Masud Husain
@MasudHusain
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Professor of Neurology & Cognitive Neuroscience @UniofOxford , Editor-in-Chief @Brain1878 , Fellow @NewCollegeOx
University of Oxford
Joined April 2015
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I'm delighted to announce that we're going to host a (virtual) Oxford Autumn School in Neuroscience this year with a great range of topics - and free to anyone.
Details, including registration, here:
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Why small mindedness is having big consequences
@Brain1878
I live under its shadow. I suspect most of you do too. It is the great mountain of small things. The higher it gets, the bigger the shadow it casts: a malignant darkness that pervades our lives.
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Announcing a new Essay competition
@Brain1878
Submissions from early career researchers and students particularly encouraged
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Free registration for this year's Oxford Autumn School in Neuroscience, September 30th and October 1st, 2021
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Interested in the controversy on the functional roles of the anterior cingulate cortex and dorsomedial prefrontal cortex? This new review
@Brain1878
by
@ClairisN
@LopezPersem
is well worth a read
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How does deep brain stimulation work?
@neumann_wj
@Steiner_LA
@lukamneuro
explain in their new Update in
@Brain1878
#DBS
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Impact factors aren't everything but nevertheless very pleased to hear this week that our Impact Factor
@Brain1878
is now 15.2 through all the efforts of the editorial team and
@Newrotrash
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Latest edition of
@Brain1878
now out with a wonderful cover of the lower motor neuron homunculus shown in proportion to the classical motor homunculus
…
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Eye-opening work on brain mechanisms underlying the effects of different components of cognitive behavioural therapy by
@AgnesNorbury
@TobiasUHauser
@smfleming
@docqhuys
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Perhaps the most amusing cover
@Brain1878
for a long time. Police cordon holding back Beatles fans, illustrating concept of inhibitory restraint around a seizure focus. When GABA release collapses, seizures escape local inhibitory restraint
@Newrotrash
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Impact Factors are not everything but we're a little pleased
@Brain1878
to see ours go up to 13.5 this year! All due of course to the hard work of the previous editorial team led by Dimitri Kullmann
@Newrotrash
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This is what makes you think that aging is complex.
Of the >1000 brains that underwent post mortem analysis, 94% had evidence of at least one pathology, 78% had 2 or more, 58% had 3 or more while 34% had 4 or more. Remarkably >230 different combinations of pathology were found!
#ANAJournalHighlight
: This study in Annals of Neurology suggests an urgent need for novel therapeutic approaches that embrace the complexity of disease to combat cognitive decline in old age
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Delighted to see this out. What started as some whimsical discussions with
@PetitetPierre
@bahaatallah
@BrainInTheMind
came up trumps. How do people decide when to stop gathering information before they commit to a decision? Find out
@NatureHumBehav
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This month's
@Brain1878
contains a set of important articles on
#Parkinsons
and
#LewyBody
dementia, including reviews on alpha-synuclein and bradykinesia, papers on cholinergic loss, mechanisms underlying rigidity, impulse control disorder and cognition
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Did you know that Proust had a functional neurological disorder, among his many talents? See this month's
@Brain1878
Editorial, Essay and Update on FNDs, including their psychology and neuroimaging
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It's one thing to have plasma biomarkers for
#Alzheimers
but which one is most closely related to cognitive function. Our
@UniofOxford
experience led by
@toniolo_sofia
&
@sijiazhao92
using digital cognitive testing platform reveals pTau to be the winner
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The very complex enigma of tau and its role in neurodegenerative diseases discussed in
@Brain1878
editoral
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I’ve been passionate about writing this book over the last two years. It’s great to see it taking shape. Thanks to
@STWevents
@wellcometrust
@WoollardJessica
and
@simnthrgd
for getting me here
There's no better guide to the Brain, we're delighted to be publishing
@MasudHusain
's Our Brains, Our Selves - his debut book on brain disorders and identity in February 2025!
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Only 4 days until the biggest Oxford Autumn School in Neuroscience ever, run by
@OxNeuro
with 16 great talks and >7500 registered delegates each day.
