Greta Karen Wood
@gkwood3
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NIHR Academic Clinical Fellow @NIHRresearch Infectious Diseases @LSTMnews/ @LivUni | CRF @covidcns | @RCPLondon Rep | she/her | Views my own
Liverpool, UK
Joined April 2016
2 minute summary of our work published in @NatureMedicine this week:. 1 year after hospitalisation with COVID-19 we found cognitive deficits equivalent to 20 years of ageing associated with raised brain injury proteins and reduced grey matter volume.
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Do cognitive deficits persist after COVID-19 and, if so, what is their biological basis?. Our NEW pre-print under review in @NaturePortfolio We report one-year cognitive, serum biomarker, and neuroimaging findings in 351 patients . A thread 1/n
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At one year, in those who had required hospitalisation, cognitive deficits were global and equivalent in magnitude to 20 years of ageing. Scores are compared to 2,927 matched normative community volunteers 3/n
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Cognitive deficits were associated with elevated brain injury biomarkers and reduced grey matter volume. The half-lives of the brain injury markers mean that this is objective evidence of *ongoing* brain injury one year after COVID-19. 4/n
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There is growing biochemical evidence that neurological complications in COVID-19, including cognitive impairment, are immune-mediated which is corroborated here by clinical demonstration of the protective effect of acute treatment with corticosteroids 9/n.
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Treatment with corticosteroids during the acute phase appeared *protective* against post-acute cognitive deficits 7/n.
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The severity of the initial infection, infection early in the pandemic, post-acute psychiatric symptoms and a history of encephalopathy were associated with greatest deficits. Importantly this means our findings don't generalised to COVID-19 today or mild respiratory disease 6/n.
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Deficits were correlated with symptoms of depression and the anterior cingulate cortex volume, which has functional roles in connecting cognition, attention, and emotion 5/n
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Mechanisms underpinning this potentially immune-mediated construct of depression, cognition and brain injury need to be further elucidated, to allow the development of targeted therapeutic interventions 10/n.
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Despite some improvement at the first follow-up, by the second there was plateau in the cognitive recovery trajectory 8/n
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Thank you very much to the national @covidcns Consortium for the hard work to get to this point - thank you to our study funders @The_MRC @UKRI_News and to @NIHRresearch for funding my ACF.
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Over the moon to accept an @NIHRresearch Academic Clinical Fellowship in Infectious Diseases! . I'll be with @LSTMnews @LivUni and @LivHospitals researching tuberculosis with Dr Tom Wingfield, @petermacp , Dr Eve Worrall and Prof K Mortimer. Can't wait to get started!
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Thank you to our PPIE Panel including the brilliant @encephalitis with @encephalitisava @NeuroAlliance @StrokeAssocNews and @MQmentalhealth. We worked together on study design, ongoing review and reporting of findings.
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Research made possible by @_brendan95 @psychgenomics @ProfHampshire @AlanCarson15 @ProfTonyDavid @Frosty_Immunity @Frankongho @Menon_Cambridge @edbullmore @bettyonthebrain @topherhuebel @RunningMadProf and many more!.
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@_brendan95 @psychgenomics @ProfHampshire @AlanCarson15 @ProfTonyDavid @Frosty_Immunity @Frankongho @Menon_Cambridge @edbullmore @bettyonthebrain @topherhuebel @RunningMadProf @matthewrbroome @John_PaulTaylor @Tim_R_Nicholson @MasudHusain @MatthewHotopf @Cunningham_Colm @delirious_dr @tompollak @rai_bethlehem @valegiunca @RachelUTG @fmrib_steve @fmrib_karla @BrainImagingLiv.
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Today had paper accepted in major cardiothoracics journal. 4/7 authors female. Change is in the air! #ILookLikeASurgeon #CTsurgery #surgery @WomenSurgeons.
