@EmmanuelMacron @narendramodi @marseille A.

@bjcohenmd @JEscaned @PCRonline @shci_sec @sbrugaletta @GreggWStone @egutiMD The difficulty is not being able to predict which patient will have a cardiac death. Reconciling personal sentimentality with societal responsibility is challenging in clinical practice.

@djc795 @DrMarthaGulati @SmidtHeart @jgharoldmd @EugenioCingolan @GreggWStone @MarbanLab @CedarsSinaiMed @DrNathanWong @ditchhaporia Winning or losing a debate is not important as long as more light (and levity) than heat is generated! David, I learnt a lot from the cogent & thoughtful points you made. It clearly illuminated my understanding of the placebo effect.

@dr_benoy_n_shah Be prepared to be amused or intrigued by the coding data!

@KPHeartDoc @CaravitaSergio Which properly conducted (sham-controlled) RCT has shown benefit with LA shunting therapy?

@bjcohenmd @DrRyanPDaly @DrMarthaGulati @HeartOTXHeartMD @hvanspall @DrJMarine @FNULNU1 Beware of the Tulip bubble!

@DrDamluji So, 30% mortality you cite is an overestimate. Or these trials selected a lower risk cohort, or OMT was stellar!

@DrDamluji What was the 1y mortality in the control arm of the pivotal trials of T-TEER and TTVR?

@bjcohenmd @hvanspall @DrRyanPDaly @DrJMarine @HeartOTXHeartMD @FNULNU1 @DrMarthaGulati Can I pay mortgage with BTC? Does it have real value?

@hvanspall @bjcohenmd @DrRyanPDaly @DrJMarine @HeartOTXHeartMD @FNULNU1 @DrMarthaGulati I will have to put ‘mortgage-free and retirement-safe’ on my resume when (and if) I get to that stage!

@DrToddLee @NEJM Old news!

@DFCapodanno "Two-Year Outcomes of Transcatheter Tricuspid Valve Edge-to-Edge Repair For Tricuspid Regurgitation: The Triluminate Pivotal Trial" What can be learnt at 2 years from a trial where control arm (OMT alone) is allowed to crossover to T-TEER after 1 year?

@DrMarthaGulati @NEJM @khurramn1 @LindaGillamMD @WilliamZoghbi @SmidtHeart @CedarsSinaiMed @MarkDrazner @BiykemB @SVRaoMD Thank you!

@BaimInstitute @ACCinTouch @JJheart_doc Congrats, Jim!

@CMichaelGibson @BaimInstitute Congrats!

@dr_benoy_n_shah @CASivaram1 @AJamilTajik @AnkurKalraMD @iamritu @purviparwani @alexsfelixecho @NMerke @chiragbavishiMD @JGrapsa @Sarah_Moharem Excellent discussion. Thank you for sharing. Best wishes for the New Year!

@dr_benoy_n_shah @iamritu @purviparwani @mswami001 @rajdoc2005 @senguptasp @DrRajeshG1 @HiteshiKc He along with Prime Minister, PV Narasimha Rao, were responsible for the economic turnaround of India. Dr. Manmohan Singh was an able technocrat and a more accomplished economist than a politician. RIP!

@DrToddLee As @f2harrell would say ‘people were experimented on, effort and money (whatever little they had) was spent, and little was learnt’. I know you would argue the ‘little’ part.

@DrToddLee I am not questioning clinical utility or potential of the drug. My issue is with trial design & conduct. Why did DSMB not take appropriate steps to increase sample size or f/u? Underpowered trials should not be salvaged by simply pooling results to overcome hurdle of p<0.05!