See what you're missing! Free registration and details here:
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Perhaps difficult for our colleagues
@UCL
to say what they think about the University's response to reports of unacceptable behaviour
@BartlettArchUCL
: Predictably, it was more training required for everyone who *wasn't* involved! My response:
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Delighted to learn that
@Brain1878
's sister journal
@braincomms
now has its first impact factor (4.8 just in case your were interested). Congratulations to
@TSpiresJones
and the editorial team
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The Oxford Autumn School in Neuroscience has a fabulous line up of speakers with symposia on sleep, neurodegeneration and dementia, mental health, neuroplasticity and neurprotection. 2nd and 3rd Oct 2023. Free and open to all with registration
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Was Broca wrong? Find out
@Brain1878
Editorial on a new paper which examines brain correlates of non-fluent primary progressive aphasia and primary progressive apraxia of speech
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How does hippocampal volume decline with age? Here are the data from >19,000 people in
@UKBIOBANK
With
@l_nobis
@BrainInTheMind
and
@ClareEMackay
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Very frustrated! Waited 3 months to start a grant across 3 sites. Often takes longer to get sign-offs.
If Universities are going to pretend they work like businesses, they need leadership and support services - quality and quantity - to match that aspiration. Absolutely hopeless
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Great to see so much interesting debate and vigorous responses to this Editorial in
@Brain1878
We need to lobby for change with organisations that are supposed to represent us, but also locally within our institutions. Why should we accept the status quo?
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Our free to download new paper on Clinical Assessment of Parietal Lobe Function now out in
@PracticalNeurol
with
@NeuroYounes
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Booked a conference hotel. Travel agency
@UniofOxford
quoted 11% more than if I booked it myself. Decided to do that anyway but need to show University that travel agency quote was higher. Madness! Let's increase admin burden and ensure that we and our funders get screwed over.
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New issue of
@Brain1878
with an Essay on why we need to sleep by Matt Walker
@sleepdiplomat
, imaging evidence that one night's sleep deprivation impairs molecular clearance from the brain & Editorial on sleep and neurodegenerative diseases
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Too much
#Dopamine
tips you into impulsivity?
The answer's more complex. Heightened sensitivity to rewards even OFF dopamine in
#Parkinsons
impulse control disorder. Our new one
@Brain1878
with Dan Drew
@BrainInTheMind
@KinanMuhammed
@YoussufSaleh
@davidokai
@OxfordPDCentre
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New issue of
@Brain1878
now out with some great original articles and Commentaries, an Essay on the 400th anniversary of the brith of Thomas Willis and an Editorial on why we need to think about N-of-1 trials in clinical decision-making.
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Couldn’t agree more. My own editorial on Why the next generation of UK clinician scientists is under threat appeared in
@Brain1878
and is free to read here
Academic clinician–scientists risk becoming an endangered species.
World View from
@StephenORahilly
@Cambridge_Uni
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Latest issue of
@Brain1878
out with a first: Cover image painted by a six year old Mateo Serratrice. We encourage an interest in neuroscience to start early in life!
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Happy New Year from the Team
@Brain1878
and my thanks to the Editorial staff, Deputy Editors, Associate Editors, Editorial Board and reviewers in what has been a very challenging year. Here's to a much better 2022!
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Some suggestions to change the culture:
1/ Push back on requests that seem unreasonable
2/ Question why they're required & by whom
3/ What's the evidence it will make any difference?
4/ Why does it have to be done on an (arbitrary) annual basis?
Any others?
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We have a great new postdoc position at Oxford for someone with a background in neuroimaging interested in studying motivation and apathy in healthy people and neurological patients. job/BZB804/postdoctoral-research-associate-in-cognitive-neuroscience
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For those interested in the big picture, this is where we think apathy and anhedonia research dovetails with fundamental neuroscience findings on motivation, in animals and humans.
New in
@NatRevNeurosci
from
@MasudHusain
and
@jonroiser
: Neuroscience of apathy and anhedonia: a transdiagnostic approach
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My faith is restored
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@Brain1878
joins over 200 journals today in publishing the same editorial calling for emergency action on
#ClimateCrisis
to protect health and restore biodiveristy
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Absolutely delighted to hear that
@YoussufSaleh
has just won the European Academy of Neurology Tournament for clinical neurologists in training with his talk on Apathy in small vessel cerebrovascular disease. Congratulations and very well deserved, Youssuf!
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Take a closer look at the cover of the latest issue of
@Brain1878
An aerial view of houses and roads at night? Yes but the source was an image of oligodendrocytes cocultured with T cells, with each bright spot corresponding to their contact.
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We don't need more training. We just need leaderships of our universities to understand how shockingly badly they are run. Poor oversight, no real understanding of what it's like on the shop floor, and little formal opportunity to blow the whistle is what needs attention.
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Why is the APOE e4 allele still present in the general population when it confers an increased risk of
#Alzheimers
and worse episodic / long-term memory? Perhaps the answer is that it is actually associated with superior working / short-term memory. …
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Understanding the neural control of hand movement discussed in the latest issue of
@Brain1878
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New developments in frontotemporal dementia presented in three new papers
@Brain1878
discussed in an editorial in the latest issue (We're catching up!)