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Huge pleasure to work with @GarethLipunga BIGlobal Study Coordinator for Malawi. Currently together at the @BIGlobal_NIHR Group Meeting in the beautiful #Malawi
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How do infections impact the brain? .Each year we learn more with the help of The @encephalitis Society and everyone that contributes to research 🧠🔬. Happy #WorldEncephalitisDay from the Infection Neuroscience Lab. #Red4WED
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The #PandemicDebate between scientists on Channel 4 has really reinforced the value of listening to people who. 1) Know what they're talking about .and.2) Answer the question posed. Thank you to.@RunningMadProf @SunetraGupta @krishgm and all others who contributed.
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Exciting news!.I just moved to Belgium to start studying at @ITMantwerp .Fantastic so far - looking forward to the months of Tropical Medicine & International Health to come!.#Antwerpen #globalhealth
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I’m an F1. I recently raised concerns re our exception reporting system .- within 2 months discussed at level of Trust Board. Then asked for more computers in Drs Mess.- today they were installed. Would encourage all juniors to speak up, it can help!. Credit to @RoyalLpoolHosps.
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55% UK medical graduates female.5% UK cardiothoracic surgeons female . Can’t wait to attend #scts2018 cardiothoracics conference this weekend and start changing the balance #ILookLikeASurgeon .@WomenSurgeons @drnikkistamp.
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Acute seizures in @encephalitis are common and associated with a worse outcome. Could we predict acute seizures on admission? How does this help us?. We analysed data from 436 patients and developed a clinical scoring system. A thread (1/n).
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What a fantastic couple days at the @encephalitis Conference. Learnt a lot, met brilliant researchers in person and had a chance to share my work!. Next stop World Encephalitis Day 22 Feb 2022 🔴. #EncephalitisConf
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It was an absolute pleasure to share @covidcns results this week at The @encephalitis Conference. So excited to shortly share our full analysis on the impact of COVID-19 on cognition, including associated biomarkers and neuroimaging 🧠🦠.More to come soon!.#Encephalitis2023
What a fab Encephalitis Conf 2023: Tarun Dua, on @WHO Neurological Disorders Plan; super Neurological Covid talk - @gkwood3 of @InfectNeuroLab; amazing debate; plus our long-awaited study of steroids in HSV encephalitis @dexenceph hopefully published soon. 👏to @encephalitisava
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The govt’s policy of charging migrants for healthcare is irreconcilable with our duty as a doctor. At the Royal Liverpool Hospital we are calling for the suspension of charges. Please read our campaign statement and offer your support:.Please Retweet .
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The brilliant @Frosty_Immunity sharing our @covidcns work defining the biomarkers of neurological complications of COVID-19 across 2 UK wide cohorts 🧠🧪.The @InfectNeuroLab well represented at #APAM2023 !
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"For those who have given the gift of life to others". At @WaltonCentre there is a tree sculpture in which in each leaf represents and honours an individual organ donor. You could save up to 9 lives: talk to your family about organ donation. #OrganDonation .@NHSOrganDonor
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Who gets seizures in encephalitis and why does it matter? .A pleasure to speak to @encephalitisava about our @LivUni Infection Neuro research. @BenedictNeuro @RunningMadProf @Sdefres1 .@LivUni_IVES @LivuniIcat @TonyMarson2 @bettyonthebrain @Frosty_Immunity.
In this newest episode of our podcast, @encephalitisava is joined by @gkwood3 for a discussion around seizures and encephalitis. Watch on YouTube below or listen on all good podcast channels 🎙.
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Amazing first week on site @LivUni @WaltonCentre working on @covidcns .2 new recruits ✅.First participant scanned ✅ .Vaccinated ✅.Let's find out how COVID-19 affects the brain!! 🧠.@BenedictNeuro @psychgenomics
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It's #WorldEncephalitisDay so I've gone #Red4WED !.78% of people do not know what #encephalitis is yet in many countries it is *more common* than motor neurone disease, bacterial meningitis and cerebral palsy! .Let's raise awareness!
