Eduardo Marban, MD, PhD
@MarbanLab
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Dr. Eduardo Marban | Executive Director, Smidt Heart Institute @SmidtHeart @CedarsSinai Views are my own
Cedars-Sinai Medical Center
Joined May 2021
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Congratulations to
@SumeetSChugh
, the American College of Cardiology 2024 Distinguished Scientist (Clinical Domain)! This yearly award recognizes exceptional leaders in
#Cardiology
. Having rewritten the canon on
#SuddenDeath
, Sumeet certainly qualifies!
@ACCinTouch
#EPeeps
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21
133
Congratulations
@MKIttlesonMD
on being named Associate Editor of
#JACC
! You make all of us at
@SmidtHeart
extremely proud!
@CedarsSinaiMed
@CedarsSinai
6
9
110
Congratulations to Raj Makkar, recognized by the
@CedarsSinai
medical staff as Pioneer in Medicine 2023. Criteria: innovative work done at
@CedarsSinaiMed
that has changed the world; outstanding scholar and educator. Raj fulfills all these and more! His work on
7
16
100
Got invited to a meeting in Japan where a featured speaker had been fired as journal editor, and demoted at his home institution, for anti-LGBTQ hate speech. My reply: "No thanks!" Colleagues, it's time to vote with your feet. Say no to meetings and societies that promote bigots.
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13
92
Ever wondered how a busy
#clinician
-
#scientist
and ASCI member (Eugenio Cingolani) responds when his $6M
@CIRMnews
grant is funded? This
#CLIN1
will fund IND-enabling studies on
#exosomes
for lethal
#arrhythmia
. Hope to be in human testing within 2 years!
@SmidtHeart
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Congratulations to
@SumeetSChugh
on being inducted to the prestigious Association of American Physicians! Your exceptional
#research
contributions to the field of
#cardiology
, and the
#epidemiology
of
#SuddenCardiacDeath
, are truly inspiring.
#AAP
#PhysicianScientist
#medicine
5
15
82
Delighted that the great
@1jvaneyk
was awarded the
@CedarsSinaiMed
PRISM prize, recognizing important contributions that have changed our understanding of medicine. Go Jenny!! 👍🍾🎊
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13
75
Proud of our national ranking, now ahead of
@MayoClinicCV
and ahead of all the elite heart programs on both coasts! Meanwhile we are in our 11th consecutive year as the
#1
heart and vascular program in the western USA.
@SmidtHeart
It takes a lot of heart to give patients the best care possible. We’re honored to be the best in California in Cardiology, Heart & Vascular Surgery. ❤️
See why we earned that ranking by learning more about our Cardiology services at
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CONGRATULATIONS to outstanding
@SmidtHeart
#T32
#postdoc
@ke_liaoPhD
on receiving a $2.3M grant from
@CIRMnews
! Ke will use a novel
#RNA
-based approach to combat viral
#myocarditis
.... he has discovered a long noncoding RNA that augments and activates regulatory T cells, just
6
10
69
Beautiful day for a building naming ceremony. The Susanne and Ervin Bard Pavilion
@CedarsSinai
, their incredible gift will allow us to continue to serve our community, advance our research and train future healthcare professionals.
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13
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Our two EP honorees:
@EugenioCingolan
inducted into ASCI, and ASCI member
@SumeetSChugh
inducted into AAP!
@SmidtHeart
@CedarsSinai
@EPeeps
5
7
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Noel has single-handedly established
@CedarsSinai
as the world’s leading center in women’s heart disease. Congratulations on receiving this year's Master of ACC Award!
@WomensHeartCS
#ACC23
Congratulations to Dr. Noel Bairey Merz, director of the Barbra Streisand Women's Heart Center, for receiving the 2023 Master of the ACC Award!
Her pioneering contributions to cardiovascular medicine have been outstanding, and we're excited to see her recognized at
#ACC23
.
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10
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Cool
#data
of the week: obese
#HFpEF
mice are prone to
#VentricularTachycardia
, with an underlying substrate of slow conduction and increased
#fibrosis
. May help explain why
#HFpEF
patients have increased
#SuddenDeath
.