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Great new contribution by
@Dick_retired
on the functions of prefrontal cortex reviewed by
@BadreLab
in
@Brain1878
Navigating the recurrent perplexity of prefrontal function.
David Badre reviews Dick Passingham's new book on the PFC.
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Introducing the first in a new series of articles
@Brain1878
:
the Brain Essay by
@ajlees
A beautiful reflection on childhood, observational skills and being a neurologist. Bird watching on the asphalt
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@Newrotrash
@Brain1878
@BrainEditorial
A very big thank you to Dimitri Kullmann
@Newrotrash
for all his efforts over the last 7 years in keeping
@Brain1878
at the forefront of clinical neuroscience and neurology. No easy task but performed with style! Thank you, Dimitri. How are you going to fill all that spare time?
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A big thank you to
@Neurosharp
@NeuroDocLucia
@nialljbourke
and all the
@Brain1878
team involved in hosting the 2021 BRAIN Conference. A fabulous bringing together of great neurology and the neurological community. Thank you!
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Two postdoc positions to study decision-making, motivation and memory at the Cognitive Neurology lab, Oxford.
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Our new paper on the impact of blood pressure, diabetes and other vascular risk factors on executive function in
@uk_biobank
with
@micheleveldsman
Xin You Tai
@BrainInTheMind
@fmrib_steve
@ten_photos
is out and in The Guardian
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Stunning!
Sneak Peek: Using AR to see into patient’s brain and tumor prior to surgery.
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We’re looking for a dynamic postdoc with experience in psychology or cognitive neuroscience to join us
@husain_lab
@OxExpPsy
@NDCNOxford
@UniofOxford
. For more information, contact me
@MasudHusain
.
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January issue of
@Brain1878
now out
with 'Double Vision', the winning contribution in our Essay Competition by
@popkirov
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A very big congratulations to
@tm_brainscience
for passing her DPhil viva in style, and also to her primary supervisor
@brain_apps
for a great job too!
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Our first in-person
@Brain
Conference in London on March 15th, 2024. Details and registration here
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I never used to think like that but it’s certainly the case now. I’m sure many of us don’t apply for a lot of grants because we can’t face the admin burden that we’d need to confront. It’s a broken system which is killing motivation to innovate in the name of risk management
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Our latest issue from
@Brain1878
with the cover from an article by Qi Wang et al who investigated BBB dysfunction linked to changes in brain endothelial cells in human
#Alzheimer
brains and how this can be alleviated by targeting the Wnt/β-catenin pathway.
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Our new one on loss of motivation in schizophrenia: Both cognitive impairment and negative symptoms have an impact on effort based decision making for reward. With
@saleh_youssuf
@icjb25
@PetitetPierre
@EFernandezEgea
@BrainInTheMind
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Get ready! The
@Brain1878
podcast is coming soon with in-depth interviews with authors hosted by
@XinYouTai
and Sarosh Irani
@ANG_Oxford
Launching Sept 12
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Point taken! This is why we need real-world recruitment into clinical trials.
What proportion of patients with mild cognitive impairment or mild Alzheimer disease seen in a memory clinic would meet the inclusion criteria used in the clinical trials of
#aducanumab
and
#lecanemab
? Read the article to learn more:
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In the new issue of
@Brain1878
we're delighted to publish a provocative new Essay on the Biology of Consciousness by Antonio Damasio
@damasiousc
and Hanna Damasio
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Emerging findings from different patient groups suggest that impulsivity and apathy might co-occur. Here, with
@PetitetPierre
@JacquieScholl
@BrainInTheMind
@bahaatallah
& Dan Drew, we show they also correlate in healthy people, but it's complicated:
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Out now, the February issue of
@Brain1878
with a beautiful blazing hippocampus on the cover
from the authors of Hippocampal innate inflammatory gliosis only
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Maybe it is time to realize that amyloid pulled the trigger a long time ago, producing a cascade of long-range network effects that aren’t going to be reversed by targeting it. Time to focus on the brain, not just the molecules
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OK, so we
@Brain1878
definitely thought we need to celebrate this: 50 years since the advent of CT with the first brain scan performed at Atkinson Morley Hospital, Wimbledon. Find out more
Lutters & Koehler mark the 50th anniversary of the introduction of CT scanners into clinical practice. By enabling clinicians to perform ‘a living autopsy’ of the brain, the scanners transformed neurological care.
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Latest research on cognitive, mood, anxiety and psychotic symptoms following
#COVID
#LongCovid
summarised in an Update by Paul Harrison &
@MaximeTaquet
Open access article
@Brain1878
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If only we had this when we learnt anatomy at medical school!