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Just come back after a brilliant 3 months at @MlwTrust Malawi as part of my Academic Foundation Programme with @LivHospitals and @IGHLiverpool . Learnt so much. One happy trainee!.Very grateful for the support I’ve had!.@LivuniIcat .#AcademicTwitter #medtwitter
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Delighted we recruited and scanned another participant for @covidcns today! .Very grateful to each participant. This is an unprecedented chance to understand how pandemic infection impacts the brain 🧠 . @BenedictNeuro @BrainImagingUoL @psychgenomics @edbullmore
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A BIG THANK YOU! Hundreds of patients invested their time and energy in @covidcns .Thanks to them, we have the first and best opportunity to learn how pandemic infection impacts the brain 🧠 .We look forward to sharing results soon!.@NIHRBioResource @encephalitis @LivUni_IVES.
Infection Neuroscience group helping to package some thank you information for the over 800 participants recruited for the @covidcns study. We all can’t say thank you enough! @BenedictNeuro @gkwood3 @Frosty_Immunity @RajishShil
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Looking forward to presenting at The @encephalitis Conference in December 20.Programme looks fantastic.Keynotes from @RunningMadProf @BenedictNeuro and @carstenfinke . Early bird tickets now available.
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Step 1: support each other #WomeninGH #WLGH17
Root for women, trust women, & trust yourself. Know that you did the best you could with what you had, & move forward. #WLGH17 #womeninGH
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THANK YOU to the wonderful @covidcns team who surprised me with a birthday cake today! 🎂.Feel v appreciated! .@BenedictNeuro trying to steal first slice. #birthday #happyteam
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Great to learn about RNA quantification with the brilliant @Frosty_Immunity today. And then examined a new participant. @covidcns and @NIHRBioResource are literally working from bench to bedside to understand how #COVID19 affects the brain 🧠 . @BenedictNeuro @psychgenomics
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We received a very warm welcome from the team in Chiradzulu today- thank you @papi_mbinge for hosting us!.Study coordinator @GarethLipunga presented about @BIGlobal_NIHR . The aim? Improve the management of acute brain infections. Data collection starts in 1 month!.#globalhealth
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It was a pleasure to speak to @encephalitisava to share @covidcns findings today:. Raised brain injury biomarkers and reduced grey matter volume one year after #covid19, particularly in those with brain complications . Thank you to the participants!.#ppi
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A week ago I found out I passed finals and am now a Dr! The last 6 years at @UniofNewcastle have been incredible. Now to move across the North and start work in Liverpool!!. #FridayFeeling #getnorth2018 #WomenInMedicine
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Have you heard of encephalitis? Could you recognise it in time?. Today on #WorldEncephalitisDay we desperately need donations to help improve early recognition of encephalitis worldwide. Don't delay. Give today. #WEDAppeal
Our CEO, @encephalitisava is calling on you. With your support, we aim to raise £40,000 towards providing training opportunities for medical professionals around the world on the early diagnosis and treatment of encephalitis. Don’t Delay. Give today:
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There's always good reason to celebrate #InternationalWomensDay in our Infection Neuroscience Lab @InfectNeuroLab . Here's to our exciting team and its love of ridiculous photo opportunities 🧠🧑🤝🧑👭@BrainInMyDNA @Frosty_Immunity @hetheringtoncd @bettyonthebrain @SarahAimeeB
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Undetectable = Untransmittable. Happy #WorldAIDSDay . Let's share positive messages about living with HIV!. #letstalkpositive2020 #AIDSday #HIV #SIDA . @ITMantwerp
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About to post my vote for @TheBMA Council Elections!.Please VOTE- we must engage if we want things to change. Good luck @DancingTheMind , @HannahPopsy and @anilkjain61
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So exciting to present today at the National Foundation Drs Presentation Day in Bristol! Outlined my AFP working on @BIGlobal_NIHR.in @MlwTrust. Conc:.- Worthwhile academic placements outside UK are possible within training.- We need more flexible and responsive training. #NFDPD
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Walking home from hospital through a practically deserted and absolutely beautiful Liverpool. THANK YOU to everyone doing their bit and staying home to save lives! . #StayHomeSaveLives .#COVID19.@livuninews
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Looking forward to the women in global health chat. Would love to hear female leaders perspectives #WomeninGH.