@ThassioMesquita
@EugenioCingolan
#EPeeps
@SmidtHeart
2
16
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Here’s the
@CedarsSinai
contingent in
@Melbourne
for
@IsevOrg
2024 meeting. Great to see
@doldivizio
whose groundbreaking work on
#cancer
EVs is highlighted today. I’m on tomorrow talking about
#RNAdrugs
bioinspired by EV cargo.
2
10
55
Congratulations
@aakriti_15
on being appointed as Executive Associate Editor of
#JACC
! Huge honor for our stellar young interventionalist
@SmidtHeart
!
@CedarsSinaiMed
5
5
50
My pleasure to have presented at
@ISHR_NAS
on
#RNAtherapeutics
in a session on
#extracellularvesicles
Work done in collaboration with
@TheIbrahimLab
@rrogerslab
@XMichaelJonesMD
@AleCiulloPhD
and other very talented coworkers
@SmidtHeart
@CedarsSinaiMed
4
13
50
My son Paul, an environmental scientist, asked for tips on public speaking. Here’s my response:
1) Talk to an audience as you would to a friend: stay alert, engaged, light, & humorous
2) Tell a story. Make it relatable
3) Explain any jargon or key phrases that are above a
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5
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At
@AAEV_org
meeting in Boston with organizer and my former postdoc Ke Cheng — great to see his success since he left
@CedarsSinaiMed
, now endowed chair holder
@Columbia
BME
#exosome
@SmidtHeart
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1
48
Immigrants… we get the job done!
(1) > 1/2 of the most valuable startups in the US were founded by immigrants
(2) 2/3 of billion-dollar companies (unicorns) were founded by immigrants/children of immigrants
(3) ~ 80% of unicorn companies have an immigrant founder or key leader
Ref:
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0
5
48
Inspiring
@ISHRglobal
President’s Lecture
@ISHR_NAS
by
@1jvaneyk
, here honored by
@yingge2121
of
@UWMadison
. Awed by Jenny’s phenomenal trajectory leading to
@SmidtHeart
!
#WIC
#proteomics
1
5
47
Congratulations to
@rrogerslab
(Russell Rogers) on an outstanding score on his first R01! Russell will be studying novel anti-fibrotic
#RNAtherapeutics
in
#Duchenne
#cardiomyopathy
. Very proud of our home-grown talent!
@nih_nhlbi
@CedarsSinaiMed
@SmidtHeart
@TheIbrahimLab
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9
44
Today’s inaugural
@Caltech
-
@CedarsSinai
symposium on
#stemcells
and developmental biology was a great success. Such stellar science! 🙏
@OphirKlein
,
@BronnerMarianne
,
@ZernickaGoetz
and
@Jeff_golden1
for organizing.
@SmidtHeart
@CedarsSinaiMed
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10
46
The happiest of birthdays to ace electrophysiologist and thought leader
@SumeetSChugh
! Wonderful celebration surrounded by family and friends.
#EPeeps
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1
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The home of the Smidt Heart Institute is henceforth to be known as the Susanne and Ervin Bard Pavilion. Their amazing $140M bequest is the largest gift in Cedars-Sinai history!
Cedars-Sinai has received a historic gift of over $140 million from the estate of Susanne and Ervin Bard.
The gift will name the Susanne and Ervin Bard Pavilion, a state-of-the-art healthcare facility home to renowned institutes and research centers.
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So proud! I’ve admired Michelle since she was a fellow at
@hopkinsheart
while I was Chief… and a fateful lunch after I moved to
@CedarsSinai
led to the transformative recruitment of Jon Kobashigawa and his group to
@SmidtHeart
. The rest is history…
@SmidtHeart
is pleased to announce that our very own
@MkittlesonMD
has been appointed Interim Editor-In-Chief for the prestigious Journal of Heart and Lung Transplantation!
@TheJHLT
@CedarsSinai
@CedarsSinaiMed
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My invention—cardiosphere-derived cells, now Deramiocel, developed at
@CedarsSinaiMed
for
#Duchenne
— moves a step closer to FDA approval! Finally a
#celltherapy
product may work for ❤️🩹 (most
#DMD
patients develop a severe
#cardiomyopathy
). Exciting example of how translation,
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4
44
❤️ when
#patents
are granted; codification that your hard work is novel, useful and practicable. This- my 48th awarded patent- teaches the use of
#CDCs
(aka
#Deramiocel
) in
#Duchenne
#musculardystrophy
— the basis for HOPE clinical trials. Btw, is an
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4
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Outstanding affirmation of Paul Noble's transformational leadership over the last decade!