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The April issue of
@Brain1878
is now out with a wonderfully diverse array of original papers, reviews and book reviews. Feed the mind!
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New edition of
@Brain1878
with an editorial by our Associate Editor
@MessoudAshina
on new drug targets for migraine
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Very few doctors are motivated to teach students any more. Most have had the enthusiasm squeezed out of them by the very institutions which trained them: universities & hospitals. Something has gone fundamentally wrong within a generation. Up to us to do something about it.
Before formal job descriptions all or almost all neurology consultants were expected to do formal teaching sessions. It was part of the business ov neurology. Where did it all go wrong?
Drowning in mounds of bureaucratic bumf
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Fantastic to read an extremely positive review of
@camillalnord
's 'Masterfully nuanced' new book The Balanced Brain: The Science of Mental Health
@ObserverUK
today
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New issue of
@Brain1878
now out with some extremely thoughtful contributions across neurological diseases.
Cover image: stressed motor neurones in ALS
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Sorry the Oxford Autumn School in Neuroscience sold out overnight. We really weren't expecting such a big demand! Registration now reopened.
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Dopamine modulates cognitive control over contents of working memory. The new elegant study by
@agonistofmind
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We're looking for a dynamic person to join us
@UniofOxford
as a Research Co-ordinator on an exciting new
@wellcometrust
Discovery Award to study motivation and apathy in health and in brain disorders, with Cath Harmer
@OxfordPERL
@brain_apps
@littleneuro
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June issue of
@Brain1878
now out
including negative results from the tilavonemab anti-tau monoclonal antibody trial for
#Alzheimers
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We’re looking for a new assistant psychologist and research co-ordinator to work with the Cognitive Neurology group at Oxford on memory disorders and apathy in neurological patients
See what we do here:
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Want learn more about how filtering out irrelevant material at encoding, maintenance and retrieval are related - or not? Our new paper by
@NeuroYounes
@neuroRaquel
@l_nobis
@RobertUdale
@imranidris
@BrainInTheMind
free to download
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New paper in
@Brain1878
: Antemortem plasma p-tau (181) predicts Alzheimer’s disease neuropathology and regional tau at post-mortem, providing further confidence in plasma biomarkers for
#AlzheimersDisease
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Delighted to get this one led by
@sijiazhao92
out: Evidence for generalised cognitive slowing on even simple tasks in some people who suffer
#LongCovid
Pronounced cognitive slowing with
#LongCovid
as compared with matched controls in a multicenter new report
@eClinicalMed
@sijiazhao92
@MasudHusain
@Uniof
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A new computational fMRI study on the behavioural components and brain correlates of fatigue now out by
@tm_brainscience
@MKFlugge
@BrainInTheMind
@brain_apps
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@DervisSalih1
@Brain1878
If, as a Society, you had invested in educating and developing some of the smartest people you had, would you then kill off their ability to tackle big questions by making sure they couldn't? We just need the courage to point out the obvious.
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A great visit to Padova to see my enthusiastic neurological colleagues led by
@MauCorbetta
Never visited before but this is a city of wonderful views, including of La Specola, the Observatory tower
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Great to have been involved in this fast moving project with
@MaximeTaquet
Paul Harrison & John Geddes: Risk of cerebral venous thrombosis (CVT) post COVID is 8 times higher than current estimates of CVT post AZ vaccination
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Cholinesterase inhibitors have different effects to dopaminergic drugs on attention and working memory in Lewy body dementias. An ON vs OFF rivastigmine study with
@dopaminded
@BrainInTheMind
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In healthy ageing, two factors - female sex and APOE e4 status - confer selective vulnerability of specific hippocampal subfields to volume loss.
New preprint with
@l_nobis
@NeuroFidelity
@BrainInTheMind
and
@MasudHusain
The human hippocampus and its subfield volume across age, sex and APOE e4 status
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This year it will be hybrid event with a small live audience Oxford and streamed around the world via Zoom and YouTube. Full details and registration via
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Review of Brain mechanisms underlying apathy with Campbell Le Heron, Clay Holroyd and John Salamone now out
@JNNP_BMJ
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A magisterial and, more importantly, a really interesting read on the history of
#Parkinsons
disease, including the big issues that we are still uncertain about and certainly shouldn’t assume have been answered. Free to download
@Brain1878
I'm putting this out again for those who might be interested showing my longstanding scepticsm to the notion of abnormal alpha synuclein aggregation as the cause of Parkinson's disease
@AlbertoEspay
An essay on the shaking palsy
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