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Exciting @encephalitis programme kicks off discussing infectious encephalitis with @BenedictNeuro from @InfectNeuroLab . Take homes so far .- ensure you don't miss treatable causes.- vaccines work. 🧠🦠
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My grandma was a refugee as a child. Her descendants in the UK include:. - 2x nurse and 2x doctor (all of whom worked/work in our NHS).- 1x chef in care homes/schools.- 1x new Cambridge grad. #RefugeesWelcome #NHS #migrants .@Medact.
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Very excited to share that after months of planning I recently moved to Malawi for my F2 research block! I'll be working on @BIGlobal_NIHR.It has taken months of planning - very big thanks to.@RoyalLpoolHosps @LivUni @MlwTrust & @LivuniIcat.Could not feel more supported!
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PGCert Tropical Med and International Health ✅. Belgium, from Bruges to the wonderful @ITMantwerp library, it's been a blast!. Now onwards and upwards to exciting @covidcns work 🧠. #globalhealth #research
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The excellent #EncephalitisConf is about to start!! Got my coffee!. Cant wait to hear from @RunningMadProf @BenedictNeuro @carstenfinke @jessfish and many more + @deerbrian telling us about his new book. Let's make progress in managing @encephalitis !!
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Want to join our international network @GlobalBrainHea1 ? Read more about our workshops and collaborative research in NEW @WnfoNeurology blog:. @ATamborska @Frankongho . Thank you to @LivUni for funding 🧠🌍
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Highly recommend other medical students get involved. Learn about research and contribute to a collaborative, worthwhile project that should be an example r.e. how we do global health/ surgery research #meded #research #globalsurgery
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Absolute pleasure to present our @covidcns cognitive work at #APAM2023 today. Message:.Covid is associated with post-acute cog deficits and raised brain injury biomarkers. Brilliant conference from @AoPgbi essentially for ECRs .#neuroscience #COVID19.
Great end to the @AoPgbi #APAM2023 with a 🧠 #Neurology symposium inc. a strong representation from @LivUni_IVES. First, Gash Mbizvo on risks for death in epilepsy and then @gkwood3 with first results of the multicentre @covidcns study. 👏👏
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Excellent Celebration lecture at @MlwTrust from Dr @JamieRylance about partnerships in clinical research to improve the care of critically unwell patients. Really interesting work highlighting the value of team science!.@wellcometrust @LSTMnews
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So exciting to be back at the Liverpool Brain Infections Group research retreat in beautiful Wales 🏴.Can hard work always be like this?! . With Stephen Ray, @Frankongho and @BenedictNeuro . #teamscience #neurotwitter.@InfectNeuroLab
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Delighted to see our #GlobalSurg2 study published! This kind of collaboration is exactly what we need in #globalsurgery
Our new paper in @TheLancetInfDis: Patients in the poorest countries have the most wound infection & may have higher anitibiotic resistance. A big problem needing collaborative solutions. #GlobalSurg2 #VisualAbstract
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NeuroPASS: Neurology for Finals.Registration now open! . Very excited to launch today our one-day intensive neurology teaching course for finals!.Proceeds to @encephalitis . @livuninews @SKeshwara @BenedictNeuro @WaltonCentre
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Always a pleasure and something of interest in the @covidcns Clinical Case Evaluation Panel! .Today ADEM, catatonia, eating disorder, anti-MOG, orofacial dyskinesia, novel CNS autoantibodies. Input from @AgnesAyton @psychgenomics @BenedictNeuro @KatyCDodd
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The predictors of seizures in encephalitis: GCS, aetiology, age, fever.It was a pleasure to share our work at the #EncephalitisConf today.