@Paulwnoblemd
Congratulations to him and to ALL our partners in the thoracic cavity
@CedarsSinaiMed
...😄🩺🫀🫁
A few of the things we deliver on: top-ranked specialists. Personalized care. Ranked
#1
in California (highest U.S. News ranking in the region) for Pulmonology & Lung Surgery. 🎉
Learn more about our expert Pulmonology services at
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Stellar young investigator and award finalist Ke Liao presented his work on
#Tregs
in
#MI
. He’s found a
#lncRNA
that unregulates Tregs in vivo, decreasing
#infarct
size. Could be game changer for disorders of
#inflammation
!
@nih_nhlbi
@CIRMnews
@SmidtHeart
@CedarsSinaiMed
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5
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Love it when the days are long and (kinda) warm so you can
#sail
after work, especially with great guys like
@jgoldhaber
and
@EugenioCingolan
.
#EPeeps
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Congratulations to
@AkhmerovShah
on receiving the
@CedarsSinaiMed
2024 Clinical Fellows Award for Excellence in
#Research
! Shah’s discovery that CDC-EVs upregulate
#Tregs
paved the way for molecular dissection with
@ke_liaoPhD
and the generation of new
#RNAdrugs
- spectacular
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10
40
The 3 year data for cardiosphere-derived cells (deramiocel) are striking: the progression of
#Duchenne
#cardiomyopathy
is entirely halted, and perhaps even reversed. New hope indeed!
7
8
40
Congratulations to
@RyanMidd448
and Ke Liao on their ms, just published in
@SciReports
. Newts can
#regenerate
severed spinal cords and entire limbs. Here they show
#EVs
from newts promote mammalian nerve sprouting… regenerative cross-species bioactivity despite 300M+ years of
0
7
39
Eid mubarak to our Muslim coworkers
@TheIbrahimLab
,
@AsmaNawaz_BME
and
@soussi_salwa
! You inspired us with your great work even while observing the
#Ramadan
fast... not easy!
@SmidtHeart
@CedarsSinai
4
6
39
Fascinating
#labmeeting
by
@ThassioMesquita
on
#fibrosis
in
#HFpEF
. Targeting FOXO1 in
#fibroblasts
improves
#diastole
and reduces
#VT
#inducibility
in 2-hit mice.
@SmidtHeart
@CedarsSinaiMed
1
4
39
Cool
#data
of the week: obese
#HFpEF
mice become less prone to
#VentricularTachycardia
when transcription factor FoxO1 is inhibited... a strategy to mitigate
#SuddenDeath
risk in HFpEF patients?🤔
@ThassioMesquita
@EugenioCingolan
#EPeeps
@SmidtHeart
@CedarsSinai
@CedarsSinaiMed
0
10
38
Today was a good day...
#NoA
came in for our new
#R01
...
The weather in
#SantaMonica
was perfect to celebrate with a sail...
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@SmidtHeart
is honored to welcome
@FLOTUS
Dr Jill Biden as she kicks off new focus on
#WomensHealth
#research
. Hosted by Dr Noel Bairey Merz, the FL toured
@1jvaneyk
’s lab and heard about our advances in the Barbra Streisand
@WomensHeartCS
.
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So proud! Plus… am I the only one to note that women form the majority of our honorees? 👍
#WomenInSTEM
Congratulations to all of the
@SmidtHeart
faculty that made it on this quarter’s
@CedarsSinai
Faculty Honor Roll!
#CedarsSinaiProud
@JoChikweMD
@EugenioCingolan
@DrMarthaGulati
@1jvaneyk
@JanetWeiMD
#CardioTwitter
1
14
50
2
6
36
Insightful
@SmidtHeart
#cardiology
grand rounds on
#geneticscreening
for dilated
#cardiomyopathy
#DCM
by our
#HF
cardiologist Evan Kransdorf. DCM is often associated with genetic variants, but causation can be dubious.
