used or copied values in a different font or whatever.

@pastramimachine @vsbuffalo I mean for people who can't handle VBA, sure...

@vsbuffalo @pastramimachine Because we already have Excel for data?

@elizabeth_fels @ItsAndyRyan @MuseZack My sense it that it was more the psychological and social consequences of the end of the Empire that were harmful, rather than the economic consequences.