A fascinating overview from @gkwood3 of the importance of investigating the predictors of seizures in #encephalitis and the opportunities this presents. #EncephalitisConf
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Lively and informative #ECR workshop with @charlot_summers , @RunningMadProf and many others. No one path fits all and mentorship definitely key! Great start to #APAM2023 .@AoPgbi @RCPhysicians
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A few pictures from my walk home from work today. One of the many reasons I’m glad I chose @LivUni , @LivuniIcat and @RoyalLpoolHosps for foundation years! Congrats to all the final years who recently found out they’re coming here! #medtwitter #liverpool
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NEW pre-print: Frequency of neurological manifestations in COVID-19: a systematic review and meta-analysis of 350 studies .- 145,634 patients.- 1 in 3 neuro manifestation.- 1 in 50 stroke.- >60yr: almost 2x mortality.@BenedictNeuro @kiranthakurmd @covidcns.
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NEW + now free access + download next 50 days. Encephalopathy, encephalitis, and psychosis often misdiagnosed in the context of infection. International collaboration with @wfneurology and WHO/@LivUni_IVES -funded @GlobalBrainHea1
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Team arriving for Liverpool NeuroID course organised by @BIGlobal_NIHR in @MlwTrust .Brilliant programme can't wait to get started!.Talks from Prof Henry Mwandumba, Prof Mac Mallewa, Dr Mwapatsa Mipando, Prof V Ravi, @RunningMadProf , @encephalitisava and many many others!
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The Infection Neuroscience Lab is officially on the wall!.Could not recommend working with @BenedictNeuro highly enough!.Interested in the 🧠 and want to join us? .Apply for exciting RA position @LivUni_IVES here .
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You know you're doing an @NIHRresearch ACF in @LSTMnews when this is the birthday card from your supervisor!.Thank you @DrTomWingfield !
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As med student it can be a challenge working out who’s who in theatre. Can’t imagine what patient thinks!. #TheatreCapChallenge
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What neurological disease do we see with #Covid_19 in Malawi?. *Interactive WHO COVID-Neuro Clinical Exchange 8th September 1400 BST*. Chairs @livingitlight @BenedictNeuro .Speaker @GarethLipunga . Register .
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The @BIGlobal_NIHR Annual Meeting opened today by Dr Charles Mwansambo, Chief of Heath Services in Malawi and @RunningMadProf . The message was clear: this work has the potential to make a real difference in the management of patients with suspected brain infection. #globalhealth
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Beautiful views over Liverpool to finish our @LivuniIcat Clinical Academic Careers Day at @RCPhysicians Spine. Dr Wootton tells @NIHRresearch.ACFs/ACLs:.- Be visible.- Sell your vision.- Get support
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I just moved from UK to Belgium to study. Benefits so far from relationship with EU. - Right to study + work here.- Course ~£5500 cheaper.- Free health insurance.- Phone works at no extra cost.- No visa.- 2 min passport check. Leaving EU mistake for many reasons. #EuropeanUnion
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CEO @encephalitisava interviews @deerbrian . The more you hear, the more shocking it gets. Vaccines saves lives and we need to find ways to effectively counter the current anti-vax rhetoric . #Encephalitisconf #vaccine #VaccinesWork.
On stage now at the #EncephalitisConf are @deerbrian and @encephalitisava - they are talking about The Doctor Who Fooled the World.
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Unexpectedly got vaccinated today at @LivHospitals @WaltonCentre! .What a treat, I'm delighted!.Thank you to everyone contributing to this massive effort!. #COVID19 #COVIDVaccination #CovidVaccine #Covid19UK
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F1 starts soon.Positive: Got a rota.Negative: Got 2 rotas and they are different. And so we begin.
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How do we translate the growing and largely untapped NHS clinical data resource into patient benefit?. Excited to get funding from @NHSEngland to study PGCert Clinical Data Science @officialUoM . 1 year of data engineering, stats & machine learning and digital 🙌
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First day on A&E was a bit of a shock to the system after the academic block!.Can confirm that I don’t think the new skills in systematic review, R or stats are going to come in handy. #medtwitter
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Please take a read of this case. It affects all of us. Particularly note: .- There were recognised failings of the system and multiple errors but individual prosecuted. - Consultant asked her to write reflection then typed it up for use in investigation. #BawaGarba
Next year I will start work as a junior doctor in an overstretched and underfunded NHS. This makes for some very uncomfortable reading #LearnNotBlame
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Process mapping at @BrainInfections Global Group Meeting in Liverpool with @Suzie_Lant . Over the next 3 years our @OfficialNIHR study, lead by @RunningMadProf , will look at how to improve diagnosis and management of brain infections worldwide!