#CardioTwitter
@CedarsSinaiMed
0
6
37
Cool
#data
of the week: bioactive tRNA fragment mined from
#exosomes
improves heart function in mdx mice with
#Duchenne
#cardiomyopathy
, but only when
#macrophages
are present. The effect is specific: not mimicked by scrambled
#RNA
. Work of Russell Rogers and Alice Rannou.
1
7
37
Extortionate pricing from
@Sarepta
for their
#AAV
microdystrophin for
#Duchenne
#musculardystrophy
. Cost of goods is no more than $50k per dose! This is NOT a cure. Pharma greed at its worst.
#FDA
3
8
35
The
@CedarsSinai
Hispanic/Latino Doctors group… includes scientists and trainees… launched during the
#pandemic
. I was privileged to deliver the first “plenary” talk, but it is MUCH better to be here in person at lunch today. Shocking that only 2.5% of our faculty are Hispanic,
1
4
36
Bang-up journal club by Josh Goldhaber! If you knock out enough membrane ion transfer proteins in
#hESCs
, are the resulting
#cardiomyocytes
still… cardiomyocytes?
2
7
37
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7
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Provocative
@SmidtHeart
#research
seminar by Olujimi Ajijola on
#neurocardiology
. Killing the afferents helps heal the infarcted
#heart
!
@CedarsSinaiMed
2
6
35
#T32
fellow Jessica Mao asks: What’s up with asymptomatic
#afib
? with
@CMAlbertEP
as mentor. It’s more common in men, and not benign! High risk of MI, stroke.
#EPeeps
#cardionerds
@nih_nhlbi
@CedarsSinaiMed
@SmidtHeart
0
7
33
We have been working on
#Duchenne
for almost 10 years, catalyzed early on by Cath Jayasuriya and
@CoalitionDMD
. Some reflections:
1) Exon skipping and gene therapy, in their current iterations, are at best palliative
2) Heart failure is often the terminal event... but none of
3
8
37
Thank YOU, Josh, for your transformative leadership including securing (and renewing) an
@nih_nhlbi
T32, whilst making an excellent fellowship program outstanding! Best wishes in your new role as Vice Dean of
@CedarsSinaiMed
!
@SmidtHeart
@CMAlbertEP
@JTVuongMD
@RishiKTrivedi
@CedarsCards
@SmidtHeart
@JanetWeiMD
Congratulations to both of you and to your graduating colleagues! So proud of all the achievements highlighted at my final
@SmidtHeart
cardiology fellowship graduation as program director. Thank you everyone for 12 wonderful years!
@JanetWeiMD
@CMAlbertEP
@CedarsSinaiMed
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Bang-up
@MarbanLab
mtg presentation by
@nih_nhlbi
#T32
fellow
@XMichaelJonesMD
gives new hope for
#scleroderma
. In two
#mouse
models and human
#SSc
#macrophages
(🙏
@fboinMD
),
#ncRNA
drug TY1 attenuates
#DNAdamage
and reverses disease. 👍. Thanks Mike for your great work!
6
8
35
Great
@SmidtHeart
#research
seminar by X. Mike Jones. Lead
#ncRNA
compound TY1 reverses the key manifestations of
#scleroderma
in two complementary mouse models! It even works orally. Next goal: first-in-human studies in
#systemicsclerosis
patients!
@CedarsSinaiMed
2
5
35
Data review with
@ThassioMesquita
and
@EugenioCingolan
. Sometimes the
#data
are compelling not only in their quality, but also in their beauty!
@SmidtHeart
@CedarsSinaiMed
#EPeeps
1
1
34
Delighted to participate in the 5th Annual Precision Health Symposium
@CedarsSinai
. Stimulating talk by
@euanashley
who points out just how cheap ($100) and quick (4 hours or less!) it is to get
#genomesequencing
now…
#PrecisionHealth
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6
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CONGRATS to Ahmed
@TheIbrahimLab
on a fundable score
@CIRMnews
for his TRAN1 grant to develop
#RNAdrug
TY1 for first-in-human testing in
#scleroderma
! So proud of my PhD student, now faculty
@SmidtHeart
…but he’s still got to learn: whose house???
#RamsHouse
8
1
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@SmidtHeart
#cardiology
grand rounds: Jim Januzzi helpfully emphasizes that
#diabetic
#cardiomyopathy
is a primary illness, not just an association.
#Mechanisms
mysterious but likely include
#inflammation
leading to
#fibrosis
@CedarsSinaiMed
1
7
33
From
#5
to now being
#1
in the Western USA. It’s been an amazing 15 years. Thank you to the Smidt Heart Institute team and
@CedarsSinai
The Smidt Heart Institute is celebrating 15 years of innovative patient care! We sat down with Executive Director Dr. Eduardo Marbán to chat about how the institute has grown and the future of cardiac medicine. ❤️
@MarbanLab
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Department of Cardiology Chair Dr.
@CMAlbertEP
gave a wonderful lecture on her work and, more broadly, that at
@CedarsSinai
#CardioTwitter
#EPeeps
#WomenInScience
3
8
32
Kudos Shah! Not easy to talk about
#Tregs
and their modulation by
#ncRNA
, especially when you’re busy completing a fellowship in
#thoracic
#transplant
#surgery
. Shout out to collaborator
@ke_liaoPhD
for his revelatory discoveries.
@SmidtHeart
@CedarsSinaiMed
@JoChikweMD
Superb presentation by our very own
@AkhmerovShah
describing his work on the role of EV-derived long non-coding RNA in mobilizing Tregs! Congratulations to all the finalists at the Clinical Fellows Award!
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33
.
@HarryPotter
fans rejoice: new
#micropeptide
Slitharin is
#cardioprotective
!
@SmidtHeart
@CedarsSinaiMed
@TheIbrahimLab
1
8
33
Looking forward to my visit!
@SmidtHeart
@CedarsSinaiMed
Mark your calendars for our next
#seminar
! 🗓
This Thursday, we welcome Dr. Eduardo Marbán. Dr. Marbán discusses novel noncoding RNA drugs for cardiac fibrosis and inflammation. You won't want to miss it!
@MarbanLab
#hearthealth
#cardiovascularresearch
#heartdisease
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Only 5 of U.S. News & World Report's 2023-24 Honor Roll hospitals were also listed on Healthgrades' 2023 "America's 50 Best Hospitals" list.
@CedarsSinai
was one of the 5. To achieve Healthgrades' high ranking, hospitals had to be in the top 1% nationally for "consistently
0
10
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Great DOM Grand Rounds,
@Paulwnoblemd
's department, by
@drmikefarkouh
. Mike's impressive life trajectory in clinical trials gives good reason to expect he will turbocharge our efforts
@CedarsSinaiMed
as Associate Dean for Research and Clinical Trials ().
1
10
32
Congratulations
@MiguelVldrbno
on this well-deserved recognition! How many of us have shepherded an idea from inception through clinical trials into actual practice, as Miguel has done with
#EtOH
#ablation
for
#VT
?
#EPeeps
@shivkumarmd
@EugenioCingolan
We are pleased to announce the election of 100 new Active and International members for 2024. See the full list here:
These members will be officially inducted on April 5, as part of the 2024 AAP/ASCI/APSA
@JointMeeting
!
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3
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31
.
@SmidtHeart
#cardiology
grand rounds by
@RobGersztenMD
on
#biomarkers
of
#heartdisease
. If you get lucky, you identify strong unexpected associations (eg,
#SECTM1
) that illuminate pathogenesis. SECTM1 augments circulating
#Ly6Chi
#monocytes
, rationalizing the link to
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Thanks, Robin, for welcoming me! It was especially gratifying to see my mentees Ravi Ranjan (my PhD student at
@HopkinsMedicine
, next to me in Robin’s post) and Eleni Tseliou (my
#postdoc
at
@CedarsSinaiMed
, pictured below— who heroically came to hear me talk just 6 days after
@MarbanLab
gave a thrilling
@NEH_CVRTI
seminar yesterday on how his group is able to harness the dark web of genomic DNA by using noncoding RNA for therapeutic benefit. (Dinner was pretty good as well.)
@UofUHealth
@CedarsSinai
@StavrosDrakos
@ChaudhuriLab
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Smidt Heart Institute is proud to have our experts featured at
#ACC23
@CMAlbertEP
@JoChikweMD
@nataliebello9
@DrMarthaGulati
@David_Ouyang
@JanetWeiMD
@WomensHeartCS
@alanckwan
@MKIttlesonMD
@AnaIribarren10
@DrBowdish
@minissianm
@CedarsSinaiMed
0
12
32
Looking forward to representing
@SmidtHeart
in
#Mexico
at
@cadecigdl
meeting, attended by >3000 cardiologists from
#Latinoam
érica eager to learn about the latest advances in
#cardiology
.