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Today in @LivHospitals we recruited 2 patients to @covidcns with 5 more approached who may chose to join tomorrow 🧠. Very grateful to each participant and to all the supportive clinical teams! . #brainhealth #COVID19 @BenedictNeuro
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*DEADLINE 30th June*.Abstract submission open for 5 final days for Encephalitis 2021 *the* key global conference for encephalitis. Welcomes submission for epidemiology, pathogenesis, dx, rx and rehab. Keynote @kiranthakurmd .
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Prof @MelitaGordon5 tells big audience at @MlwTrust :.“Don’t be afraid to ask questions if other people don’t know the answer” .Very interesting and motivating talk - thank you!.#WomenInSTEM #globalhealth
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Which pre-existing neurological conditions are risk factors for COVID-19 severity and infection?. *Out today* @wfneurology . Global collaboration inc colleagues @WHO Brain Health Unit and @LivUni @RunningMadProf & @BenedictNeuro
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Excellent presentation from @ArinaTamborska for @BIGlobal_NIHR webinar with @BenedictNeuro . - Appears to be association with GBS & adenoviral vector #Covid_19 vaccines.- GBS variants common.- Risk lower than with COVID-19 -> get 💉.- Need @covidcns to understand mechanisms🧠🔬.
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Vaccine-preventable diseases include:.Cervical cancer.Cholera.Diphtheria.Hep B.Influenza.Japanese encephalitis.Measles.Mumps.Pertussis.Pneumonia.Polio.Rabies.Rotavirus.Rubella.Tetanus.Typhoid.Varicella.Yellow Fever.#VaccinesWork!.Here are 5 facts on vaccines you need to know
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State school in Derby (but a good one). Started medicine Newcastle 2012, now final year. Involved in widening participation. Intercalated MRes Global Health. Accepted AFP post in @RoyalLpoolHosps starting August #MyPathToMedicine.
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Live in 15 minutes! .How does #covid19 impact the brain? 🧠.Join us to discuss @covidcns findings with @encephalitisava @BenedictNeuro @Menon_Cambridge and many more!.
2 weeks to go to book your place! Tune into this free webinar to hear experts from @covidcns discuss their insights into the neurological and neuropsychiatric complications of #COVID19 . Book now 👉
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COVID-19 has a profound and lasting impact on those with a brain 🧠 complication. UK-wide @covidcns team want to find out *how* COVID-19 damages the brain. Only then may we know what to do about it. #brainhealth #neurotwitter #neuroscience . @BenedictNeuro @BrainImagingUoL.
Hi, I'm Dr. Greta K Wood @gkwood3, Clinical Research Fellow. I hope our team can better understand how COVID-19 impacts the brain, as this information could guide future treatment and prevention strategies. Here with Kieran (Research Radiographer), Liverpool COVID CNS MRI team.
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Snippet from @dailytelegraph Independent School paper. 61% senior doctors .74% senior judges .Yet 7% children Independent school educated. Designed as advertisement but quite depressing. Should be recruiting talent not privilege. #inequality @SocialMobilityF
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Enormous thanks to @MedResFdn who made it possible to create this shared resource including tools to harmonise #MRI data, research data, clinical assessments and @encephalitis seizure risk stratification 🧠🌎.
Join our collaborative network & access our FREE Neuro Resources Centre. Open to all healthcare & research professionals within clinical neurology. These research tools will help unify the reporting & methods used by professionals globally. 👏 @MedResFdn
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Why did no one tell me microscopy was so exciting!?.Do you know what I found today?. #microbiology #helminth #WomenInSTEM
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