@CedarsSinai
1
6
32
Great lab meeting presentation by postdoc Alice Rannou on
#RNAdrug
TY1 in
#mdx
mice with
#Duchenne
phenotype. Striking benefits.
#Macrophages
are key!
@SmidtHeart
@CedarsSinai
3
4
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.
@SmidtHeart
#Cardiology
grand rounds by Keith Ferdinand of
@Tulane
points out shameful discrepancies in
#mortality
by
#race
in USA. Why does the richest country on earth—indeed, the richest country in history—tolerate such horrible
#publichealth
?
#DEI
@CedarsSinaiMed
1
6
32
Pleased to speak at
@APSPhysiology
#summit
on our
#ncRNA
#drugs
. My former PhD student
@HopkinsMedicine
Kate Hsu
@Hsubooks
was in the audience; great to see her again!
@SmidtHeart
@CedarsSinaiMed
0
3
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Bittersweet saying
#goodbye
to two lab members, Shukuro Yamaguchi and
@Yeojin__hong
. Heartfelt speeches preceded a group photo with 🫶🫶.
1
7
32
We
@SmidtHeart
are delighted to welcome David Kass as the Inaugural Asher Kimchi Memorial Lecture. Busting myths about
#HFpEF
— not just bad diastole!
@JohnsHopkins
@dkassjhu
@hopkinsheart
0
4
31
Cool
#data
of the week: our synthetic noncoding
#RNA
lead compound, TY1, reverses established cardiac fibrosis in mice with
#Duchenne
muscular dystrophy. Work of
@rrogerslab
and Alice Rannou.
#cardiotwitter
#heartresearch
@CIRMnews
#heartfailure
#RNAtherapeutics
@CoalitionDMD
0
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Ted ended up at
@hopkinsheart
because Roselle came to work with me and refused to return to
@MayoClinicCV
… the rest is history!
Great
@SmidtHeart
#cardiology
grand rounds by Ted Abraham of
@UCSFHospitals
on
#hypertrophiccardiomyopathy
— non-obstructive is not benign! Is exercise bad? 😳 Stay tuned for his trial EXCITE HCM funded by
@nih_nhlbi
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Stellar
@SmidtHeart
#research
seminar by Peter Heeger, ace clinical
#immunologist
@CedarsSinaiMed
. How to improve
#transplant
graft function? One promising approach is C1 inhibition, already in clinical trials.
0
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30
Cool
#data
of the week: our synthetic noncoding
#RNAlead
compound, TY1, reverses the diastolic dysfunction of
#HFpEF
in obese mice with
#hypertension
! Even one dose every two weeks sufficed. Thanks to
@CIRMnews
for support!
@TheIbrahimLab
#CardioTwitter
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31
Congratulations
@DrMarthaGulati
on receiving the Agatston Award at
#SCCT2023
! You make
@SmidtHeart
proud!
#CardioTwitter
2
6
31
Inspiring
@SmidtHeart
seminar by Howard Rockman on
#GPCR
#signaling
, a remarkably fast journey from “do
#receptors
exist?” to selective
#allosteric
modulators.
1
6
31
Cool
#data
of the week: tacking at 6.2 knots with 8 knot winds, no waves, 70 degree air temp on Audacious… discussing
#ECcoupling
and marine
#biology
in
#SantaMonica
bay with
@jgoldhaber
!
@SmidtHeart
#CardioTwitter
6
1
31
Stimulating
@SmidtHeart
#research
#seminar
by
@LongShengSong1
:
#junctophilin
#genetherapy
using
#AAV
vector reverses established
#HeartFailure
!!
@CedarsSinaiMed
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3
30
Great
@SmidtHeart
cardiology grand rounds by
@suzannejbaron
, engaged here in lively discussion with Raj Makkar, on cost effectiveness of
#TAVR
and other percutaneous valve interventions. Bottom line: decrease LOS, complications, and find niche populations for new interventions.
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Pleased to participate in the upcoming joint
@CedarsSinai
@Caltech
#symposia
. Great opportunity for the
#1
#academicmedicine
program in
#LosAngeles
to interact with the transformational thinkers in nearby
#Pasadena
.
@SmidtHeart
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30
Cool
#Data
of the week:
#tRNA
-based lead compound, tREX-1, mined from
#ExtracellularVesicles
, reverses dysfunction in a mouse model of
#Duchenne
#musculardystrophy
! Active drug (but not scrambled RNA), administered twice weekly, improved both cardiac & skeletal muscle function.
0
6
29
Our latest
#clinicaltrial
with
#cardiosphere
derived cells, this one for
#PAH
; safe with signals of efficacy on top of
#GDMT
, despite single dose only. Sponsored by
@CIRMnews
@SmidtHeart
#celltherapy
1
8
29
Cool
#Data
of the week: our synthetic noncoding
#RNA
lead compound, based on
#exosome
contents, is cardioprotective in a rat model of
#MyocardialInfarction
! After active drug (TY1) was administered just once, circulating Troponin I and infarct size were reduced by >50% compared
0
9
28
So proud to have Jon as Associate Director of the
#SmidtHeartInstitute
and as a wise colleague
@CedarsSinai
! Few others have done as much to advance
#hearttransplant
care. Kudos Jon!
@CedarsSinaiMed
#CardioTwitter
Now
@ISHLTPres
introduces 2023 Lifetime Achievement Award recipient, Jon Kobashigawa, MD.
#ISHLT2023
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28
Provocative
#lab
#meeting
by postdoc Rodrigo dos Santos on
#biopacemaker
induced by
#AAV
Tbx18. Notable efficacy in supporting heart rate during exercise.
#EKG
#vectors
c/w impulse initiation at the LV injection site. Humans next?
#EPeeps
#CardioTwitter
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6
28
Cool
#data
of the week: the falls of Silver Creek OR flow over the largest basalt deposits on the planet. Western red cedars line the creek; they can live 700+ years— some were already huge when Europeans first colonized the western hemisphere.
3
1
29
Wonderful conference hosted by
@cadecigdl
bringing together thousands of Cardiologists from around the world. Thank you for your invitation to share our work.
@EugenioCingolan
@CedarsSinaiMed
@CedarsSinai
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8
29
Great
@SmidtHeart
cardiology grand rounds by Norm Lepor who reviewed the nefarious consequences of
#obesity
… an independent risk factor even in those with no apparent metabolic abnormalities!
@CedarsSinaiMed
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3
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I look forward to the day when we will regard conventional VT ablations as barbaric. Why not regrow healthy myocardium, rather than kill it?
#EPeeps
@CMAlbertEP
@SumeetSChugh
@CIRMnews
#Substrate
#Mapping
in a PreClinical Model of
#VT
#ICM
by
@coralf_reef
and James Dawkins
@SmidtHeart
@CedarsSinaiMed
➡️
#BiologicalSubstrateMod
#VT
#AblateVT
0
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2
29
🤔provoking
#journalclub
presentations today on how to rewind the
#aging
clock:
@ariel_omidfar
on STAT6 on DNA damage,
@ke_liaoPhD
on
#CAR
-T
#celltherapy
as a
#senolytic
, and
@rrogerslab
on
#IL4
and
#apoptosis
#signaling
in macrophages. Great discussion from
@MarbanLab
trainees
0
8
28
Cool
#data
of the week, with an Easter egg for
#HarryPotter
fans: novel micropeptide
#Slitharin
, secreted by
#CardiosphereDerivedCells
, is cardioprotective in a
#myocardialinfarction
model! Work of
@TheIbrahimLab
with collaboration of
@1jvaneyk
and
@Daniesoe
1
9
28
Way to go Raj! You join a distinguished lineage; prior recipients include Jeremy Swan & Willie Ganz, Myron Prinzmetal, Noel Bairey Merz,
@ArditiMd
... and somehow, also, me 🤨☺️😆
#interventionalcardiology
It's with great pride we share that
@SmidtHeart
Raj Makkar, MD has been awarded this year's prestigious
@CedarsSinai
Pioneer in Medicine Award! He has reshaped the landscape of interventional cardiology worldwide. Congrats Raj!
@CedarsSinaiMed
#CardioTwitter
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